PHD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1S3_LEIIN

TriTrypDb:

LINF_250029500

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I1S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1S3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.473
CLV_NRD_NRD_1	123	125	PF00675	0.596
CLV_NRD_NRD_1	134	136	PF00675	0.532
CLV_NRD_NRD_1	327	329	PF00675	0.418
CLV_PCSK_KEX2_1	123	125	PF00082	0.524
CLV_PCSK_KEX2_1	136	138	PF00082	0.523
CLV_PCSK_KEX2_1	327	329	PF00082	0.418
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.558
CLV_PCSK_SKI1_1	123	127	PF00082	0.650
CLV_PCSK_SKI1_1	328	332	PF00082	0.440
DEG_APCC_DBOX_1	257	265	PF00400	0.465
DEG_Nend_Nbox_1	1	3	PF02207	0.526
DEG_SPOP_SBC_1	232	236	PF00917	0.440
DOC_CKS1_1	45	50	PF01111	0.527
DOC_CYCLIN_RxL_1	120	130	PF00134	0.524
DOC_MAPK_gen_1	32	40	PF00069	0.524
DOC_MAPK_gen_1	82	91	PF00069	0.543
DOC_MAPK_JIP1_4	85	91	PF00069	0.547
DOC_MAPK_MEF2A_6	162	169	PF00069	0.577
DOC_PP2B_LxvP_1	106	109	PF13499	0.749
DOC_PP2B_LxvP_1	220	223	PF13499	0.435
DOC_PP2B_PxIxI_1	110	116	PF00149	0.514
DOC_USP7_MATH_1	117	121	PF00917	0.513
DOC_USP7_MATH_1	127	131	PF00917	0.549
DOC_WW_Pin1_4	107	112	PF00397	0.446
DOC_WW_Pin1_4	168	173	PF00397	0.562
DOC_WW_Pin1_4	44	49	PF00397	0.564
DOC_WW_Pin1_4	94	99	PF00397	0.580
LIG_14-3-3_CanoR_1	135	145	PF00244	0.538
LIG_14-3-3_CanoR_1	304	310	PF00244	0.417
LIG_14-3-3_CanoR_1	85	90	PF00244	0.652
LIG_BRCT_BRCA1_1	101	105	PF00533	0.549
LIG_BRCT_BRCA1_1	52	56	PF00533	0.554
LIG_FHA_1	235	241	PF00498	0.425
LIG_FHA_1	247	253	PF00498	0.355
LIG_FHA_1	297	303	PF00498	0.408
LIG_FHA_1	86	92	PF00498	0.766
LIG_FHA_2	159	165	PF00498	0.677
LIG_FHA_2	270	276	PF00498	0.430
LIG_LIR_Apic_2	311	317	PF02991	0.391
LIG_LIR_Gen_1	102	113	PF02991	0.529
LIG_LIR_Gen_1	61	69	PF02991	0.492
LIG_LIR_Nem_3	102	108	PF02991	0.539
LIG_LIR_Nem_3	120	125	PF02991	0.506
LIG_LIR_Nem_3	150	155	PF02991	0.665
LIG_LIR_Nem_3	53	59	PF02991	0.575
LIG_LIR_Nem_3	61	67	PF02991	0.440
LIG_LIR_Nem_3	77	83	PF02991	0.564
LIG_LYPXL_S_1	79	83	PF13949	0.565
LIG_LYPXL_yS_3	80	83	PF13949	0.567
LIG_MLH1_MIPbox_1	52	56	PF16413	0.506
LIG_MYND_1	259	263	PF01753	0.465
LIG_MYND_1	99	103	PF01753	0.688
LIG_NRP_CendR_1	331	332	PF00754	0.456
LIG_SH2_CRK	2	6	PF00017	0.480
LIG_SH2_PTP2	306	309	PF00017	0.389
LIG_SH2_STAP1	64	68	PF00017	0.525
LIG_SH2_STAT5	246	249	PF00017	0.607
LIG_SH2_STAT5	306	309	PF00017	0.398
LIG_SH2_STAT5	315	318	PF00017	0.331
LIG_SH3_1	43	49	PF00018	0.518
LIG_SH3_3	166	172	PF00018	0.565
LIG_SH3_3	212	218	PF00018	0.571
LIG_SH3_3	42	48	PF00018	0.534
LIG_SH3_3	93	99	PF00018	0.564
LIG_SUMO_SIM_par_1	87	93	PF11976	0.574
LIG_TRAF2_1	187	190	PF00917	0.570
LIG_UBA3_1	261	268	PF00899	0.429
LIG_WRC_WIRS_1	264	269	PF05994	0.414
LIG_WRC_WIRS_1	52	57	PF05994	0.457
MOD_CK1_1	234	240	PF00069	0.428
MOD_CK1_1	310	316	PF00069	0.399
MOD_CK1_1	90	96	PF00069	0.573
MOD_CK2_1	269	275	PF00069	0.427
MOD_GlcNHglycan	200	203	PF01048	0.712
MOD_GlcNHglycan	206	209	PF01048	0.662
MOD_GSK3_1	127	134	PF00069	0.593
MOD_GSK3_1	135	142	PF00069	0.614
MOD_GSK3_1	189	196	PF00069	0.594
MOD_GSK3_1	24	31	PF00069	0.623
MOD_GSK3_1	305	312	PF00069	0.419
MOD_GSK3_1	90	97	PF00069	0.700
MOD_N-GLC_1	203	208	PF02516	0.616
MOD_NEK2_1	309	314	PF00069	0.417
MOD_NEK2_1	57	62	PF00069	0.568
MOD_NEK2_2	147	152	PF00069	0.498
MOD_NEK2_2	263	268	PF00069	0.423
MOD_OFUCOSY	146	151	PF10250	0.492
MOD_PIKK_1	223	229	PF00454	0.441
MOD_PK_1	193	199	PF00069	0.597
MOD_PK_1	87	93	PF00069	0.537
MOD_PKA_1	135	141	PF00069	0.545
MOD_PKA_2	136	142	PF00069	0.535
MOD_PKA_2	192	198	PF00069	0.608
MOD_PKB_1	133	141	PF00069	0.564
MOD_PKB_1	85	93	PF00069	0.646
MOD_Plk_1	117	123	PF00069	0.484
MOD_Plk_1	24	30	PF00069	0.509
MOD_Plk_2-3	211	217	PF00069	0.580
MOD_Plk_4	117	123	PF00069	0.509
MOD_Plk_4	298	304	PF00069	0.406
MOD_Plk_4	310	316	PF00069	0.332
MOD_Plk_4	51	57	PF00069	0.563
MOD_ProDKin_1	107	113	PF00069	0.445
MOD_ProDKin_1	168	174	PF00069	0.566
MOD_ProDKin_1	44	50	PF00069	0.562
MOD_ProDKin_1	94	100	PF00069	0.580
TRG_DiLeu_BaLyEn_6	121	126	PF01217	0.509
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.574
TRG_ENDOCYTIC_2	2	5	PF00928	0.478
TRG_ENDOCYTIC_2	306	309	PF00928	0.405
TRG_ENDOCYTIC_2	64	67	PF00928	0.518
TRG_ENDOCYTIC_2	80	83	PF00928	0.567
TRG_ER_diArg_1	122	124	PF00400	0.541
TRG_ER_diArg_1	258	261	PF00400	0.484
TRG_ER_diArg_1	32	35	PF00400	0.512
TRG_ER_diArg_1	326	328	PF00400	0.418
TRG_ER_diArg_1	40	43	PF00400	0.519
TRG_ER_diArg_1	84	87	PF00400	0.700
TRG_NLS_Bipartite_1	123	139	PF00514	0.539
TRG_NLS_MonoExtN_4	133	139	PF00514	0.556
TRG_Pf-PMV_PEXEL_1	87	92	PF00026	0.694

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGR6	Leishmania donovani	99%	100%
E9AXV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	98%
Q4Q9L3	Leishmania major	83%	99%