TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/Tetratricopeptide repeat - putative

Species:

Leishmania infantum

UniProt:

A4I1Q9_LEIIN

TriTrypDb:

LINF_250028000

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1Q9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1Q9

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	17
GO:0009987	cellular process	1	17

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	19
GO:0005515	protein binding	2	17
GO:0008270	zinc ion binding	6	9
GO:0030544	Hsp70 protein binding	4	17
GO:0031072	heat shock protein binding	3	17
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0051879	Hsp90 protein binding	4	17
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.326
CLV_C14_Caspase3-7	110	114	PF00656	0.290
CLV_C14_Caspase3-7	132	136	PF00656	0.415
CLV_C14_Caspase3-7	30	34	PF00656	0.583
CLV_NRD_NRD_1	263	265	PF00675	0.496
CLV_NRD_NRD_1	327	329	PF00675	0.525
CLV_PCSK_FUR_1	327	331	PF00082	0.552
CLV_PCSK_KEX2_1	327	329	PF00082	0.541
CLV_PCSK_KEX2_1	8	10	PF00082	0.471
CLV_PCSK_KEX2_1	89	91	PF00082	0.520
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.541
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.471
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.481
CLV_PCSK_SKI1_1	238	242	PF00082	0.434
DOC_CYCLIN_RxL_1	160	172	PF00134	0.518
DOC_MAPK_gen_1	62	70	PF00069	0.320
DOC_USP7_MATH_1	260	264	PF00917	0.568
DOC_USP7_MATH_1	290	294	PF00917	0.579
DOC_USP7_MATH_1	302	306	PF00917	0.566
DOC_USP7_UBL2_3	223	227	PF12436	0.426
DOC_USP7_UBL2_3	241	245	PF12436	0.281
LIG_14-3-3_CanoR_1	90	98	PF00244	0.383
LIG_Actin_WH2_2	212	229	PF00022	0.409
LIG_APCC_ABBA_1	23	28	PF00400	0.234
LIG_BIR_II_1	1	5	PF00653	0.395
LIG_FHA_1	151	157	PF00498	0.557
LIG_FHA_1	235	241	PF00498	0.397
LIG_FHA_1	273	279	PF00498	0.575
LIG_FHA_1	280	286	PF00498	0.491
LIG_FHA_1	34	40	PF00498	0.522
LIG_FHA_2	108	114	PF00498	0.539
LIG_FHA_2	172	178	PF00498	0.555
LIG_FHA_2	264	270	PF00498	0.505
LIG_LIR_Gen_1	231	240	PF02991	0.360
LIG_LIR_Gen_1	24	32	PF02991	0.511
LIG_LIR_Gen_1	308	315	PF02991	0.566
LIG_LIR_Gen_1	48	59	PF02991	0.438
LIG_LIR_Nem_3	231	236	PF02991	0.360
LIG_LIR_Nem_3	24	29	PF02991	0.499
LIG_LIR_Nem_3	308	312	PF02991	0.526
LIG_LIR_Nem_3	48	54	PF02991	0.438
LIG_LIR_Nem_3	95	100	PF02991	0.461
LIG_PTB_Apo_2	105	112	PF02174	0.337
LIG_PTB_Phospho_1	105	111	PF10480	0.337
LIG_RPA_C_Fungi	180	192	PF08784	0.362
LIG_RPA_C_Fungi	259	271	PF08784	0.587
LIG_SH2_CRK	233	237	PF00017	0.360
LIG_SH2_CRK	51	55	PF00017	0.320
LIG_SH2_NCK_1	26	30	PF00017	0.426
LIG_SH2_NCK_1	91	95	PF00017	0.398
LIG_SH2_NCK_1	98	102	PF00017	0.396
LIG_SH2_SRC	111	114	PF00017	0.363
LIG_SH2_SRC	155	158	PF00017	0.555
LIG_SH2_STAP1	139	143	PF00017	0.498
LIG_SH2_STAT5	111	114	PF00017	0.463
LIG_SH2_STAT5	155	158	PF00017	0.441
LIG_SH2_STAT5	189	192	PF00017	0.550
LIG_SH2_STAT5	309	312	PF00017	0.432
LIG_TRAF2_1	266	269	PF00917	0.507
LIG_TRAF2_1	83	86	PF00917	0.492
MOD_CK1_1	171	177	PF00069	0.510
MOD_CK1_1	183	189	PF00069	0.388
MOD_CK1_1	24	30	PF00069	0.466
MOD_CK1_1	263	269	PF00069	0.580
MOD_CK1_1	305	311	PF00069	0.637
MOD_CK1_1	92	98	PF00069	0.362
MOD_CK1_1	99	105	PF00069	0.345
MOD_CK2_1	151	157	PF00069	0.526
MOD_CK2_1	171	177	PF00069	0.453
MOD_CK2_1	24	30	PF00069	0.444
MOD_CK2_1	263	269	PF00069	0.501
MOD_CK2_1	316	322	PF00069	0.448
MOD_GlcNHglycan	129	132	PF01048	0.511
MOD_GlcNHglycan	14	17	PF01048	0.453
MOD_GlcNHglycan	185	188	PF01048	0.364
MOD_GlcNHglycan	196	200	PF01048	0.400
MOD_GlcNHglycan	304	307	PF01048	0.635
MOD_GlcNHglycan	47	50	PF01048	0.317
MOD_GSK3_1	168	175	PF00069	0.529
MOD_GSK3_1	279	286	PF00069	0.571
MOD_GSK3_1	298	305	PF00069	0.725
MOD_GSK3_1	92	99	PF00069	0.429
MOD_N-GLC_1	183	188	PF02516	0.358
MOD_N-GLC_1	313	318	PF02516	0.554
MOD_N-GLC_1	45	50	PF02516	0.287
MOD_N-GLC_2	311	313	PF02516	0.557
MOD_NEK2_1	150	155	PF00069	0.493
MOD_NEK2_1	96	101	PF00069	0.484
MOD_PKA_1	328	334	PF00069	0.575
MOD_PKA_1	89	95	PF00069	0.486
MOD_PKA_2	263	269	PF00069	0.555
MOD_PKA_2	283	289	PF00069	0.312
MOD_PKA_2	89	95	PF00069	0.491
MOD_PKB_1	270	278	PF00069	0.488
MOD_Plk_1	139	145	PF00069	0.501
MOD_Plk_1	208	214	PF00069	0.413
MOD_Plk_1	92	98	PF00069	0.336
MOD_Plk_4	107	113	PF00069	0.368
MOD_Plk_4	151	157	PF00069	0.511
MOD_Plk_4	177	183	PF00069	0.488
MOD_Plk_4	92	98	PF00069	0.511
MOD_SUMO_rev_2	130	136	PF00179	0.496
MOD_SUMO_rev_2	2	10	PF00179	0.520
TRG_DiLeu_BaEn_1	177	182	PF01217	0.518
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.373
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.454
TRG_ENDOCYTIC_2	233	236	PF00928	0.360
TRG_ENDOCYTIC_2	26	29	PF00928	0.378
TRG_ENDOCYTIC_2	309	312	PF00928	0.561
TRG_ENDOCYTIC_2	51	54	PF00928	0.382
TRG_ENDOCYTIC_2	97	100	PF00928	0.399
TRG_ER_diArg_1	326	328	PF00400	0.531
TRG_ER_diArg_1	330	333	PF00400	0.548
TRG_ER_diArg_1	39	42	PF00400	0.389
TRG_NLS_MonoExtC_3	327	332	PF00514	0.525
TRG_NLS_MonoExtN_4	327	333	PF00514	0.534
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTR8	Leptomonas seymouri	26%	100%
A0A0N1IBD2	Leptomonas seymouri	63%	100%
A0A0S4JRK3	Bodo saltans	35%	95%
A0A1X0NZH9	Trypanosomatidae	38%	91%
A0A3Q8IJP8	Leishmania donovani	24%	100%
A0A3R7LE97	Trypanosoma rangeli	41%	94%
A0A3S7WZC1	Leishmania donovani	99%	100%
A4HEB3	Leishmania braziliensis	84%	100%
A4HNL2	Leishmania braziliensis	24%	100%
A4ICY0	Leishmania infantum	24%	100%
C9ZKB4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	96%
E9ASC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AXU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q271	Leishmania major	25%	100%
Q4Q9M8	Leishmania major	95%	100%
V5BA34	Trypanosoma cruzi	25%	100%
V5BCJ3	Trypanosoma cruzi	41%	94%