Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1S4_LEIIN

TriTrypDb:

LINF_250029600

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4I1S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1S4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	402	406	PF00656	0.436
CLV_NRD_NRD_1	151	153	PF00675	0.645
CLV_NRD_NRD_1	399	401	PF00675	0.733
CLV_NRD_NRD_1	437	439	PF00675	0.683
CLV_NRD_NRD_1	469	471	PF00675	0.644
CLV_NRD_NRD_1	516	518	PF00675	0.478
CLV_NRD_NRD_1	526	528	PF00675	0.401
CLV_PCSK_KEX2_1	153	155	PF00082	0.662
CLV_PCSK_KEX2_1	399	401	PF00082	0.698
CLV_PCSK_KEX2_1	436	438	PF00082	0.633
CLV_PCSK_KEX2_1	469	471	PF00082	0.644
CLV_PCSK_KEX2_1	516	518	PF00082	0.477
CLV_PCSK_KEX2_1	526	528	PF00082	0.399
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.662
CLV_PCSK_SKI1_1	153	157	PF00082	0.581
CLV_PCSK_SKI1_1	249	253	PF00082	0.635
CLV_PCSK_SKI1_1	411	415	PF00082	0.656
CLV_Separin_Metazoa	372	376	PF03568	0.431
DEG_COP1_1	250	260	PF00400	0.416
DOC_ANK_TNKS_1	322	329	PF00023	0.402
DOC_CYCLIN_yCln2_LP_2	206	209	PF00134	0.506
DOC_CYCLIN_yCln2_LP_2	330	336	PF00134	0.433
DOC_MAPK_DCC_7	203	212	PF00069	0.504
DOC_MAPK_gen_1	152	159	PF00069	0.378
DOC_MAPK_gen_1	436	443	PF00069	0.474
DOC_MAPK_MEF2A_6	203	212	PF00069	0.460
DOC_PP1_RVXF_1	364	370	PF00149	0.450
DOC_PP2B_LxvP_1	206	209	PF13499	0.506
DOC_USP7_MATH_1	127	131	PF00917	0.413
DOC_USP7_MATH_1	256	260	PF00917	0.461
DOC_USP7_MATH_1	376	380	PF00917	0.483
DOC_USP7_MATH_1	398	402	PF00917	0.543
DOC_USP7_MATH_1	447	451	PF00917	0.535
DOC_USP7_MATH_1	462	466	PF00917	0.411
DOC_USP7_MATH_1	71	75	PF00917	0.472
DOC_WW_Pin1_4	14	19	PF00397	0.529
DOC_WW_Pin1_4	26	31	PF00397	0.418
DOC_WW_Pin1_4	309	314	PF00397	0.432
DOC_WW_Pin1_4	334	339	PF00397	0.501
LIG_14-3-3_CanoR_1	147	151	PF00244	0.421
LIG_14-3-3_CanoR_1	19	28	PF00244	0.476
LIG_14-3-3_CanoR_1	249	255	PF00244	0.372
LIG_14-3-3_CanoR_1	296	304	PF00244	0.395
LIG_14-3-3_CanoR_1	332	337	PF00244	0.482
LIG_14-3-3_CanoR_1	366	370	PF00244	0.438
LIG_14-3-3_CanoR_1	375	384	PF00244	0.522
LIG_14-3-3_CanoR_1	436	442	PF00244	0.543
LIG_14-3-3_CanoR_1	469	474	PF00244	0.461
LIG_Actin_WH2_2	360	377	PF00022	0.445
LIG_Actin_WH2_2	500	518	PF00022	0.305
LIG_APCC_ABBA_1	322	327	PF00400	0.323
LIG_FHA_1	114	120	PF00498	0.420
LIG_FHA_1	130	136	PF00498	0.272
LIG_FHA_1	167	173	PF00498	0.445
LIG_FHA_1	175	181	PF00498	0.360
LIG_FHA_1	232	238	PF00498	0.385
LIG_FHA_1	27	33	PF00498	0.422
LIG_FHA_1	275	281	PF00498	0.412
LIG_FHA_1	316	322	PF00498	0.331
LIG_FHA_1	341	347	PF00498	0.482
LIG_FHA_1	430	436	PF00498	0.483
LIG_FHA_2	269	275	PF00498	0.500
LIG_GBD_Chelix_1	507	515	PF00786	0.274
LIG_LIR_Apic_2	34	38	PF02991	0.491
LIG_LIR_Apic_2	472	478	PF02991	0.448
LIG_LIR_Gen_1	499	510	PF02991	0.337
LIG_LIR_Nem_3	222	228	PF02991	0.508
LIG_LIR_Nem_3	26	31	PF02991	0.434
LIG_LIR_Nem_3	418	424	PF02991	0.507
LIG_LIR_Nem_3	499	505	PF02991	0.337
LIG_LYPXL_S_1	125	129	PF13949	0.596
LIG_LYPXL_yS_3	126	129	PF13949	0.396
LIG_NRBOX	48	54	PF00104	0.368
LIG_NRBOX	510	516	PF00104	0.304
LIG_PCNA_yPIPBox_3	133	147	PF02747	0.378
LIG_SH2_CRK	225	229	PF00017	0.497
LIG_SH2_CRK	502	506	PF00017	0.441
LIG_SH2_STAP1	166	170	PF00017	0.363
LIG_SH2_STAP1	299	303	PF00017	0.406
LIG_SH2_STAP1	352	356	PF00017	0.360
LIG_SH2_STAT5	166	169	PF00017	0.442
LIG_SH2_STAT5	299	302	PF00017	0.371
LIG_SH2_STAT5	502	505	PF00017	0.387
LIG_SH2_STAT5	54	57	PF00017	0.445
LIG_SH3_3	239	245	PF00018	0.420
LIG_SH3_3	367	373	PF00018	0.478
LIG_SH3_3	450	456	PF00018	0.493
LIG_Sin3_3	168	175	PF02671	0.387
LIG_SUMO_SIM_par_1	312	318	PF11976	0.465
LIG_TRAF2_1	362	365	PF00917	0.545
LIG_TYR_ITIM	124	129	PF00017	0.396
LIG_WRC_WIRS_1	421	426	PF05994	0.515
LIG_WRC_WIRS_1	82	87	PF05994	0.386
MOD_CDK_SPK_2	14	19	PF00069	0.443
MOD_CK1_1	23	29	PF00069	0.497
MOD_CK1_1	250	256	PF00069	0.446
MOD_CK1_1	337	343	PF00069	0.479
MOD_CK1_1	422	428	PF00069	0.536
MOD_CK2_1	268	274	PF00069	0.491
MOD_CK2_1	491	497	PF00069	0.399
MOD_GlcNHglycan	105	108	PF01048	0.543
MOD_GlcNHglycan	116	119	PF01048	0.567
MOD_GlcNHglycan	129	132	PF01048	0.496
MOD_GlcNHglycan	184	187	PF01048	0.622
MOD_GlcNHglycan	22	25	PF01048	0.685
MOD_GlcNHglycan	258	261	PF01048	0.621
MOD_GlcNHglycan	443	446	PF01048	0.725
MOD_GlcNHglycan	497	501	PF01048	0.441
MOD_GlcNHglycan	56	60	PF01048	0.605
MOD_GSK3_1	160	167	PF00069	0.384
MOD_GSK3_1	19	26	PF00069	0.474
MOD_GSK3_1	328	335	PF00069	0.471
MOD_GSK3_1	399	406	PF00069	0.486
MOD_GSK3_1	437	444	PF00069	0.432
MOD_N-GLC_1	340	345	PF02516	0.693
MOD_N-GLC_1	42	47	PF02516	0.569
MOD_NEK2_1	148	153	PF00069	0.432
MOD_NEK2_1	233	238	PF00069	0.503
MOD_NEK2_1	273	278	PF00069	0.427
MOD_NEK2_1	304	309	PF00069	0.424
MOD_NEK2_1	31	36	PF00069	0.487
MOD_NEK2_1	315	320	PF00069	0.330
MOD_NEK2_1	346	351	PF00069	0.442
MOD_NEK2_1	41	46	PF00069	0.351
MOD_NEK2_1	441	446	PF00069	0.416
MOD_NEK2_1	481	486	PF00069	0.523
MOD_NEK2_1	496	501	PF00069	0.229
MOD_NEK2_2	447	452	PF00069	0.505
MOD_PIKK_1	304	310	PF00454	0.399
MOD_PIKK_1	315	321	PF00454	0.374
MOD_PIKK_1	346	352	PF00454	0.440
MOD_PIKK_1	405	411	PF00454	0.538
MOD_PIKK_1	95	101	PF00454	0.405
MOD_PK_1	247	253	PF00069	0.435
MOD_PK_1	469	475	PF00069	0.404
MOD_PK_1	526	532	PF00069	0.622
MOD_PKA_1	399	405	PF00069	0.541
MOD_PKA_1	437	443	PF00069	0.476
MOD_PKA_1	469	475	PF00069	0.480
MOD_PKA_1	526	532	PF00069	0.622
MOD_PKA_2	146	152	PF00069	0.414
MOD_PKA_2	365	371	PF00069	0.435
MOD_PKA_2	398	404	PF00069	0.540
MOD_PKA_2	437	443	PF00069	0.566
MOD_PKA_2	469	475	PF00069	0.444
MOD_PKA_2	526	532	PF00069	0.779
MOD_Plk_1	315	321	PF00069	0.354
MOD_Plk_1	340	346	PF00069	0.489
MOD_Plk_1	352	358	PF00069	0.394
MOD_Plk_1	42	48	PF00069	0.310
MOD_Plk_1	496	502	PF00069	0.357
MOD_Plk_2-3	268	274	PF00069	0.430
MOD_Plk_4	208	214	PF00069	0.539
MOD_Plk_4	233	239	PF00069	0.461
MOD_Plk_4	268	274	PF00069	0.506
MOD_Plk_4	31	37	PF00069	0.489
MOD_Plk_4	352	358	PF00069	0.443
MOD_Plk_4	365	371	PF00069	0.369
MOD_Plk_4	447	453	PF00069	0.524
MOD_Plk_4	471	477	PF00069	0.421
MOD_Plk_4	491	497	PF00069	0.347
MOD_ProDKin_1	14	20	PF00069	0.535
MOD_ProDKin_1	26	32	PF00069	0.419
MOD_ProDKin_1	309	315	PF00069	0.427
MOD_ProDKin_1	334	340	PF00069	0.495
MOD_SUMO_for_1	36	39	PF00179	0.431
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.477
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.518
TRG_ENDOCYTIC_2	126	129	PF00928	0.398
TRG_ENDOCYTIC_2	225	228	PF00928	0.509
TRG_ENDOCYTIC_2	266	269	PF00928	0.490
TRG_ENDOCYTIC_2	502	505	PF00928	0.414
TRG_ER_diArg_1	246	249	PF00400	0.435
TRG_ER_diArg_1	435	438	PF00400	0.421
TRG_ER_diArg_1	469	471	PF00400	0.414
TRG_ER_diArg_1	515	517	PF00400	0.668
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.714

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD48	Leptomonas seymouri	36%	100%
A0A3S7WZJ8	Leishmania donovani	99%	100%
A4HEC9	Leishmania braziliensis	74%	100%
E9AXV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q9L2	Leishmania major	91%	100%