Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4I1P7_LEIIN

TriTrypDb:

LINF_250026800

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1P7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1P7

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004672	protein kinase activity	3	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.586
CLV_C14_Caspase3-7	390	394	PF00656	0.545
CLV_NRD_NRD_1	384	386	PF00675	0.717
CLV_NRD_NRD_1	402	404	PF00675	0.548
CLV_NRD_NRD_1	484	486	PF00675	0.559
CLV_NRD_NRD_1	507	509	PF00675	0.590
CLV_NRD_NRD_1	76	78	PF00675	0.325
CLV_NRD_NRD_1	8	10	PF00675	0.332
CLV_PCSK_KEX2_1	402	404	PF00082	0.548
CLV_PCSK_KEX2_1	409	411	PF00082	0.518
CLV_PCSK_KEX2_1	484	486	PF00082	0.559
CLV_PCSK_KEX2_1	507	509	PF00082	0.590
CLV_PCSK_KEX2_1	76	78	PF00082	0.325
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.542
CLV_PCSK_SKI1_1	114	118	PF00082	0.310
CLV_PCSK_SKI1_1	132	136	PF00082	0.219
CLV_PCSK_SKI1_1	403	407	PF00082	0.566
CLV_PCSK_SKI1_1	434	438	PF00082	0.613
DEG_APCC_DBOX_1	113	121	PF00400	0.325
DEG_Nend_UBRbox_2	1	3	PF02207	0.419
DOC_ANK_TNKS_1	75	82	PF00023	0.367
DOC_CDC14_PxL_1	437	445	PF14671	0.575
DOC_CKS1_1	140	145	PF01111	0.367
DOC_CKS1_1	200	205	PF01111	0.325
DOC_MAPK_gen_1	132	141	PF00069	0.291
DOC_MAPK_gen_1	409	418	PF00069	0.544
DOC_MAPK_gen_1	76	84	PF00069	0.308
DOC_MAPK_MEF2A_6	76	84	PF00069	0.325
DOC_USP7_MATH_1	262	266	PF00917	0.696
DOC_USP7_MATH_1	280	284	PF00917	0.370
DOC_USP7_MATH_1	460	464	PF00917	0.661
DOC_USP7_MATH_1	486	490	PF00917	0.706
DOC_USP7_MATH_1	516	520	PF00917	0.715
DOC_USP7_MATH_1	526	530	PF00917	0.576
DOC_USP7_MATH_1	544	548	PF00917	0.652
DOC_USP7_MATH_1	558	562	PF00917	0.704
DOC_USP7_UBL2_3	174	178	PF12436	0.234
DOC_USP7_UBL2_3	282	286	PF12436	0.574
DOC_USP7_UBL2_3	6	10	PF12436	0.385
DOC_WW_Pin1_4	139	144	PF00397	0.385
DOC_WW_Pin1_4	159	164	PF00397	0.367
DOC_WW_Pin1_4	181	186	PF00397	0.498
DOC_WW_Pin1_4	199	204	PF00397	0.214
DOC_WW_Pin1_4	264	269	PF00397	0.677
DOC_WW_Pin1_4	337	342	PF00397	0.377
DOC_WW_Pin1_4	456	461	PF00397	0.697
DOC_WW_Pin1_4	479	484	PF00397	0.680
DOC_WW_Pin1_4	506	511	PF00397	0.704
LIG_14-3-3_CanoR_1	369	376	PF00244	0.400
LIG_14-3-3_CanoR_1	485	491	PF00244	0.686
LIG_Actin_WH2_2	353	371	PF00022	0.325
LIG_BRCT_BRCA1_1	240	244	PF00533	0.593
LIG_FHA_1	111	117	PF00498	0.391
LIG_FHA_1	124	130	PF00498	0.253
LIG_FHA_1	452	458	PF00498	0.765
LIG_FHA_1	65	71	PF00498	0.466
LIG_FHA_2	258	264	PF00498	0.587
LIG_FHA_2	297	303	PF00498	0.329
LIG_FHA_2	307	313	PF00498	0.333
LIG_FHA_2	369	375	PF00498	0.400
LIG_FHA_2	433	439	PF00498	0.665
LIG_FHA_2	567	573	PF00498	0.638
LIG_LIR_Apic_2	202	208	PF02991	0.359
LIG_LIR_Apic_2	274	280	PF02991	0.554
LIG_LIR_Apic_2	35	41	PF02991	0.367
LIG_LIR_Gen_1	309	319	PF02991	0.331
LIG_LIR_Gen_1	356	364	PF02991	0.277
LIG_LIR_Gen_1	529	539	PF02991	0.582
LIG_LIR_Gen_1	572	580	PF02991	0.751
LIG_LIR_Nem_3	275	281	PF02991	0.604
LIG_LIR_Nem_3	309	314	PF02991	0.331
LIG_LIR_Nem_3	356	360	PF02991	0.303
LIG_LIR_Nem_3	435	440	PF02991	0.567
LIG_LIR_Nem_3	529	535	PF02991	0.573
LIG_LIR_Nem_3	572	576	PF02991	0.706
LIG_MYND_1	379	383	PF01753	0.454
LIG_Pex14_2	244	248	PF04695	0.577
LIG_SH2_CRK	278	282	PF00017	0.581
LIG_SH2_CRK	532	536	PF00017	0.574
LIG_SH2_GRB2like	277	280	PF00017	0.589
LIG_SH2_NCK_1	311	315	PF00017	0.401
LIG_SH2_STAP1	112	116	PF00017	0.325
LIG_SH2_STAP1	297	301	PF00017	0.291
LIG_SH2_STAP1	364	368	PF00017	0.385
LIG_SH2_STAT5	112	115	PF00017	0.335
LIG_SH2_STAT5	122	125	PF00017	0.241
LIG_SH2_STAT5	195	198	PF00017	0.385
LIG_SH2_STAT5	297	300	PF00017	0.323
LIG_SH2_STAT5	88	91	PF00017	0.317
LIG_SH2_STAT5	96	99	PF00017	0.360
LIG_SH3_3	160	166	PF00018	0.385
LIG_SH3_3	197	203	PF00018	0.325
LIG_SH3_3	339	345	PF00018	0.325
LIG_SH3_3	446	452	PF00018	0.564
LIG_SH3_3	454	460	PF00018	0.727
LIG_SH3_4	400	407	PF00018	0.601
LIG_TYR_ITSM	307	314	PF00017	0.366
LIG_WRC_WIRS_1	354	359	PF05994	0.363
LIG_WW_1	269	272	PF00397	0.668
MOD_CDC14_SPxK_1	482	485	PF00782	0.637
MOD_CDK_SPK_2	181	186	PF00069	0.307
MOD_CDK_SPK_2	479	484	PF00069	0.588
MOD_CDK_SPxK_1	159	165	PF00069	0.258
MOD_CDK_SPxK_1	479	485	PF00069	0.632
MOD_CDK_SPxxK_3	139	146	PF00069	0.385
MOD_CDK_SPxxK_3	181	188	PF00069	0.307
MOD_CK1_1	273	279	PF00069	0.537
MOD_CK1_1	459	465	PF00069	0.700
MOD_CK1_1	501	507	PF00069	0.667
MOD_CK1_1	509	515	PF00069	0.569
MOD_CK1_1	518	524	PF00069	0.466
MOD_CK1_1	547	553	PF00069	0.739
MOD_CK1_1	565	571	PF00069	0.613
MOD_CK1_1	90	96	PF00069	0.385
MOD_CK2_1	244	250	PF00069	0.651
MOD_CK2_1	306	312	PF00069	0.331
MOD_CK2_1	368	374	PF00069	0.342
MOD_CK2_1	393	399	PF00069	0.743
MOD_CK2_1	518	524	PF00069	0.569
MOD_CK2_1	566	572	PF00069	0.637
MOD_Cter_Amidation	407	410	PF01082	0.544
MOD_GlcNHglycan	240	243	PF01048	0.561
MOD_GlcNHglycan	244	247	PF01048	0.575
MOD_GlcNHglycan	254	257	PF01048	0.587
MOD_GlcNHglycan	263	267	PF01048	0.658
MOD_GlcNHglycan	299	302	PF01048	0.366
MOD_GlcNHglycan	327	330	PF01048	0.360
MOD_GlcNHglycan	350	353	PF01048	0.431
MOD_GlcNHglycan	389	392	PF01048	0.727
MOD_GlcNHglycan	395	398	PF01048	0.676
MOD_GlcNHglycan	413	416	PF01048	0.703
MOD_GlcNHglycan	462	465	PF01048	0.728
MOD_GlcNHglycan	470	473	PF01048	0.677
MOD_GlcNHglycan	495	498	PF01048	0.724
MOD_GlcNHglycan	500	503	PF01048	0.530
MOD_GlcNHglycan	546	549	PF01048	0.680
MOD_GlcNHglycan	552	555	PF01048	0.665
MOD_GlcNHglycan	89	92	PF01048	0.402
MOD_GSK3_1	195	202	PF00069	0.293
MOD_GSK3_1	238	245	PF00069	0.765
MOD_GSK3_1	246	253	PF00069	0.546
MOD_GSK3_1	291	298	PF00069	0.357
MOD_GSK3_1	302	309	PF00069	0.280
MOD_GSK3_1	451	458	PF00069	0.662
MOD_GSK3_1	491	498	PF00069	0.610
MOD_GSK3_1	511	518	PF00069	0.616
MOD_GSK3_1	558	565	PF00069	0.627
MOD_N-GLC_1	393	398	PF02516	0.625
MOD_N-GLC_2	229	231	PF02516	0.526
MOD_NEK2_1	123	128	PF00069	0.385
MOD_NEK2_1	244	249	PF00069	0.533
MOD_NEK2_1	257	262	PF00069	0.758
MOD_NEK2_1	271	276	PF00069	0.605
MOD_NEK2_1	368	373	PF00069	0.357
MOD_NEK2_1	493	498	PF00069	0.640
MOD_NEK2_1	566	571	PF00069	0.652
MOD_NEK2_2	432	437	PF00069	0.546
MOD_NEK2_2	486	491	PF00069	0.586
MOD_PKA_1	409	415	PF00069	0.539
MOD_PKA_2	368	374	PF00069	0.307
MOD_PKA_2	409	415	PF00069	0.567
MOD_PKA_2	486	492	PF00069	0.649
MOD_PKA_2	542	548	PF00069	0.658
MOD_Plk_2-3	353	359	PF00069	0.392
MOD_Plk_4	273	279	PF00069	0.616
MOD_Plk_4	280	286	PF00069	0.587
MOD_Plk_4	306	312	PF00069	0.298
MOD_Plk_4	353	359	PF00069	0.363
MOD_Plk_4	562	568	PF00069	0.715
MOD_ProDKin_1	139	145	PF00069	0.385
MOD_ProDKin_1	159	165	PF00069	0.367
MOD_ProDKin_1	181	187	PF00069	0.498
MOD_ProDKin_1	199	205	PF00069	0.214
MOD_ProDKin_1	264	270	PF00069	0.677
MOD_ProDKin_1	337	343	PF00069	0.377
MOD_ProDKin_1	456	462	PF00069	0.697
MOD_ProDKin_1	479	485	PF00069	0.683
MOD_ProDKin_1	506	512	PF00069	0.703
MOD_SUMO_rev_2	393	401	PF00179	0.600
TRG_DiLeu_BaEn_2	352	358	PF01217	0.385
TRG_DiLeu_BaEn_2	571	577	PF01217	0.595
TRG_DiLeu_BaLyEn_6	438	443	PF01217	0.639
TRG_ENDOCYTIC_2	20	23	PF00928	0.348
TRG_ENDOCYTIC_2	278	281	PF00928	0.608
TRG_ENDOCYTIC_2	311	314	PF00928	0.331
TRG_ENDOCYTIC_2	532	535	PF00928	0.566
TRG_ER_diArg_1	185	188	PF00400	0.389
TRG_ER_diArg_1	401	403	PF00400	0.541
TRG_ER_diArg_1	483	485	PF00400	0.553
TRG_ER_diArg_1	535	538	PF00400	0.647
TRG_NES_CRM1_1	118	133	PF08389	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W2	Leptomonas seymouri	55%	97%
A0A0S4JI27	Bodo saltans	24%	81%
A0A3S7WZA6	Leishmania donovani	99%	100%
A4HEA1	Leishmania braziliensis	77%	98%
C9ZK98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AXT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4Q9P0	Leishmania major	93%	99%