LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I1W3_LEIIN
TriTrypDb:
LINF_260007600
Length:
610

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1W3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1W3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 214 218 PF00656 0.515
CLV_C14_Caspase3-7 70 74 PF00656 0.605
CLV_NRD_NRD_1 143 145 PF00675 0.539
CLV_NRD_NRD_1 173 175 PF00675 0.543
CLV_NRD_NRD_1 346 348 PF00675 0.356
CLV_NRD_NRD_1 403 405 PF00675 0.488
CLV_NRD_NRD_1 414 416 PF00675 0.502
CLV_NRD_NRD_1 488 490 PF00675 0.392
CLV_NRD_NRD_1 529 531 PF00675 0.359
CLV_PCSK_FUR_1 401 405 PF00082 0.509
CLV_PCSK_KEX2_1 136 138 PF00082 0.620
CLV_PCSK_KEX2_1 145 147 PF00082 0.527
CLV_PCSK_KEX2_1 173 175 PF00082 0.553
CLV_PCSK_KEX2_1 38 40 PF00082 0.495
CLV_PCSK_KEX2_1 401 403 PF00082 0.476
CLV_PCSK_KEX2_1 488 490 PF00082 0.392
CLV_PCSK_KEX2_1 529 531 PF00082 0.359
CLV_PCSK_PC1ET2_1 136 138 PF00082 0.705
CLV_PCSK_PC1ET2_1 145 147 PF00082 0.669
CLV_PCSK_PC1ET2_1 173 175 PF00082 0.553
CLV_PCSK_PC1ET2_1 38 40 PF00082 0.413
CLV_PCSK_SKI1_1 175 179 PF00082 0.621
CLV_PCSK_SKI1_1 230 234 PF00082 0.448
CLV_PCSK_SKI1_1 265 269 PF00082 0.433
CLV_PCSK_SKI1_1 272 276 PF00082 0.337
CLV_PCSK_SKI1_1 326 330 PF00082 0.460
CLV_PCSK_SKI1_1 365 369 PF00082 0.462
CLV_PCSK_SKI1_1 39 43 PF00082 0.511
CLV_PCSK_SKI1_1 404 408 PF00082 0.555
CLV_PCSK_SKI1_1 469 473 PF00082 0.466
DEG_APCC_DBOX_1 229 237 PF00400 0.404
DEG_APCC_DBOX_1 257 265 PF00400 0.518
DEG_APCC_DBOX_1 402 410 PF00400 0.496
DOC_ANK_TNKS_1 68 75 PF00023 0.401
DOC_CDC14_PxL_1 376 384 PF14671 0.405
DOC_CYCLIN_yCln2_LP_2 124 130 PF00134 0.669
DOC_CYCLIN_yCln2_LP_2 370 376 PF00134 0.378
DOC_MAPK_gen_1 144 153 PF00069 0.555
DOC_MAPK_gen_1 263 270 PF00069 0.468
DOC_MAPK_MEF2A_6 146 155 PF00069 0.538
DOC_MAPK_MEF2A_6 365 374 PF00069 0.298
DOC_MAPK_NFAT4_5 365 373 PF00069 0.300
DOC_PP1_RVXF_1 228 235 PF00149 0.420
DOC_PP2B_LxvP_1 124 127 PF13499 0.669
DOC_PP2B_LxvP_1 370 373 PF13499 0.446
DOC_PP4_FxxP_1 184 187 PF00568 0.545
DOC_SPAK_OSR1_1 52 56 PF12202 0.410
DOC_USP7_MATH_1 218 222 PF00917 0.528
DOC_USP7_MATH_1 492 496 PF00917 0.594
DOC_USP7_MATH_1 536 540 PF00917 0.540
DOC_USP7_MATH_1 99 103 PF00917 0.530
DOC_WW_Pin1_4 223 228 PF00397 0.410
DOC_WW_Pin1_4 393 398 PF00397 0.486
DOC_WW_Pin1_4 457 462 PF00397 0.384
LIG_14-3-3_CanoR_1 121 125 PF00244 0.551
LIG_14-3-3_CanoR_1 182 187 PF00244 0.542
LIG_14-3-3_CanoR_1 283 289 PF00244 0.589
LIG_14-3-3_CanoR_1 404 410 PF00244 0.431
LIG_14-3-3_CanoR_1 415 420 PF00244 0.488
LIG_14-3-3_CanoR_1 46 55 PF00244 0.554
LIG_14-3-3_CanoR_1 537 541 PF00244 0.489
LIG_14-3-3_CanoR_1 577 586 PF00244 0.405
LIG_APCC_ABBA_1 156 161 PF00400 0.544
LIG_APCC_ABBA_1 53 58 PF00400 0.443
LIG_APCC_ABBAyCdc20_2 52 58 PF00400 0.448
LIG_BIR_III_4 217 221 PF00653 0.540
LIG_BRCT_BRCA1_1 438 442 PF00533 0.368
LIG_CtBP_PxDLS_1 583 589 PF00389 0.351
LIG_CtBP_PxDLS_1 592 596 PF00389 0.416
LIG_eIF4E_1 103 109 PF01652 0.462
LIG_eIF4E_1 435 441 PF01652 0.451
LIG_FHA_1 283 289 PF00498 0.588
LIG_FHA_1 74 80 PF00498 0.503
LIG_FHA_2 212 218 PF00498 0.501
LIG_FHA_2 40 46 PF00498 0.480
LIG_FHA_2 406 412 PF00498 0.450
LIG_FHA_2 472 478 PF00498 0.486
LIG_FHA_2 551 557 PF00498 0.458
LIG_FHA_2 569 575 PF00498 0.465
LIG_LIR_Gen_1 102 109 PF02991 0.332
LIG_LIR_Gen_1 226 236 PF02991 0.395
LIG_LIR_Gen_1 241 252 PF02991 0.339
LIG_LIR_Gen_1 558 569 PF02991 0.475
LIG_LIR_Gen_1 58 68 PF02991 0.421
LIG_LIR_Nem_3 102 107 PF02991 0.257
LIG_LIR_Nem_3 179 184 PF02991 0.655
LIG_LIR_Nem_3 217 222 PF02991 0.472
LIG_LIR_Nem_3 226 231 PF02991 0.387
LIG_LIR_Nem_3 241 247 PF02991 0.369
LIG_LIR_Nem_3 311 317 PF02991 0.486
LIG_LIR_Nem_3 51 56 PF02991 0.451
LIG_LIR_Nem_3 558 564 PF02991 0.487
LIG_LIR_Nem_3 58 63 PF02991 0.367
LIG_LIR_Nem_3 94 100 PF02991 0.566
LIG_MAD2 365 373 PF02301 0.261
LIG_MYND_1 494 498 PF01753 0.511
LIG_NRBOX 232 238 PF00104 0.509
LIG_NRBOX 446 452 PF00104 0.402
LIG_NRBOX 482 488 PF00104 0.385
LIG_NRBOX 82 88 PF00104 0.433
LIG_PCNA_PIPBox_1 429 438 PF02747 0.356
LIG_PCNA_yPIPBox_3 423 436 PF02747 0.437
LIG_Pex14_2 467 471 PF04695 0.325
LIG_Rb_pABgroove_1 549 557 PF01858 0.268
LIG_SH2_CRK 219 223 PF00017 0.476
LIG_SH2_CRK 228 232 PF00017 0.446
LIG_SH2_NCK_1 56 60 PF00017 0.366
LIG_SH2_NCK_1 579 583 PF00017 0.515
LIG_SH2_PTP2 209 212 PF00017 0.489
LIG_SH2_SRC 56 59 PF00017 0.328
LIG_SH2_STAP1 118 122 PF00017 0.593
LIG_SH2_STAP1 228 232 PF00017 0.528
LIG_SH2_STAP1 248 252 PF00017 0.569
LIG_SH2_STAP1 292 296 PF00017 0.571
LIG_SH2_STAP1 56 60 PF00017 0.470
LIG_SH2_STAT5 103 106 PF00017 0.454
LIG_SH2_STAT5 209 212 PF00017 0.501
LIG_SH2_STAT5 315 318 PF00017 0.503
LIG_SH2_STAT5 435 438 PF00017 0.449
LIG_SH2_STAT5 485 488 PF00017 0.478
LIG_SH2_STAT5 524 527 PF00017 0.353
LIG_SH2_STAT5 579 582 PF00017 0.520
LIG_SH3_1 488 494 PF00018 0.533
LIG_SH3_3 148 154 PF00018 0.524
LIG_SH3_3 488 494 PF00018 0.533
LIG_SH3_3 497 503 PF00018 0.347
LIG_SUMO_SIM_anti_2 28 35 PF11976 0.430
LIG_SUMO_SIM_par_1 449 455 PF11976 0.362
LIG_TRAF2_1 138 141 PF00917 0.601
LIG_TRAF2_1 274 277 PF00917 0.520
LIG_TRAF2_1 42 45 PF00917 0.509
LIG_UBA3_1 183 189 PF00899 0.632
LIG_WRC_WIRS_1 23 28 PF05994 0.429
LIG_WRC_WIRS_1 456 461 PF05994 0.464
MOD_CDK_SPxxK_3 223 230 PF00069 0.400
MOD_CK1_1 25 31 PF00069 0.536
MOD_CK1_1 425 431 PF00069 0.654
MOD_CK1_1 455 461 PF00069 0.288
MOD_CK2_1 114 120 PF00069 0.621
MOD_CK2_1 135 141 PF00069 0.590
MOD_CK2_1 39 45 PF00069 0.428
MOD_CK2_1 471 477 PF00069 0.388
MOD_CK2_1 567 573 PF00069 0.498
MOD_GlcNHglycan 244 247 PF01048 0.394
MOD_GlcNHglycan 294 297 PF01048 0.489
MOD_GlcNHglycan 322 325 PF01048 0.494
MOD_GlcNHglycan 419 422 PF01048 0.636
MOD_GlcNHglycan 424 427 PF01048 0.680
MOD_GlcNHglycan 48 51 PF01048 0.564
MOD_GSK3_1 116 123 PF00069 0.574
MOD_GSK3_1 22 29 PF00069 0.385
MOD_GSK3_1 415 422 PF00069 0.589
MOD_GSK3_1 424 431 PF00069 0.677
MOD_GSK3_1 467 474 PF00069 0.402
MOD_GSK3_1 573 580 PF00069 0.558
MOD_N-GLC_1 239 244 PF02516 0.337
MOD_NEK2_1 275 280 PF00069 0.437
MOD_NEK2_1 419 424 PF00069 0.595
MOD_NEK2_1 436 441 PF00069 0.473
MOD_NEK2_1 467 472 PF00069 0.381
MOD_NEK2_1 509 514 PF00069 0.458
MOD_NEK2_1 567 572 PF00069 0.415
MOD_NEK2_1 79 84 PF00069 0.516
MOD_NEK2_2 218 223 PF00069 0.532
MOD_NEK2_2 536 541 PF00069 0.447
MOD_NEK2_2 550 555 PF00069 0.212
MOD_PIKK_1 425 431 PF00454 0.621
MOD_PKA_1 415 421 PF00069 0.614
MOD_PKA_2 120 126 PF00069 0.544
MOD_PKA_2 282 288 PF00069 0.424
MOD_PKA_2 414 420 PF00069 0.564
MOD_PKA_2 536 542 PF00069 0.524
MOD_Plk_1 239 245 PF00069 0.340
MOD_Plk_1 275 281 PF00069 0.509
MOD_Plk_2-3 135 141 PF00069 0.543
MOD_Plk_4 120 126 PF00069 0.579
MOD_Plk_4 161 167 PF00069 0.670
MOD_Plk_4 239 245 PF00069 0.512
MOD_Plk_4 284 290 PF00069 0.487
MOD_Plk_4 405 411 PF00069 0.435
MOD_Plk_4 431 437 PF00069 0.342
MOD_Plk_4 452 458 PF00069 0.371
MOD_Plk_4 492 498 PF00069 0.503
MOD_Plk_4 550 556 PF00069 0.340
MOD_Plk_4 99 105 PF00069 0.465
MOD_ProDKin_1 223 229 PF00069 0.402
MOD_ProDKin_1 393 399 PF00069 0.478
MOD_ProDKin_1 457 463 PF00069 0.384
TRG_DiLeu_BaEn_1 120 125 PF01217 0.574
TRG_DiLeu_BaEn_1 452 457 PF01217 0.457
TRG_DiLeu_BaEn_3 477 483 PF01217 0.506
TRG_DiLeu_BaEn_4 478 484 PF01217 0.505
TRG_DiLeu_BaLyEn_6 227 232 PF01217 0.454
TRG_DiLeu_BaLyEn_6 370 375 PF01217 0.334
TRG_DiLeu_BaLyEn_6 82 87 PF01217 0.427
TRG_ENDOCYTIC_2 181 184 PF00928 0.572
TRG_ENDOCYTIC_2 209 212 PF00928 0.390
TRG_ENDOCYTIC_2 219 222 PF00928 0.434
TRG_ENDOCYTIC_2 228 231 PF00928 0.443
TRG_ENDOCYTIC_2 506 509 PF00928 0.478
TRG_ER_diArg_1 401 404 PF00400 0.476
TRG_ER_diArg_1 487 489 PF00400 0.419
TRG_ER_diArg_1 529 531 PF00400 0.468
TRG_ER_diArg_1 540 543 PF00400 0.524
TRG_NLS_MonoCore_2 171 176 PF00514 0.528
TRG_NLS_MonoExtC_3 171 176 PF00514 0.544
TRG_NLS_MonoExtN_4 171 177 PF00514 0.528
TRG_NLS_MonoExtN_4 401 408 PF00514 0.532
TRG_Pf-PMV_PEXEL_1 39 43 PF00026 0.557
TRG_Pf-PMV_PEXEL_1 529 534 PF00026 0.423
TRG_Pf-PMV_PEXEL_1 85 89 PF00026 0.518

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P504 Leptomonas seymouri 67% 88%
A0A0S4IN30 Bodo saltans 26% 68%
A0A1X0NT69 Trypanosomatidae 33% 80%
A0A3Q8IGU6 Leishmania donovani 100% 100%
A0A3S5IS00 Trypanosoma rangeli 34% 86%
A4HEN5 Leishmania braziliensis 86% 100%
C9ZS57 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 82%
E9AY08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q9G5 Leishmania major 93% 100%
V5BZE7 Trypanosoma cruzi 35% 86%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS