Acylphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Acylphosphatase

Gene product:

acylphosphatase - putative

Species:

Leishmania infantum

UniProt:

A4I1P4_LEIIN

TriTrypDb:

LINF_250026500

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1P4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0003998	acylphosphatase activity	6	5
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.490
CLV_MEL_PAP_1	5	11	PF00089	0.438
CLV_NRD_NRD_1	142	144	PF00675	0.337
CLV_NRD_NRD_1	31	33	PF00675	0.530
CLV_NRD_NRD_1	38	40	PF00675	0.483
CLV_PCSK_KEX2_1	30	32	PF00082	0.542
CLV_PCSK_KEX2_1	38	40	PF00082	0.482
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.464
CLV_PCSK_SKI1_1	31	35	PF00082	0.489
CLV_PCSK_SKI1_1	47	51	PF00082	0.437
CLV_PCSK_SKI1_1	74	78	PF00082	0.457
CLV_PCSK_SKI1_1	80	84	PF00082	0.434
DEG_Nend_UBRbox_4	1	3	PF02207	0.447
DOC_ANK_TNKS_1	159	166	PF00023	0.287
DOC_PP4_FxxP_1	58	61	PF00568	0.473
DOC_WW_Pin1_4	186	191	PF00397	0.287
DOC_WW_Pin1_4	66	71	PF00397	0.515
DOC_WW_Pin1_4	96	101	PF00397	0.471
LIG_14-3-3_CanoR_1	124	130	PF00244	0.351
LIG_14-3-3_CanoR_1	8	12	PF00244	0.603
LIG_Actin_WH2_2	133	151	PF00022	0.287
LIG_FHA_1	126	132	PF00498	0.287
LIG_FHA_1	154	160	PF00498	0.287
LIG_FHA_1	201	207	PF00498	0.443
LIG_FHA_1	89	95	PF00498	0.486
LIG_FHA_2	106	112	PF00498	0.464
LIG_FHA_2	193	199	PF00498	0.287
LIG_LIR_Nem_3	128	132	PF02991	0.287
LIG_PCNA_yPIPBox_3	217	228	PF02747	0.383
LIG_SH2_CRK	145	149	PF00017	0.287
LIG_SH2_GRB2like	88	91	PF00017	0.456
LIG_SH2_STAP1	127	131	PF00017	0.287
LIG_SH2_STAP1	48	52	PF00017	0.437
LIG_SH2_STAT5	125	128	PF00017	0.334
LIG_SH2_STAT5	145	148	PF00017	0.287
LIG_SH2_STAT5	88	91	PF00017	0.631
LIG_SH3_3	113	119	PF00018	0.490
LIG_SH3_3	15	21	PF00018	0.537
LIG_SH3_3	202	208	PF00018	0.489
LIG_SH3_3	6	12	PF00018	0.479
LIG_Sin3_3	113	120	PF02671	0.423
LIG_SUMO_SIM_par_1	60	66	PF11976	0.456
MOD_CDK_SPK_2	186	191	PF00069	0.287
MOD_CK1_1	66	72	PF00069	0.513
MOD_Cter_Amidation	28	31	PF01082	0.460
MOD_GlcNHglycan	133	136	PF01048	0.366
MOD_GlcNHglycan	208	211	PF01048	0.518
MOD_GlcNHglycan	224	227	PF01048	0.464
MOD_GSK3_1	62	69	PF00069	0.512
MOD_N-GLC_1	220	225	PF02516	0.391
MOD_NEK2_1	120	125	PF00069	0.411
MOD_NEK2_1	153	158	PF00069	0.330
MOD_NEK2_1	220	225	PF00069	0.391
MOD_NEK2_1	62	67	PF00069	0.550
MOD_PIKK_1	200	206	PF00454	0.269
MOD_PIKK_1	7	13	PF00454	0.532
MOD_PKA_1	143	149	PF00069	0.287
MOD_PKA_2	7	13	PF00069	0.600
MOD_Plk_1	120	126	PF00069	0.398
MOD_Plk_1	200	206	PF00069	0.269
MOD_Plk_1	220	226	PF00069	0.387
MOD_Plk_1	72	78	PF00069	0.464
MOD_ProDKin_1	186	192	PF00069	0.287
MOD_ProDKin_1	66	72	PF00069	0.513
MOD_ProDKin_1	96	102	PF00069	0.465
MOD_SUMO_rev_2	10	19	PF00179	0.457
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.458
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.439
TRG_ENDOCYTIC_2	129	132	PF00928	0.287
TRG_ENDOCYTIC_2	145	148	PF00928	0.287
TRG_ER_diArg_1	31	33	PF00400	0.496
TRG_ER_diArg_1	38	40	PF00400	0.483
TRG_NLS_MonoExtN_4	27	34	PF00514	0.460
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDK0	Leishmania donovani	100%	100%
E9AXS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q9P3	Leishmania major	90%	100%