Tricarboxylic acid cycle, succinyl-CoA synthetase alpha subunit
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 30 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | yes | yes: 16 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005739 | mitochondrion | 5 | 12 |
| GO:0043226 | organelle | 2 | 12 |
| GO:0043227 | membrane-bounded organelle | 3 | 12 |
| GO:0043229 | intracellular organelle | 3 | 12 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 12 |
| GO:0110165 | cellular anatomical entity | 1 | 12 |
| GO:0009361 | succinate-CoA ligase complex (ADP-forming) | 5 | 1 |
| GO:0032991 | protein-containing complex | 1 | 1 |
| GO:0042709 | succinate-CoA ligase complex | 4 | 1 |
| GO:0045239 | tricarboxylic acid cycle enzyme complex | 3 | 1 |
| GO:1902494 | catalytic complex | 2 | 1 |
Related structures:
AlphaFold database: A4I1R2
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006099 | tricarboxylic acid cycle | 3 | 12 |
| GO:0008152 | metabolic process | 1 | 12 |
| GO:0044238 | primary metabolic process | 2 | 12 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000166 | nucleotide binding | 3 | 12 |
| GO:0003824 | catalytic activity | 1 | 12 |
| GO:0004774 | succinate-CoA ligase activity | 5 | 12 |
| GO:0004775 | succinate-CoA ligase (ADP-forming) activity | 6 | 12 |
| GO:0005488 | binding | 1 | 12 |
| GO:0016874 | ligase activity | 2 | 12 |
| GO:0016877 | ligase activity, forming carbon-sulfur bonds | 3 | 12 |
| GO:0016878 | acid-thiol ligase activity | 4 | 12 |
| GO:0036094 | small molecule binding | 2 | 12 |
| GO:0097159 | organic cyclic compound binding | 2 | 12 |
| GO:1901265 | nucleoside phosphate binding | 3 | 12 |
| GO:1901363 | heterocyclic compound binding | 2 | 12 |
| GO:0004776 | succinate-CoA ligase (GDP-forming) activity | 6 | 1 |
| GO:0016740 | transferase activity | 2 | 1 |
| GO:0016746 | acyltransferase activity | 3 | 1 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 280 | 284 | PF00656 | 0.467 |
| CLV_C14_Caspase3-7 | 90 | 94 | PF00656 | 0.313 |
| CLV_NRD_NRD_1 | 251 | 253 | PF00675 | 0.289 |
| CLV_NRD_NRD_1 | 8 | 10 | PF00675 | 0.505 |
| CLV_PCSK_KEX2_1 | 251 | 253 | PF00082 | 0.281 |
| CLV_PCSK_KEX2_1 | 8 | 10 | PF00082 | 0.544 |
| CLV_PCSK_PC7_1 | 4 | 10 | PF00082 | 0.519 |
| CLV_PCSK_SKI1_1 | 115 | 119 | PF00082 | 0.371 |
| CLV_PCSK_SKI1_1 | 200 | 204 | PF00082 | 0.399 |
| CLV_PCSK_SKI1_1 | 271 | 275 | PF00082 | 0.366 |
| DEG_Nend_Nbox_1 | 1 | 3 | PF02207 | 0.452 |
| DOC_CYCLIN_yCln2_LP_2 | 55 | 61 | PF00134 | 0.366 |
| DOC_MAPK_gen_1 | 235 | 241 | PF00069 | 0.278 |
| DOC_PP2B_LxvP_1 | 55 | 58 | PF13499 | 0.270 |
| DOC_PP2B_LxvP_1 | 77 | 80 | PF13499 | 0.392 |
| DOC_USP7_MATH_1 | 237 | 241 | PF00917 | 0.290 |
| DOC_USP7_MATH_1 | 258 | 262 | PF00917 | 0.290 |
| DOC_USP7_MATH_1 | 72 | 76 | PF00917 | 0.407 |
| DOC_USP7_MATH_1 | 80 | 84 | PF00917 | 0.403 |
| DOC_WW_Pin1_4 | 229 | 234 | PF00397 | 0.414 |
| DOC_WW_Pin1_4 | 281 | 286 | PF00397 | 0.412 |
| DOC_WW_Pin1_4 | 43 | 48 | PF00397 | 0.423 |
| LIG_14-3-3_CanoR_1 | 113 | 118 | PF00244 | 0.341 |
| LIG_AP2alpha_2 | 188 | 190 | PF02296 | 0.270 |
| LIG_DLG_GKlike_1 | 113 | 121 | PF00625 | 0.350 |
| LIG_FHA_1 | 101 | 107 | PF00498 | 0.289 |
| LIG_FHA_1 | 122 | 128 | PF00498 | 0.329 |
| LIG_FHA_1 | 13 | 19 | PF00498 | 0.275 |
| LIG_FHA_1 | 191 | 197 | PF00498 | 0.271 |
| LIG_FHA_1 | 206 | 212 | PF00498 | 0.270 |
| LIG_FHA_1 | 37 | 43 | PF00498 | 0.278 |
| LIG_FHA_1 | 50 | 56 | PF00498 | 0.451 |
| LIG_FHA_1 | 71 | 77 | PF00498 | 0.431 |
| LIG_FHA_2 | 170 | 176 | PF00498 | 0.313 |
| LIG_FHA_2 | 218 | 224 | PF00498 | 0.315 |
| LIG_FHA_2 | 278 | 284 | PF00498 | 0.494 |
| LIG_FHA_2 | 60 | 66 | PF00498 | 0.278 |
| LIG_LIR_Gen_1 | 163 | 174 | PF02991 | 0.270 |
| LIG_LIR_LC3C_4 | 95 | 100 | PF02991 | 0.270 |
| LIG_LIR_Nem_3 | 163 | 169 | PF02991 | 0.270 |
| LIG_SH2_NCK_1 | 166 | 170 | PF00017 | 0.270 |
| LIG_SH2_SRC | 78 | 81 | PF00017 | 0.270 |
| LIG_SH2_STAP1 | 166 | 170 | PF00017 | 0.298 |
| LIG_SH2_STAT5 | 78 | 81 | PF00017 | 0.270 |
| LIG_SH3_3 | 126 | 132 | PF00018 | 0.311 |
| LIG_SH3_3 | 76 | 82 | PF00018 | 0.297 |
| LIG_SUMO_SIM_anti_2 | 207 | 216 | PF11976 | 0.293 |
| LIG_SUMO_SIM_par_1 | 207 | 216 | PF11976 | 0.273 |
| LIG_SUMO_SIM_par_1 | 97 | 104 | PF11976 | 0.270 |
| LIG_TRAF2_1 | 220 | 223 | PF00917 | 0.270 |
| LIG_TRAF2_1 | 87 | 90 | PF00917 | 0.270 |
| LIG_TYR_ITIM | 164 | 169 | PF00017 | 0.270 |
| LIG_WRC_WIRS_1 | 238 | 243 | PF05994 | 0.268 |
| MOD_CDC14_SPxK_1 | 232 | 235 | PF00782 | 0.414 |
| MOD_CDC14_SPxK_1 | 46 | 49 | PF00782 | 0.366 |
| MOD_CDK_SPK_2 | 43 | 48 | PF00069 | 0.423 |
| MOD_CDK_SPxK_1 | 229 | 235 | PF00069 | 0.414 |
| MOD_CDK_SPxK_1 | 43 | 49 | PF00069 | 0.366 |
| MOD_CDK_SPxxK_3 | 229 | 236 | PF00069 | 0.414 |
| MOD_CK2_1 | 169 | 175 | PF00069 | 0.331 |
| MOD_CK2_1 | 217 | 223 | PF00069 | 0.270 |
| MOD_CK2_1 | 59 | 65 | PF00069 | 0.317 |
| MOD_CK2_1 | 84 | 90 | PF00069 | 0.367 |
| MOD_Cter_Amidation | 249 | 252 | PF01082 | 0.270 |
| MOD_Cter_Amidation | 268 | 271 | PF01082 | 0.270 |
| MOD_GlcNHglycan | 160 | 163 | PF01048 | 0.293 |
| MOD_GlcNHglycan | 260 | 263 | PF01048 | 0.271 |
| MOD_GlcNHglycan | 4 | 7 | PF01048 | 0.615 |
| MOD_GSK3_1 | 113 | 120 | PF00069 | 0.351 |
| MOD_GSK3_1 | 156 | 163 | PF00069 | 0.298 |
| MOD_GSK3_1 | 277 | 284 | PF00069 | 0.552 |
| MOD_GSK3_1 | 80 | 87 | PF00069 | 0.309 |
| MOD_N-GLC_1 | 121 | 126 | PF02516 | 0.360 |
| MOD_N-GLC_1 | 190 | 195 | PF02516 | 0.270 |
| MOD_NEK2_1 | 117 | 122 | PF00069 | 0.359 |
| MOD_NEK2_1 | 177 | 182 | PF00069 | 0.271 |
| MOD_NEK2_1 | 190 | 195 | PF00069 | 0.270 |
| MOD_NEK2_1 | 2 | 7 | PF00069 | 0.470 |
| MOD_PIKK_1 | 117 | 123 | PF00454 | 0.361 |
| MOD_Plk_1 | 121 | 127 | PF00069 | 0.354 |
| MOD_Plk_4 | 113 | 119 | PF00069 | 0.349 |
| MOD_Plk_4 | 237 | 243 | PF00069 | 0.289 |
| MOD_Plk_4 | 72 | 78 | PF00069 | 0.290 |
| MOD_ProDKin_1 | 229 | 235 | PF00069 | 0.414 |
| MOD_ProDKin_1 | 281 | 287 | PF00069 | 0.413 |
| MOD_ProDKin_1 | 43 | 49 | PF00069 | 0.423 |
| TRG_DiLeu_BaEn_1 | 209 | 214 | PF01217 | 0.290 |
| TRG_DiLeu_BaEn_3 | 223 | 229 | PF01217 | 0.290 |
| TRG_DiLeu_BaLyEn_6 | 122 | 127 | PF01217 | 0.352 |
| TRG_ENDOCYTIC_2 | 166 | 169 | PF00928 | 0.270 |
| TRG_ER_diArg_1 | 251 | 253 | PF00400 | 0.290 |
| TRG_ER_diArg_1 | 7 | 9 | PF00400 | 0.570 |
| TRG_NES_CRM1_1 | 110 | 121 | PF08389 | 0.344 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0S4JKD5 | Bodo saltans | 75% | 100% |
| A0A1X0NY43 | Trypanosomatidae | 83% | 99% |
| A0A3Q8IFF5 | Leishmania donovani | 100% | 100% |
| A0A3R7N4H2 | Trypanosoma rangeli | 80% | 100% |
| A4HEB6 | Leishmania braziliensis | 96% | 100% |
| B3FHT4 | Blastocystis sp. subtype 1 (strain ATCC 50177 / NandII) | 68% | 94% |
| C9ZKB8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 78% | 99% |
| E9AXU6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 98% | 100% |
| E9AXU7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 99% | 100% |
| O08371 | Rickettsia prowazekii (strain Madrid E) | 66% | 100% |
| O13750 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 65% | 90% |
| O19069 | Sus scrofa | 67% | 86% |
| O26663 | Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) | 51% | 100% |
| O28098 | Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) | 52% | 100% |
| O28733 | Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) | 50% | 100% |
| O67547 | Aquifex aeolicus (strain VF5) | 56% | 98% |
| P09143 | Thermus thermophilus | 55% | 100% |
| P0AGE9 | Escherichia coli (strain K12) | 62% | 100% |
| P0AGF0 | Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) | 62% | 100% |
| P0AGF1 | Escherichia coli O157:H7 | 62% | 100% |
| P13086 | Rattus norvegicus | 69% | 86% |
| P36967 | Dictyostelium discoideum | 66% | 95% |
| P45102 | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) | 62% | 100% |
| P53399 | Trichomonas vaginalis | 57% | 97% |
| P53400 | Trichomonas vaginalis | 57% | 97% |
| P53401 | Trichomonas vaginalis | 57% | 97% |
| P53591 | Coxiella burnetii (strain RSA 493 / Nine Mile phase I) | 61% | 100% |
| P53595 | Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) | 52% | 100% |
| P53596 | Caenorhabditis elegans | 71% | 93% |
| P53597 | Homo sapiens | 67% | 86% |
| P53598 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 59% | 91% |
| P66866 | Staphylococcus aureus (strain Mu50 / ATCC 700699) | 59% | 99% |
| P68209 | Arabidopsis thaliana | 69% | 86% |
| P80865 | Bacillus subtilis (strain 168) | 61% | 100% |
| P99070 | Staphylococcus aureus (strain N315) | 59% | 99% |
| P9WGC6 | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) | 49% | 99% |
| P9WGC7 | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | 49% | 99% |
| Q1RH56 | Rickettsia bellii (strain RML369-C) | 69% | 100% |
| Q4Q9M4 | Leishmania major | 100% | 100% |
| Q4ULQ8 | Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) | 67% | 100% |
| Q51567 | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 65% | 100% |
| Q58643 | Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) | 50% | 100% |
| Q58DR8 | Bos taurus | 66% | 86% |
| Q5HGI6 | Staphylococcus aureus (strain COL) | 59% | 99% |
| Q5HPU4 | Staphylococcus epidermidis (strain ATCC 35984 / RP62A) | 58% | 99% |
| Q6DQL1 | Solanum lycopersicum | 70% | 89% |
| Q6G9W7 | Staphylococcus aureus (strain MSSA476) | 59% | 99% |
| Q6GHI9 | Staphylococcus aureus (strain MRSA252) | 59% | 99% |
| Q6ZL94 | Oryza sativa subsp. japonica | 69% | 90% |
| Q7U0Z0 | Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) | 49% | 99% |
| Q8CPH4 | Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) | 58% | 99% |
| Q8GTQ9 | Solanum lycopersicum | 69% | 90% |
| Q8LAD2 | Arabidopsis thaliana | 70% | 88% |
| Q8NX01 | Staphylococcus aureus (strain MW2) | 59% | 99% |
| Q92I22 | Rickettsia conorii (strain ATCC VR-613 / Malish 7) | 66% | 100% |
| Q94522 | Drosophila melanogaster | 67% | 91% |
| Q9AKE1 | Rickettsia typhi (strain ATCC VR-144 / Wilmington) | 66% | 100% |
| Q9P727 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 66% | 90% |
| Q9WUM5 | Mus musculus | 68% | 86% |
| Q9YGD2 | Columba livia | 65% | 98% |
| V5B829 | Trypanosoma cruzi | 79% | 100% |