Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rieske [2Fe-2S] domain/Rieske-like [2Fe-2S] domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I1Q5_LEIIN

TriTrypDb:

LINF_250027600

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I1Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1Q5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0051536	iron-sulfur cluster binding	3	12
GO:0051537	2 iron, 2 sulfur cluster binding	4	12
GO:0051540	metal cluster binding	2	12
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0003824	catalytic activity	1	2
GO:0016491	oxidoreductase activity	2	2
GO:0008942	nitrite reductase [NAD(P)H] activity	5	1
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	3	1
GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	4	1
GO:0098809	nitrite reductase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	388	392	PF00656	0.454
CLV_NRD_NRD_1	273	275	PF00675	0.647
CLV_NRD_NRD_1	302	304	PF00675	0.447
CLV_NRD_NRD_1	363	365	PF00675	0.513
CLV_NRD_NRD_1	445	447	PF00675	0.744
CLV_PCSK_KEX2_1	14	16	PF00082	0.441
CLV_PCSK_KEX2_1	273	275	PF00082	0.737
CLV_PCSK_KEX2_1	301	303	PF00082	0.470
CLV_PCSK_KEX2_1	363	365	PF00082	0.549
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.441
CLV_PCSK_SKI1_1	430	434	PF00082	0.594
CLV_PCSK_SKI1_1	447	451	PF00082	0.319
CLV_PCSK_SKI1_1	78	82	PF00082	0.450
CLV_Separin_Metazoa	298	302	PF03568	0.524
DEG_APCC_DBOX_1	38	46	PF00400	0.475
DOC_CDC14_PxL_1	412	420	PF14671	0.578
DOC_CKS1_1	457	462	PF01111	0.523
DOC_CYCLIN_RxL_1	9	22	PF00134	0.475
DOC_CYCLIN_yCln2_LP_2	340	346	PF00134	0.534
DOC_MAPK_gen_1	110	118	PF00069	0.418
DOC_MAPK_gen_1	148	156	PF00069	0.559
DOC_MAPK_gen_1	446	456	PF00069	0.555
DOC_MAPK_JIP1_4	150	156	PF00069	0.562
DOC_MAPK_MEF2A_6	148	156	PF00069	0.559
DOC_MAPK_MEF2A_6	450	458	PF00069	0.509
DOC_PP1_RVXF_1	12	19	PF00149	0.475
DOC_PP1_RVXF_1	366	372	PF00149	0.523
DOC_PP2B_LxvP_1	163	166	PF13499	0.705
DOC_PP2B_LxvP_1	266	269	PF13499	0.434
DOC_PP2B_LxvP_1	340	343	PF13499	0.556
DOC_PP4_FxxP_1	457	460	PF00568	0.486
DOC_USP7_MATH_1	103	107	PF00917	0.509
DOC_USP7_MATH_1	139	143	PF00917	0.571
DOC_USP7_MATH_1	228	232	PF00917	0.519
DOC_USP7_MATH_1	276	280	PF00917	0.680
DOC_USP7_MATH_1	329	333	PF00917	0.466
DOC_USP7_MATH_1	494	498	PF00917	0.570
DOC_USP7_MATH_1	526	530	PF00917	0.556
DOC_USP7_MATH_1	73	77	PF00917	0.421
DOC_USP7_MATH_2	211	217	PF00917	0.671
DOC_WW_Pin1_4	220	225	PF00397	0.773
DOC_WW_Pin1_4	376	381	PF00397	0.420
DOC_WW_Pin1_4	456	461	PF00397	0.602
DOC_WW_Pin1_4	472	477	PF00397	0.720
DOC_WW_Pin1_4	91	96	PF00397	0.519
LIG_14-3-3_CanoR_1	150	155	PF00244	0.587
LIG_14-3-3_CanoR_1	198	204	PF00244	0.685
LIG_14-3-3_CanoR_1	227	235	PF00244	0.523
LIG_14-3-3_CanoR_1	469	477	PF00244	0.662
LIG_Actin_WH2_2	241	258	PF00022	0.547
LIG_BIR_II_1	1	5	PF00653	0.718
LIG_FHA_1	28	34	PF00498	0.466
LIG_FHA_1	371	377	PF00498	0.488
LIG_FHA_1	522	528	PF00498	0.516
LIG_FHA_2	293	299	PF00498	0.605
LIG_FHA_2	303	309	PF00498	0.366
LIG_FHA_2	468	474	PF00498	0.727
LIG_KLC1_Yacidic_2	391	396	PF13176	0.525
LIG_LIR_Apic_2	455	460	PF02991	0.523
LIG_LIR_Gen_1	122	133	PF02991	0.459
LIG_LIR_Gen_1	137	146	PF02991	0.440
LIG_LIR_Gen_1	262	270	PF02991	0.570
LIG_LIR_Gen_1	314	323	PF02991	0.409
LIG_LIR_Gen_1	379	389	PF02991	0.369
LIG_LIR_Nem_3	122	128	PF02991	0.435
LIG_LIR_Nem_3	262	266	PF02991	0.552
LIG_LIR_Nem_3	314	319	PF02991	0.392
LIG_LIR_Nem_3	379	385	PF02991	0.390
LIG_LIR_Nem_3	85	91	PF02991	0.417
LIG_MYND_3	415	419	PF01753	0.492
LIG_Pex14_1	424	428	PF04695	0.549
LIG_PTB_Apo_2	37	44	PF02174	0.341
LIG_PTB_Phospho_1	37	43	PF10480	0.340
LIG_PTB_Phospho_1	44	50	PF10480	0.318
LIG_SH2_CRK	382	386	PF00017	0.397
LIG_SH2_PTP2	125	128	PF00017	0.475
LIG_SH2_PTP2	263	266	PF00017	0.516
LIG_SH2_SRC	394	397	PF00017	0.441
LIG_SH2_STAT5	11	14	PF00017	0.449
LIG_SH2_STAT5	125	128	PF00017	0.453
LIG_SH2_STAT5	263	266	PF00017	0.504
LIG_SH2_STAT5	394	397	PF00017	0.641
LIG_SH2_STAT5	452	455	PF00017	0.378
LIG_SH2_STAT5	503	506	PF00017	0.530
LIG_SH2_STAT5	512	515	PF00017	0.502
LIG_SH2_STAT5	88	91	PF00017	0.551
LIG_SH3_3	510	516	PF00018	0.417
LIG_SUMO_SIM_par_1	54	60	PF11976	0.475
LIG_TRAF2_1	464	467	PF00917	0.561
LIG_UBA3_1	315	321	PF00899	0.411
LIG_WRC_WIRS_1	214	219	PF05994	0.503
MOD_CDK_SPxxK_3	220	227	PF00069	0.652
MOD_CK1_1	131	137	PF00069	0.579
MOD_CK1_1	2	8	PF00069	0.714
MOD_CK1_1	216	222	PF00069	0.799
MOD_CK1_1	223	229	PF00069	0.640
MOD_CK1_1	314	320	PF00069	0.376
MOD_CK1_1	408	414	PF00069	0.507
MOD_CK1_1	440	446	PF00069	0.772
MOD_CK1_1	471	477	PF00069	0.732
MOD_CK2_1	292	298	PF00069	0.620
MOD_CK2_1	467	473	PF00069	0.762
MOD_Cter_Amidation	12	15	PF01082	0.449
MOD_GlcNHglycan	1	4	PF01048	0.730
MOD_GlcNHglycan	129	133	PF01048	0.541
MOD_GlcNHglycan	177	180	PF01048	0.615
MOD_GlcNHglycan	289	292	PF01048	0.669
MOD_GlcNHglycan	329	332	PF01048	0.468
MOD_GlcNHglycan	396	399	PF01048	0.605
MOD_GlcNHglycan	430	433	PF01048	0.655
MOD_GlcNHglycan	439	442	PF01048	0.725
MOD_GlcNHglycan	470	473	PF01048	0.629
MOD_GlcNHglycan	496	499	PF01048	0.548
MOD_GlcNHglycan	528	531	PF01048	0.495
MOD_GSK3_1	213	220	PF00069	0.796
MOD_GSK3_1	385	392	PF00069	0.474
MOD_GSK3_1	428	435	PF00069	0.659
MOD_GSK3_1	436	443	PF00069	0.773
MOD_GSK3_1	467	474	PF00069	0.698
MOD_GSK3_1	476	483	PF00069	0.637
MOD_GSK3_1	532	539	PF00069	0.482
MOD_N-GLC_1	19	24	PF02516	0.449
MOD_N-GLC_1	276	281	PF02516	0.548
MOD_N-GLC_1	311	316	PF02516	0.514
MOD_N-GLC_1	385	390	PF02516	0.506
MOD_N-GLC_1	408	413	PF02516	0.560
MOD_N-GLC_1	494	499	PF02516	0.494
MOD_N-GLC_2	47	49	PF02516	0.328
MOD_N-GLC_2	478	480	PF02516	0.652
MOD_N-GLC_2	521	523	PF02516	0.341
MOD_NEK2_1	1	6	PF00069	0.646
MOD_NEK2_1	16	21	PF00069	0.352
MOD_NEK2_1	217	222	PF00069	0.720
MOD_NEK2_1	286	291	PF00069	0.671
MOD_NEK2_1	370	375	PF00069	0.408
MOD_NEK2_1	385	390	PF00069	0.352
MOD_PIKK_1	324	330	PF00454	0.587
MOD_PKA_1	302	308	PF00069	0.416
MOD_PKA_2	302	308	PF00069	0.416
MOD_PKA_2	468	474	PF00069	0.731
MOD_PKB_1	148	156	PF00069	0.559
MOD_Plk_1	336	342	PF00069	0.582
MOD_Plk_1	385	391	PF00069	0.525
MOD_Plk_1	408	414	PF00069	0.498
MOD_Plk_4	311	317	PF00069	0.475
MOD_Plk_4	389	395	PF00069	0.601
MOD_Plk_4	448	454	PF00069	0.473
MOD_ProDKin_1	220	226	PF00069	0.759
MOD_ProDKin_1	376	382	PF00069	0.420
MOD_ProDKin_1	456	462	PF00069	0.620
MOD_ProDKin_1	472	478	PF00069	0.718
MOD_ProDKin_1	91	97	PF00069	0.520
MOD_SUMO_for_1	416	419	PF00179	0.509
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.566
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.328
TRG_ENDOCYTIC_2	125	128	PF00928	0.453
TRG_ENDOCYTIC_2	140	143	PF00928	0.437
TRG_ENDOCYTIC_2	263	266	PF00928	0.504
TRG_ENDOCYTIC_2	382	385	PF00928	0.374
TRG_ENDOCYTIC_2	88	91	PF00928	0.443
TRG_ER_diArg_1	273	275	PF00400	0.550
TRG_ER_diArg_1	300	303	PF00400	0.456
TRG_ER_diArg_1	362	364	PF00400	0.518
TRG_ER_diArg_1	488	491	PF00400	0.505
TRG_NES_CRM1_1	259	272	PF08389	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I7	Leptomonas seymouri	59%	100%
A0A0S4JP70	Bodo saltans	38%	100%
A0A1X0NYR2	Trypanosomatidae	37%	100%
A0A3S5ISQ1	Trypanosoma rangeli	35%	100%
A0A3S7WZH8	Leishmania donovani	100%	100%
A4HEA9	Leishmania braziliensis	73%	99%
C9ZKA9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AXT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q9N2	Leishmania major	91%	100%
V5BS23	Trypanosoma cruzi	36%	100%