LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I1Y0_LEIIN
TriTrypDb:
LINF_260009400
Length:
332

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
GO:0005743 mitochondrial inner membrane 5 1
GO:0019866 organelle inner membrane 4 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I1Y0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1Y0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 163 167 PF00656 0.602
CLV_NRD_NRD_1 16 18 PF00675 0.478
CLV_NRD_NRD_1 27 29 PF00675 0.406
CLV_PCSK_KEX2_1 16 18 PF00082 0.478
CLV_PCSK_KEX2_1 27 29 PF00082 0.406
CLV_PCSK_SKI1_1 224 228 PF00082 0.266
DEG_Nend_UBRbox_3 1 3 PF02207 0.627
DOC_CYCLIN_RxL_1 218 230 PF00134 0.558
DOC_MAPK_gen_1 16 26 PF00069 0.689
DOC_PP1_RVXF_1 222 229 PF00149 0.413
DOC_USP7_MATH_1 144 148 PF00917 0.661
DOC_USP7_MATH_1 155 159 PF00917 0.624
DOC_USP7_MATH_1 239 243 PF00917 0.213
DOC_USP7_MATH_1 64 68 PF00917 0.671
DOC_USP7_MATH_1 77 81 PF00917 0.603
DOC_WW_Pin1_4 100 105 PF00397 0.670
DOC_WW_Pin1_4 201 206 PF00397 0.710
DOC_WW_Pin1_4 44 49 PF00397 0.690
DOC_WW_Pin1_4 78 83 PF00397 0.656
LIG_14-3-3_CanoR_1 27 32 PF00244 0.633
LIG_14-3-3_CanoR_1 95 104 PF00244 0.628
LIG_BRCT_BRCA1_1 96 100 PF00533 0.640
LIG_CtBP_PxDLS_1 48 52 PF00389 0.584
LIG_deltaCOP1_diTrp_1 302 311 PF00928 0.406
LIG_FHA_1 19 25 PF00498 0.715
LIG_FHA_2 122 128 PF00498 0.609
LIG_FHA_2 158 164 PF00498 0.680
LIG_FHA_2 56 62 PF00498 0.717
LIG_LIR_Gen_1 230 239 PF02991 0.267
LIG_LIR_Gen_1 309 317 PF02991 0.317
LIG_LIR_Nem_3 230 235 PF02991 0.267
LIG_LIR_Nem_3 301 307 PF02991 0.350
LIG_LIR_Nem_3 309 314 PF02991 0.320
LIG_PCNA_PIPBox_1 182 191 PF02747 0.616
LIG_Pex14_1 228 232 PF04695 0.273
LIG_SH2_CRK 223 227 PF00017 0.442
LIG_SH2_CRK 250 254 PF00017 0.419
LIG_SH2_NCK_1 272 276 PF00017 0.317
LIG_SH2_SRC 142 145 PF00017 0.528
LIG_SH2_STAP1 272 276 PF00017 0.317
LIG_SH2_STAT5 142 145 PF00017 0.563
LIG_SH2_STAT5 246 249 PF00017 0.447
LIG_SH2_STAT5 293 296 PF00017 0.385
LIG_SH3_3 2 8 PF00018 0.693
LIG_SH3_3 207 213 PF00018 0.650
LIG_SH3_3 294 300 PF00018 0.437
LIG_SH3_3 42 48 PF00018 0.688
LIG_SUMO_SIM_par_1 293 298 PF11976 0.361
LIG_SUMO_SIM_par_1 46 53 PF11976 0.582
LIG_TRAF2_1 124 127 PF00917 0.637
LIG_TYR_ITIM 221 226 PF00017 0.582
MOD_CDC14_SPxK_1 209 212 PF00782 0.587
MOD_CDK_SPxK_1 206 212 PF00069 0.593
MOD_CK1_1 158 164 PF00069 0.663
MOD_CK1_1 172 178 PF00069 0.647
MOD_CK1_1 47 53 PF00069 0.660
MOD_CK1_1 80 86 PF00069 0.714
MOD_CK2_1 111 117 PF00069 0.564
MOD_CK2_1 121 127 PF00069 0.540
MOD_CK2_1 157 163 PF00069 0.715
MOD_GlcNHglycan 113 116 PF01048 0.372
MOD_GlcNHglycan 146 149 PF01048 0.463
MOD_GlcNHglycan 159 163 PF01048 0.436
MOD_GlcNHglycan 171 174 PF01048 0.502
MOD_GlcNHglycan 191 194 PF01048 0.441
MOD_GlcNHglycan 237 240 PF01048 0.402
MOD_GlcNHglycan 311 314 PF01048 0.598
MOD_GlcNHglycan 66 69 PF01048 0.488
MOD_GSK3_1 165 172 PF00069 0.728
MOD_GSK3_1 235 242 PF00069 0.394
MOD_GSK3_1 320 327 PF00069 0.433
MOD_GSK3_1 43 50 PF00069 0.645
MOD_LATS_1 25 31 PF00433 0.662
MOD_N-GLC_1 324 329 PF02516 0.643
MOD_NEK2_1 189 194 PF00069 0.642
MOD_NEK2_1 227 232 PF00069 0.292
MOD_NEK2_1 235 240 PF00069 0.276
MOD_NEK2_1 49 54 PF00069 0.689
MOD_NEK2_1 94 99 PF00069 0.654
MOD_NEK2_2 249 254 PF00069 0.428
MOD_PIKK_1 175 181 PF00454 0.559
MOD_PIKK_1 95 101 PF00454 0.689
MOD_PK_1 27 33 PF00069 0.706
MOD_PKA_1 27 33 PF00069 0.685
MOD_PKA_2 27 33 PF00069 0.685
MOD_PKA_2 94 100 PF00069 0.636
MOD_Plk_1 324 330 PF00069 0.428
MOD_Plk_4 285 291 PF00069 0.415
MOD_ProDKin_1 100 106 PF00069 0.668
MOD_ProDKin_1 201 207 PF00069 0.710
MOD_ProDKin_1 44 50 PF00069 0.691
MOD_ProDKin_1 78 84 PF00069 0.656
TRG_ENDOCYTIC_2 223 226 PF00928 0.522
TRG_ENDOCYTIC_2 250 253 PF00928 0.415
TRG_ER_diArg_1 15 17 PF00400 0.683
TRG_ER_diArg_1 19 22 PF00400 0.657
TRG_ER_diArg_1 26 28 PF00400 0.609
TRG_Pf-PMV_PEXEL_1 254 258 PF00026 0.613
TRG_Pf-PMV_PEXEL_1 305 309 PF00026 0.536

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P498 Leptomonas seymouri 49% 100%
A0A0S4KLN6 Bodo saltans 28% 100%
A0A1X0NSG9 Trypanosomatidae 34% 100%
A0A3R7MX83 Trypanosoma rangeli 31% 100%
A0A3S7WZN6 Leishmania donovani 100% 100%
A4HEQ0 Leishmania braziliensis 63% 100%
C9ZS39 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9AY26 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4Q9E7 Leishmania major 88% 100%
V5B9G1 Trypanosoma cruzi 37% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS