LeishMANIAdb
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Protein phosphatase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein phosphatase
Gene product:
Protein phosphatase 2C/Stage II sporulation protein E (SpoIIE) - putative
Species:
Leishmania infantum
UniProt:
A4I1Q4_LEIIN
TriTrypDb:
LINF_250027500
Length:
369

Annotations

Annotations by Jardim et al.

Phosphatase, Serine/threonine phosphatases Stage II sporulation E (SpoIIE), putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I1Q4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1Q4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 13
GO:0004721 phosphoprotein phosphatase activity 3 13
GO:0004722 protein serine/threonine phosphatase activity 4 13
GO:0005488 binding 1 13
GO:0016787 hydrolase activity 2 13
GO:0016788 hydrolase activity, acting on ester bonds 3 13
GO:0016791 phosphatase activity 5 13
GO:0017018 myosin phosphatase activity 5 13
GO:0042578 phosphoric ester hydrolase activity 4 13
GO:0043167 ion binding 2 13
GO:0043169 cation binding 3 13
GO:0046872 metal ion binding 4 13
GO:0140096 catalytic activity, acting on a protein 2 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 353 359 PF00089 0.251
CLV_NRD_NRD_1 175 177 PF00675 0.236
CLV_NRD_NRD_1 334 336 PF00675 0.213
CLV_NRD_NRD_1 72 74 PF00675 0.420
CLV_NRD_NRD_1 75 77 PF00675 0.391
CLV_NRD_NRD_1 81 83 PF00675 0.353
CLV_PCSK_FUR_1 73 77 PF00082 0.410
CLV_PCSK_KEX2_1 74 76 PF00082 0.399
CLV_PCSK_KEX2_1 83 85 PF00082 0.404
CLV_PCSK_PC1ET2_1 74 76 PF00082 0.416
CLV_PCSK_PC1ET2_1 83 85 PF00082 0.381
CLV_PCSK_SKI1_1 156 160 PF00082 0.239
CLV_PCSK_SKI1_1 312 316 PF00082 0.294
DEG_SPOP_SBC_1 165 169 PF00917 0.422
DOC_CKS1_1 31 36 PF01111 0.572
DOC_CKS1_1 8 13 PF01111 0.533
DOC_MAPK_gen_1 156 165 PF00069 0.493
DOC_MAPK_gen_1 343 352 PF00069 0.422
DOC_MAPK_gen_1 82 90 PF00069 0.395
DOC_MAPK_MEF2A_6 346 354 PF00069 0.422
DOC_PP4_FxxP_1 214 217 PF00568 0.402
DOC_USP7_MATH_1 3 7 PF00917 0.697
DOC_USP7_MATH_1 329 333 PF00917 0.402
DOC_WW_Pin1_4 278 283 PF00397 0.511
DOC_WW_Pin1_4 30 35 PF00397 0.570
DOC_WW_Pin1_4 325 330 PF00397 0.400
DOC_WW_Pin1_4 58 63 PF00397 0.390
DOC_WW_Pin1_4 7 12 PF00397 0.534
LIG_14-3-3_CanoR_1 356 363 PF00244 0.326
LIG_14-3-3_CanoR_1 4 8 PF00244 0.656
LIG_14-3-3_CanoR_1 75 80 PF00244 0.384
LIG_14-3-3_CanoR_1 82 88 PF00244 0.383
LIG_BIR_III_4 341 345 PF00653 0.402
LIG_BRCT_BRCA1_1 51 55 PF00533 0.395
LIG_BRCT_BRCA1_2 51 57 PF00533 0.400
LIG_FHA_1 153 159 PF00498 0.468
LIG_FHA_1 167 173 PF00498 0.333
LIG_FHA_1 254 260 PF00498 0.434
LIG_FHA_1 349 355 PF00498 0.415
LIG_FHA_1 44 50 PF00498 0.487
LIG_FHA_2 31 37 PF00498 0.557
LIG_FHA_2 357 363 PF00498 0.328
LIG_LIR_Apic_2 30 34 PF02991 0.477
LIG_LIR_Apic_2 302 306 PF02991 0.451
LIG_LIR_Gen_1 151 162 PF02991 0.414
LIG_LIR_Gen_1 328 337 PF02991 0.403
LIG_LIR_Gen_1 86 94 PF02991 0.350
LIG_LIR_Nem_3 151 157 PF02991 0.414
LIG_LIR_Nem_3 202 207 PF02991 0.415
LIG_LIR_Nem_3 86 90 PF02991 0.388
LIG_Pex14_2 214 218 PF04695 0.402
LIG_Pex14_2 260 264 PF04695 0.422
LIG_RPA_C_Fungi 258 270 PF08784 0.322
LIG_SH2_CRK 103 107 PF00017 0.254
LIG_SH2_CRK 154 158 PF00017 0.349
LIG_SH2_PTP2 303 306 PF00017 0.283
LIG_SH2_SRC 303 306 PF00017 0.283
LIG_SH2_STAP1 154 158 PF00017 0.403
LIG_SH2_STAT5 154 157 PF00017 0.403
LIG_SH2_STAT5 204 207 PF00017 0.336
LIG_SH2_STAT5 303 306 PF00017 0.246
LIG_SH3_3 5 11 PF00018 0.626
LIG_SH3_4 59 66 PF00018 0.553
LIG_SPRY_1 362 367 PF00622 0.505
LIG_SUMO_SIM_anti_2 192 199 PF11976 0.283
LIG_SUMO_SIM_anti_2 250 257 PF11976 0.322
LIG_SUMO_SIM_anti_2 348 355 PF11976 0.284
LIG_SUMO_SIM_par_1 348 355 PF11976 0.284
LIG_TRAF2_1 245 248 PF00917 0.325
LIG_TRAF2_1 359 362 PF00917 0.367
LIG_TRAF2_2 245 250 PF00917 0.370
MOD_CDK_SPxK_1 58 64 PF00069 0.472
MOD_CDK_SPxxK_3 278 285 PF00069 0.403
MOD_CK1_1 30 36 PF00069 0.613
MOD_CK1_1 355 361 PF00069 0.350
MOD_CK2_1 355 361 PF00069 0.322
MOD_CK2_1 83 89 PF00069 0.392
MOD_GlcNHglycan 11 14 PF01048 0.606
MOD_GlcNHglycan 15 18 PF01048 0.583
MOD_GlcNHglycan 192 195 PF01048 0.254
MOD_GlcNHglycan 293 296 PF01048 0.292
MOD_GSK3_1 3 10 PF00069 0.517
MOD_GSK3_1 325 332 PF00069 0.280
MOD_GSK3_1 348 355 PF00069 0.272
MOD_N-GLC_1 364 369 PF02516 0.486
MOD_NEK2_1 136 141 PF00069 0.336
MOD_NEK2_1 190 195 PF00069 0.322
MOD_NEK2_1 291 296 PF00069 0.269
MOD_NEK2_2 171 176 PF00069 0.381
MOD_NEK2_2 93 98 PF00069 0.284
MOD_NMyristoyl 1 7 PF02799 0.568
MOD_PK_1 75 81 PF00069 0.476
MOD_PKA_1 75 81 PF00069 0.386
MOD_PKA_1 83 89 PF00069 0.393
MOD_PKA_2 240 246 PF00069 0.299
MOD_PKA_2 3 9 PF00069 0.656
MOD_PKA_2 355 361 PF00069 0.321
MOD_PKA_2 75 81 PF00069 0.382
MOD_PKA_2 83 89 PF00069 0.393
MOD_PKB_1 73 81 PF00069 0.392
MOD_Plk_1 348 354 PF00069 0.254
MOD_Plk_1 93 99 PF00069 0.273
MOD_Plk_4 120 126 PF00069 0.317
MOD_Plk_4 329 335 PF00069 0.242
MOD_Plk_4 83 89 PF00069 0.396
MOD_Plk_4 93 99 PF00069 0.276
MOD_ProDKin_1 278 284 PF00069 0.406
MOD_ProDKin_1 30 36 PF00069 0.577
MOD_ProDKin_1 325 331 PF00069 0.251
MOD_ProDKin_1 58 64 PF00069 0.403
MOD_ProDKin_1 7 13 PF00069 0.532
MOD_SUMO_for_1 299 302 PF00179 0.327
MOD_SUMO_rev_2 294 301 PF00179 0.269
MOD_SUMO_rev_2 36 45 PF00179 0.470
TRG_DiLeu_BaEn_2 93 99 PF01217 0.284
TRG_ENDOCYTIC_2 103 106 PF00928 0.297
TRG_ENDOCYTIC_2 154 157 PF00928 0.349
TRG_ENDOCYTIC_2 204 207 PF00928 0.291
TRG_ER_diArg_1 198 201 PF00400 0.267
TRG_ER_diArg_1 73 76 PF00400 0.409
TRG_ER_diArg_1 81 84 PF00400 0.357
TRG_NLS_MonoExtN_4 73 78 PF00514 0.455
TRG_Pf-PMV_PEXEL_1 312 316 PF00026 0.403

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2Z6 Leptomonas seymouri 82% 100%
A0A0N1IH92 Leptomonas seymouri 27% 100%
A0A0S4IN49 Bodo saltans 36% 100%
A0A0S4JF75 Bodo saltans 24% 70%
A0A0S4JK95 Bodo saltans 63% 100%
A0A0S4JS91 Bodo saltans 63% 100%
A0A1X0NY52 Trypanosomatidae 62% 97%
A0A1X0P4F0 Trypanosomatidae 26% 100%
A0A1X0P973 Trypanosomatidae 28% 100%
A0A3Q8IBW1 Leishmania donovani 100% 100%
A0A3R7N5R3 Trypanosoma rangeli 28% 100%
A0A3R7RFR7 Trypanosoma rangeli 29% 100%
A0A422P4L0 Trypanosoma rangeli 68% 100%
A4HEA8 Leishmania braziliensis 94% 100%
B3MTI8 Drosophila ananassae 34% 100%
B3P5D3 Drosophila erecta 36% 100%
B4G653 Drosophila persimilis 34% 100%
B4HZE7 Drosophila sechellia 36% 100%
B4JYN1 Drosophila grimshawi 35% 100%
B4K616 Drosophila mojavensis 38% 100%
B4M5T5 Drosophila virilis 37% 100%
B4NBL6 Drosophila willistoni 38% 100%
B4PPK3 Drosophila yakuba 36% 100%
B4R089 Drosophila simulans 36% 100%
C9ZKA8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
C9ZN10 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
D0A5X5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9AXT8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O64730 Arabidopsis thaliana 32% 100%
P38797 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 100%
Q09189 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 31% 100%
Q29AP0 Drosophila pseudoobscura pseudoobscura 35% 100%
Q339D2 Oryza sativa subsp. japonica 31% 79%
Q4Q9N3 Leishmania major 96% 100%
Q5U3N5 Danio rerio 37% 100%
Q6GR25 Xenopus laevis 37% 100%
Q6H7J3 Oryza sativa subsp. japonica 32% 100%
Q6H7J4 Oryza sativa subsp. japonica 28% 100%
Q6NVE9 Mus musculus 38% 100%
Q8NI37 Homo sapiens 38% 100%
Q942P9 Oryza sativa subsp. japonica 31% 100%
Q9LVQ8 Arabidopsis thaliana 34% 89%
Q9SUK9 Arabidopsis thaliana 33% 79%
Q9VAH4 Drosophila melanogaster 36% 100%
V5AT69 Trypanosoma cruzi 27% 100%
V5AUW7 Trypanosoma cruzi 31% 100%
V5BMI3 Trypanosoma cruzi 65% 85%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS