LeishMANIAdb
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Putative mitotic cyclin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative mitotic cyclin
Gene product:
mitotic cyclin - putative
Species:
Leishmania infantum
UniProt:
A4I1W9_LEIIN
TriTrypDb:
LINF_260008300
Length:
448

Annotations

LeishMANIAdb annotations

Cyclin protein, certainly non-TM

Annotations by Jardim et al.

Cell Cycle, mitotic cyclin CYC8

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000307 cyclin-dependent protein kinase holoenzyme complex 7 1
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0005813 centrosome 3 1
GO:0005815 microtubule organizing center 2 1
GO:0016020 membrane 2 5
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0061695 transferase complex, transferring phosphorus-containing groups 4 1
GO:0110165 cellular anatomical entity 1 5
GO:1902494 catalytic complex 2 1
GO:1902554 serine/threonine protein kinase complex 6 1
GO:1902911 protein kinase complex 5 1
GO:1990234 transferase complex 3 1

Expansion

Sequence features

A4I1W9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1W9

Function

Biological processes
Term Name Level Count
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 6 1
GO:0001932 regulation of protein phosphorylation 7 1
GO:0009987 cellular process 1 1
GO:0019220 regulation of phosphate metabolic process 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0022402 cell cycle process 2 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031399 regulation of protein modification process 6 1
GO:0042325 regulation of phosphorylation 7 1
GO:0043549 regulation of kinase activity 5 1
GO:0044770 cell cycle phase transition 3 1
GO:0044772 mitotic cell cycle phase transition 4 1
GO:0045859 regulation of protein kinase activity 6 1
GO:0050789 regulation of biological process 2 1
GO:0050790 regulation of catalytic activity 3 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051174 regulation of phosphorus metabolic process 5 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0051338 regulation of transferase activity 4 1
GO:0051726 regulation of cell cycle 4 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0065009 regulation of molecular function 2 1
GO:0071900 regulation of protein serine/threonine kinase activity 7 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903047 mitotic cell cycle process 3 1
GO:1904029 regulation of cyclin-dependent protein kinase activity 5 1
Molecular functions
Term Name Level Count
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 5 1
GO:0019207 kinase regulator activity 3 1
GO:0019887 protein kinase regulator activity 4 1
GO:0030234 enzyme regulator activity 2 1
GO:0098772 molecular function regulator activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 176 182 PF00089 0.556
CLV_NRD_NRD_1 100 102 PF00675 0.341
CLV_NRD_NRD_1 258 260 PF00675 0.454
CLV_NRD_NRD_1 87 89 PF00675 0.542
CLV_PCSK_KEX2_1 100 102 PF00082 0.428
CLV_PCSK_KEX2_1 258 260 PF00082 0.422
CLV_PCSK_PC7_1 254 260 PF00082 0.456
CLV_PCSK_SKI1_1 119 123 PF00082 0.484
CLV_PCSK_SKI1_1 20 24 PF00082 0.536
CLV_PCSK_SKI1_1 343 347 PF00082 0.496
CLV_PCSK_SKI1_1 380 384 PF00082 0.603
CLV_PCSK_SKI1_1 391 395 PF00082 0.440
CLV_PCSK_SKI1_1 49 53 PF00082 0.481
CLV_PCSK_SKI1_1 59 63 PF00082 0.436
CLV_Separin_Metazoa 388 392 PF03568 0.475
DEG_APCC_DBOX_1 342 350 PF00400 0.403
DEG_APCC_DBOX_1 390 398 PF00400 0.514
DOC_AGCK_PIF_1 180 185 PF00069 0.595
DOC_CYCLIN_yCln2_LP_2 126 132 PF00134 0.526
DOC_MAPK_DCC_7 16 24 PF00069 0.557
DOC_MAPK_FxFP_2 60 63 PF00069 0.521
DOC_MAPK_gen_1 100 106 PF00069 0.515
DOC_MAPK_gen_1 222 231 PF00069 0.447
DOC_PP1_RVXF_1 18 25 PF00149 0.596
DOC_PP4_FxxP_1 60 63 PF00568 0.521
DOC_USP7_MATH_1 204 208 PF00917 0.613
DOC_USP7_MATH_1 217 221 PF00917 0.549
DOC_USP7_MATH_1 257 261 PF00917 0.449
DOC_USP7_MATH_1 371 375 PF00917 0.483
DOC_WW_Pin1_4 258 263 PF00397 0.493
DOC_WW_Pin1_4 336 341 PF00397 0.543
DOC_WW_Pin1_4 406 411 PF00397 0.548
DOC_WW_Pin1_4 426 431 PF00397 0.231
LIG_14-3-3_CanoR_1 20 25 PF00244 0.497
LIG_14-3-3_CanoR_1 203 209 PF00244 0.595
LIG_14-3-3_CanoR_1 258 262 PF00244 0.428
LIG_14-3-3_CanoR_1 267 272 PF00244 0.378
LIG_14-3-3_CanoR_1 423 429 PF00244 0.566
LIG_14-3-3_CanoR_1 441 445 PF00244 0.502
LIG_14-3-3_CanoR_1 49 57 PF00244 0.466
LIG_14-3-3_CanoR_1 88 97 PF00244 0.491
LIG_Actin_WH2_2 159 175 PF00022 0.522
LIG_APCC_ABBA_1 330 335 PF00400 0.517
LIG_APCC_Cbox_1 253 259 PF00515 0.480
LIG_APCC_Cbox_2 253 259 PF00515 0.408
LIG_Clathr_ClatBox_1 197 201 PF01394 0.501
LIG_deltaCOP1_diTrp_1 281 291 PF00928 0.447
LIG_DLG_GKlike_1 267 274 PF00625 0.447
LIG_EH1_1 268 276 PF00400 0.447
LIG_eIF4E_1 269 275 PF01652 0.480
LIG_FHA_1 429 435 PF00498 0.535
LIG_FHA_1 52 58 PF00498 0.501
LIG_FHA_2 110 116 PF00498 0.439
LIG_FHA_2 129 135 PF00498 0.309
LIG_FHA_2 190 196 PF00498 0.470
LIG_FHA_2 259 265 PF00498 0.449
LIG_FHA_2 303 309 PF00498 0.434
LIG_LIR_Apic_2 58 63 PF02991 0.534
LIG_LIR_Gen_1 243 252 PF02991 0.342
LIG_LIR_Gen_1 288 299 PF02991 0.449
LIG_LIR_Nem_3 23 27 PF02991 0.481
LIG_LIR_Nem_3 233 238 PF02991 0.353
LIG_LIR_Nem_3 243 249 PF02991 0.292
LIG_LIR_Nem_3 281 287 PF02991 0.430
LIG_LIR_Nem_3 288 294 PF02991 0.443
LIG_LIR_Nem_3 357 362 PF02991 0.415
LIG_LYPXL_SIV_4 244 252 PF13949 0.434
LIG_LYPXL_yS_3 190 193 PF13949 0.511
LIG_MYND_1 285 289 PF01753 0.447
LIG_PCNA_PIPBox_1 28 37 PF02747 0.538
LIG_PCNA_PIPBox_1 342 351 PF02747 0.490
LIG_PTB_Apo_2 44 51 PF02174 0.466
LIG_PTB_Phospho_1 44 50 PF10480 0.472
LIG_SH2_CRK 398 402 PF00017 0.467
LIG_SH2_NCK_1 269 273 PF00017 0.474
LIG_SH2_NCK_1 418 422 PF00017 0.516
LIG_SH2_SRC 348 351 PF00017 0.466
LIG_SH2_STAP1 269 273 PF00017 0.432
LIG_SH2_STAT3 358 361 PF00017 0.490
LIG_SH2_STAT5 245 248 PF00017 0.392
LIG_SH2_STAT5 348 351 PF00017 0.354
LIG_SH2_STAT5 4 7 PF00017 0.518
LIG_SH2_STAT5 50 53 PF00017 0.535
LIG_SH3_2 386 391 PF14604 0.461
LIG_SH3_3 206 212 PF00018 0.572
LIG_SH3_3 334 340 PF00018 0.529
LIG_SH3_3 383 389 PF00018 0.506
LIG_SH3_3 430 436 PF00018 0.532
LIG_SUMO_SIM_anti_2 109 115 PF11976 0.538
LIG_SUMO_SIM_anti_2 160 167 PF11976 0.354
LIG_SUMO_SIM_par_1 164 170 PF11976 0.327
LIG_SUMO_SIM_par_1 238 243 PF11976 0.411
LIG_SUMO_SIM_par_1 91 99 PF11976 0.502
LIG_TRAF2_1 158 161 PF00917 0.504
LIG_TRAF2_1 225 228 PF00917 0.434
LIG_TRAF2_1 305 308 PF00917 0.447
LIG_TRAF2_1 7 10 PF00917 0.564
LIG_TYR_ITIM 396 401 PF00017 0.457
LIG_UBA3_1 113 119 PF00899 0.525
MOD_CDK_SPK_2 258 263 PF00069 0.480
MOD_CDK_SPxxK_3 336 343 PF00069 0.525
MOD_CK1_1 283 289 PF00069 0.480
MOD_CK1_1 354 360 PF00069 0.452
MOD_CK1_1 439 445 PF00069 0.631
MOD_CK2_1 109 115 PF00069 0.424
MOD_CK2_1 128 134 PF00069 0.387
MOD_CK2_1 258 264 PF00069 0.430
MOD_CK2_1 302 308 PF00069 0.434
MOD_CK2_1 442 448 PF00069 0.641
MOD_GlcNHglycan 185 188 PF01048 0.510
MOD_GlcNHglycan 444 447 PF01048 0.692
MOD_GSK3_1 315 322 PF00069 0.517
MOD_GSK3_1 380 387 PF00069 0.560
MOD_GSK3_1 402 409 PF00069 0.539
MOD_GSK3_1 424 431 PF00069 0.533
MOD_GSK3_1 436 443 PF00069 0.629
MOD_GSK3_1 80 87 PF00069 0.615
MOD_NEK2_1 183 188 PF00069 0.536
MOD_NEK2_1 230 235 PF00069 0.340
MOD_NEK2_1 275 280 PF00069 0.376
MOD_NEK2_1 349 354 PF00069 0.461
MOD_NEK2_1 372 377 PF00069 0.496
MOD_NEK2_2 217 222 PF00069 0.498
MOD_NEK2_2 319 324 PF00069 0.379
MOD_NEK2_2 351 356 PF00069 0.462
MOD_NEK2_2 436 441 PF00069 0.583
MOD_PKA_1 88 94 PF00069 0.531
MOD_PKA_2 257 263 PF00069 0.411
MOD_PKA_2 362 368 PF00069 0.446
MOD_PKA_2 440 446 PF00069 0.653
MOD_PKB_1 82 90 PF00069 0.600
MOD_Plk_1 109 115 PF00069 0.505
MOD_Plk_1 280 286 PF00069 0.447
MOD_Plk_4 109 115 PF00069 0.524
MOD_Plk_4 189 195 PF00069 0.476
MOD_Plk_4 204 210 PF00069 0.539
MOD_Plk_4 354 360 PF00069 0.457
MOD_ProDKin_1 258 264 PF00069 0.493
MOD_ProDKin_1 336 342 PF00069 0.536
MOD_ProDKin_1 406 412 PF00069 0.543
MOD_ProDKin_1 426 432 PF00069 0.235
MOD_SUMO_for_1 7 10 PF00179 0.580
TRG_DiLeu_BaEn_1 161 166 PF01217 0.353
TRG_DiLeu_BaEn_1 341 346 PF01217 0.513
TRG_ENDOCYTIC_2 190 193 PF00928 0.421
TRG_ENDOCYTIC_2 398 401 PF00928 0.546
TRG_ER_diArg_1 154 157 PF00400 0.482
TRG_ER_diArg_1 221 224 PF00400 0.537
TRG_Pf-PMV_PEXEL_1 136 141 PF00026 0.583
TRG_Pf-PMV_PEXEL_1 25 29 PF00026 0.551
TRG_Pf-PMV_PEXEL_1 343 347 PF00026 0.496
TRG_Pf-PMV_PEXEL_1 37 41 PF00026 0.538
TRG_Pf-PMV_PEXEL_1 74 78 PF00026 0.507
TRG_Pf-PMV_PEXEL_1 88 92 PF00026 0.480

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2Q6 Leptomonas seymouri 79% 90%
A0A0S4JSJ6 Bodo saltans 24% 90%
A0A3Q8ICR6 Leishmania donovani 100% 100%
A0A422NVH3 Trypanosoma rangeli 34% 96%
A4HEP0 Leishmania braziliensis 91% 100%
C9ZS50 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 96%
E9AY15 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4Q9F8 Leishmania major 96% 100%
V5BQ13 Trypanosoma cruzi 33% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS