COP9 signalosome complex subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PCI domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I1S0_LEIIN

TriTrypDb:

LINF_250029200

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0008180	COP9 signalosome	3	12
GO:0032991	protein-containing complex	1	12
GO:0110165	cellular anatomical entity	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0000502	proteasome complex	3	3
GO:0140535	intracellular protein-containing complex	2	3
GO:1902494	catalytic complex	2	3
GO:1905368	peptidase complex	3	3
GO:1905369	endopeptidase complex	4	3

Expansion

Sequence features

A4I1S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1S0

Function

Biological processes
Term	Name	Level	Count
GO:0000338	protein deneddylation	6	1
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070646	protein modification by small protein removal	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.413
CLV_NRD_NRD_1	204	206	PF00675	0.454
CLV_NRD_NRD_1	214	216	PF00675	0.499
CLV_NRD_NRD_1	404	406	PF00675	0.315
CLV_PCSK_KEX2_1	214	216	PF00082	0.389
CLV_PCSK_SKI1_1	108	112	PF00082	0.340
CLV_PCSK_SKI1_1	405	409	PF00082	0.296
CLV_PCSK_SKI1_1	68	72	PF00082	0.300
CLV_PCSK_SKI1_1	78	82	PF00082	0.349
DEG_Nend_UBRbox_2	1	3	PF02207	0.537
DOC_CYCLIN_RxL_1	194	202	PF00134	0.343
DOC_CYCLIN_RxL_1	400	414	PF00134	0.502
DOC_MAPK_DCC_7	222	232	PF00069	0.414
DOC_MAPK_gen_1	127	135	PF00069	0.343
DOC_PP1_RVXF_1	404	411	PF00149	0.567
DOC_PP2B_LxvP_1	118	121	PF13499	0.293
DOC_PP2B_LxvP_1	318	321	PF13499	0.283
DOC_PP2B_LxvP_1	327	330	PF13499	0.379
DOC_PP4_FxxP_1	96	99	PF00568	0.513
DOC_USP7_MATH_1	226	230	PF00917	0.417
DOC_USP7_MATH_1	236	240	PF00917	0.159
DOC_USP7_MATH_1	256	260	PF00917	0.168
DOC_USP7_MATH_1	416	420	PF00917	0.404
DOC_USP7_MATH_1	57	61	PF00917	0.522
DOC_USP7_UBL2_3	108	112	PF12436	0.323
DOC_WW_Pin1_4	25	30	PF00397	0.341
LIG_14-3-3_CanoR_1	125	130	PF00244	0.482
LIG_14-3-3_CanoR_1	154	158	PF00244	0.326
LIG_14-3-3_CanoR_1	64	68	PF00244	0.340
LIG_Actin_WH2_2	20	35	PF00022	0.627
LIG_Actin_WH2_2	216	233	PF00022	0.466
LIG_APCC_ABBAyCdc20_2	154	160	PF00400	0.441
LIG_BRCT_BRCA1_1	361	365	PF00533	0.457
LIG_deltaCOP1_diTrp_1	247	257	PF00928	0.319
LIG_FHA_1	130	136	PF00498	0.351
LIG_FHA_1	154	160	PF00498	0.330
LIG_FHA_1	19	25	PF00498	0.504
LIG_FHA_1	196	202	PF00498	0.392
LIG_FHA_1	353	359	PF00498	0.547
LIG_FHA_1	365	371	PF00498	0.465
LIG_FHA_1	387	393	PF00498	0.515
LIG_FHA_1	429	435	PF00498	0.520
LIG_FHA_1	89	95	PF00498	0.360
LIG_LIR_Gen_1	322	330	PF02991	0.360
LIG_LIR_Gen_1	88	97	PF02991	0.367
LIG_LIR_Nem_3	10	16	PF02991	0.645
LIG_LIR_Nem_3	141	146	PF02991	0.431
LIG_LIR_Nem_3	202	207	PF02991	0.386
LIG_LIR_Nem_3	322	326	PF02991	0.346
LIG_LIR_Nem_3	339	345	PF02991	0.439
LIG_LIR_Nem_3	362	368	PF02991	0.455
LIG_LIR_Nem_3	66	70	PF02991	0.295
LIG_LIR_Nem_3	88	93	PF02991	0.356
LIG_Rb_pABgroove_1	77	85	PF01858	0.335
LIG_RPA_C_Fungi	250	262	PF08784	0.362
LIG_SH2_CRK	143	147	PF00017	0.355
LIG_SH2_CRK	204	208	PF00017	0.351
LIG_SH2_CRK	273	277	PF00017	0.459
LIG_SH2_CRK	90	94	PF00017	0.322
LIG_SH2_GRB2like	17	20	PF00017	0.660
LIG_SH2_PTP2	278	281	PF00017	0.431
LIG_SH2_PTP2	345	348	PF00017	0.435
LIG_SH2_SRC	17	20	PF00017	0.541
LIG_SH2_SRC	34	37	PF00017	0.222
LIG_SH2_SRC	345	348	PF00017	0.379
LIG_SH2_SRC	357	360	PF00017	0.305
LIG_SH2_STAP1	361	365	PF00017	0.348
LIG_SH2_STAP1	83	87	PF00017	0.289
LIG_SH2_STAP1	90	94	PF00017	0.291
LIG_SH2_STAT3	89	92	PF00017	0.368
LIG_SH2_STAT5	278	281	PF00017	0.285
LIG_SH2_STAT5	34	37	PF00017	0.382
LIG_SH2_STAT5	345	348	PF00017	0.317
LIG_SH2_STAT5	357	360	PF00017	0.224
LIG_SH2_STAT5	90	93	PF00017	0.357
LIG_SH3_3	143	149	PF00018	0.463
LIG_SUMO_SIM_anti_2	367	372	PF11976	0.353
LIG_SUMO_SIM_anti_2	419	426	PF11976	0.613
LIG_SUMO_SIM_par_1	131	137	PF11976	0.475
LIG_SUMO_SIM_par_1	21	28	PF11976	0.435
LIG_SUMO_SIM_par_1	366	372	PF11976	0.335
LIG_TRAF2_1	294	297	PF00917	0.494
LIG_TYR_ITIM	276	281	PF00017	0.278
LIG_WRC_WIRS_1	320	325	PF05994	0.425
MOD_CK1_1	181	187	PF00069	0.611
MOD_CK1_1	364	370	PF00069	0.391
MOD_CK1_1	428	434	PF00069	0.512
MOD_CK2_1	232	238	PF00069	0.382
MOD_CK2_1	25	31	PF00069	0.393
MOD_CK2_1	366	372	PF00069	0.423
MOD_CK2_1	40	46	PF00069	0.374
MOD_GlcNHglycan	234	237	PF01048	0.417
MOD_GlcNHglycan	238	241	PF01048	0.331
MOD_GlcNHglycan	258	261	PF01048	0.226
MOD_GlcNHglycan	266	269	PF01048	0.426
MOD_GlcNHglycan	389	392	PF01048	0.349
MOD_GSK3_1	125	132	PF00069	0.448
MOD_GSK3_1	195	202	PF00069	0.452
MOD_GSK3_1	232	239	PF00069	0.492
MOD_GSK3_1	36	43	PF00069	0.386
MOD_GSK3_1	425	432	PF00069	0.446
MOD_N-GLC_1	18	23	PF02516	0.514
MOD_NEK2_1	199	204	PF00069	0.391
MOD_NEK2_1	232	237	PF00069	0.356
MOD_NEK2_1	387	392	PF00069	0.367
MOD_NEK2_1	40	45	PF00069	0.411
MOD_NEK2_2	63	68	PF00069	0.302
MOD_PIKK_1	88	94	PF00454	0.389
MOD_PKA_2	129	135	PF00069	0.385
MOD_PKA_2	153	159	PF00069	0.355
MOD_PKA_2	411	417	PF00069	0.561
MOD_PKA_2	63	69	PF00069	0.345
MOD_Plk_1	114	120	PF00069	0.430
MOD_Plk_1	164	170	PF00069	0.504
MOD_Plk_1	178	184	PF00069	0.507
MOD_Plk_1	295	301	PF00069	0.506
MOD_Plk_1	45	51	PF00069	0.460
MOD_Plk_2-3	18	24	PF00069	0.599
MOD_Plk_4	147	153	PF00069	0.369
MOD_Plk_4	164	170	PF00069	0.295
MOD_Plk_4	178	184	PF00069	0.501
MOD_Plk_4	280	286	PF00069	0.348
MOD_Plk_4	319	325	PF00069	0.457
MOD_Plk_4	36	42	PF00069	0.376
MOD_Plk_4	366	372	PF00069	0.310
MOD_ProDKin_1	25	31	PF00069	0.332
MOD_SUMO_rev_2	26	35	PF00179	0.459
TRG_ENDOCYTIC_2	143	146	PF00928	0.454
TRG_ENDOCYTIC_2	204	207	PF00928	0.342
TRG_ENDOCYTIC_2	210	213	PF00928	0.364
TRG_ENDOCYTIC_2	217	220	PF00928	0.455
TRG_ENDOCYTIC_2	273	276	PF00928	0.365
TRG_ENDOCYTIC_2	278	281	PF00928	0.299
TRG_ENDOCYTIC_2	83	86	PF00928	0.306
TRG_ENDOCYTIC_2	90	93	PF00928	0.307
TRG_ER_diArg_1	124	127	PF00400	0.416
TRG_ER_diArg_1	213	215	PF00400	0.472
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKE5	Leptomonas seymouri	64%	98%
A0A0S4J4F8	Bodo saltans	27%	96%
A0A1X0NY12	Trypanosomatidae	32%	99%
A0A3S7WZD2	Leishmania donovani	99%	100%
A0A422P4P2	Trypanosoma rangeli	32%	99%
A4HEC5	Leishmania braziliensis	85%	100%
C9ZKC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	99%
E9AXV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O01422	Caenorhabditis elegans	21%	88%
P61201	Homo sapiens	22%	99%
P61202	Mus musculus	22%	99%
P61203	Rattus norvegicus	22%	99%
Q4Q9L6	Leishmania major	92%	100%
Q54HL6	Dictyostelium discoideum	21%	97%
Q5B3U7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	22%	86%
Q6IQT4	Danio rerio	23%	99%
Q6IR75	Xenopus laevis	23%	99%
Q7SI58	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	21%	89%
Q8W207	Arabidopsis thaliana	22%	100%
Q94899	Drosophila melanogaster	21%	98%
Q9HFR0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	20%	100%
V5BH20	Trypanosoma cruzi	31%	99%