Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase - putative

Species:

Leishmania infantum

UniProt:

A4I1Q1_LEIIN

TriTrypDb:

LINF_250027200

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1Q1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	18
GO:0016787	hydrolase activity	2	18
GO:0016788	hydrolase activity, acting on ester bonds	3	18
GO:0016791	phosphatase activity	5	18
GO:0042578	phosphoric ester hydrolase activity	4	18
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.559
CLV_C14_Caspase3-7	345	349	PF00656	0.373
CLV_Separin_Metazoa	326	330	PF03568	0.395
DEG_Nend_UBRbox_2	1	3	PF02207	0.739
DEG_SCF_FBW7_1	76	81	PF00400	0.521
DEG_SPOP_SBC_1	39	43	PF00917	0.710
DOC_CDC14_PxL_1	328	336	PF14671	0.352
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.541
DOC_MAPK_gen_1	179	188	PF00069	0.298
DOC_MAPK_gen_1	260	269	PF00069	0.441
DOC_MAPK_MEF2A_6	179	188	PF00069	0.301
DOC_MAPK_MEF2A_6	202	211	PF00069	0.260
DOC_MAPK_MEF2A_6	213	221	PF00069	0.243
DOC_MAPK_NFAT4_5	181	189	PF00069	0.291
DOC_MAPK_RevD_3	168	182	PF00069	0.371
DOC_USP7_MATH_1	126	130	PF00917	0.634
DOC_USP7_MATH_1	166	170	PF00917	0.558
DOC_USP7_MATH_1	31	35	PF00917	0.680
DOC_USP7_MATH_1	314	318	PF00917	0.241
DOC_USP7_MATH_1	39	43	PF00917	0.650
DOC_WW_Pin1_4	157	162	PF00397	0.444
DOC_WW_Pin1_4	298	303	PF00397	0.338
DOC_WW_Pin1_4	48	53	PF00397	0.678
DOC_WW_Pin1_4	60	65	PF00397	0.652
DOC_WW_Pin1_4	68	73	PF00397	0.611
DOC_WW_Pin1_4	7	12	PF00397	0.701
DOC_WW_Pin1_4	74	79	PF00397	0.527
LIG_APCC_ABBA_1	267	272	PF00400	0.318
LIG_FHA_1	141	147	PF00498	0.541
LIG_FHA_1	157	163	PF00498	0.438
LIG_FHA_1	242	248	PF00498	0.280
LIG_FHA_1	277	283	PF00498	0.351
LIG_FHA_1	71	77	PF00498	0.795
LIG_FHA_2	247	253	PF00498	0.470
LIG_FHA_2	340	346	PF00498	0.354
LIG_LIR_Apic_2	248	253	PF02991	0.278
LIG_LIR_Gen_1	341	352	PF02991	0.301
LIG_LIR_Nem_3	12	18	PF02991	0.519
LIG_LIR_Nem_3	341	347	PF02991	0.294
LIG_LIR_Nem_3	348	353	PF02991	0.311
LIG_MYND_1	168	172	PF01753	0.457
LIG_REV1ctd_RIR_1	12	20	PF16727	0.516
LIG_SH2_CRK	350	354	PF00017	0.285
LIG_SH2_GRB2like	197	200	PF00017	0.228
LIG_SH2_STAP1	203	207	PF00017	0.362
LIG_SH2_STAT3	305	308	PF00017	0.289
LIG_SH2_STAT5	151	154	PF00017	0.474
LIG_SH2_STAT5	220	223	PF00017	0.312
LIG_SH2_STAT5	250	253	PF00017	0.302
LIG_SH2_STAT5	281	284	PF00017	0.289
LIG_SH2_STAT5	305	308	PF00017	0.267
LIG_SH3_2	49	54	PF14604	0.549
LIG_SH3_3	202	208	PF00018	0.338
LIG_SH3_3	46	52	PF00018	0.646
LIG_SUMO_SIM_anti_2	284	289	PF11976	0.234
LIG_SUMO_SIM_anti_2	293	299	PF11976	0.225
LIG_SUMO_SIM_par_1	184	191	PF11976	0.307
LIG_SUMO_SIM_par_1	207	212	PF11976	0.430
LIG_UBA3_1	254	260	PF00899	0.352
MOD_CDC14_SPxK_1	51	54	PF00782	0.550
MOD_CDK_SPxK_1	48	54	PF00069	0.549
MOD_CK1_1	110	116	PF00069	0.669
MOD_CK1_1	133	139	PF00069	0.627
MOD_CK1_1	246	252	PF00069	0.250
MOD_CK1_1	41	47	PF00069	0.655
MOD_CK1_1	66	72	PF00069	0.636
MOD_CK1_1	74	80	PF00069	0.579
MOD_CK2_1	319	325	PF00069	0.356
MOD_GlcNHglycan	109	113	PF01048	0.641
MOD_GlcNHglycan	114	118	PF01048	0.608
MOD_GlcNHglycan	163	167	PF01048	0.507
MOD_GlcNHglycan	33	36	PF01048	0.820
MOD_GlcNHglycan	361	365	PF01048	0.554
MOD_GlcNHglycan	66	69	PF01048	0.637
MOD_GlcNHglycan	98	101	PF01048	0.750
MOD_GSK3_1	126	133	PF00069	0.641
MOD_GSK3_1	162	169	PF00069	0.501
MOD_GSK3_1	188	195	PF00069	0.309
MOD_GSK3_1	241	248	PF00069	0.274
MOD_GSK3_1	272	279	PF00069	0.416
MOD_GSK3_1	31	38	PF00069	0.638
MOD_GSK3_1	60	67	PF00069	0.605
MOD_GSK3_1	68	75	PF00069	0.619
MOD_GSK3_1	77	84	PF00069	0.632
MOD_N-GLC_1	157	162	PF02516	0.403
MOD_N-GLC_1	7	12	PF02516	0.741
MOD_NEK2_1	192	197	PF00069	0.317
MOD_NEK2_1	243	248	PF00069	0.308
MOD_PIKK_1	21	27	PF00454	0.570
MOD_PIKK_1	81	87	PF00454	0.536
MOD_PKA_2	212	218	PF00069	0.370
MOD_PKA_2	35	41	PF00069	0.556
MOD_PKA_2	4	10	PF00069	0.774
MOD_Plk_1	188	194	PF00069	0.305
MOD_Plk_1	283	289	PF00069	0.284
MOD_Plk_2-3	339	345	PF00069	0.404
MOD_Plk_4	10	16	PF00069	0.512
MOD_Plk_4	166	172	PF00069	0.391
MOD_Plk_4	188	194	PF00069	0.316
MOD_Plk_4	272	278	PF00069	0.305
MOD_Plk_4	283	289	PF00069	0.263
MOD_Plk_4	314	320	PF00069	0.309
MOD_Plk_4	339	345	PF00069	0.328
MOD_Plk_4	78	84	PF00069	0.553
MOD_ProDKin_1	157	163	PF00069	0.449
MOD_ProDKin_1	298	304	PF00069	0.338
MOD_ProDKin_1	48	54	PF00069	0.680
MOD_ProDKin_1	60	66	PF00069	0.653
MOD_ProDKin_1	68	74	PF00069	0.611
MOD_ProDKin_1	7	13	PF00069	0.695
TRG_DiLeu_BaEn_1	326	331	PF01217	0.292
TRG_DiLeu_LyEn_5	326	331	PF01217	0.302
TRG_ENDOCYTIC_2	220	223	PF00928	0.328
TRG_ENDOCYTIC_2	344	347	PF00928	0.319
TRG_ENDOCYTIC_2	350	353	PF00928	0.320
TRG_ER_diArg_1	137	140	PF00400	0.521
TRG_ER_diArg_1	148	151	PF00400	0.344
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG96	Leptomonas seymouri	68%	100%
A0A0S4IJH3	Bodo saltans	46%	100%
A0A0S4IMS1	Bodo saltans	65%	100%
A0A0S4JCX0	Bodo saltans	46%	100%
A0A1X0NYI7	Trypanosomatidae	45%	91%
A0A3Q8IDG4	Leishmania donovani	100%	100%
A0A3S7WZH2	Leishmania donovani	52%	100%
A0A422P4K3	Trypanosoma rangeli	40%	89%
A4HEA5	Leishmania braziliensis	88%	100%
A4HEM1	Leishmania braziliensis	50%	100%
A4I1V3	Leishmania infantum	51%	100%
A4ICB8	Leishmania infantum	27%	100%
C9ZKA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	87%
E9AXT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AXZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
Q4Q9H6	Leishmania major	51%	100%
Q4Q9N6	Leishmania major	96%	100%
V5BAV0	Trypanosoma cruzi	24%	100%