6-phosphofructo-2-kinase/fructose-2,6-biphosphata se-1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

6-phosphofructo-2-kinase/fructose-2 -6-biphosphatase-1-like protein

Species:

Leishmania infantum

UniProt:

A4I1W7_LEIIN

TriTrypDb:

LINF_260008100

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4I1W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1W7

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0005996	monosaccharide metabolic process	3	12
GO:0006000	fructose metabolic process	5	12
GO:0006003	fructose 2,6-bisphosphate metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0019318	hexose metabolic process	4	12
GO:0019637	organophosphate metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901135	carbohydrate derivative metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003873	6-phosphofructo-2-kinase activity	6	12
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	8	7
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008443	phosphofructokinase activity	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0017076	purine nucleotide binding	4	12
GO:0019200	carbohydrate kinase activity	5	12
GO:0019203	carbohydrate phosphatase activity	6	7
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0050308	sugar-phosphatase activity	7	7
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	613	617	PF00656	0.494
CLV_C14_Caspase3-7	653	657	PF00656	0.329
CLV_NRD_NRD_1	240	242	PF00675	0.376
CLV_NRD_NRD_1	260	262	PF00675	0.122
CLV_NRD_NRD_1	28	30	PF00675	0.612
CLV_NRD_NRD_1	31	33	PF00675	0.592
CLV_NRD_NRD_1	319	321	PF00675	0.243
CLV_PCSK_FUR_1	29	33	PF00082	0.603
CLV_PCSK_KEX2_1	240	242	PF00082	0.336
CLV_PCSK_KEX2_1	259	261	PF00082	0.167
CLV_PCSK_KEX2_1	30	32	PF00082	0.641
CLV_PCSK_KEX2_1	319	321	PF00082	0.243
CLV_PCSK_KEX2_1	488	490	PF00082	0.412
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.676
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.400
CLV_PCSK_SKI1_1	107	111	PF00082	0.243
CLV_PCSK_SKI1_1	124	128	PF00082	0.243
CLV_PCSK_SKI1_1	264	268	PF00082	0.389
CLV_PCSK_SKI1_1	31	35	PF00082	0.690
CLV_PCSK_SKI1_1	337	341	PF00082	0.339
CLV_PCSK_SKI1_1	353	357	PF00082	0.243
CLV_PCSK_SKI1_1	359	363	PF00082	0.363
CLV_PCSK_SKI1_1	418	422	PF00082	0.388
CLV_PCSK_SKI1_1	464	468	PF00082	0.305
DOC_CKS1_1	363	368	PF01111	0.264
DOC_CYCLIN_RxL_1	458	468	PF00134	0.388
DOC_CYCLIN_RxL_1	518	532	PF00134	0.301
DOC_CYCLIN_yClb1_LxF_4	416	421	PF00134	0.388
DOC_MAPK_DCC_7	29	38	PF00069	0.533
DOC_MAPK_gen_1	29	38	PF00069	0.660
DOC_MAPK_MEF2A_6	135	143	PF00069	0.307
DOC_PP1_RVXF_1	32	39	PF00149	0.638
DOC_PP1_RVXF_1	335	341	PF00149	0.243
DOC_PP1_RVXF_1	416	422	PF00149	0.388
DOC_PP1_RVXF_1	522	529	PF00149	0.307
DOC_PP2B_PxIxI_1	395	401	PF00149	0.264
DOC_USP7_MATH_1	11	15	PF00917	0.719
DOC_USP7_MATH_1	147	151	PF00917	0.376
DOC_USP7_MATH_1	25	29	PF00917	0.537
DOC_USP7_MATH_1	498	502	PF00917	0.350
DOC_USP7_MATH_1	60	64	PF00917	0.622
DOC_USP7_UBL2_3	30	34	PF12436	0.668
DOC_WW_Pin1_4	155	160	PF00397	0.258
DOC_WW_Pin1_4	197	202	PF00397	0.582
DOC_WW_Pin1_4	2	7	PF00397	0.639
DOC_WW_Pin1_4	275	280	PF00397	0.345
DOC_WW_Pin1_4	362	367	PF00397	0.264
DOC_WW_Pin1_4	424	429	PF00397	0.342
DOC_WW_Pin1_4	590	595	PF00397	0.363
LIG_14-3-3_CanoR_1	135	139	PF00244	0.433
LIG_14-3-3_CanoR_1	230	235	PF00244	0.277
LIG_14-3-3_CanoR_1	454	462	PF00244	0.336
LIG_14-3-3_CanoR_1	489	495	PF00244	0.255
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_BIR_III_4	102	106	PF00653	0.441
LIG_BRCT_BRCA1_1	175	179	PF00533	0.388
LIG_Dynein_DLC8_1	487	493	PF01221	0.336
LIG_eIF4E_1	121	127	PF01652	0.388
LIG_FHA_1	138	144	PF00498	0.264
LIG_FHA_1	247	253	PF00498	0.268
LIG_FHA_1	296	302	PF00498	0.264
LIG_FHA_1	328	334	PF00498	0.246
LIG_FHA_1	403	409	PF00498	0.266
LIG_FHA_1	475	481	PF00498	0.328
LIG_FHA_1	489	495	PF00498	0.185
LIG_FHA_1	590	596	PF00498	0.314
LIG_FHA_1	76	82	PF00498	0.642
LIG_FHA_1	89	95	PF00498	0.436
LIG_FHA_2	156	162	PF00498	0.288
LIG_FHA_2	281	287	PF00498	0.389
LIG_FHA_2	363	369	PF00498	0.292
LIG_FHA_2	389	395	PF00498	0.283
LIG_FHA_2	528	534	PF00498	0.277
LIG_FHA_2	611	617	PF00498	0.490
LIG_FHA_2	75	81	PF00498	0.621
LIG_Integrin_isoDGR_2	133	135	PF01839	0.307
LIG_Integrin_RGD_1	272	274	PF01839	0.187
LIG_LIR_Gen_1	208	217	PF02991	0.451
LIG_LIR_Gen_1	37	44	PF02991	0.470
LIG_LIR_Gen_1	371	382	PF02991	0.236
LIG_LIR_Gen_1	394	402	PF02991	0.243
LIG_LIR_Gen_1	440	449	PF02991	0.245
LIG_LIR_Gen_1	628	639	PF02991	0.340
LIG_LIR_Nem_3	165	171	PF02991	0.318
LIG_LIR_Nem_3	208	212	PF02991	0.502
LIG_LIR_Nem_3	371	377	PF02991	0.258
LIG_LIR_Nem_3	381	387	PF02991	0.221
LIG_LIR_Nem_3	394	400	PF02991	0.236
LIG_LIR_Nem_3	440	444	PF02991	0.254
LIG_LIR_Nem_3	628	634	PF02991	0.399
LIG_MLH1_MIPbox_1	175	179	PF16413	0.370
LIG_SH2_CRK	384	388	PF00017	0.258
LIG_SH2_PTP2	397	400	PF00017	0.258
LIG_SH2_PTP2	441	444	PF00017	0.302
LIG_SH2_STAP1	406	410	PF00017	0.388
LIG_SH2_STAP1	462	466	PF00017	0.258
LIG_SH2_STAP1	608	612	PF00017	0.258
LIG_SH2_STAT5	178	181	PF00017	0.370
LIG_SH2_STAT5	234	237	PF00017	0.255
LIG_SH2_STAT5	242	245	PF00017	0.227
LIG_SH2_STAT5	300	303	PF00017	0.336
LIG_SH2_STAT5	322	325	PF00017	0.307
LIG_SH2_STAT5	397	400	PF00017	0.269
LIG_SH2_STAT5	434	437	PF00017	0.295
LIG_SH2_STAT5	441	444	PF00017	0.298
LIG_SH2_STAT5	469	472	PF00017	0.258
LIG_SH2_STAT5	496	499	PF00017	0.302
LIG_SH2_STAT5	527	530	PF00017	0.243
LIG_SH2_STAT5	564	567	PF00017	0.325
LIG_SH2_STAT5	610	613	PF00017	0.267
LIG_SH3_3	209	215	PF00018	0.524
LIG_SH3_3	222	228	PF00018	0.182
LIG_SH3_3	273	279	PF00018	0.451
LIG_SH3_3	360	366	PF00018	0.336
LIG_SH3_3	62	68	PF00018	0.617
LIG_SH3_3	78	84	PF00018	0.580
LIG_SUMO_SIM_anti_2	137	144	PF11976	0.264
LIG_SUMO_SIM_anti_2	219	225	PF11976	0.258
LIG_SUMO_SIM_anti_2	304	311	PF11976	0.261
LIG_SUMO_SIM_anti_2	440	447	PF11976	0.302
LIG_SUMO_SIM_anti_2	476	485	PF11976	0.391
LIG_SUMO_SIM_par_1	139	144	PF11976	0.466
LIG_SUMO_SIM_par_1	158	165	PF11976	0.170
LIG_SUMO_SIM_par_1	591	599	PF11976	0.245
LIG_SUMO_SIM_par_1	88	93	PF11976	0.371
LIG_TRAF2_1	512	515	PF00917	0.398
LIG_TYR_ITAM	371	387	PF00017	0.277
LIG_UBA3_1	223	232	PF00899	0.243
MOD_CK1_1	137	143	PF00069	0.264
MOD_CK1_1	196	202	PF00069	0.587
MOD_CK1_1	2	8	PF00069	0.536
MOD_CK1_1	277	283	PF00069	0.334
MOD_CK1_1	453	459	PF00069	0.243
MOD_CK2_1	155	161	PF00069	0.350
MOD_CK2_1	280	286	PF00069	0.373
MOD_CK2_1	509	515	PF00069	0.372
MOD_CK2_1	576	582	PF00069	0.392
MOD_CK2_1	658	664	PF00069	0.373
MOD_GlcNHglycan	14	17	PF01048	0.703
MOD_GlcNHglycan	175	178	PF01048	0.330
MOD_GlcNHglycan	208	212	PF01048	0.605
MOD_GlcNHglycan	304	307	PF01048	0.319
MOD_GlcNHglycan	511	514	PF01048	0.231
MOD_GlcNHglycan	99	102	PF01048	0.374
MOD_GSK3_1	193	200	PF00069	0.643
MOD_GSK3_1	400	407	PF00069	0.408
MOD_GSK3_1	474	481	PF00069	0.293
MOD_GSK3_1	547	554	PF00069	0.267
MOD_GSK3_1	606	613	PF00069	0.306
MOD_GSK3_1	660	667	PF00069	0.428
MOD_N-GLC_1	333	338	PF02516	0.364
MOD_N-GLC_1	424	429	PF02516	0.366
MOD_N-GLC_1	74	79	PF02516	0.684
MOD_NEK2_1	216	221	PF00069	0.266
MOD_NEK2_1	310	315	PF00069	0.256
MOD_NEK2_1	433	438	PF00069	0.277
MOD_NEK2_1	596	601	PF00069	0.243
MOD_NEK2_2	490	495	PF00069	0.277
MOD_NEK2_2	498	503	PF00069	0.277
MOD_PIKK_1	310	316	PF00454	0.347
MOD_PIKK_1	400	406	PF00454	0.307
MOD_PIKK_1	488	494	PF00454	0.323
MOD_PKA_1	488	494	PF00069	0.388
MOD_PKA_2	134	140	PF00069	0.433
MOD_PKA_2	287	293	PF00069	0.280
MOD_PKA_2	327	333	PF00069	0.305
MOD_PKA_2	453	459	PF00069	0.277
MOD_PKA_2	488	494	PF00069	0.255
MOD_PKB_1	458	466	PF00069	0.307
MOD_Plk_1	147	153	PF00069	0.333
MOD_Plk_1	207	213	PF00069	0.501
MOD_Plk_1	295	301	PF00069	0.277
MOD_Plk_1	333	339	PF00069	0.388
MOD_Plk_1	498	504	PF00069	0.277
MOD_Plk_4	134	140	PF00069	0.396
MOD_Plk_4	147	153	PF00069	0.284
MOD_Plk_4	216	222	PF00069	0.246
MOD_Plk_4	230	236	PF00069	0.255
MOD_Plk_4	296	302	PF00069	0.420
MOD_Plk_4	478	484	PF00069	0.336
MOD_Plk_4	606	612	PF00069	0.315
MOD_ProDKin_1	155	161	PF00069	0.258
MOD_ProDKin_1	197	203	PF00069	0.581
MOD_ProDKin_1	2	8	PF00069	0.637
MOD_ProDKin_1	275	281	PF00069	0.345
MOD_ProDKin_1	362	368	PF00069	0.264
MOD_ProDKin_1	424	430	PF00069	0.342
MOD_ProDKin_1	590	596	PF00069	0.363
MOD_SUMO_rev_2	512	520	PF00179	0.345
MOD_SUMO_rev_2	56	66	PF00179	0.600
TRG_DiLeu_BaEn_1	440	445	PF01217	0.277
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.264
TRG_ENDOCYTIC_2	373	376	PF00928	0.254
TRG_ENDOCYTIC_2	384	387	PF00928	0.224
TRG_ENDOCYTIC_2	397	400	PF00928	0.243
TRG_ENDOCYTIC_2	441	444	PF00928	0.252
TRG_ENDOCYTIC_2	608	611	PF00928	0.307
TRG_ER_diArg_1	239	241	PF00400	0.385
TRG_ER_diArg_1	259	261	PF00400	0.122
TRG_ER_diArg_1	29	32	PF00400	0.607
TRG_ER_diArg_1	521	524	PF00400	0.418
TRG_NES_CRM1_1	80	93	PF08389	0.409
TRG_NLS_MonoCore_2	28	33	PF00514	0.581
TRG_NLS_MonoExtC_3	29	34	PF00514	0.671
TRG_NLS_MonoExtN_4	29	34	PF00514	0.625
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXF4	Leptomonas seymouri	74%	98%
A0A0S4IN06	Bodo saltans	44%	90%
A0A0S4KH03	Bodo saltans	24%	100%
A0A1X0NU02	Trypanosomatidae	54%	100%
A0A3R7MQ36	Trypanosoma rangeli	55%	100%
A0A3S7WZP0	Leishmania donovani	100%	100%
A4HEN8	Leishmania braziliensis	86%	100%
C9ZS53	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
C9ZUM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	95%
E9AY13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O35552	Rattus norvegicus	27%	100%
P07953	Rattus norvegicus	29%	100%
P16118	Homo sapiens	28%	100%
P25114	Rattus norvegicus	27%	100%
P26285	Bos taurus	27%	100%
P49872	Bos taurus	28%	100%
P70265	Mus musculus	27%	100%
P70266	Mus musculus	28%	100%
Q16875	Homo sapiens	27%	100%
Q16877	Homo sapiens	27%	100%
Q21122	Caenorhabditis elegans	29%	100%
Q28901	Bos taurus	27%	100%
Q4Q9G0	Leishmania major	96%	100%
Q4R8B6	Macaca fascicularis	27%	100%
Q5NVT1	Pongo abelii	26%	100%
Q5R9C1	Pongo abelii	27%	100%
Q6DTY7	Mus musculus	27%	100%
Q8TFH0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9UTE1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
V5DR58	Trypanosoma cruzi	57%	97%