LeishMANIAdb
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Galactofuranosyltransferase lpg1-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Galactofuranosyltransferase lpg1-like protein
Gene product:
galactofuranosyltransferase lpg1-like protein
Species:
Leishmania infantum
UniProt:
A4I1Y7_LEIIN
TriTrypDb:
LINF_260010500
Length:
538

Annotations

LeishMANIAdb annotations

A large family of glycosyltransferases expanded in parazitic kinetoplastids (and even more in T cruzi). Localization: ER (by homology)

Annotations by Jardim et al.

Glycolipid biosynthesis, Galactofuranosyltransferase lpg1-like LPG1L

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4I1Y7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1Y7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 20
GO:0016740 transferase activity 2 20

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 267 271 PF00656 0.399
CLV_C14_Caspase3-7 414 418 PF00656 0.507
CLV_C14_Caspase3-7 70 74 PF00656 0.603
CLV_NRD_NRD_1 112 114 PF00675 0.493
CLV_NRD_NRD_1 195 197 PF00675 0.331
CLV_NRD_NRD_1 308 310 PF00675 0.731
CLV_NRD_NRD_1 330 332 PF00675 0.342
CLV_NRD_NRD_1 429 431 PF00675 0.666
CLV_NRD_NRD_1 449 451 PF00675 0.367
CLV_NRD_NRD_1 480 482 PF00675 0.648
CLV_NRD_NRD_1 519 521 PF00675 0.574
CLV_PCSK_KEX2_1 112 114 PF00082 0.566
CLV_PCSK_KEX2_1 195 197 PF00082 0.522
CLV_PCSK_KEX2_1 330 332 PF00082 0.342
CLV_PCSK_KEX2_1 480 482 PF00082 0.491
CLV_PCSK_KEX2_1 519 521 PF00082 0.566
CLV_PCSK_PC7_1 108 114 PF00082 0.369
CLV_PCSK_PC7_1 515 521 PF00082 0.524
CLV_PCSK_SKI1_1 195 199 PF00082 0.504
CLV_PCSK_SKI1_1 224 228 PF00082 0.392
CLV_PCSK_SKI1_1 294 298 PF00082 0.610
CLV_PCSK_SKI1_1 324 328 PF00082 0.357
CLV_PCSK_SKI1_1 431 435 PF00082 0.718
CLV_PCSK_SKI1_1 450 454 PF00082 0.361
CLV_PCSK_SKI1_1 519 523 PF00082 0.543
DEG_APCC_DBOX_1 503 511 PF00400 0.463
DEG_SPOP_SBC_1 21 25 PF00917 0.535
DOC_CDC14_PxL_1 231 239 PF14671 0.288
DOC_CKS1_1 299 304 PF01111 0.421
DOC_CKS1_1 325 330 PF01111 0.371
DOC_CYCLIN_yClb5_NLxxxL_5 506 514 PF00134 0.334
DOC_CYCLIN_yCln2_LP_2 169 175 PF00134 0.302
DOC_CYCLIN_yCln2_LP_2 493 499 PF00134 0.329
DOC_MAPK_gen_1 112 119 PF00069 0.445
DOC_MAPK_gen_1 330 336 PF00069 0.337
DOC_MAPK_gen_1 381 389 PF00069 0.324
DOC_MAPK_gen_1 80 88 PF00069 0.687
DOC_MAPK_MEF2A_6 357 365 PF00069 0.398
DOC_PP1_RVXF_1 110 117 PF00149 0.471
DOC_PP2B_LxvP_1 169 172 PF13499 0.307
DOC_PP2B_LxvP_1 296 299 PF13499 0.545
DOC_PP2B_LxvP_1 493 496 PF13499 0.357
DOC_WW_Pin1_4 127 132 PF00397 0.314
DOC_WW_Pin1_4 181 186 PF00397 0.435
DOC_WW_Pin1_4 281 286 PF00397 0.559
DOC_WW_Pin1_4 298 303 PF00397 0.507
DOC_WW_Pin1_4 324 329 PF00397 0.590
DOC_WW_Pin1_4 436 441 PF00397 0.498
LIG_14-3-3_CanoR_1 112 117 PF00244 0.423
LIG_14-3-3_CanoR_1 126 130 PF00244 0.412
LIG_14-3-3_CanoR_1 203 207 PF00244 0.326
LIG_14-3-3_CanoR_1 245 255 PF00244 0.429
LIG_BIR_II_1 1 5 PF00653 0.551
LIG_BIR_III_2 30 34 PF00653 0.557
LIG_BIR_III_2 73 77 PF00653 0.538
LIG_BIR_III_3 1 5 PF00653 0.540
LIG_BIR_III_4 415 419 PF00653 0.501
LIG_BRCT_BRCA1_1 227 231 PF00533 0.525
LIG_BRCT_BRCA1_1 339 343 PF00533 0.421
LIG_deltaCOP1_diTrp_1 379 389 PF00928 0.394
LIG_FHA_1 157 163 PF00498 0.493
LIG_FHA_1 182 188 PF00498 0.463
LIG_FHA_1 199 205 PF00498 0.342
LIG_FHA_1 264 270 PF00498 0.603
LIG_FHA_1 282 288 PF00498 0.506
LIG_FHA_1 293 299 PF00498 0.625
LIG_FHA_1 313 319 PF00498 0.369
LIG_FHA_1 527 533 PF00498 0.503
LIG_FHA_1 66 72 PF00498 0.577
LIG_FHA_2 131 137 PF00498 0.398
LIG_FHA_2 260 266 PF00498 0.416
LIG_FHA_2 477 483 PF00498 0.391
LIG_FHA_2 68 74 PF00498 0.744
LIG_LIR_Gen_1 115 124 PF02991 0.420
LIG_LIR_Gen_1 228 239 PF02991 0.316
LIG_LIR_Gen_1 349 358 PF02991 0.363
LIG_LIR_Nem_3 115 119 PF02991 0.423
LIG_LIR_Nem_3 144 150 PF02991 0.501
LIG_LIR_Nem_3 170 176 PF02991 0.382
LIG_LIR_Nem_3 188 194 PF02991 0.423
LIG_LIR_Nem_3 228 234 PF02991 0.372
LIG_LIR_Nem_3 282 286 PF02991 0.463
LIG_LIR_Nem_3 349 353 PF02991 0.435
LIG_LIR_Nem_3 367 373 PF02991 0.326
LIG_MYND_1 436 440 PF01753 0.393
LIG_NRBOX 292 298 PF00104 0.402
LIG_Pex14_2 366 370 PF04695 0.318
LIG_REV1ctd_RIR_1 188 196 PF16727 0.284
LIG_SH2_CRK 173 177 PF00017 0.402
LIG_SH2_CRK 283 287 PF00017 0.455
LIG_SH2_CRK 325 329 PF00017 0.411
LIG_SH2_CRK 350 354 PF00017 0.414
LIG_SH2_CRK 454 458 PF00017 0.540
LIG_SH2_NCK_1 350 354 PF00017 0.414
LIG_SH2_PTP2 175 178 PF00017 0.387
LIG_SH2_STAP1 350 354 PF00017 0.405
LIG_SH2_STAP1 92 96 PF00017 0.368
LIG_SH2_STAT3 461 464 PF00017 0.311
LIG_SH2_STAT5 175 178 PF00017 0.416
LIG_SH2_STAT5 283 286 PF00017 0.458
LIG_SH2_STAT5 350 353 PF00017 0.410
LIG_SH3_3 103 109 PF00018 0.506
LIG_SH3_3 296 302 PF00018 0.593
LIG_SH3_3 58 64 PF00018 0.605
LIG_SUMO_SIM_anti_2 201 208 PF11976 0.303
LIG_SUMO_SIM_anti_2 356 362 PF11976 0.385
LIG_SUMO_SIM_par_1 150 155 PF11976 0.343
LIG_SUMO_SIM_par_1 310 316 PF11976 0.394
LIG_SUMO_SIM_par_1 520 525 PF11976 0.471
LIG_TRFH_1 105 109 PF08558 0.388
LIG_UBA3_1 268 274 PF00899 0.349
LIG_WRC_WIRS_1 401 406 PF05994 0.427
MOD_CDK_SPK_2 436 441 PF00069 0.359
MOD_CDK_SPxK_1 324 330 PF00069 0.339
MOD_CDK_SPxxK_3 185 192 PF00069 0.287
MOD_CDK_SPxxK_3 281 288 PF00069 0.556
MOD_CDK_SPxxK_3 324 331 PF00069 0.354
MOD_CDK_SPxxK_3 436 443 PF00069 0.484
MOD_CK1_1 130 136 PF00069 0.475
MOD_CK1_1 38 44 PF00069 0.589
MOD_CK2_1 112 118 PF00069 0.432
MOD_CK2_1 130 136 PF00069 0.339
MOD_CK2_1 246 252 PF00069 0.328
MOD_CK2_1 343 349 PF00069 0.464
MOD_CK2_1 467 473 PF00069 0.539
MOD_CK2_1 476 482 PF00069 0.478
MOD_Cter_Amidation 517 520 PF01082 0.458
MOD_GlcNHglycan 18 21 PF01048 0.625
MOD_GlcNHglycan 315 318 PF01048 0.401
MOD_GlcNHglycan 484 487 PF01048 0.604
MOD_GSK3_1 11 18 PF00069 0.587
MOD_GSK3_1 152 159 PF00069 0.450
MOD_GSK3_1 181 188 PF00069 0.460
MOD_GSK3_1 198 205 PF00069 0.405
MOD_GSK3_1 22 29 PF00069 0.547
MOD_GSK3_1 225 232 PF00069 0.335
MOD_GSK3_1 259 266 PF00069 0.472
MOD_GSK3_1 34 41 PF00069 0.531
MOD_GSK3_1 349 356 PF00069 0.384
MOD_GSK3_1 505 512 PF00069 0.600
MOD_GSK3_1 65 72 PF00069 0.586
MOD_LATS_1 110 116 PF00433 0.318
MOD_N-GLC_1 167 172 PF02516 0.365
MOD_NEK2_1 150 155 PF00069 0.423
MOD_NEK2_1 198 203 PF00069 0.380
MOD_NEK2_1 246 251 PF00069 0.364
MOD_NEK2_1 343 348 PF00069 0.431
MOD_PIKK_1 156 162 PF00454 0.502
MOD_PKA_1 112 118 PF00069 0.334
MOD_PKA_2 11 17 PF00069 0.617
MOD_PKA_2 112 118 PF00069 0.469
MOD_PKA_2 125 131 PF00069 0.421
MOD_PKA_2 202 208 PF00069 0.378
MOD_PKA_2 263 269 PF00069 0.500
MOD_PKA_2 505 511 PF00069 0.529
MOD_PKA_2 82 88 PF00069 0.562
MOD_Plk_1 167 173 PF00069 0.350
MOD_Plk_1 348 354 PF00069 0.432
MOD_Plk_4 202 208 PF00069 0.457
MOD_Plk_4 337 343 PF00069 0.413
MOD_Plk_4 349 355 PF00069 0.248
MOD_ProDKin_1 127 133 PF00069 0.326
MOD_ProDKin_1 181 187 PF00069 0.431
MOD_ProDKin_1 281 287 PF00069 0.557
MOD_ProDKin_1 298 304 PF00069 0.496
MOD_ProDKin_1 324 330 PF00069 0.591
MOD_ProDKin_1 436 442 PF00069 0.488
MOD_SUMO_rev_2 157 165 PF00179 0.414
TRG_DiLeu_BaLyEn_6 189 194 PF01217 0.473
TRG_DiLeu_LyEn_5 282 287 PF01217 0.588
TRG_ENDOCYTIC_2 147 150 PF00928 0.389
TRG_ENDOCYTIC_2 173 176 PF00928 0.410
TRG_ENDOCYTIC_2 283 286 PF00928 0.458
TRG_ENDOCYTIC_2 350 353 PF00928 0.360
TRG_ENDOCYTIC_2 454 457 PF00928 0.570
TRG_ENDOCYTIC_2 459 462 PF00928 0.425
TRG_ER_diArg_1 112 114 PF00400 0.524
TRG_ER_diArg_1 194 196 PF00400 0.330
TRG_ER_diArg_1 322 325 PF00400 0.415
TRG_ER_diArg_1 492 495 PF00400 0.525
TRG_ER_diArg_1 504 507 PF00400 0.402
TRG_ER_diArg_1 519 521 PF00400 0.563
TRG_NES_CRM1_1 98 111 PF08389 0.359
TRG_Pf-PMV_PEXEL_1 519 523 PF00026 0.648

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJD9 Leptomonas seymouri 50% 95%
A0A0N1PC27 Leptomonas seymouri 27% 100%
A0A0N1PES8 Leptomonas seymouri 31% 100%
A0A1X0NWM3 Trypanosomatidae 30% 100%
A0A3R7N1J7 Trypanosoma rangeli 30% 100%
A0A3S5H7D9 Leishmania donovani 29% 100%
A0A3S7WZK8 Leishmania donovani 99% 100%
A0A3S7X6F1 Leishmania donovani 29% 100%
A4HDU8 Leishmania braziliensis 29% 98%
A4HER0 Leishmania braziliensis 78% 100%
A4I143 Leishmania infantum 29% 100%
A4I8P7 Leishmania infantum 29% 100%
E9AXX9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 99%
E9AY34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9B3L0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
Q05889 Leishmania donovani 28% 100%
Q4Q9D9 Leishmania major 92% 100%
Q6XFB5 Leishmania major 29% 100%
Q9NC61 Leishmania major 29% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS