PUM-HD domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1W5_LEIIN

TriTrypDb:

LINF_260007800

Length:

202

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	2

Expansion

Sequence features

A4I1W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1W5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.493
CLV_PCSK_KEX2_1	140	142	PF00082	0.510
CLV_PCSK_SKI1_1	119	123	PF00082	0.494
CLV_PCSK_SKI1_1	184	188	PF00082	0.520
DEG_APCC_DBOX_1	139	147	PF00400	0.533
DOC_MAPK_MEF2A_6	79	87	PF00069	0.460
LIG_14-3-3_CanoR_1	133	139	PF00244	0.490
LIG_14-3-3_CanoR_1	4	8	PF00244	0.599
LIG_Actin_WH2_2	184	202	PF00022	0.366
LIG_BIR_III_2	158	162	PF00653	0.520
LIG_FHA_1	113	119	PF00498	0.464
LIG_FHA_1	166	172	PF00498	0.472
LIG_FHA_1	186	192	PF00498	0.537
LIG_FHA_1	38	44	PF00498	0.534
LIG_FHA_1	71	77	PF00498	0.402
LIG_FHA_2	106	112	PF00498	0.488
LIG_FHA_2	94	100	PF00498	0.409
LIG_LIR_Gen_1	39	46	PF02991	0.397
LIG_LIR_Nem_3	39	45	PF02991	0.377
LIG_Rb_pABgroove_1	81	89	PF01858	0.408
LIG_SH2_STAT5	169	172	PF00017	0.472
LIG_SH2_STAT5	194	197	PF00017	0.555
LIG_TRAF2_1	148	151	PF00917	0.559
LIG_UBA3_1	85	91	PF00899	0.427
MOD_GlcNHglycan	92	96	PF01048	0.544
MOD_GSK3_1	170	177	PF00069	0.535
MOD_N-GLC_1	37	42	PF02516	0.504
MOD_NEK2_1	105	110	PF00069	0.423
MOD_NEK2_1	170	175	PF00069	0.505
MOD_NEK2_1	186	191	PF00069	0.505
MOD_NEK2_1	37	42	PF00069	0.540
MOD_NEK2_1	70	75	PF00069	0.374
MOD_NEK2_2	93	98	PF00069	0.518
MOD_NMyristoyl	1	7	PF02799	0.513
MOD_PKA_2	3	9	PF00069	0.610
MOD_Plk_1	37	43	PF00069	0.522
MOD_Plk_4	134	140	PF00069	0.490
MOD_Plk_4	165	171	PF00069	0.531
MOD_Plk_4	37	43	PF00069	0.504
MOD_SUMO_for_1	178	181	PF00179	0.492
MOD_SUMO_rev_2	6	11	PF00179	0.553
TRG_DiLeu_BaEn_1	151	156	PF01217	0.513
TRG_ER_diArg_1	139	141	PF00400	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5J3	Leptomonas seymouri	72%	100%
A0A0S4IJA5	Bodo saltans	23%	79%
A0A1X0NST0	Trypanosomatidae	36%	100%
A0A3S7WZL3	Leishmania donovani	99%	100%
A0A422NVH2	Trypanosoma rangeli	38%	100%
C9ZS55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AIS0	Leishmania braziliensis	80%	100%
E9AY10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q9G3	Leishmania major	92%	100%
V5DR87	Trypanosoma cruzi	40%	100%