IU_nuc_hydro domain-containing protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Inosine-uridine preferring nucleoside hydrolase - putative

Species:

Leishmania infantum

UniProt:

A4I1X0_LEIIN

TriTrypDb:

LINF_260008400

Length:

342

Annotations

Annotations by Jardim et al.

Pyrimidine metabolism, Inosine-uridine preferring nucleoside hydrolase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I1X0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1X0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0006152	purine nucleoside catabolic process	6	1
GO:0009056	catabolic process	2	1
GO:0009116	nucleoside metabolic process	4	1
GO:0009164	nucleoside catabolic process	5	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034656	nucleobase-containing small molecule catabolic process	4	1
GO:0042278	purine nucleoside metabolic process	5	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072523	purine-containing compound catabolic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901657	glycosyl compound metabolic process	4	1
GO:1901658	glycosyl compound catabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	7
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	7
GO:0008477	purine nucleosidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.301
CLV_NRD_NRD_1	76	78	PF00675	0.490
CLV_PCSK_KEX2_1	76	78	PF00082	0.450
CLV_PCSK_SKI1_1	217	221	PF00082	0.437
CLV_PCSK_SKI1_1	319	323	PF00082	0.452
DEG_Nend_UBRbox_2	1	3	PF02207	0.536
DOC_MAPK_DCC_7	217	226	PF00069	0.237
DOC_MAPK_DCC_7	49	59	PF00069	0.297
DOC_MAPK_gen_1	18	28	PF00069	0.411
DOC_MAPK_MEF2A_6	167	175	PF00069	0.237
DOC_MAPK_MEF2A_6	76	83	PF00069	0.236
DOC_PP4_FxxP_1	132	135	PF00568	0.201
DOC_USP7_MATH_1	141	145	PF00917	0.284
DOC_USP7_MATH_1	165	169	PF00917	0.237
DOC_USP7_MATH_1	213	217	PF00917	0.175
DOC_USP7_MATH_1	277	281	PF00917	0.252
DOC_USP7_UBL2_3	142	146	PF12436	0.219
DOC_WW_Pin1_4	125	130	PF00397	0.340
DOC_WW_Pin1_4	313	318	PF00397	0.261
DOC_WW_Pin1_4	60	65	PF00397	0.357
LIG_14-3-3_CanoR_1	217	222	PF00244	0.303
LIG_14-3-3_CanoR_1	267	272	PF00244	0.245
LIG_14-3-3_CanoR_1	296	304	PF00244	0.214
LIG_14-3-3_CanoR_1	319	325	PF00244	0.321
LIG_BRCT_BRCA1_1	143	147	PF00533	0.224
LIG_Clathr_ClatBox_1	221	225	PF01394	0.237
LIG_Clathr_ClatBox_1	333	337	PF01394	0.271
LIG_eIF4E_1	31	37	PF01652	0.226
LIG_FHA_1	114	120	PF00498	0.294
LIG_FHA_1	268	274	PF00498	0.261
LIG_FHA_1	48	54	PF00498	0.312
LIG_LIR_Apic_2	131	135	PF02991	0.179
LIG_LIR_Gen_1	144	152	PF02991	0.296
LIG_LIR_Gen_1	232	242	PF02991	0.242
LIG_LIR_Gen_1	287	297	PF02991	0.237
LIG_LIR_Gen_1	327	336	PF02991	0.274
LIG_LIR_Nem_3	144	150	PF02991	0.296
LIG_LIR_Nem_3	232	238	PF02991	0.242
LIG_LIR_Nem_3	287	293	PF02991	0.237
LIG_LIR_Nem_3	327	333	PF02991	0.242
LIG_NRBOX	32	38	PF00104	0.226
LIG_PCNA_PIPBox_1	1	10	PF02747	0.534
LIG_PCNA_yPIPBox_3	66	77	PF02747	0.261
LIG_Pex14_2	28	32	PF04695	0.290
LIG_SH2_CRK	235	239	PF00017	0.201
LIG_SH2_CRK	290	294	PF00017	0.269
LIG_SH2_NCK_1	290	294	PF00017	0.273
LIG_SH2_SRC	201	204	PF00017	0.175
LIG_SH2_STAP1	115	119	PF00017	0.292
LIG_SH2_STAP1	235	239	PF00017	0.303
LIG_SH2_STAP1	278	282	PF00017	0.237
LIG_SH2_STAT3	65	68	PF00017	0.252
LIG_SH2_STAT3	72	75	PF00017	0.259
LIG_SH2_STAT5	115	118	PF00017	0.297
LIG_SH2_STAT5	188	191	PF00017	0.336
LIG_SH2_STAT5	201	204	PF00017	0.242
LIG_SH2_STAT5	209	212	PF00017	0.229
LIG_SH2_STAT5	290	293	PF00017	0.273
LIG_SH2_STAT5	31	34	PF00017	0.325
LIG_SH2_STAT5	72	75	PF00017	0.254
LIG_SH3_3	236	242	PF00018	0.274
LIG_SUMO_SIM_anti_2	50	56	PF11976	0.306
LIG_SUMO_SIM_par_1	222	227	PF11976	0.268
LIG_SUMO_SIM_par_1	50	56	PF11976	0.355
LIG_SUMO_SIM_par_1	82	87	PF11976	0.253
LIG_TRFH_1	200	204	PF08558	0.175
MOD_CDK_SPxK_1	313	319	PF00069	0.219
MOD_CK1_1	124	130	PF00069	0.352
MOD_CK1_1	240	246	PF00069	0.248
MOD_CK1_1	248	254	PF00069	0.262
MOD_CK1_1	265	271	PF00069	0.272
MOD_GlcNHglycan	107	110	PF01048	0.593
MOD_GlcNHglycan	313	316	PF01048	0.442
MOD_GSK3_1	121	128	PF00069	0.282
MOD_GSK3_1	213	220	PF00069	0.246
MOD_GSK3_1	224	231	PF00069	0.270
MOD_GSK3_1	237	244	PF00069	0.215
MOD_GSK3_1	259	266	PF00069	0.210
MOD_GSK3_1	284	291	PF00069	0.259
MOD_GSK3_1	302	309	PF00069	0.221
MOD_GSK3_1	43	50	PF00069	0.374
MOD_GSK3_1	53	60	PF00069	0.251
MOD_LATS_1	215	221	PF00433	0.237
MOD_N-GLC_1	302	307	PF02516	0.437
MOD_NEK2_1	289	294	PF00069	0.266
MOD_NEK2_1	43	48	PF00069	0.362
MOD_NEK2_2	141	146	PF00069	0.237
MOD_NEK2_2	325	330	PF00069	0.243
MOD_PKA_2	266	272	PF00069	0.285
MOD_PKA_2	284	290	PF00069	0.212
MOD_Plk_1	224	230	PF00069	0.229
MOD_Plk_4	217	223	PF00069	0.296
MOD_Plk_4	325	331	PF00069	0.224
MOD_Plk_4	53	59	PF00069	0.256
MOD_ProDKin_1	125	131	PF00069	0.334
MOD_ProDKin_1	313	319	PF00069	0.261
MOD_ProDKin_1	60	66	PF00069	0.357
MOD_SUMO_for_1	194	197	PF00179	0.237
MOD_SUMO_rev_2	197	207	PF00179	0.175
TRG_DiLeu_BaEn_2	154	160	PF01217	0.237
TRG_ENDOCYTIC_2	235	238	PF00928	0.201
TRG_ENDOCYTIC_2	260	263	PF00928	0.242
TRG_ENDOCYTIC_2	290	293	PF00928	0.269
TRG_ENDOCYTIC_2	31	34	PF00928	0.290
TRG_ER_diArg_1	295	298	PF00400	0.237
TRG_NLS_MonoExtN_4	15	22	PF00514	0.506
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P506	Leptomonas seymouri	55%	99%
A0A0S4JP56	Bodo saltans	22%	78%
A0A3Q8INW1	Leishmania donovani	100%	100%
E9AY16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q9F7	Leishmania major	93%	100%