LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Scaffold protein Nfu/NifU N terminal/NifU-like domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I1V6_LEIIN
TriTrypDb:
LINF_260006900
Length:
284

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I1V6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1V6

Function

Biological processes
Term Name Level Count
GO:0006790 sulfur compound metabolic process 3 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016043 cellular component organization 3 11
GO:0016226 iron-sulfur cluster assembly 4 11
GO:0022607 cellular component assembly 4 11
GO:0031163 metallo-sulfur cluster assembly 5 11
GO:0044237 cellular metabolic process 2 11
GO:0071840 cellular component organization or biogenesis 2 11
GO:0006807 nitrogen compound metabolic process 2 1
GO:0019538 protein metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044238 primary metabolic process 2 1
GO:0051604 protein maturation 4 1
GO:0071704 organic substance metabolic process 2 1
GO:0097428 protein maturation by iron-sulfur cluster transfer 5 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 11
GO:0005506 iron ion binding 6 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
GO:0046914 transition metal ion binding 5 11
GO:0051536 iron-sulfur cluster binding 3 11
GO:0051540 metal cluster binding 2 11
GO:0051539 4 iron, 4 sulfur cluster binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 130 132 PF00675 0.290
CLV_NRD_NRD_1 270 272 PF00675 0.426
CLV_NRD_NRD_1 36 38 PF00675 0.490
CLV_NRD_NRD_1 6 8 PF00675 0.594
CLV_PCSK_KEX2_1 268 270 PF00082 0.391
CLV_PCSK_KEX2_1 36 38 PF00082 0.482
CLV_PCSK_KEX2_1 6 8 PF00082 0.624
CLV_PCSK_PC1ET2_1 268 270 PF00082 0.476
CLV_PCSK_SKI1_1 189 193 PF00082 0.215
CLV_PCSK_SKI1_1 197 201 PF00082 0.237
CLV_PCSK_SKI1_1 272 276 PF00082 0.512
CLV_PCSK_SKI1_1 37 41 PF00082 0.571
DEG_APCC_KENBOX_2 155 159 PF00400 0.446
DEG_Nend_UBRbox_2 1 3 PF02207 0.399
DEG_SPOP_SBC_1 30 34 PF00917 0.674
DOC_CYCLIN_RxL_1 186 194 PF00134 0.245
DOC_MAPK_MEF2A_6 80 88 PF00069 0.224
DOC_MAPK_RevD_3 116 132 PF00069 0.324
DOC_PP4_FxxP_1 88 91 PF00568 0.274
DOC_USP7_MATH_1 30 34 PF00917 0.674
DOC_USP7_UBL2_3 268 272 PF12436 0.458
DOC_WW_Pin1_4 103 108 PF00397 0.220
DOC_WW_Pin1_4 70 75 PF00397 0.265
DOC_WW_Pin1_4 96 101 PF00397 0.283
LIG_14-3-3_CanoR_1 11 16 PF00244 0.599
LIG_14-3-3_CanoR_1 36 46 PF00244 0.449
LIG_14-3-3_CanoR_1 80 85 PF00244 0.261
LIG_FHA_1 214 220 PF00498 0.423
LIG_FHA_1 38 44 PF00498 0.469
LIG_FHA_2 173 179 PF00498 0.476
LIG_LIR_Apic_2 85 91 PF02991 0.245
LIG_LIR_Gen_1 125 134 PF02991 0.254
LIG_LIR_Gen_1 137 145 PF02991 0.228
LIG_LIR_Gen_1 216 222 PF02991 0.422
LIG_LIR_Nem_3 125 130 PF02991 0.245
LIG_LIR_Nem_3 137 141 PF02991 0.245
LIG_LIR_Nem_3 216 221 PF02991 0.444
LIG_SH2_CRK 104 108 PF00017 0.264
LIG_SH2_PTP2 127 130 PF00017 0.245
LIG_SH2_STAT5 127 130 PF00017 0.259
LIG_SUMO_SIM_anti_2 40 47 PF11976 0.430
LIG_SUMO_SIM_par_1 179 190 PF11976 0.365
LIG_TRAF2_1 163 166 PF00917 0.493
LIG_UBA3_1 141 146 PF00899 0.301
MOD_CK1_1 224 230 PF00069 0.418
MOD_CK1_1 231 237 PF00069 0.398
MOD_CK1_1 24 30 PF00069 0.546
MOD_CK1_1 38 44 PF00069 0.517
MOD_CK1_1 52 58 PF00069 0.553
MOD_CK2_1 234 240 PF00069 0.502
MOD_GlcNHglycan 160 163 PF01048 0.426
MOD_GlcNHglycan 236 239 PF01048 0.232
MOD_GlcNHglycan 51 54 PF01048 0.493
MOD_GlcNHglycan 7 10 PF01048 0.539
MOD_GSK3_1 224 231 PF00069 0.410
MOD_GSK3_1 31 38 PF00069 0.573
MOD_GSK3_1 80 87 PF00069 0.245
MOD_N-GLC_1 172 177 PF02516 0.455
MOD_N-GLC_1 70 75 PF02516 0.324
MOD_NEK2_1 191 196 PF00069 0.447
MOD_NEK2_1 221 226 PF00069 0.419
MOD_NEK2_1 39 44 PF00069 0.532
MOD_NEK2_1 5 10 PF00069 0.501
MOD_NEK2_1 51 56 PF00069 0.506
MOD_NEK2_1 84 89 PF00069 0.250
MOD_NEK2_2 31 36 PF00069 0.446
MOD_PKA_2 35 41 PF00069 0.514
MOD_PKA_2 5 11 PF00069 0.526
MOD_Plk_1 84 90 PF00069 0.245
MOD_Plk_1 91 97 PF00069 0.245
MOD_Plk_4 213 219 PF00069 0.425
MOD_Plk_4 39 45 PF00069 0.629
MOD_Plk_4 84 90 PF00069 0.212
MOD_ProDKin_1 103 109 PF00069 0.220
MOD_ProDKin_1 70 76 PF00069 0.265
MOD_ProDKin_1 96 102 PF00069 0.283
MOD_SUMO_for_1 89 92 PF00179 0.377
TRG_DiLeu_BaEn_2 213 219 PF01217 0.463
TRG_ENDOCYTIC_2 127 130 PF00928 0.245
TRG_ER_diArg_1 195 198 PF00400 0.408
TRG_ER_diArg_1 35 37 PF00400 0.492
TRG_ER_diArg_1 5 7 PF00400 0.601
TRG_Pf-PMV_PEXEL_1 272 276 PF00026 0.493

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2Q0 Leptomonas seymouri 80% 97%
A0A0N1I735 Leptomonas seymouri 31% 100%
A0A0S4IJH0 Bodo saltans 55% 100%
A0A0S4IVB5 Bodo saltans 34% 100%
A0A1X0NST9 Trypanosomatidae 59% 100%
A0A1X0P8F8 Trypanosomatidae 30% 100%
A0A3R7MX73 Trypanosoma rangeli 59% 100%
A0A3S5H7F5 Leishmania donovani 99% 100%
A0A3S7XAI2 Leishmania donovani 34% 95%
A4HEM5 Leishmania braziliensis 81% 100%
A4HNU8 Leishmania braziliensis 32% 100%
A4ICP6 Leishmania infantum 34% 95%
B3MRT7 Drosophila ananassae 41% 99%
B3NYF7 Drosophila erecta 43% 100%
B4H303 Drosophila persimilis 42% 100%
B4IMF6 Drosophila sechellia 42% 100%
B4JWR9 Drosophila grimshawi 42% 95%
B4M375 Drosophila virilis 40% 95%
B4NE93 Drosophila willistoni 41% 98%
B4PZ52 Drosophila yakuba 42% 100%
B4R3T1 Drosophila simulans 42% 100%
B5DKJ8 Drosophila pseudoobscura pseudoobscura 42% 99%
C9ZS65 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 69% 100%
D0A2R6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
E9ASK8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9AY01 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
P32860 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 33% 100%
Q4Q1Y8 Leishmania major 33% 100%
Q4Q9H2 Leishmania major 95% 100%
Q8SY96 Drosophila melanogaster 42% 100%
Q9C8J2 Arabidopsis thaliana 40% 100%
Q9LIG6 Arabidopsis thaliana 38% 100%
Q9QZ23 Mus musculus 40% 100%
Q9UMS0 Homo sapiens 40% 100%
Q9UUB8 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 39% 100%
V5DRN0 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS