BEACH-type PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1Z5_LEIIN

TriTrypDb:

LINF_260011300

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1Z5

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0006633	fatty acid biosynthetic process	5	2
GO:0008152	metabolic process	1	2
GO:0008610	lipid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0016053	organic acid biosynthetic process	4	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046394	carboxylic acid biosynthetic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0072330	monocarboxylic acid biosynthetic process	6	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016790	thiolester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.626
CLV_C14_Caspase3-7	68	72	PF00656	0.311
CLV_NRD_NRD_1	228	230	PF00675	0.327
CLV_NRD_NRD_1	285	287	PF00675	0.285
CLV_PCSK_KEX2_1	147	149	PF00082	0.367
CLV_PCSK_KEX2_1	228	230	PF00082	0.343
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.483
CLV_PCSK_SKI1_1	258	262	PF00082	0.319
DEG_APCC_DBOX_1	147	155	PF00400	0.310
DEG_Nend_UBRbox_3	1	3	PF02207	0.312
DEG_SPOP_SBC_1	332	336	PF00917	0.495
DOC_CKS1_1	137	142	PF01111	0.405
DOC_CKS1_1	25	30	PF01111	0.504
DOC_CKS1_1	33	38	PF01111	0.533
DOC_MAPK_FxFP_2	306	309	PF00069	0.310
DOC_MAPK_gen_1	371	380	PF00069	0.339
DOC_MAPK_RevD_3	274	287	PF00069	0.456
DOC_PP2B_LxvP_1	202	205	PF13499	0.457
DOC_PP4_FxxP_1	306	309	PF00568	0.310
DOC_PP4_FxxP_1	77	80	PF00568	0.538
DOC_USP7_MATH_1	186	190	PF00917	0.441
DOC_USP7_MATH_2	46	52	PF00917	0.486
DOC_USP7_UBL2_3	157	161	PF12436	0.443
DOC_WW_Pin1_4	136	141	PF00397	0.522
DOC_WW_Pin1_4	197	202	PF00397	0.569
DOC_WW_Pin1_4	24	29	PF00397	0.508
DOC_WW_Pin1_4	32	37	PF00397	0.520
DOC_WW_Pin1_4	344	349	PF00397	0.594
LIG_14-3-3_CanoR_1	172	180	PF00244	0.521
LIG_14-3-3_CanoR_1	373	379	PF00244	0.444
LIG_Actin_WH2_2	219	236	PF00022	0.484
LIG_APCC_Cbox_2	372	378	PF00515	0.370
LIG_BRCT_BRCA1_1	181	185	PF00533	0.388
LIG_BRCT_BRCA1_1	83	87	PF00533	0.414
LIG_Clathr_ClatBox_1	251	255	PF01394	0.288
LIG_Clathr_ClatBox_1	307	311	PF01394	0.329
LIG_EVH1_2	206	210	PF00568	0.326
LIG_FHA_1	247	253	PF00498	0.419
LIG_FHA_1	333	339	PF00498	0.529
LIG_FHA_1	345	351	PF00498	0.537
LIG_FHA_1	357	363	PF00498	0.342
LIG_FHA_1	375	381	PF00498	0.358
LIG_FHA_1	383	389	PF00498	0.433
LIG_FHA_2	108	114	PF00498	0.440
LIG_FHA_2	234	240	PF00498	0.409
LIG_FHA_2	25	31	PF00498	0.469
LIG_FHA_2	53	59	PF00498	0.409
LIG_IBAR_NPY_1	72	74	PF08397	0.350
LIG_LIR_Apic_2	303	309	PF02991	0.412
LIG_LIR_Apic_2	76	80	PF02991	0.405
LIG_LIR_Nem_3	100	105	PF02991	0.314
LIG_LIR_Nem_3	60	66	PF02991	0.316
LIG_LIR_Nem_3	71	77	PF02991	0.337
LIG_LIR_Nem_3	89	95	PF02991	0.299
LIG_PCNA_yPIPBox_3	245	258	PF02747	0.318
LIG_Pex14_2	122	126	PF04695	0.341
LIG_PTB_Apo_2	10	17	PF02174	0.450
LIG_PTB_Apo_2	96	103	PF02174	0.355
LIG_PTB_Phospho_1	96	102	PF10480	0.418
LIG_SH2_CRK	105	109	PF00017	0.314
LIG_SH2_CRK	199	203	PF00017	0.611
LIG_SH2_CRK	268	272	PF00017	0.451
LIG_SH2_STAP1	268	272	PF00017	0.441
LIG_SH2_STAT5	109	112	PF00017	0.351
LIG_SH2_STAT5	14	17	PF00017	0.452
LIG_SH2_STAT5	292	295	PF00017	0.338
LIG_SH2_STAT5	54	57	PF00017	0.459
LIG_SH2_STAT5	93	96	PF00017	0.522
LIG_SH3_1	157	163	PF00018	0.442
LIG_SH3_2	309	314	PF14604	0.357
LIG_SH3_3	157	163	PF00018	0.434
LIG_SH3_3	209	215	PF00018	0.409
LIG_SH3_3	271	277	PF00018	0.383
LIG_SH3_3	306	312	PF00018	0.329
LIG_SH3_3	357	363	PF00018	0.410
LIG_SUMO_SIM_anti_2	249	255	PF11976	0.356
LIG_SUMO_SIM_par_1	249	255	PF11976	0.412
LIG_TRFH_1	77	81	PF08558	0.450
LIG_WRC_WIRS_1	123	128	PF05994	0.409
LIG_WW_3	79	83	PF00397	0.449
MOD_CAAXbox	386	389	PF01239	0.381
MOD_CK1_1	100	106	PF00069	0.313
MOD_CK1_1	200	206	PF00069	0.587
MOD_CK1_1	57	63	PF00069	0.467
MOD_CK2_1	150	156	PF00069	0.360
MOD_CK2_1	24	30	PF00069	0.397
MOD_GlcNHglycan	156	160	PF01048	0.491
MOD_GlcNHglycan	181	184	PF01048	0.365
MOD_GlcNHglycan	188	191	PF01048	0.450
MOD_GlcNHglycan	202	205	PF01048	0.608
MOD_GlcNHglycan	324	327	PF01048	0.454
MOD_GSK3_1	122	129	PF00069	0.343
MOD_GSK3_1	146	153	PF00069	0.520
MOD_GSK3_1	186	193	PF00069	0.465
MOD_GSK3_1	296	303	PF00069	0.443
MOD_GSK3_1	317	324	PF00069	0.447
MOD_GSK3_1	48	55	PF00069	0.721
MOD_N-GLC_1	186	191	PF02516	0.596
MOD_N-GLC_1	98	103	PF02516	0.352
MOD_N-GLC_2	13	15	PF02516	0.453
MOD_NEK2_1	122	127	PF00069	0.306
MOD_NEK2_1	179	184	PF00069	0.384
MOD_NEK2_1	210	215	PF00069	0.397
MOD_NEK2_1	374	379	PF00069	0.434
MOD_PIKK_1	146	152	PF00454	0.448
MOD_PKA_2	171	177	PF00069	0.409
MOD_PKA_2	233	239	PF00069	0.362
MOD_PKA_2	81	87	PF00069	0.398
MOD_Plk_1	186	192	PF00069	0.448
MOD_Plk_1	3	9	PF00069	0.308
MOD_Plk_1	57	63	PF00069	0.356
MOD_Plk_1	98	104	PF00069	0.389
MOD_Plk_4	100	106	PF00069	0.477
MOD_Plk_4	107	113	PF00069	0.406
MOD_Plk_4	57	63	PF00069	0.439
MOD_ProDKin_1	136	142	PF00069	0.520
MOD_ProDKin_1	197	203	PF00069	0.570
MOD_ProDKin_1	24	30	PF00069	0.508
MOD_ProDKin_1	32	38	PF00069	0.529
MOD_ProDKin_1	344	350	PF00069	0.576
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.305
TRG_ENDOCYTIC_2	105	108	PF00928	0.309
TRG_ENDOCYTIC_2	109	112	PF00928	0.342
TRG_ENDOCYTIC_2	199	202	PF00928	0.613
TRG_ENDOCYTIC_2	268	271	PF00928	0.452
TRG_ENDOCYTIC_2	74	77	PF00928	0.511
TRG_NES_CRM1_1	351	366	PF08389	0.455
TRG_NLS_MonoExtC_3	285	291	PF00514	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IG55	Leptomonas seymouri	57%	92%
A0A1X0NSG4	Trypanosomatidae	36%	100%
A0A3Q8INZ4	Leishmania donovani	100%	94%
A0A3R7M5A1	Trypanosoma rangeli	35%	100%
A4HER8	Leishmania braziliensis	74%	100%
C9ZS19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AY42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q9D1	Leishmania major	91%	100%
V5B9E8	Trypanosoma cruzi	34%	100%