Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania infantum

UniProt:

A4I1Y1_LEIIN

TriTrypDb:

LINF_260009500

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 3
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4I1Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1Y1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.423
CLV_NRD_NRD_1	106	108	PF00675	0.396
CLV_NRD_NRD_1	284	286	PF00675	0.442
CLV_NRD_NRD_1	92	94	PF00675	0.585
CLV_PCSK_KEX2_1	106	108	PF00082	0.366
CLV_PCSK_KEX2_1	92	94	PF00082	0.615
CLV_PCSK_SKI1_1	151	155	PF00082	0.459
CLV_PCSK_SKI1_1	285	289	PF00082	0.491
CLV_PCSK_SKI1_1	445	449	PF00082	0.427
DEG_APCC_DBOX_1	136	144	PF00400	0.472
DEG_APCC_DBOX_1	284	292	PF00400	0.448
DEG_APCC_DBOX_1	316	324	PF00400	0.518
DOC_CKS1_1	256	261	PF01111	0.557
DOC_CKS1_1	58	63	PF01111	0.578
DOC_MAPK_HePTP_8	8	20	PF00069	0.492
DOC_MAPK_MEF2A_6	11	20	PF00069	0.392
DOC_MAPK_MEF2A_6	233	242	PF00069	0.387
DOC_MAPK_MEF2A_6	73	82	PF00069	0.379
DOC_MAPK_RevD_3	77	93	PF00069	0.376
DOC_PP2B_LxvP_1	122	125	PF13499	0.421
DOC_PP4_FxxP_1	154	157	PF00568	0.434
DOC_USP7_MATH_1	136	140	PF00917	0.550
DOC_USP7_MATH_1	248	252	PF00917	0.406
DOC_USP7_MATH_1	384	388	PF00917	0.463
DOC_USP7_MATH_1	437	441	PF00917	0.497
DOC_WW_Pin1_4	255	260	PF00397	0.611
DOC_WW_Pin1_4	433	438	PF00397	0.524
DOC_WW_Pin1_4	57	62	PF00397	0.569
LIG_14-3-3_CanoR_1	119	123	PF00244	0.575
LIG_14-3-3_CanoR_1	137	141	PF00244	0.464
LIG_14-3-3_CanoR_1	223	230	PF00244	0.537
LIG_14-3-3_CanoR_1	279	288	PF00244	0.447
LIG_14-3-3_CanoR_1	385	389	PF00244	0.650
LIG_14-3-3_CanoR_1	55	59	PF00244	0.550
LIG_Actin_WH2_2	136	153	PF00022	0.412
LIG_BRCT_BRCA1_1	110	114	PF00533	0.343
LIG_BRCT_BRCA1_1	395	399	PF00533	0.419
LIG_BRCT_BRCA1_1	425	429	PF00533	0.459
LIG_FHA_1	276	282	PF00498	0.367
LIG_FHA_1	307	313	PF00498	0.476
LIG_FHA_1	7	13	PF00498	0.429
LIG_FHA_2	130	136	PF00498	0.580
LIG_FHA_2	182	188	PF00498	0.568
LIG_FHA_2	256	262	PF00498	0.505
LIG_FHA_2	384	390	PF00498	0.433
LIG_LIR_Apic_2	254	259	PF02991	0.413
LIG_LIR_Gen_1	161	171	PF02991	0.441
LIG_LIR_LC3C_4	236	240	PF02991	0.389
LIG_LIR_Nem_3	161	166	PF02991	0.397
LIG_LIR_Nem_3	398	404	PF02991	0.499
LIG_NRP_CendR_1	449	450	PF00754	0.407
LIG_Pex14_2	342	346	PF04695	0.523
LIG_PTAP_UEV_1	354	359	PF05743	0.476
LIG_PTB_Apo_2	177	184	PF02174	0.581
LIG_PTB_Phospho_1	177	183	PF10480	0.376
LIG_SH2_CRK	163	167	PF00017	0.513
LIG_SH2_CRK	213	217	PF00017	0.374
LIG_SH2_CRK	369	373	PF00017	0.589
LIG_SH2_STAP1	213	217	PF00017	0.374
LIG_SH2_STAP1	299	303	PF00017	0.484
LIG_SH2_STAP1	443	447	PF00017	0.420
LIG_SH2_STAT3	295	298	PF00017	0.375
LIG_SH2_STAT5	183	186	PF00017	0.453
LIG_SH2_STAT5	208	211	PF00017	0.495
LIG_SH2_STAT5	213	216	PF00017	0.505
LIG_SH2_STAT5	272	275	PF00017	0.390
LIG_SH2_STAT5	280	283	PF00017	0.334
LIG_SH2_STAT5	296	299	PF00017	0.417
LIG_SH2_STAT5	7	10	PF00017	0.506
LIG_SH3_2	355	360	PF14604	0.478
LIG_SH3_3	167	173	PF00018	0.477
LIG_SH3_3	352	358	PF00018	0.653
LIG_SH3_3	55	61	PF00018	0.535
LIG_SUMO_SIM_anti_2	236	242	PF11976	0.452
LIG_SUMO_SIM_anti_2	318	324	PF11976	0.523
LIG_SUMO_SIM_par_1	238	244	PF11976	0.443
LIG_SUMO_SIM_par_1	78	84	PF11976	0.425
LIG_TRAF2_1	185	188	PF00917	0.516
LIG_TYR_ITSM	159	166	PF00017	0.441
MOD_CDK_SPK_2	255	260	PF00069	0.478
MOD_CK1_1	129	135	PF00069	0.639
MOD_CK1_1	182	188	PF00069	0.419
MOD_CK1_1	251	257	PF00069	0.580
MOD_CK1_1	321	327	PF00069	0.617
MOD_CK1_1	395	401	PF00069	0.552
MOD_CK1_1	57	63	PF00069	0.533
MOD_CK1_1	65	71	PF00069	0.487
MOD_CK1_1	88	94	PF00069	0.545
MOD_CK2_1	136	142	PF00069	0.433
MOD_CK2_1	181	187	PF00069	0.530
MOD_CK2_1	383	389	PF00069	0.436
MOD_GlcNHglycan	110	113	PF01048	0.421
MOD_GlcNHglycan	225	228	PF01048	0.539
MOD_GlcNHglycan	348	351	PF01048	0.665
MOD_GlcNHglycan	355	358	PF01048	0.648
MOD_GlcNHglycan	408	411	PF01048	0.496
MOD_GSK3_1	251	258	PF00069	0.419
MOD_GSK3_1	346	353	PF00069	0.543
MOD_GSK3_1	393	400	PF00069	0.644
MOD_GSK3_1	433	440	PF00069	0.517
MOD_GSK3_1	53	60	PF00069	0.547
MOD_GSK3_1	62	69	PF00069	0.482
MOD_N-GLC_1	158	163	PF02516	0.391
MOD_N-GLC_1	179	184	PF02516	0.604
MOD_N-GLC_1	326	331	PF02516	0.645
MOD_N-GLC_1	337	342	PF02516	0.475
MOD_N-GLC_1	350	355	PF02516	0.629
MOD_N-GLC_1	416	421	PF02516	0.648
MOD_N-GLC_1	95	100	PF02516	0.539
MOD_NEK2_1	181	186	PF00069	0.594
MOD_NEK2_1	336	341	PF00069	0.620
MOD_NEK2_1	346	351	PF00069	0.555
MOD_NEK2_1	394	399	PF00069	0.573
MOD_NEK2_1	66	71	PF00069	0.386
MOD_NEK2_2	248	253	PF00069	0.495
MOD_NEK2_2	280	285	PF00069	0.433
MOD_PIKK_1	200	206	PF00454	0.460
MOD_PKA_2	118	124	PF00069	0.523
MOD_PKA_2	136	142	PF00069	0.550
MOD_PKA_2	384	390	PF00069	0.642
MOD_PKA_2	54	60	PF00069	0.540
MOD_Plk_1	158	164	PF00069	0.384
MOD_Plk_1	179	185	PF00069	0.610
MOD_Plk_1	200	206	PF00069	0.502
MOD_Plk_1	318	324	PF00069	0.706
MOD_Plk_1	337	343	PF00069	0.654
MOD_Plk_4	318	324	PF00069	0.590
MOD_Plk_4	54	60	PF00069	0.558
MOD_Plk_4	85	91	PF00069	0.485
MOD_ProDKin_1	255	261	PF00069	0.615
MOD_ProDKin_1	433	439	PF00069	0.515
MOD_ProDKin_1	57	63	PF00069	0.574
TRG_ENDOCYTIC_2	163	166	PF00928	0.518
TRG_ENDOCYTIC_2	213	216	PF00928	0.390
TRG_ENDOCYTIC_2	369	372	PF00928	0.546
TRG_ENDOCYTIC_2	404	407	PF00928	0.422
TRG_ER_diArg_1	105	107	PF00400	0.495
TRG_ER_diArg_1	448	450	PF00400	0.388
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P2	Leptomonas seymouri	37%	97%
A0A1X0NSG2	Trypanosomatidae	21%	100%
A0A3Q8ICS7	Leishmania donovani	100%	100%
A0A3R7NPG1	Trypanosoma rangeli	24%	100%
A4HEQ1	Leishmania braziliensis	72%	100%
C9ZS38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AY27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q9E6	Leishmania major	90%	100%