Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1U4_LEIIN

TriTrypDb:

LINF_260005500

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1U4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	45	49	PF00656	0.712
CLV_NRD_NRD_1	120	122	PF00675	0.642
CLV_PCSK_KEX2_1	19	21	PF00082	0.640
CLV_PCSK_KEX2_1	249	251	PF00082	0.634
CLV_PCSK_KEX2_1	72	74	PF00082	0.672
CLV_PCSK_KEX2_1	82	84	PF00082	0.661
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.640
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.634
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.672
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.661
CLV_PCSK_SKI1_1	110	114	PF00082	0.662
CLV_PCSK_SKI1_1	115	119	PF00082	0.650
CLV_PCSK_SKI1_1	229	233	PF00082	0.609
CLV_PCSK_SKI1_1	8	12	PF00082	0.559
CLV_Separin_Metazoa	135	139	PF03568	0.551
DEG_Nend_UBRbox_2	1	3	PF02207	0.553
DEG_SPOP_SBC_1	179	183	PF00917	0.564
DEG_SPOP_SBC_1	230	234	PF00917	0.654
DOC_MAPK_gen_1	82	92	PF00069	0.656
DOC_USP7_MATH_1	148	152	PF00917	0.664
DOC_USP7_MATH_1	179	183	PF00917	0.640
DOC_USP7_MATH_1	18	22	PF00917	0.634
DOC_USP7_MATH_1	230	234	PF00917	0.727
DOC_USP7_MATH_1	30	34	PF00917	0.592
DOC_USP7_MATH_1	46	50	PF00917	0.511
DOC_USP7_UBL2_3	245	249	PF12436	0.690
DOC_USP7_UBL2_3	68	72	PF12436	0.750
DOC_USP7_UBL2_3	8	12	PF12436	0.559
LIG_14-3-3_CanoR_1	115	123	PF00244	0.755
LIG_14-3-3_CanoR_1	20	25	PF00244	0.667
LIG_14-3-3_CanoR_1	207	215	PF00244	0.662
LIG_14-3-3_CanoR_1	229	238	PF00244	0.609
LIG_Actin_WH2_2	129	146	PF00022	0.598
LIG_CtBP_PxDLS_1	221	225	PF00389	0.589
LIG_FHA_1	124	130	PF00498	0.618
LIG_FHA_1	161	167	PF00498	0.601
LIG_FHA_2	157	163	PF00498	0.681
LIG_FHA_2	232	238	PF00498	0.722
LIG_FHA_2	249	255	PF00498	0.510
LIG_FHA_2	29	35	PF00498	0.597
LIG_Integrin_isoDGR_2	227	229	PF01839	0.720
LIG_LIR_Gen_1	86	93	PF02991	0.626
LIG_LIR_Nem_3	86	90	PF02991	0.650
LIG_MAD2	91	99	PF02301	0.629
LIG_Pex14_2	6	10	PF04695	0.548
LIG_SH2_STAT5	74	77	PF00017	0.737
LIG_SH3_2	244	249	PF14604	0.786
LIG_SH3_3	152	158	PF00018	0.635
LIG_SH3_3	187	193	PF00018	0.744
LIG_SH3_3	215	221	PF00018	0.781
LIG_SH3_3	241	247	PF00018	0.766
LIG_SUMO_SIM_par_1	162	170	PF11976	0.693
LIG_TRAF2_1	239	242	PF00917	0.717
LIG_WRC_WIRS_1	7	12	PF05994	0.557
MOD_CK1_1	175	181	PF00069	0.658
MOD_CK1_1	197	203	PF00069	0.664
MOD_CK2_1	121	127	PF00069	0.512
MOD_CK2_1	156	162	PF00069	0.689
MOD_CK2_1	248	254	PF00069	0.626
MOD_CK2_1	30	36	PF00069	0.760
MOD_CK2_1	44	50	PF00069	0.592
MOD_Cter_Amidation	70	73	PF01082	0.632
MOD_GlcNHglycan	150	153	PF01048	0.702
MOD_GlcNHglycan	174	177	PF01048	0.625
MOD_GlcNHglycan	44	47	PF01048	0.717
MOD_GlcNHglycan	96	99	PF01048	0.592
MOD_GSK3_1	117	124	PF00069	0.534
MOD_GSK3_1	156	163	PF00069	0.519
MOD_GSK3_1	175	182	PF00069	0.741
MOD_GSK3_1	194	201	PF00069	0.707
MOD_GSK3_1	20	27	PF00069	0.675
MOD_GSK3_1	203	210	PF00069	0.777
MOD_GSK3_1	42	49	PF00069	0.713
MOD_GSK3_1	72	79	PF00069	0.559
MOD_N-GLC_1	76	81	PF02516	0.767
MOD_NEK2_1	1	6	PF00069	0.560
MOD_NEK2_1	128	133	PF00069	0.621
MOD_NEK2_1	143	148	PF00069	0.651
MOD_NEK2_1	161	166	PF00069	0.371
MOD_NEK2_1	172	177	PF00069	0.532
MOD_NEK2_1	198	203	PF00069	0.598
MOD_PIKK_1	1	7	PF00454	0.558
MOD_PIKK_1	156	162	PF00454	0.546
MOD_PK_1	20	26	PF00069	0.665
MOD_PKA_1	121	127	PF00069	0.512
MOD_PKA_1	19	25	PF00069	0.662
MOD_PKA_1	248	254	PF00069	0.626
MOD_PKA_1	72	78	PF00069	0.696
MOD_PKA_2	143	149	PF00069	0.647
MOD_PKA_2	19	25	PF00069	0.730
MOD_PKA_2	201	207	PF00069	0.595
MOD_PKA_2	72	78	PF00069	0.710
MOD_Plk_1	1	7	PF00069	0.558
MOD_Plk_1	161	167	PF00069	0.567
MOD_Plk_4	161	167	PF00069	0.545
MOD_Plk_4	181	187	PF00069	0.770
MOD_Plk_4	220	226	PF00069	0.587
TRG_DiLeu_BaEn_1	167	172	PF01217	0.694
TRG_DiLeu_BaEn_4	241	247	PF01217	0.693
TRG_ER_diArg_1	137	140	PF00400	0.650
TRG_NLS_MonoExtC_3	247	252	PF00514	0.644
TRG_NLS_MonoExtN_4	245	252	PF00514	0.670

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS9	Leptomonas seymouri	45%	99%
A0A3S5H7F4	Leishmania donovani	100%	100%
A4HEL3	Leishmania braziliensis	62%	100%
E9AXY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q9I6	Leishmania major	88%	100%