Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1S6_LEIIN

TriTrypDb:

LINF_250029800

Length:

123

Annotations

LeishMANIAdb annotations

Conserved in kinetoplastids, without more distant homologs.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4I1S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1S6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.737
CLV_NRD_NRD_1	4	6	PF00675	0.465
CLV_PCSK_KEX2_1	119	121	PF00082	0.685
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.646
CLV_PCSK_SKI1_1	102	106	PF00082	0.653
DEG_Nend_UBRbox_2	1	3	PF02207	0.633
DOC_CKS1_1	46	51	PF01111	0.292
DOC_CYCLIN_RxL_1	99	109	PF00134	0.454
DOC_CYCLIN_yCln2_LP_2	46	52	PF00134	0.402
DOC_MAPK_gen_1	33	41	PF00069	0.428
DOC_PP4_FxxP_1	68	71	PF00568	0.468
DOC_WW_Pin1_4	18	23	PF00397	0.601
DOC_WW_Pin1_4	45	50	PF00397	0.292
LIG_14-3-3_CterR_2	120	123	PF00244	0.430
LIG_LIR_Apic_2	70	75	PF02991	0.381
LIG_Pex14_2	47	51	PF04695	0.300
LIG_Pex14_2	52	56	PF04695	0.251
LIG_SH2_NCK_1	72	76	PF00017	0.377
LIG_SH2_STAP1	42	46	PF00017	0.419
LIG_SH2_STAP1	57	61	PF00017	0.266
LIG_SH2_STAT5	57	60	PF00017	0.417
LIG_TRAF2_1	94	97	PF00917	0.468
MOD_CK2_1	83	89	PF00069	0.407
MOD_CK2_1	91	97	PF00069	0.423
MOD_GlcNHglycan	93	96	PF01048	0.633
MOD_GSK3_1	79	86	PF00069	0.459
MOD_NEK2_1	55	60	PF00069	0.445
MOD_PKA_2	28	34	PF00069	0.579
MOD_ProDKin_1	18	24	PF00069	0.598
MOD_ProDKin_1	45	51	PF00069	0.292
MOD_SUMO_rev_2	2	8	PF00179	0.610
MOD_SUMO_rev_2	76	82	PF00179	0.395
TRG_NLS_MonoExtN_4	116	122	PF00514	0.450
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE87	Leptomonas seymouri	72%	100%
A0A1X0NZF8	Trypanosomatidae	56%	100%
A0A3Q8IFG6	Leishmania donovani	100%	100%
A0A3R7KZB6	Trypanosoma rangeli	56%	99%
A0A3R7MC34	Trypanosoma rangeli	52%	94%
C9ZKD4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AXW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q9L0	Leishmania major	91%	100%