LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Protein of unknown function (DUF525) - putative
Species:
Leishmania infantum
UniProt:
A4I1Z0_LEIIN
TriTrypDb:
LINF_260010800
Length:
578

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0009295 nucleoid 2 1
GO:0042645 mitochondrial nucleoid 3 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I1Z0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1Z0

Function

Biological processes
Term Name Level Count
GO:0000731 DNA synthesis involved in DNA repair 6 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006259 DNA metabolic process 4 1
GO:0006281 DNA repair 5 1
GO:0006301 postreplication repair 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006950 response to stress 2 1
GO:0006974 DNA damage response 4 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009059 macromolecule biosynthetic process 4 1
GO:0009987 cellular process 1 1
GO:0018130 heterocycle biosynthetic process 4 1
GO:0019438 aromatic compound biosynthetic process 4 1
GO:0019985 translesion synthesis 7 1
GO:0033554 cellular response to stress 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034654 nucleobase-containing compound biosynthetic process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0046483 heterocycle metabolic process 3 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
GO:0070987 error-free translesion synthesis 8 1
GO:0071704 organic substance metabolic process 2 1
GO:0071897 DNA biosynthetic process 5 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901362 organic cyclic compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 102 104 PF00675 0.431
CLV_NRD_NRD_1 182 184 PF00675 0.453
CLV_NRD_NRD_1 290 292 PF00675 0.608
CLV_NRD_NRD_1 321 323 PF00675 0.335
CLV_NRD_NRD_1 84 86 PF00675 0.340
CLV_PCSK_KEX2_1 102 104 PF00082 0.431
CLV_PCSK_KEX2_1 181 183 PF00082 0.510
CLV_PCSK_KEX2_1 321 323 PF00082 0.335
CLV_PCSK_KEX2_1 421 423 PF00082 0.315
CLV_PCSK_KEX2_1 84 86 PF00082 0.340
CLV_PCSK_PC1ET2_1 421 423 PF00082 0.315
CLV_PCSK_PC7_1 178 184 PF00082 0.509
CLV_PCSK_SKI1_1 291 295 PF00082 0.579
CLV_PCSK_SKI1_1 519 523 PF00082 0.510
CLV_PCSK_SKI1_1 9 13 PF00082 0.337
CLV_Separin_Metazoa 318 322 PF03568 0.409
DEG_APCC_DBOX_1 312 320 PF00400 0.356
DEG_SCF_FBW7_1 128 133 PF00400 0.568
DEG_SPOP_SBC_1 369 373 PF00917 0.660
DOC_MAPK_gen_1 291 298 PF00069 0.543
DOC_MAPK_MEF2A_6 479 486 PF00069 0.309
DOC_PP4_FxxP_1 206 209 PF00568 0.450
DOC_PP4_FxxP_1 59 62 PF00568 0.395
DOC_SPAK_OSR1_1 205 209 PF12202 0.467
DOC_USP7_MATH_1 118 122 PF00917 0.569
DOC_USP7_MATH_1 130 134 PF00917 0.585
DOC_USP7_MATH_1 146 150 PF00917 0.545
DOC_USP7_MATH_1 210 214 PF00917 0.454
DOC_USP7_MATH_1 217 221 PF00917 0.354
DOC_USP7_MATH_1 246 250 PF00917 0.433
DOC_USP7_MATH_1 286 290 PF00917 0.620
DOC_USP7_MATH_1 353 357 PF00917 0.552
DOC_USP7_MATH_1 362 366 PF00917 0.704
DOC_USP7_MATH_1 369 373 PF00917 0.667
DOC_USP7_MATH_1 459 463 PF00917 0.250
DOC_USP7_MATH_1 561 565 PF00917 0.585
DOC_USP7_MATH_1 74 78 PF00917 0.492
DOC_WW_Pin1_4 124 129 PF00397 0.622
DOC_WW_Pin1_4 351 356 PF00397 0.655
DOC_WW_Pin1_4 371 376 PF00397 0.560
LIG_14-3-3_CanoR_1 13 19 PF00244 0.281
LIG_14-3-3_CanoR_1 268 275 PF00244 0.506
LIG_14-3-3_CanoR_1 504 508 PF00244 0.399
LIG_14-3-3_CanoR_1 75 83 PF00244 0.393
LIG_Actin_WH2_2 48 63 PF00022 0.376
LIG_Actin_WH2_2 76 92 PF00022 0.412
LIG_APCC_ABBA_1 484 489 PF00400 0.387
LIG_BIR_III_2 125 129 PF00653 0.546
LIG_BRCT_BRCA1_1 143 147 PF00533 0.593
LIG_BRCT_BRCA1_1 461 465 PF00533 0.309
LIG_BRCT_BRCA1_1 76 80 PF00533 0.401
LIG_Clathr_ClatBox_1 432 436 PF01394 0.309
LIG_CtBP_PxDLS_1 196 200 PF00389 0.517
LIG_EVH1_2 202 206 PF00568 0.478
LIG_FHA_1 153 159 PF00498 0.610
LIG_FHA_1 226 232 PF00498 0.333
LIG_FHA_1 298 304 PF00498 0.511
LIG_FHA_1 323 329 PF00498 0.387
LIG_FHA_1 338 344 PF00498 0.460
LIG_FHA_1 371 377 PF00498 0.567
LIG_FHA_1 504 510 PF00498 0.422
LIG_FHA_1 55 61 PF00498 0.372
LIG_FHA_2 15 21 PF00498 0.362
LIG_FHA_2 309 315 PF00498 0.370
LIG_LIR_Apic_2 19 25 PF02991 0.355
LIG_LIR_Apic_2 57 62 PF02991 0.383
LIG_LIR_Gen_1 27 37 PF02991 0.371
LIG_LIR_Gen_1 77 86 PF02991 0.394
LIG_LIR_LC3C_4 429 434 PF02991 0.309
LIG_LIR_Nem_3 220 225 PF02991 0.376
LIG_LIR_Nem_3 27 33 PF02991 0.313
LIG_LIR_Nem_3 49 54 PF02991 0.365
LIG_LIR_Nem_3 6 11 PF02991 0.328
LIG_LIR_Nem_3 77 83 PF02991 0.393
LIG_MYND_1 455 459 PF01753 0.250
LIG_PTB_Apo_2 41 48 PF02174 0.366
LIG_PTB_Phospho_1 41 47 PF10480 0.364
LIG_SH2_CRK 8 12 PF00017 0.326
LIG_SH2_NCK_1 22 26 PF00017 0.412
LIG_SH2_PTP2 408 411 PF00017 0.309
LIG_SH2_SRC 22 25 PF00017 0.410
LIG_SH2_SRC 408 411 PF00017 0.309
LIG_SH2_STAT5 214 217 PF00017 0.411
LIG_SH2_STAT5 342 345 PF00017 0.420
LIG_SH2_STAT5 408 411 PF00017 0.288
LIG_SH3_3 140 146 PF00018 0.522
LIG_SH3_3 155 161 PF00018 0.608
LIG_SH3_3 190 196 PF00018 0.455
LIG_SH3_3 206 212 PF00018 0.337
LIG_SUMO_SIM_par_1 213 221 PF11976 0.534
LIG_SUMO_SIM_par_1 228 235 PF11976 0.223
LIG_SUMO_SIM_par_1 331 337 PF11976 0.338
LIG_SUMO_SIM_par_1 431 436 PF11976 0.309
LIG_SUMO_SIM_par_1 505 511 PF11976 0.448
LIG_TRAF2_1 148 151 PF00917 0.505
LIG_TRAF2_1 281 284 PF00917 0.588
LIG_TRAF2_1 312 315 PF00917 0.438
LIG_TRAF2_1 521 524 PF00917 0.520
LIG_TYR_ITIM 406 411 PF00017 0.309
MOD_CDK_SPxK_1 371 377 PF00069 0.567
MOD_CK1_1 121 127 PF00069 0.582
MOD_CK1_1 149 155 PF00069 0.750
MOD_CK1_1 235 241 PF00069 0.307
MOD_CK1_1 345 351 PF00069 0.508
MOD_CK1_1 371 377 PF00069 0.547
MOD_CK1_1 390 396 PF00069 0.669
MOD_CK1_1 467 473 PF00069 0.250
MOD_CK1_1 73 79 PF00069 0.503
MOD_CK2_1 278 284 PF00069 0.584
MOD_CK2_1 308 314 PF00069 0.376
MOD_CK2_1 353 359 PF00069 0.615
MOD_CK2_1 469 475 PF00069 0.309
MOD_GlcNHglycan 112 115 PF01048 0.523
MOD_GlcNHglycan 120 123 PF01048 0.545
MOD_GlcNHglycan 133 136 PF01048 0.738
MOD_GlcNHglycan 234 237 PF01048 0.285
MOD_GlcNHglycan 254 257 PF01048 0.580
MOD_GlcNHglycan 264 267 PF01048 0.558
MOD_GlcNHglycan 269 272 PF01048 0.561
MOD_GlcNHglycan 347 350 PF01048 0.520
MOD_GlcNHglycan 355 358 PF01048 0.505
MOD_GlcNHglycan 387 390 PF01048 0.702
MOD_GlcNHglycan 466 469 PF01048 0.250
MOD_GlcNHglycan 471 474 PF01048 0.250
MOD_GlcNHglycan 5 8 PF01048 0.393
MOD_GlcNHglycan 510 513 PF01048 0.590
MOD_GlcNHglycan 531 535 PF01048 0.690
MOD_GlcNHglycan 537 540 PF01048 0.781
MOD_GlcNHglycan 555 558 PF01048 0.525
MOD_GlcNHglycan 72 75 PF01048 0.365
MOD_GlcNHglycan 76 79 PF01048 0.338
MOD_GSK3_1 120 127 PF00069 0.517
MOD_GSK3_1 149 156 PF00069 0.609
MOD_GSK3_1 258 265 PF00069 0.632
MOD_GSK3_1 324 331 PF00069 0.385
MOD_GSK3_1 503 510 PF00069 0.454
MOD_GSK3_1 70 77 PF00069 0.436
MOD_N-GLC_1 185 190 PF02516 0.468
MOD_N-GLC_1 287 292 PF02516 0.571
MOD_NEK2_1 232 237 PF00069 0.277
MOD_NEK2_1 262 267 PF00069 0.518
MOD_NEK2_1 297 302 PF00069 0.454
MOD_NEK2_1 370 375 PF00069 0.558
MOD_NEK2_1 478 483 PF00069 0.309
MOD_NEK2_1 515 520 PF00069 0.548
MOD_NEK2_1 89 94 PF00069 0.553
MOD_PIKK_1 146 152 PF00454 0.564
MOD_PKA_2 170 176 PF00069 0.484
MOD_PKA_2 177 183 PF00069 0.512
MOD_PKA_2 267 273 PF00069 0.598
MOD_PKA_2 478 484 PF00069 0.250
MOD_PKA_2 503 509 PF00069 0.414
MOD_PKA_2 529 535 PF00069 0.544
MOD_PKA_2 567 573 PF00069 0.605
MOD_PKA_2 60 66 PF00069 0.352
MOD_PKA_2 74 80 PF00069 0.341
MOD_PKB_1 528 536 PF00069 0.560
MOD_Plk_2-3 273 279 PF00069 0.619
MOD_Plk_4 170 176 PF00069 0.425
MOD_Plk_4 210 216 PF00069 0.462
MOD_Plk_4 235 241 PF00069 0.362
MOD_ProDKin_1 124 130 PF00069 0.620
MOD_ProDKin_1 351 357 PF00069 0.647
MOD_ProDKin_1 371 377 PF00069 0.567
MOD_SUMO_for_1 521 524 PF00179 0.496
MOD_SUMO_rev_2 398 402 PF00179 0.313
MOD_SUMO_rev_2 544 554 PF00179 0.588
TRG_DiLeu_BaEn_1 165 170 PF01217 0.467
TRG_DiLeu_BaEn_1 211 216 PF01217 0.457
TRG_DiLeu_BaEn_1 315 320 PF01217 0.427
TRG_DiLeu_BaLyEn_6 452 457 PF01217 0.250
TRG_ENDOCYTIC_2 408 411 PF00928 0.246
TRG_ENDOCYTIC_2 8 11 PF00928 0.328
TRG_ER_diArg_1 101 103 PF00400 0.440
TRG_ER_diArg_1 181 183 PF00400 0.510
TRG_ER_diArg_1 320 322 PF00400 0.346
TRG_ER_diArg_1 411 414 PF00400 0.309
TRG_ER_diArg_1 83 85 PF00400 0.342
TRG_ER_diArg_1 96 99 PF00400 0.427
TRG_ER_diLys_1 573 578 PF00400 0.655
TRG_NES_CRM1_1 27 41 PF08389 0.313
TRG_Pf-PMV_PEXEL_1 84 88 PF00026 0.409

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I464 Leptomonas seymouri 62% 97%
A0A1X0NSE4 Trypanosomatidae 33% 100%
A0A3Q8IGW6 Leishmania donovani 100% 100%
A4HER3 Leishmania braziliensis 81% 100%
E9AY37 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q9D6 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS