Methenyltetrahydrofolate cyclohydrolase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C-1-tetrahydrofolate synthase - cytoplasmic - putative

Species:

Leishmania infantum

UniProt:

A4I1W8_LEIIN

TriTrypDb:

LINF_260008200

Length:

298

Annotations

Annotations by Jardim et al.

Metal Binding, C-1-tetrahydrofolate synthase, cytoplasmic

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0020023	kinetoplast	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4I1W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1W8

PDB structure(s): 4a26_A , 4a26_B

Function

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Biological processes
Term	Name	Level	Count
GO:0006575	cellular modified amino acid metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006730	one-carbon metabolic process	3	10
GO:0006760	folic acid-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0035999	tetrahydrofolate interconversion	4	1
GO:0042558	pteridine-containing compound metabolic process	4	1
GO:0044237	cellular metabolic process	2	10

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	6	8
GO:0004486	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity	5	10
GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	6	1
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	6	10
GO:0016491	oxidoreductase activity	2	10
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	10
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	4	10
GO:0016787	hydrolase activity	2	8
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.319
CLV_PCSK_KEX2_1	155	157	PF00082	0.363
CLV_PCSK_KEX2_1	164	166	PF00082	0.327
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.381
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.371
CLV_PCSK_SKI1_1	292	296	PF00082	0.507
DEG_APCC_KENBOX_2	184	188	PF00400	0.452
DEG_COP1_1	235	244	PF00400	0.377
DOC_CKS1_1	141	146	PF01111	0.420
DOC_MAPK_DCC_7	120	130	PF00069	0.377

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCP1	Leptomonas seymouri	59%	99%
A0A0S4J4J5	Bodo saltans	41%	100%
A0A1X0NSY8	Trypanosomatidae	65%	98%
A0A1X0NT48	Trypanosomatidae	31%	71%
A0A422NSL2	Trypanosoma rangeli	33%	86%
A0AIG1	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	49%	100%
A0JTZ0	Arthrobacter sp. (strain FB24)	46%	99%
A0KJD4	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	46%	100%
A0KYM1	Shewanella sp. (strain ANA-3)	48%	100%
A0LE04	Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)	49%	100%

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