Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1R4_LEIIN

TriTrypDb:

LINF_250028600

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1R4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1R4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.583
CLV_PCSK_KEX2_1	213	215	PF00082	0.779
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.779
CLV_PCSK_SKI1_1	135	139	PF00082	0.471
CLV_PCSK_SKI1_1	145	149	PF00082	0.434
CLV_PCSK_SKI1_1	170	174	PF00082	0.585
DEG_Nend_UBRbox_2	1	3	PF02207	0.717
DEG_SCF_FBW7_1	227	234	PF00400	0.641
DOC_CKS1_1	228	233	PF01111	0.556
DOC_MAPK_gen_1	151	161	PF00069	0.534
DOC_USP7_MATH_1	121	125	PF00917	0.458
DOC_USP7_MATH_1	146	150	PF00917	0.547
DOC_USP7_MATH_1	231	235	PF00917	0.638
DOC_USP7_MATH_1	72	76	PF00917	0.651
DOC_USP7_MATH_1	86	90	PF00917	0.689
DOC_WW_Pin1_4	227	232	PF00397	0.651
DOC_WW_Pin1_4	36	41	PF00397	0.757
DOC_WW_Pin1_4	67	72	PF00397	0.733
DOC_WW_Pin1_4	78	83	PF00397	0.811
LIG_14-3-3_CanoR_1	145	151	PF00244	0.565
LIG_Actin_RPEL_3	174	193	PF02755	0.472
LIG_Actin_WH2_2	4	21	PF00022	0.587
LIG_CaM_IQ_9	156	172	PF13499	0.424
LIG_FHA_1	103	109	PF00498	0.472
LIG_FHA_1	127	133	PF00498	0.445
LIG_FHA_1	216	222	PF00498	0.696
LIG_FHA_1	237	243	PF00498	0.505
LIG_FHA_1	43	49	PF00498	0.690
LIG_FHA_2	8	14	PF00498	0.650
LIG_LIR_Gen_1	130	139	PF02991	0.639
LIG_LIR_Gen_1	182	192	PF02991	0.489
LIG_LIR_Gen_1	25	31	PF02991	0.550
LIG_LIR_Gen_1	99	109	PF02991	0.614
LIG_LIR_Nem_3	130	136	PF02991	0.641
LIG_LIR_Nem_3	149	153	PF02991	0.475
LIG_LIR_Nem_3	182	187	PF02991	0.597
LIG_LIR_Nem_3	243	249	PF02991	0.523
LIG_LIR_Nem_3	25	30	PF02991	0.578
LIG_LIR_Nem_3	99	104	PF02991	0.626
LIG_NRBOX	237	243	PF00104	0.542
LIG_Rb_LxCxE_1	182	202	PF01857	0.550
LIG_SH2_CRK	27	31	PF00017	0.594
LIG_SH2_NCK_1	27	31	PF00017	0.563
LIG_SH2_STAP1	176	180	PF00017	0.495
LIG_SH2_STAP1	27	31	PF00017	0.703
LIG_SH3_3	225	231	PF00018	0.574
LIG_SUMO_SIM_anti_2	191	197	PF11976	0.500
LIG_UBA3_1	132	138	PF00899	0.459
MOD_CDK_SPxxK_3	78	85	PF00069	0.814
MOD_CK1_1	126	132	PF00069	0.514
MOD_CK1_1	168	174	PF00069	0.626
MOD_CK1_1	179	185	PF00069	0.430
MOD_CK1_1	206	212	PF00069	0.727
MOD_CK1_1	29	35	PF00069	0.765
MOD_CK1_1	58	64	PF00069	0.620
MOD_CK1_1	70	76	PF00069	0.659
MOD_CK1_1	88	94	PF00069	0.631
MOD_CK2_1	196	202	PF00069	0.518
MOD_CK2_1	7	13	PF00069	0.651
MOD_CK2_1	86	92	PF00069	0.798
MOD_GlcNHglycan	165	170	PF01048	0.544
MOD_GlcNHglycan	177	181	PF01048	0.384
MOD_GlcNHglycan	7	10	PF01048	0.368
MOD_GSK3_1	122	129	PF00069	0.436
MOD_GSK3_1	175	182	PF00069	0.543
MOD_GSK3_1	203	210	PF00069	0.608
MOD_GSK3_1	227	234	PF00069	0.589
MOD_GSK3_1	32	39	PF00069	0.770
MOD_GSK3_1	5	12	PF00069	0.376
MOD_GSK3_1	54	61	PF00069	0.676
MOD_GSK3_1	84	91	PF00069	0.725
MOD_NEK2_1	104	109	PF00069	0.341
MOD_NEK2_1	31	36	PF00069	0.612
MOD_NEK2_2	146	151	PF00069	0.548
MOD_PIKK_1	29	35	PF00454	0.765
MOD_PIKK_1	72	78	PF00454	0.654
MOD_PIKK_1	86	92	PF00454	0.700
MOD_PKA_2	58	64	PF00069	0.747
MOD_PKA_2	84	90	PF00069	0.811
MOD_Plk_1	14	20	PF00069	0.554
MOD_Plk_4	104	110	PF00069	0.538
MOD_Plk_4	26	32	PF00069	0.685
MOD_ProDKin_1	227	233	PF00069	0.646
MOD_ProDKin_1	36	42	PF00069	0.757
MOD_ProDKin_1	67	73	PF00069	0.733
MOD_ProDKin_1	78	84	PF00069	0.812
MOD_SUMO_for_1	137	140	PF00179	0.449
MOD_SUMO_rev_2	206	215	PF00179	0.641
TRG_DiLeu_BaEn_1	191	196	PF01217	0.582
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.548
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.645
TRG_ENDOCYTIC_2	27	30	PF00928	0.588
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYI0	Leptomonas seymouri	32%	100%
A0A3Q8INN7	Leishmania donovani	98%	100%
A4HEB9	Leishmania braziliensis	65%	100%
E9AXU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q9M2	Leishmania major	85%	100%