LeishMANIAdb
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Pseudouridylate synthase-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Pseudouridylate synthase-like protein
Gene product:
pseudouridylate synthase-like protein
Species:
Leishmania infantum
UniProt:
A4I1X8_LEIIN
TriTrypDb:
LINF_260009200
Length:
696

Annotations

Annotations by Jardim et al.

Pyrimidine metabolism, Pseudouridylate synthase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 5
GO:0043227 membrane-bounded organelle 3 5
GO:0043229 intracellular organelle 3 5
GO:0043231 intracellular membrane-bounded organelle 4 5
GO:0110165 cellular anatomical entity 1 5

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I1X8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1X8

Function

Biological processes
Term Name Level Count
GO:0001522 pseudouridine synthesis 6 7
GO:0006139 nucleobase-containing compound metabolic process 3 7
GO:0006396 RNA processing 6 7
GO:0006399 tRNA metabolic process 7 7
GO:0006400 tRNA modification 6 5
GO:0006725 cellular aromatic compound metabolic process 3 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008033 tRNA processing 8 7
GO:0008152 metabolic process 1 7
GO:0009451 RNA modification 5 7
GO:0009987 cellular process 1 7
GO:0016070 RNA metabolic process 5 7
GO:0016071 mRNA metabolic process 6 1
GO:0016556 mRNA modification 6 1
GO:0031119 tRNA pseudouridine synthesis 7 5
GO:0034470 ncRNA processing 7 7
GO:0034641 cellular nitrogen compound metabolic process 3 7
GO:0034660 ncRNA metabolic process 6 7
GO:0043170 macromolecule metabolic process 3 7
GO:0043412 macromolecule modification 4 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0046483 heterocycle metabolic process 3 7
GO:0071704 organic substance metabolic process 2 7
GO:0090304 nucleic acid metabolic process 4 7
GO:1901360 organic cyclic compound metabolic process 3 7
GO:1990481 mRNA pseudouridine synthesis 7 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0003824 catalytic activity 1 12
GO:0004730 pseudouridylate synthase activity 5 8
GO:0005488 binding 1 12
GO:0009982 pseudouridine synthase activity 4 12
GO:0016829 lyase activity 2 8
GO:0016835 carbon-oxygen lyase activity 3 8
GO:0016836 hydro-lyase activity 4 8
GO:0016853 isomerase activity 2 12
GO:0016866 intramolecular transferase activity 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0106029 tRNA pseudouridine synthase activity 5 1
GO:0140098 catalytic activity, acting on RNA 3 1
GO:0140101 catalytic activity, acting on a tRNA 4 1
GO:0140640 catalytic activity, acting on a nucleic acid 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 330 334 PF00656 0.697
CLV_C14_Caspase3-7 681 685 PF00656 0.708
CLV_NRD_NRD_1 13 15 PF00675 0.508
CLV_NRD_NRD_1 149 151 PF00675 0.258
CLV_NRD_NRD_1 246 248 PF00675 0.456
CLV_NRD_NRD_1 380 382 PF00675 0.240
CLV_NRD_NRD_1 407 409 PF00675 0.344
CLV_NRD_NRD_1 446 448 PF00675 0.454
CLV_NRD_NRD_1 561 563 PF00675 0.520
CLV_NRD_NRD_1 691 693 PF00675 0.676
CLV_NRD_NRD_1 694 696 PF00675 0.677
CLV_NRD_NRD_1 8 10 PF00675 0.541
CLV_PCSK_FUR_1 444 448 PF00082 0.474
CLV_PCSK_FUR_1 689 693 PF00082 0.570
CLV_PCSK_KEX2_1 13 15 PF00082 0.501
CLV_PCSK_KEX2_1 149 151 PF00082 0.277
CLV_PCSK_KEX2_1 246 248 PF00082 0.481
CLV_PCSK_KEX2_1 407 409 PF00082 0.320
CLV_PCSK_KEX2_1 446 448 PF00082 0.454
CLV_PCSK_KEX2_1 653 655 PF00082 0.422
CLV_PCSK_KEX2_1 691 693 PF00082 0.676
CLV_PCSK_KEX2_1 694 696 PF00082 0.677
CLV_PCSK_KEX2_1 7 9 PF00082 0.544
CLV_PCSK_PC1ET2_1 653 655 PF00082 0.438
CLV_PCSK_PC7_1 442 448 PF00082 0.319
CLV_PCSK_PC7_1 9 15 PF00082 0.670
CLV_PCSK_SKI1_1 105 109 PF00082 0.364
CLV_PCSK_SKI1_1 153 157 PF00082 0.366
CLV_PCSK_SKI1_1 225 229 PF00082 0.476
CLV_PCSK_SKI1_1 286 290 PF00082 0.258
CLV_PCSK_SKI1_1 407 411 PF00082 0.377
CLV_PCSK_SKI1_1 515 519 PF00082 0.487
DEG_APCC_DBOX_1 441 449 PF00400 0.321
DEG_Nend_UBRbox_1 1 4 PF02207 0.696
DEG_SPOP_SBC_1 338 342 PF00917 0.565
DOC_CKS1_1 409 414 PF01111 0.444
DOC_CYCLIN_yCln2_LP_2 161 164 PF00134 0.369
DOC_MAPK_DCC_7 194 204 PF00069 0.428
DOC_MAPK_FxFP_2 288 291 PF00069 0.351
DOC_MAPK_gen_1 149 158 PF00069 0.331
DOC_MAPK_gen_1 19 29 PF00069 0.312
DOC_MAPK_MEF2A_6 22 31 PF00069 0.280
DOC_MAPK_MEF2A_6 280 289 PF00069 0.261
DOC_MAPK_MEF2A_6 96 103 PF00069 0.265
DOC_PP1_RVXF_1 284 290 PF00149 0.387
DOC_PP2B_LxvP_1 101 104 PF13499 0.322
DOC_PP2B_LxvP_1 161 164 PF13499 0.321
DOC_PP4_FxxP_1 288 291 PF00568 0.291
DOC_USP7_MATH_1 216 220 PF00917 0.540
DOC_USP7_MATH_1 323 327 PF00917 0.664
DOC_USP7_MATH_1 394 398 PF00917 0.403
DOC_USP7_MATH_1 525 529 PF00917 0.370
DOC_USP7_MATH_1 567 571 PF00917 0.621
DOC_USP7_MATH_1 579 583 PF00917 0.722
DOC_WD40_RPTOR_TOS_1 251 256 PF00400 0.465
DOC_WW_Pin1_4 325 330 PF00397 0.545
DOC_WW_Pin1_4 348 353 PF00397 0.555
DOC_WW_Pin1_4 354 359 PF00397 0.413
DOC_WW_Pin1_4 401 406 PF00397 0.353
DOC_WW_Pin1_4 408 413 PF00397 0.324
DOC_WW_Pin1_4 573 578 PF00397 0.550
DOC_WW_Pin1_4 601 606 PF00397 0.706
DOC_WW_Pin1_4 633 638 PF00397 0.509
LIG_14-3-3_CanoR_1 259 269 PF00244 0.475
LIG_14-3-3_CanoR_1 324 329 PF00244 0.627
LIG_14-3-3_CanoR_1 407 412 PF00244 0.386
LIG_14-3-3_CanoR_1 84 92 PF00244 0.298
LIG_14-3-3_CanoR_1 96 102 PF00244 0.249
LIG_Actin_WH2_2 49 64 PF00022 0.282
LIG_APCC_ABBA_1 304 309 PF00400 0.517
LIG_APCC_ABBAyCdc20_2 666 672 PF00400 0.438
LIG_BIR_III_4 450 454 PF00653 0.370
LIG_BIR_III_4 662 666 PF00653 0.482
LIG_BRCT_BRCA1_1 137 141 PF00533 0.337
LIG_EH1_1 92 100 PF00400 0.265
LIG_FHA_1 126 132 PF00498 0.349
LIG_FHA_1 358 364 PF00498 0.404
LIG_FHA_1 408 414 PF00498 0.404
LIG_FHA_1 529 535 PF00498 0.307
LIG_FHA_1 617 623 PF00498 0.624
LIG_FHA_2 167 173 PF00498 0.341
LIG_FHA_2 268 274 PF00498 0.490
LIG_FHA_2 310 316 PF00498 0.581
LIG_FHA_2 325 331 PF00498 0.482
LIG_FHA_2 499 505 PF00498 0.458
LIG_FHA_2 595 601 PF00498 0.758
LIG_FHA_2 602 608 PF00498 0.634
LIG_FHA_2 634 640 PF00498 0.491
LIG_FHA_2 674 680 PF00498 0.771
LIG_LIR_Apic_2 195 200 PF02991 0.304
LIG_LIR_Gen_1 106 114 PF02991 0.320
LIG_LIR_Gen_1 166 176 PF02991 0.296
LIG_LIR_Gen_1 198 209 PF02991 0.373
LIG_LIR_Gen_1 245 255 PF02991 0.310
LIG_LIR_Gen_1 531 539 PF02991 0.411
LIG_LIR_Gen_1 627 637 PF02991 0.360
LIG_LIR_Nem_3 166 171 PF02991 0.269
LIG_LIR_Nem_3 198 204 PF02991 0.335
LIG_LIR_Nem_3 245 251 PF02991 0.288
LIG_LIR_Nem_3 36 41 PF02991 0.282
LIG_LIR_Nem_3 424 429 PF02991 0.282
LIG_LIR_Nem_3 513 517 PF02991 0.444
LIG_LIR_Nem_3 531 536 PF02991 0.373
LIG_LIR_Nem_3 627 633 PF02991 0.366
LIG_PAM2_1 356 368 PF00658 0.319
LIG_PCNA_yPIPBox_3 144 155 PF02747 0.288
LIG_Pex14_2 648 652 PF04695 0.499
LIG_RPA_C_Fungi 254 266 PF08784 0.527
LIG_SH2_CRK 154 158 PF00017 0.270
LIG_SH2_CRK 159 163 PF00017 0.284
LIG_SH2_CRK 197 201 PF00017 0.297
LIG_SH2_CRK 514 518 PF00017 0.454
LIG_SH2_GRB2like 248 251 PF00017 0.368
LIG_SH2_NCK_1 197 201 PF00017 0.273
LIG_SH2_PTP2 201 204 PF00017 0.372
LIG_SH2_SRC 660 663 PF00017 0.453
LIG_SH2_STAP1 314 318 PF00017 0.517
LIG_SH2_STAP1 429 433 PF00017 0.347
LIG_SH2_STAP1 660 664 PF00017 0.367
LIG_SH2_STAT3 420 423 PF00017 0.401
LIG_SH2_STAT5 201 204 PF00017 0.335
LIG_SH2_STAT5 418 421 PF00017 0.266
LIG_SH2_STAT5 632 635 PF00017 0.380
LIG_SH2_STAT5 647 650 PF00017 0.314
LIG_SH3_2 516 521 PF14604 0.454
LIG_SH3_3 207 213 PF00018 0.532
LIG_SH3_3 263 269 PF00018 0.397
LIG_SH3_3 406 412 PF00018 0.323
LIG_SH3_3 513 519 PF00018 0.383
LIG_SUMO_SIM_par_1 471 476 PF11976 0.320
LIG_SxIP_EBH_1 135 149 PF03271 0.335
LIG_SxIP_EBH_1 515 528 PF03271 0.396
LIG_TRAF2_1 636 639 PF00917 0.408
LIG_TRFH_1 159 163 PF08558 0.389
LIG_TYR_ITIM 199 204 PF00017 0.414
LIG_UBA3_1 376 382 PF00899 0.253
LIG_UBA3_1 57 62 PF00899 0.314
LIG_WW_3 321 325 PF00397 0.490
MOD_CDC14_SPxK_1 404 407 PF00782 0.364
MOD_CDK_SPxK_1 401 407 PF00069 0.349
MOD_CDK_SPxxK_3 401 408 PF00069 0.372
MOD_CK1_1 219 225 PF00069 0.455
MOD_CK1_1 240 246 PF00069 0.399
MOD_CK1_1 257 263 PF00069 0.386
MOD_CK1_1 340 346 PF00069 0.600
MOD_CK1_1 357 363 PF00069 0.487
MOD_CK1_1 528 534 PF00069 0.300
MOD_CK1_1 614 620 PF00069 0.673
MOD_CK1_1 85 91 PF00069 0.304
MOD_CK2_1 267 273 PF00069 0.392
MOD_CK2_1 307 313 PF00069 0.539
MOD_CK2_1 324 330 PF00069 0.451
MOD_CK2_1 394 400 PF00069 0.440
MOD_CK2_1 498 504 PF00069 0.422
MOD_CK2_1 594 600 PF00069 0.609
MOD_CK2_1 633 639 PF00069 0.480
MOD_DYRK1A_RPxSP_1 408 412 PF00069 0.444
MOD_GlcNHglycan 137 140 PF01048 0.500
MOD_GlcNHglycan 218 221 PF01048 0.473
MOD_GlcNHglycan 259 262 PF01048 0.514
MOD_GlcNHglycan 33 36 PF01048 0.402
MOD_GlcNHglycan 569 572 PF01048 0.486
MOD_GlcNHglycan 615 619 PF01048 0.522
MOD_GSK3_1 325 332 PF00069 0.574
MOD_GSK3_1 333 340 PF00069 0.572
MOD_GSK3_1 343 350 PF00069 0.489
MOD_GSK3_1 354 361 PF00069 0.426
MOD_GSK3_1 494 501 PF00069 0.494
MOD_GSK3_1 524 531 PF00069 0.458
MOD_N-GLC_1 249 254 PF02516 0.292
MOD_N-GLC_1 257 262 PF02516 0.405
MOD_N-GLC_1 358 363 PF02516 0.344
MOD_N-GLC_1 594 599 PF02516 0.692
MOD_NEK2_1 135 140 PF00069 0.428
MOD_NEK2_1 242 247 PF00069 0.325
MOD_NEK2_1 337 342 PF00069 0.737
MOD_NEK2_1 421 426 PF00069 0.263
MOD_NEK2_1 566 571 PF00069 0.394
MOD_NEK2_1 664 669 PF00069 0.389
MOD_NEK2_1 82 87 PF00069 0.343
MOD_PIKK_1 192 198 PF00454 0.490
MOD_PKA_1 407 413 PF00069 0.344
MOD_PKA_2 323 329 PF00069 0.627
MOD_PKA_2 394 400 PF00069 0.311
MOD_PKA_2 407 413 PF00069 0.347
MOD_PKB_1 492 500 PF00069 0.404
MOD_Plk_1 249 255 PF00069 0.333
MOD_Plk_1 358 364 PF00069 0.417
MOD_Plk_1 429 435 PF00069 0.444
MOD_Plk_1 528 534 PF00069 0.300
MOD_Plk_1 594 600 PF00069 0.626
MOD_Plk_1 638 644 PF00069 0.362
MOD_Plk_2-3 309 315 PF00069 0.464
MOD_Plk_2-3 673 679 PF00069 0.574
MOD_Plk_4 137 143 PF00069 0.421
MOD_Plk_4 219 225 PF00069 0.476
MOD_Plk_4 371 377 PF00069 0.281
MOD_Plk_4 383 389 PF00069 0.341
MOD_Plk_4 394 400 PF00069 0.313
MOD_Plk_4 528 534 PF00069 0.345
MOD_Plk_4 647 653 PF00069 0.374
MOD_Plk_4 664 670 PF00069 0.487
MOD_Plk_4 97 103 PF00069 0.394
MOD_ProDKin_1 325 331 PF00069 0.550
MOD_ProDKin_1 348 354 PF00069 0.548
MOD_ProDKin_1 401 407 PF00069 0.358
MOD_ProDKin_1 408 414 PF00069 0.320
MOD_ProDKin_1 573 579 PF00069 0.559
MOD_ProDKin_1 601 607 PF00069 0.705
MOD_ProDKin_1 633 639 PF00069 0.507
MOD_SUMO_rev_2 221 229 PF00179 0.310
MOD_SUMO_rev_2 510 517 PF00179 0.489
MOD_SUMO_rev_2 586 594 PF00179 0.590
TRG_DiLeu_BaEn_2 370 376 PF01217 0.252
TRG_DiLeu_BaEn_2 528 534 PF01217 0.277
TRG_DiLeu_BaLyEn_6 532 537 PF01217 0.395
TRG_ENDOCYTIC_2 152 155 PF00928 0.250
TRG_ENDOCYTIC_2 159 162 PF00928 0.231
TRG_ENDOCYTIC_2 201 204 PF00928 0.335
TRG_ENDOCYTIC_2 248 251 PF00928 0.368
TRG_ENDOCYTIC_2 418 421 PF00928 0.293
TRG_ENDOCYTIC_2 514 517 PF00928 0.445
TRG_ER_diArg_1 12 14 PF00400 0.524
TRG_ER_diArg_1 149 151 PF00400 0.277
TRG_ER_diArg_1 246 248 PF00400 0.491
TRG_ER_diArg_1 407 409 PF00400 0.344
TRG_ER_diArg_1 442 445 PF00400 0.506
TRG_ER_diArg_1 446 448 PF00400 0.466
TRG_ER_diArg_1 654 657 PF00400 0.437
TRG_ER_diArg_1 689 692 PF00400 0.697
TRG_ER_diArg_1 694 696 PF00400 0.655
TRG_ER_diArg_1 7 9 PF00400 0.583
TRG_ER_diArg_1 71 74 PF00400 0.350
TRG_NLS_MonoExtC_3 652 657 PF00514 0.496
TRG_Pf-PMV_PEXEL_1 39 44 PF00026 0.300
TRG_Pf-PMV_PEXEL_1 554 558 PF00026 0.480

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5J6 Leptomonas seymouri 59% 100%
A0A0S4JH91 Bodo saltans 26% 100%
A0A0S4KL20 Bodo saltans 36% 94%
A0A1X0NSY0 Trypanosomatidae 40% 100%
A0A3Q8ICM8 Leishmania donovani 99% 100%
A0A3R7KTM1 Trypanosoma rangeli 40% 100%
A4HEP8 Leishmania braziliensis 79% 100%
C9ZS41 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
E9AY24 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q9E9 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS