RRM domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1P1_LEIIN

TriTrypDb:

LINF_250026200

Length:

231

Annotations

Annotations by Jardim et al.

Nucleic acid binding, RNA binding

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I1P1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1P1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.467
CLV_NRD_NRD_1	212	214	PF00675	0.478
CLV_NRD_NRD_1	222	224	PF00675	0.523
CLV_PCSK_KEX2_1	129	131	PF00082	0.448
CLV_PCSK_KEX2_1	214	216	PF00082	0.482
CLV_PCSK_KEX2_1	222	224	PF00082	0.523
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.448
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.482
CLV_PCSK_PC7_1	126	132	PF00082	0.383
CLV_PCSK_SKI1_1	126	130	PF00082	0.476
CLV_PCSK_SKI1_1	37	41	PF00082	0.424
DOC_CYCLIN_RxL_1	190	200	PF00134	0.585
DOC_CYCLIN_yCln2_LP_2	120	123	PF00134	0.459
DOC_MAPK_gen_1	173	180	PF00069	0.476
DOC_PP2B_LxvP_1	120	123	PF13499	0.459
DOC_PP2B_LxvP_1	195	198	PF13499	0.654
DOC_USP7_MATH_1	79	83	PF00917	0.571
DOC_USP7_MATH_1	8	12	PF00917	0.446
LIG_14-3-3_CanoR_1	37	44	PF00244	0.429
LIG_Actin_WH2_2	113	128	PF00022	0.482
LIG_BIR_II_1	1	5	PF00653	0.552
LIG_FHA_1	17	23	PF00498	0.455
LIG_FHA_1	28	34	PF00498	0.507
LIG_FHA_1	48	54	PF00498	0.377
LIG_FHA_1	79	85	PF00498	0.576
LIG_HCF-1_HBM_1	134	137	PF13415	0.409
LIG_IRF3_LxIS_1	18	24	PF10401	0.440
LIG_LIR_Apic_2	51	57	PF02991	0.489
LIG_LIR_Apic_2	69	73	PF02991	0.445
LIG_LIR_Gen_1	134	144	PF02991	0.463
LIG_LIR_Nem_3	134	140	PF02991	0.471
LIG_LIR_Nem_3	24	29	PF02991	0.404
LIG_PCNA_yPIPBox_3	114	126	PF02747	0.351
LIG_SH2_CRK	54	58	PF00017	0.448
LIG_SH2_CRK	70	74	PF00017	0.513
LIG_SH2_GRB2like	54	57	PF00017	0.441
LIG_SH2_NCK_1	137	141	PF00017	0.451
LIG_SH2_NCK_1	54	58	PF00017	0.488
LIG_SH2_NCK_1	70	74	PF00017	0.450
LIG_SH2_STAP1	137	141	PF00017	0.459
LIG_SH2_STAP1	29	33	PF00017	0.386
LIG_SH2_STAT5	141	144	PF00017	0.366
LIG_SH2_STAT5	147	150	PF00017	0.344
LIG_SH2_STAT5	29	32	PF00017	0.373
LIG_SH2_STAT5	38	41	PF00017	0.427
LIG_SH2_STAT5	54	57	PF00017	0.441
LIG_SH3_3	158	164	PF00018	0.430
LIG_SUMO_SIM_anti_2	19	24	PF11976	0.428
LIG_SUMO_SIM_par_1	18	24	PF11976	0.383
LIG_TRFH_1	70	74	PF08558	0.526
MOD_CK1_1	12	18	PF00069	0.441
MOD_GlcNHglycan	11	14	PF01048	0.492
MOD_GlcNHglycan	110	113	PF01048	0.645
MOD_GlcNHglycan	219	222	PF01048	0.601
MOD_GlcNHglycan	224	227	PF01048	0.642
MOD_GlcNHglycan	228	231	PF01048	0.736
MOD_GlcNHglycan	23	26	PF01048	0.349
MOD_GlcNHglycan	75	78	PF01048	0.610
MOD_GlcNHglycan	81	84	PF01048	0.642
MOD_GSK3_1	148	155	PF00069	0.469
MOD_GSK3_1	222	229	PF00069	0.674
MOD_GSK3_1	48	55	PF00069	0.447
MOD_GSK3_1	8	15	PF00069	0.361
MOD_GSK3_1	88	95	PF00069	0.557
MOD_N-GLC_1	108	113	PF02516	0.493
MOD_N-GLC_1	92	97	PF02516	0.600
MOD_NEK2_1	21	26	PF00069	0.386
MOD_NEK2_1	216	221	PF00069	0.610
MOD_PIKK_1	148	154	PF00454	0.414
MOD_PKA_1	222	228	PF00069	0.644
MOD_PKA_2	152	158	PF00069	0.517
MOD_PKA_2	216	222	PF00069	0.605
MOD_PKB_1	213	221	PF00069	0.542
MOD_Plk_4	12	18	PF00069	0.408
TRG_DiLeu_BaLyEn_6	1	6	PF01217	0.503
TRG_ENDOCYTIC_2	137	140	PF00928	0.475
TRG_ENDOCYTIC_2	141	144	PF00928	0.406
TRG_ER_diArg_1	130	132	PF00400	0.385
TRG_ER_diArg_1	172	175	PF00400	0.589
TRG_ER_diArg_1	212	215	PF00400	0.519
TRG_NLS_MonoExtC_3	212	217	PF00514	0.481
TRG_NLS_MonoExtN_4	211	218	PF00514	0.542
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I303	Leptomonas seymouri	66%	100%
A0A1X0NZI8	Trypanosomatidae	45%	91%
A0A3R7P4N9	Trypanosoma rangeli	44%	98%
A0A3S7WZA1	Leishmania donovani	100%	100%
A4HE95	Leishmania braziliensis	85%	100%
C9ZK90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AXS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	95%
Q4Q9P6	Leishmania major	94%	100%