LeishMANIAdb
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Putative 60S ribosomal protein L7

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative 60S ribosomal protein L7
Gene product:
60S ribosomal protein L7 - putative
Species:
Leishmania infantum
UniProt:
A4I1V4_LEIIN
TriTrypDb:
LINF_260006600 *
Length:
271

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L7

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 32
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0015934 large ribosomal subunit 4 17
GO:0022625 cytosolic large ribosomal subunit 5 17
GO:0032991 protein-containing complex 1 17
GO:0044391 ribosomal subunit 3 17
GO:1990904 ribonucleoprotein complex 2 17
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 2
GO:0005840 ribosome 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I1V4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1V4

Function

Biological processes
Term Name Level Count
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 10 17
GO:0000470 maturation of LSU-rRNA 9 17
GO:0006139 nucleobase-containing compound metabolic process 3 17
GO:0006364 rRNA processing 8 17
GO:0006396 RNA processing 6 17
GO:0006725 cellular aromatic compound metabolic process 3 17
GO:0006807 nitrogen compound metabolic process 2 17
GO:0008152 metabolic process 1 17
GO:0009987 cellular process 1 17
GO:0016070 RNA metabolic process 5 17
GO:0016072 rRNA metabolic process 7 17
GO:0034470 ncRNA processing 7 17
GO:0034641 cellular nitrogen compound metabolic process 3 17
GO:0034660 ncRNA metabolic process 6 17
GO:0043170 macromolecule metabolic process 3 17
GO:0044237 cellular metabolic process 2 17
GO:0044238 primary metabolic process 2 17
GO:0046483 heterocycle metabolic process 3 17
GO:0071704 organic substance metabolic process 2 17
GO:0090304 nucleic acid metabolic process 4 17
GO:1901360 organic cyclic compound metabolic process 3 17
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 17
GO:0005198 structural molecule activity 1 17
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 128 130 PF00675 0.260
CLV_NRD_NRD_1 247 249 PF00675 0.380
CLV_NRD_NRD_1 61 63 PF00675 0.452
CLV_NRD_NRD_1 77 79 PF00675 0.327
CLV_NRD_NRD_1 95 97 PF00675 0.113
CLV_PCSK_FUR_1 244 248 PF00082 0.388
CLV_PCSK_KEX2_1 16 18 PF00082 0.384
CLV_PCSK_KEX2_1 179 181 PF00082 0.314
CLV_PCSK_KEX2_1 246 248 PF00082 0.391
CLV_PCSK_KEX2_1 43 45 PF00082 0.249
CLV_PCSK_KEX2_1 95 97 PF00082 0.230
CLV_PCSK_PC1ET2_1 16 18 PF00082 0.384
CLV_PCSK_PC1ET2_1 179 181 PF00082 0.314
CLV_PCSK_PC1ET2_1 246 248 PF00082 0.391
CLV_PCSK_PC1ET2_1 43 45 PF00082 0.249
CLV_PCSK_SKI1_1 129 133 PF00082 0.249
CLV_PCSK_SKI1_1 138 142 PF00082 0.249
CLV_PCSK_SKI1_1 16 20 PF00082 0.375
CLV_PCSK_SKI1_1 2 6 PF00082 0.385
CLV_PCSK_SKI1_1 225 229 PF00082 0.309
CLV_PCSK_SKI1_1 44 48 PF00082 0.249
CLV_PCSK_SKI1_1 63 67 PF00082 0.278
CLV_PCSK_SKI1_1 90 94 PF00082 0.323
DEG_APCC_DBOX_1 128 136 PF00400 0.260
DEG_Nend_UBRbox_1 1 4 PF02207 0.404
DOC_ANK_TNKS_1 247 254 PF00023 0.391
DOC_MAPK_gen_1 127 137 PF00069 0.249
DOC_MAPK_gen_1 179 185 PF00069 0.322
DOC_PP2B_LxvP_1 236 239 PF13499 0.325
DOC_USP7_UBL2_3 123 127 PF12436 0.260
DOC_USP7_UBL2_3 66 70 PF12436 0.293
DOC_WW_Pin1_4 6 11 PF00397 0.399
LIG_14-3-3_CanoR_1 17 26 PF00244 0.369
LIG_14-3-3_CanoR_1 189 198 PF00244 0.419
LIG_14-3-3_CanoR_1 225 234 PF00244 0.457
LIG_14-3-3_CanoR_1 96 106 PF00244 0.310
LIG_Actin_WH2_2 141 159 PF00022 0.249
LIG_FHA_1 141 147 PF00498 0.249
LIG_FHA_1 20 26 PF00498 0.646
LIG_FHA_1 70 76 PF00498 0.289
LIG_LIR_Gen_1 143 152 PF02991 0.249
LIG_LIR_Nem_3 160 165 PF02991 0.336
LIG_LIR_Nem_3 81 87 PF02991 0.125
LIG_LYPXL_yS_3 167 170 PF13949 0.289
LIG_PCNA_yPIPBox_3 123 135 PF02747 0.251
LIG_PCNA_yPIPBox_3 147 156 PF02747 0.260
LIG_Pex14_2 141 145 PF04695 0.249
LIG_PTB_Apo_2 139 146 PF02174 0.249
LIG_PTB_Apo_2 212 219 PF02174 0.287
LIG_PTB_Phospho_1 212 218 PF10480 0.280
LIG_Rb_LxCxE_1 206 219 PF01857 0.356
LIG_RPA_C_Fungi 57 69 PF08784 0.274
LIG_SH2_CRK 165 169 PF00017 0.281
LIG_SH2_NCK_1 202 206 PF00017 0.499
LIG_SH2_SRC 105 108 PF00017 0.274
LIG_SH2_STAP1 80 84 PF00017 0.265
LIG_SH2_STAT5 105 108 PF00017 0.260
LIG_SH2_STAT5 162 165 PF00017 0.276
LIG_SH2_STAT5 182 185 PF00017 0.458
LIG_SH2_STAT5 218 221 PF00017 0.341
LIG_SH2_STAT5 74 77 PF00017 0.391
LIG_SH3_3 30 36 PF00018 0.519
LIG_TRFH_1 234 238 PF08558 0.326
MOD_CK1_1 169 175 PF00069 0.314
MOD_CK1_1 6 12 PF00069 0.471
MOD_GlcNHglycan 39 42 PF01048 0.249
MOD_GSK3_1 2 9 PF00069 0.470
MOD_LATS_1 223 229 PF00433 0.310
MOD_N-GLC_1 27 32 PF02516 0.531
MOD_N-GLC_1 6 11 PF02516 0.392
MOD_NEK2_1 18 23 PF00069 0.412
MOD_NEK2_1 69 74 PF00069 0.304
MOD_PKA_1 16 22 PF00069 0.390
MOD_PKA_1 78 84 PF00069 0.404
MOD_PKA_2 16 22 PF00069 0.375
MOD_PKA_2 258 264 PF00069 0.323
MOD_PKB_1 76 84 PF00069 0.404
MOD_Plk_4 140 146 PF00069 0.249
MOD_Plk_4 21 27 PF00069 0.548
MOD_Plk_4 258 264 PF00069 0.323
MOD_ProDKin_1 6 12 PF00069 0.400
MOD_SUMO_rev_2 83 92 PF00179 0.251
TRG_ENDOCYTIC_2 167 170 PF00928 0.289
TRG_ENDOCYTIC_2 182 185 PF00928 0.400
TRG_ENDOCYTIC_2 84 87 PF00928 0.125
TRG_ER_diArg_1 135 138 PF00400 0.249
TRG_ER_diArg_1 75 78 PF00400 0.338
TRG_ER_diArg_1 94 96 PF00400 0.231
TRG_NLS_MonoExtN_4 244 250 PF00514 0.376
TRG_Pf-PMV_PEXEL_1 129 133 PF00026 0.260

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBU7 Leptomonas seymouri 92% 100%
A0A0S4IU62 Bodo saltans 83% 100%
A0A0S4JDH9 Bodo saltans 25% 77%
A0A1D8PDL6 Candida albicans (strain SC5314 / ATCC MYA-2876) 42% 100%
A0A1X0NSK2 Trypanosomatidae 87% 100%
A0A3Q8INU3 Leishmania donovani 100% 100%
A0A3R7M5J8 Trypanosoma rangeli 78% 100%
A0A3S7WZH9 Leishmania donovani 99% 100%
A0A422NVF3 Trypanosoma rangeli 86% 100%
A0BD73 Paramecium tetraurelia 42% 100%
A0CEY2 Paramecium tetraurelia 42% 100%
A4HEM2 Leishmania braziliensis 96% 100%
A4HEM3 Leishmania braziliensis 93% 100%
C9ZS66 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 88% 100%
C9ZS67 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 84% 100%
E9AHB0 Leishmania infantum 100% 100%
E9AXZ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
E9AXZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O01802 Caenorhabditis elegans 47% 100%
O60143 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 43% 100%
P05426 Rattus norvegicus 49% 100%
P05737 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 41% 100%
P0DJ13 Tetrahymena thermophila 40% 100%
P11874 Dictyostelium discoideum 46% 100%
P14148 Mus musculus 49% 100%
P17937 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 36% 100%
P18124 Homo sapiens 49% 100%
P25457 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 42% 100%
P32100 Drosophila melanogaster 47% 100%
P60039 Arabidopsis thaliana 44% 100%
P60040 Arabidopsis thaliana 45% 100%
Q12213 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 41% 100%
Q4Q9H4 Leishmania major 98% 100%
Q4R506 Macaca fascicularis 49% 100%
Q58DT1 Bos taurus 49% 100%
Q5R9R4 Pongo abelii 49% 100%
Q5RAH8 Pongo abelii 29% 100%
Q5ZJ56 Gallus gallus 50% 100%
Q6BTA4 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 42% 100%
Q6C603 Yarrowia lipolytica (strain CLIB 122 / E 150) 49% 100%
Q6DKI1 Homo sapiens 30% 100%
Q6FSN6 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 42% 100%
Q755A7 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 42% 100%
Q7SBD5 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 42% 100%
Q8SS93 Encephalitozoon cuniculi (strain GB-M1) 31% 100%
Q9D8M4 Mus musculus 29% 100%
Q9LHP1 Arabidopsis thaliana 45% 100%
Q9SAI5 Arabidopsis thaliana 33% 100%
V5DR72 Trypanosoma cruzi 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS