Beige/BEACH domain family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1S1_LEIIN

TriTrypDb:

LINF_250029300

Length:

637

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1S1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1S1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.538
CLV_C14_Caspase3-7	504	508	PF00656	0.622
CLV_C14_Caspase3-7	61	65	PF00656	0.532
CLV_MEL_PAP_1	218	224	PF00089	0.482
CLV_NRD_NRD_1	166	168	PF00675	0.520
CLV_NRD_NRD_1	32	34	PF00675	0.530
CLV_NRD_NRD_1	381	383	PF00675	0.501
CLV_NRD_NRD_1	435	437	PF00675	0.707
CLV_NRD_NRD_1	487	489	PF00675	0.615
CLV_NRD_NRD_1	492	494	PF00675	0.621
CLV_NRD_NRD_1	520	522	PF00675	0.533
CLV_PCSK_KEX2_1	166	168	PF00082	0.517
CLV_PCSK_KEX2_1	32	34	PF00082	0.530
CLV_PCSK_KEX2_1	487	489	PF00082	0.593
CLV_PCSK_KEX2_1	520	522	PF00082	0.540
CLV_PCSK_SKI1_1	227	231	PF00082	0.416
CLV_PCSK_SKI1_1	320	324	PF00082	0.409
CLV_PCSK_SKI1_1	521	525	PF00082	0.578
CLV_PCSK_SKI1_1	564	568	PF00082	0.569
DEG_APCC_DBOX_1	273	281	PF00400	0.522
DEG_SPOP_SBC_1	450	454	PF00917	0.600
DOC_CKS1_1	294	299	PF01111	0.490
DOC_MAPK_gen_1	326	334	PF00069	0.466
DOC_MAPK_gen_1	605	615	PF00069	0.590
DOC_MAPK_MEF2A_6	326	334	PF00069	0.458
DOC_MAPK_MEF2A_6	576	584	PF00069	0.547
DOC_PP1_RVXF_1	610	616	PF00149	0.590
DOC_USP7_MATH_1	117	121	PF00917	0.464
DOC_USP7_MATH_1	412	416	PF00917	0.760
DOC_USP7_MATH_1	421	425	PF00917	0.728
DOC_USP7_MATH_1	449	453	PF00917	0.660
DOC_USP7_MATH_1	523	527	PF00917	0.515
DOC_USP7_UBL2_3	403	407	PF12436	0.777
DOC_WW_Pin1_4	293	298	PF00397	0.437
DOC_WW_Pin1_4	366	371	PF00397	0.540
DOC_WW_Pin1_4	394	399	PF00397	0.750
DOC_WW_Pin1_4	417	422	PF00397	0.729
DOC_WW_Pin1_4	472	477	PF00397	0.632
LIG_14-3-3_CanoR_1	173	183	PF00244	0.378
LIG_14-3-3_CanoR_1	192	197	PF00244	0.297
LIG_14-3-3_CanoR_1	257	261	PF00244	0.511
LIG_14-3-3_CanoR_1	320	325	PF00244	0.468
LIG_14-3-3_CanoR_1	498	503	PF00244	0.590
LIG_Actin_WH2_2	581	599	PF00022	0.587
LIG_APCC_ABBA_1	72	77	PF00400	0.462
LIG_BRCT_BRCA1_1	130	134	PF00533	0.278
LIG_BRCT_BRCA1_1	194	198	PF00533	0.418
LIG_BRCT_BRCA1_1	43	47	PF00533	0.487
LIG_BRCT_BRCA1_1	75	79	PF00533	0.456
LIG_DLG_GKlike_1	498	505	PF00625	0.608
LIG_EH1_1	463	471	PF00400	0.611
LIG_FHA_1	121	127	PF00498	0.484
LIG_FHA_1	175	181	PF00498	0.416
LIG_FHA_1	257	263	PF00498	0.439
LIG_FHA_1	597	603	PF00498	0.580
LIG_FHA_2	239	245	PF00498	0.552
LIG_FHA_2	347	353	PF00498	0.530
LIG_FHA_2	473	479	PF00498	0.590
LIG_FHA_2	520	526	PF00498	0.610
LIG_FHA_2	585	591	PF00498	0.568
LIG_LIR_Apic_2	291	297	PF02991	0.400
LIG_LIR_Gen_1	228	238	PF02991	0.551
LIG_LIR_Gen_1	296	307	PF02991	0.480
LIG_LIR_Gen_1	48	59	PF02991	0.418
LIG_LIR_Nem_3	195	199	PF02991	0.402
LIG_LIR_Nem_3	208	213	PF02991	0.304
LIG_LIR_Nem_3	228	233	PF02991	0.508
LIG_LIR_Nem_3	296	302	PF02991	0.404
LIG_LIR_Nem_3	313	319	PF02991	0.264
LIG_LIR_Nem_3	48	54	PF02991	0.417
LIG_MLH1_MIPbox_1	43	47	PF16413	0.524
LIG_NRBOX	340	346	PF00104	0.552
LIG_PCNA_PIPBox_1	258	267	PF02747	0.514
LIG_PCNA_PIPBox_1	456	465	PF02747	0.625
LIG_PCNA_yPIPBox_3	367	375	PF02747	0.550
LIG_Pex14_2	147	151	PF04695	0.483
LIG_Pex14_2	68	72	PF04695	0.389
LIG_Pex14_2	75	79	PF04695	0.413
LIG_Rb_LxCxE_1	208	231	PF01857	0.400
LIG_Rb_pABgroove_1	128	136	PF01858	0.286
LIG_SH2_CRK	316	320	PF00017	0.437
LIG_SH2_GRB2like	159	162	PF00017	0.558
LIG_SH2_NCK_1	159	163	PF00017	0.431
LIG_SH2_PTP2	299	302	PF00017	0.448
LIG_SH2_PTP2	51	54	PF00017	0.507
LIG_SH2_SRC	299	302	PF00017	0.497
LIG_SH2_STAT3	357	360	PF00017	0.565
LIG_SH2_STAT3	634	637	PF00017	0.636
LIG_SH2_STAT5	294	297	PF00017	0.354
LIG_SH2_STAT5	299	302	PF00017	0.351
LIG_SH2_STAT5	51	54	PF00017	0.480
LIG_SH3_2	2	7	PF14604	0.719
LIG_SH3_3	13	19	PF00018	0.528
LIG_SH3_4	403	410	PF00018	0.778
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.454
LIG_SUMO_SIM_par_1	258	263	PF11976	0.520
LIG_SUMO_SIM_par_1	300	305	PF11976	0.443
LIG_TRAF2_1	241	244	PF00917	0.553
LIG_TRAF2_1	587	590	PF00917	0.466
LIG_TRAF2_1	85	88	PF00917	0.449
LIG_TYR_ITIM	314	319	PF00017	0.379
LIG_UBA3_1	179	187	PF00899	0.400
LIG_UBA3_1	99	108	PF00899	0.512
LIG_WRC_WIRS_1	363	368	PF05994	0.566
MOD_CDC14_SPxK_1	369	372	PF00782	0.516
MOD_CDK_SPxK_1	366	372	PF00069	0.524
MOD_CK1_1	120	126	PF00069	0.488
MOD_CK1_1	256	262	PF00069	0.470
MOD_CK1_1	346	352	PF00069	0.513
MOD_CK1_1	397	403	PF00069	0.721
MOD_CK1_1	415	421	PF00069	0.614
MOD_CK1_1	82	88	PF00069	0.486
MOD_CK2_1	157	163	PF00069	0.462
MOD_CK2_1	238	244	PF00069	0.572
MOD_CK2_1	421	427	PF00069	0.695
MOD_CK2_1	472	478	PF00069	0.588
MOD_CK2_1	519	525	PF00069	0.552
MOD_CK2_1	584	590	PF00069	0.484
MOD_CK2_1	603	609	PF00069	0.350
MOD_CK2_1	82	88	PF00069	0.519
MOD_GlcNHglycan	119	122	PF01048	0.486
MOD_GlcNHglycan	20	23	PF01048	0.516
MOD_GlcNHglycan	442	446	PF01048	0.686
MOD_GlcNHglycan	60	63	PF01048	0.535
MOD_GSK3_1	282	289	PF00069	0.499
MOD_GSK3_1	346	353	PF00069	0.516
MOD_GSK3_1	362	369	PF00069	0.412
MOD_GSK3_1	412	419	PF00069	0.721
MOD_GSK3_1	422	429	PF00069	0.685
MOD_GSK3_1	519	526	PF00069	0.512
MOD_GSK3_1	95	102	PF00069	0.477
MOD_N-GLC_1	310	315	PF02516	0.395
MOD_N-GLC_1	622	627	PF02516	0.668
MOD_N-GLC_1	95	100	PF02516	0.497
MOD_NEK2_1	220	225	PF00069	0.402
MOD_NEK2_1	233	238	PF00069	0.384
MOD_NEK2_1	287	292	PF00069	0.458
MOD_NEK2_1	343	348	PF00069	0.600
MOD_NEK2_1	416	421	PF00069	0.786
MOD_NEK2_1	432	437	PF00069	0.680
MOD_NEK2_1	441	446	PF00069	0.494
MOD_NEK2_1	46	51	PF00069	0.500
MOD_NEK2_1	99	104	PF00069	0.444
MOD_PKA_2	172	178	PF00069	0.436
MOD_PKA_2	220	226	PF00069	0.399
MOD_PKA_2	256	262	PF00069	0.512
MOD_PKA_2	519	525	PF00069	0.544
MOD_PKA_2	596	602	PF00069	0.567
MOD_Plk_1	283	289	PF00069	0.521
MOD_Plk_1	310	316	PF00069	0.377
MOD_Plk_1	47	53	PF00069	0.404
MOD_Plk_1	82	88	PF00069	0.487
MOD_Plk_1	95	101	PF00069	0.484
MOD_Plk_4	129	135	PF00069	0.467
MOD_Plk_4	250	256	PF00069	0.424
MOD_Plk_4	352	358	PF00069	0.469
MOD_Plk_4	41	47	PF00069	0.387
MOD_Plk_4	95	101	PF00069	0.445
MOD_ProDKin_1	293	299	PF00069	0.435
MOD_ProDKin_1	366	372	PF00069	0.548
MOD_ProDKin_1	394	400	PF00069	0.749
MOD_ProDKin_1	417	423	PF00069	0.729
MOD_ProDKin_1	472	478	PF00069	0.629
MOD_SUMO_for_1	339	342	PF00179	0.609
TRG_DiLeu_BaEn_4	243	249	PF01217	0.542
TRG_ENDOCYTIC_2	299	302	PF00928	0.376
TRG_ENDOCYTIC_2	316	319	PF00928	0.299
TRG_ENDOCYTIC_2	51	54	PF00928	0.509
TRG_ER_diArg_1	31	33	PF00400	0.507
TRG_ER_diArg_1	486	488	PF00400	0.602
TRG_ER_diArg_1	624	627	PF00400	0.667
TRG_NES_CRM1_1	480	495	PF08389	0.413
TRG_NES_CRM1_1	571	583	PF08389	0.575
TRG_NES_CRM1_1	97	112	PF08389	0.459
TRG_NLS_MonoExtC_3	435	440	PF00514	0.663
TRG_NLS_MonoExtN_4	436	441	PF00514	0.703
TRG_Pf-PMV_PEXEL_1	246	251	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P623	Leptomonas seymouri	78%	98%
A0A0N0P6N7	Leptomonas seymouri	24%	94%
A0A1X0NY32	Trypanosomatidae	44%	100%
A0A3Q8IDH9	Leishmania donovani	99%	100%
A0A422NY96	Trypanosoma rangeli	25%	100%
A0A422P4I7	Trypanosoma rangeli	45%	100%
A4HEC6	Leishmania braziliensis	90%	100%
C9ZKC9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AXV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q9L5	Leishmania major	95%	100%
V5D5U6	Trypanosoma cruzi	26%	100%
V5D8I6	Trypanosoma cruzi	41%	100%