LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I1U5_LEIIN
TriTrypDb:
LINF_260005600
Length:
302

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1U5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1U5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 41 47 PF00089 0.448
CLV_NRD_NRD_1 113 115 PF00675 0.615
CLV_NRD_NRD_1 120 122 PF00675 0.550
CLV_NRD_NRD_1 187 189 PF00675 0.713
CLV_NRD_NRD_1 242 244 PF00675 0.805
CLV_NRD_NRD_1 43 45 PF00675 0.635
CLV_NRD_NRD_1 81 83 PF00675 0.651
CLV_PCSK_KEX2_1 113 115 PF00082 0.624
CLV_PCSK_KEX2_1 187 189 PF00082 0.713
CLV_PCSK_KEX2_1 242 244 PF00082 0.805
CLV_PCSK_KEX2_1 42 44 PF00082 0.670
CLV_PCSK_KEX2_1 80 82 PF00082 0.694
CLV_PCSK_SKI1_1 114 118 PF00082 0.682
CLV_PCSK_SKI1_1 219 223 PF00082 0.622
CLV_PCSK_SKI1_1 22 26 PF00082 0.502
CLV_PCSK_SKI1_1 283 287 PF00082 0.824
DEG_APCC_DBOX_1 113 121 PF00400 0.679
DEG_APCC_DBOX_1 21 29 PF00400 0.580
DEG_COP1_1 250 260 PF00400 0.749
DEG_Nend_Nbox_1 1 3 PF02207 0.666
DOC_MAPK_MEF2A_6 151 158 PF00069 0.579
DOC_USP7_MATH_1 157 161 PF00917 0.805
DOC_USP7_MATH_1 17 21 PF00917 0.688
DOC_USP7_MATH_1 225 229 PF00917 0.715
DOC_WW_Pin1_4 15 20 PF00397 0.635
DOC_WW_Pin1_4 150 155 PF00397 0.743
DOC_WW_Pin1_4 161 166 PF00397 0.670
DOC_WW_Pin1_4 219 224 PF00397 0.655
DOC_WW_Pin1_4 245 250 PF00397 0.758
DOC_WW_Pin1_4 290 295 PF00397 0.838
DOC_WW_Pin1_4 46 51 PF00397 0.618
LIG_14-3-3_CanoR_1 81 87 PF00244 0.663
LIG_BRCT_BRCA1_1 185 189 PF00533 0.702
LIG_FHA_1 147 153 PF00498 0.704
LIG_FHA_1 95 101 PF00498 0.607
LIG_FHA_2 47 53 PF00498 0.564
LIG_FHA_2 94 100 PF00498 0.632
LIG_GBD_Chelix_1 66 74 PF00786 0.441
LIG_Integrin_RGD_1 243 245 PF01839 0.724
LIG_LIR_Apic_2 207 213 PF02991 0.650
LIG_LIR_Gen_1 196 205 PF02991 0.699
LIG_LIR_Nem_3 186 192 PF02991 0.682
LIG_LIR_Nem_3 196 202 PF02991 0.720
LIG_LIR_Nem_3 6 12 PF02991 0.703
LIG_Pex14_1 210 214 PF04695 0.701
LIG_RPA_C_Fungi 57 69 PF08784 0.475
LIG_SH2_CRK 89 93 PF00017 0.668
LIG_SH2_STAP1 89 93 PF00017 0.566
LIG_SH3_3 113 119 PF00018 0.684
LIG_SH3_3 199 205 PF00018 0.783
LIG_SH3_3 221 227 PF00018 0.649
LIG_TRAF2_1 250 253 PF00917 0.789
LIG_WRC_WIRS_1 226 231 PF05994 0.633
MOD_CDK_SPxxK_3 15 22 PF00069 0.590
MOD_CK1_1 273 279 PF00069 0.712
MOD_CK1_1 36 42 PF00069 0.586
MOD_CK2_1 105 111 PF00069 0.699
MOD_CK2_1 17 23 PF00069 0.680
MOD_CK2_1 247 253 PF00069 0.759
MOD_CK2_1 48 54 PF00069 0.566
MOD_GlcNHglycan 140 143 PF01048 0.569
MOD_GlcNHglycan 159 162 PF01048 0.690
MOD_GlcNHglycan 249 252 PF01048 0.803
MOD_GlcNHglycan 280 283 PF01048 0.646
MOD_GlcNHglycan 35 38 PF01048 0.531
MOD_GSK3_1 101 108 PF00069 0.720
MOD_GSK3_1 146 153 PF00069 0.787
MOD_GSK3_1 157 164 PF00069 0.618
MOD_GSK3_1 263 270 PF00069 0.756
MOD_GSK3_1 273 280 PF00069 0.695
MOD_GSK3_1 290 297 PF00069 0.703
MOD_GSK3_1 32 39 PF00069 0.549
MOD_N-GLC_1 15 20 PF02516 0.601
MOD_N-GLC_1 169 174 PF02516 0.747
MOD_N-GLC_1 270 275 PF02516 0.801
MOD_NEK2_1 101 106 PF00069 0.692
MOD_PIKK_1 101 107 PF00454 0.653
MOD_PKB_1 80 88 PF00069 0.642
MOD_Plk_1 169 175 PF00069 0.647
MOD_Plk_4 132 138 PF00069 0.565
MOD_Plk_4 170 176 PF00069 0.586
MOD_Plk_4 225 231 PF00069 0.665
MOD_Plk_4 256 262 PF00069 0.772
MOD_Plk_4 36 42 PF00069 0.618
MOD_Plk_4 88 94 PF00069 0.496
MOD_ProDKin_1 15 21 PF00069 0.629
MOD_ProDKin_1 150 156 PF00069 0.744
MOD_ProDKin_1 161 167 PF00069 0.668
MOD_ProDKin_1 219 225 PF00069 0.655
MOD_ProDKin_1 245 251 PF00069 0.759
MOD_ProDKin_1 290 296 PF00069 0.838
MOD_ProDKin_1 46 52 PF00069 0.613
TRG_ENDOCYTIC_2 199 202 PF00928 0.694
TRG_ENDOCYTIC_2 89 92 PF00928 0.670
TRG_ER_diArg_1 113 115 PF00400 0.617
TRG_ER_diArg_1 187 189 PF00400 0.713
TRG_ER_diArg_1 205 208 PF00400 0.532
TRG_ER_diArg_1 241 243 PF00400 0.799
TRG_ER_diArg_1 41 44 PF00400 0.639
TRG_ER_diArg_1 80 82 PF00400 0.672
TRG_Pf-PMV_PEXEL_1 22 26 PF00026 0.580
TRG_Pf-PMV_PEXEL_1 68 72 PF00026 0.447

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1M0 Leptomonas seymouri 41% 87%
A0A3Q8IDN0 Leishmania donovani 99% 100%
A4HEL4 Leishmania braziliensis 63% 100%
E9AXY9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q9I5 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS