LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Pex2 / Pex12 amino terminal region/Zinc finger - C3HC4 type (RING finger)/Ring finger domain/zinc-RING finger domain/Anaphase-promoting complex subunit 11 RING-H2 finger containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I1S9_LEIIN
TriTrypDb:
LINF_250030100
Length:
296

Annotations

Annotations by Jardim et al.

Glycosome membrane, Peroxin 10 Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005777 peroxisome 6 9
GO:0042579 microbody 5 10
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0043229 intracellular organelle 3 10
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0110165 cellular anatomical entity 1 11
GO:0005737 cytoplasm 2 1
GO:0005778 peroxisomal membrane 6 1
GO:0016020 membrane 2 3
GO:0031090 organelle membrane 3 1
GO:0031903 microbody membrane 5 1
GO:0098588 bounding membrane of organelle 4 1

Expansion

Sequence features

A4I1S9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1S9

Function

Biological processes
Term Name Level Count
GO:0006605 protein targeting 5 1
GO:0006625 protein targeting to peroxisome 5 1
GO:0006810 transport 3 1
GO:0006886 intracellular protein transport 4 1
GO:0006996 organelle organization 4 1
GO:0007031 peroxisome organization 5 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0015919 peroxisomal membrane transport 5 1
GO:0016043 cellular component organization 3 1
GO:0016558 protein import into peroxisome matrix 5 1
GO:0033036 macromolecule localization 2 1
GO:0033365 protein localization to organelle 5 1
GO:0043574 peroxisomal transport 4 1
GO:0044743 protein transmembrane import into intracellular organelle 4 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0055085 transmembrane transport 2 1
GO:0065002 intracellular protein transmembrane transport 4 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0071806 protein transmembrane transport 3 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0072594 establishment of protein localization to organelle 4 1
GO:0072662 protein localization to peroxisome 6 1
GO:0072663 establishment of protein localization to peroxisome 5 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 135 141 PF00089 0.422
CLV_NRD_NRD_1 109 111 PF00675 0.337
CLV_NRD_NRD_1 227 229 PF00675 0.260
CLV_PCSK_KEX2_1 198 200 PF00082 0.404
CLV_PCSK_PC1ET2_1 198 200 PF00082 0.443
CLV_PCSK_SKI1_1 110 114 PF00082 0.119
CLV_PCSK_SKI1_1 127 131 PF00082 0.284
CLV_PCSK_SKI1_1 195 199 PF00082 0.415
CLV_PCSK_SKI1_1 220 224 PF00082 0.278
CLV_PCSK_SKI1_1 26 30 PF00082 0.325
CLV_PCSK_SKI1_1 90 94 PF00082 0.254
CLV_Separin_Metazoa 280 284 PF03568 0.677
DEG_APCC_DBOX_1 89 97 PF00400 0.490
DEG_Nend_UBRbox_3 1 3 PF02207 0.548
DEG_SPOP_SBC_1 205 209 PF00917 0.672
DOC_CYCLIN_RxL_1 107 117 PF00134 0.536
DOC_CYCLIN_RxL_1 144 157 PF00134 0.359
DOC_MAPK_gen_1 145 154 PF00069 0.375
DOC_MAPK_gen_1 217 225 PF00069 0.552
DOC_PP1_RVXF_1 146 152 PF00149 0.376
DOC_USP7_MATH_1 114 118 PF00917 0.594
DOC_USP7_MATH_1 197 201 PF00917 0.655
DOC_WW_Pin1_4 290 295 PF00397 0.640
LIG_14-3-3_CanoR_1 150 155 PF00244 0.309
LIG_14-3-3_CanoR_1 199 206 PF00244 0.653
LIG_14-3-3_CanoR_1 26 33 PF00244 0.569
LIG_14-3-3_CanoR_1 262 272 PF00244 0.520
LIG_14-3-3_CanoR_1 63 68 PF00244 0.468
LIG_Actin_WH2_2 139 157 PF00022 0.507
LIG_BIR_III_2 215 219 PF00653 0.543
LIG_Clathr_ClatBox_1 133 137 PF01394 0.317
LIG_EH1_1 169 177 PF00400 0.314
LIG_eIF4E_1 170 176 PF01652 0.392
LIG_FHA_1 116 122 PF00498 0.577
LIG_FHA_1 265 271 PF00498 0.587
LIG_FHA_2 191 197 PF00498 0.645
LIG_FHA_2 205 211 PF00498 0.697
LIG_FHA_2 284 290 PF00498 0.734
LIG_LIR_Gen_1 54 64 PF02991 0.498
LIG_LIR_Gen_1 70 78 PF02991 0.337
LIG_LIR_LC3C_4 180 183 PF02991 0.422
LIG_LIR_Nem_3 137 142 PF02991 0.302
LIG_LIR_Nem_3 169 173 PF02991 0.261
LIG_LIR_Nem_3 54 59 PF02991 0.498
LIG_LIR_Nem_3 70 74 PF02991 0.337
LIG_SH2_STAP1 44 48 PF00017 0.449
LIG_SH2_STAT5 170 173 PF00017 0.384
LIG_SH2_STAT5 274 277 PF00017 0.569
LIG_SH2_STAT5 56 59 PF00017 0.453
LIG_SH3_1 79 85 PF00018 0.536
LIG_SH3_2 85 90 PF14604 0.536
LIG_SH3_3 79 85 PF00018 0.536
LIG_SUMO_SIM_par_1 174 180 PF11976 0.302
LIG_UBA3_1 222 229 PF00899 0.460
LIG_UBA3_1 9 15 PF00899 0.531
LIG_WW_3 280 284 PF00397 0.693
MOD_CK1_1 54 60 PF00069 0.525
MOD_CK2_1 190 196 PF00069 0.616
MOD_CK2_1 205 211 PF00069 0.647
MOD_GSK3_1 150 157 PF00069 0.312
MOD_GSK3_1 186 193 PF00069 0.590
MOD_GSK3_1 59 66 PF00069 0.526
MOD_NEK2_1 223 228 PF00069 0.490
MOD_NEK2_1 32 37 PF00069 0.557
MOD_NEK2_1 59 64 PF00069 0.504
MOD_PIKK_1 19 25 PF00454 0.547
MOD_PIKK_1 264 270 PF00454 0.571
MOD_PKA_1 198 204 PF00069 0.664
MOD_PKA_2 186 192 PF00069 0.607
MOD_PKA_2 198 204 PF00069 0.665
MOD_PKB_1 148 156 PF00069 0.359
MOD_Plk_4 166 172 PF00069 0.375
MOD_Plk_4 266 272 PF00069 0.568
MOD_Plk_4 51 57 PF00069 0.487
MOD_ProDKin_1 290 296 PF00069 0.644
MOD_SUMO_rev_2 191 200 PF00179 0.621
TRG_DiLeu_BaEn_1 70 75 PF01217 0.461
TRG_ENDOCYTIC_2 170 173 PF00928 0.361
TRG_ENDOCYTIC_2 274 277 PF00928 0.581
TRG_ENDOCYTIC_2 56 59 PF00928 0.468
TRG_ER_diArg_1 147 150 PF00400 0.355
TRG_NES_CRM1_1 123 137 PF08389 0.552
TRG_Pf-PMV_PEXEL_1 11 16 PF00026 0.337
TRG_Pf-PMV_PEXEL_1 110 115 PF00026 0.415
TRG_Pf-PMV_PEXEL_1 158 162 PF00026 0.622
TRG_Pf-PMV_PEXEL_1 243 247 PF00026 0.274
TRG_Pf-PMV_PEXEL_1 26 30 PF00026 0.263

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5N1 Leptomonas seymouri 76% 97%
A0A0S4J0W7 Bodo saltans 40% 100%
A0A1X0NY02 Trypanosomatidae 52% 96%
A0A3R7LE72 Trypanosoma rangeli 47% 100%
A0A3S7WZG1 Leishmania donovani 99% 100%
B1AUE5 Mus musculus 25% 91%
C0HKD7 Caenorhabditis elegans 24% 94%
C9ZKD7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 99%
E9AXW3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O60683 Homo sapiens 24% 91%
Q00940 Pichia angusta 27% 100%
Q05568 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 88%
Q54S31 Dictyostelium discoideum 26% 79%
Q92265 Komagataella pastoris 20% 71%
Q95ZB8 Leishmania major 96% 100%
V5D8I1 Trypanosoma cruzi 52% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS