Phosphopantothenate--cysteine ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphopantothenate--cysteine ligase - putative

Species:

Leishmania infantum

UniProt:

A4I1N8_LEIIN

TriTrypDb:

LINF_250025900

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I1N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1N8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006163	purine nucleotide metabolic process	5	12
GO:0006164	purine nucleotide biosynthetic process	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009117	nucleotide metabolic process	5	12
GO:0009150	purine ribonucleotide metabolic process	6	12
GO:0009152	purine ribonucleotide biosynthetic process	7	12
GO:0009165	nucleotide biosynthetic process	6	12
GO:0009259	ribonucleotide metabolic process	5	12
GO:0009260	ribonucleotide biosynthetic process	6	12
GO:0009987	cellular process	1	12
GO:0015936	coenzyme A metabolic process	6	12
GO:0015937	coenzyme A biosynthetic process	7	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0019637	organophosphate metabolic process	3	12
GO:0019693	ribose phosphate metabolic process	4	12
GO:0033865	nucleoside bisphosphate metabolic process	5	12
GO:0033866	nucleoside bisphosphate biosynthetic process	6	12
GO:0033875	ribonucleoside bisphosphate metabolic process	6	12
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	12
GO:0034032	purine nucleoside bisphosphate metabolic process	5	12
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0044281	small molecule metabolic process	2	12
GO:0046390	ribose phosphate biosynthetic process	5	12
GO:0046483	heterocycle metabolic process	3	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0072521	purine-containing compound metabolic process	4	12
GO:0072522	purine-containing compound biosynthetic process	5	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901293	nucleoside phosphate biosynthetic process	5	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004632	phosphopantothenate--cysteine ligase activity	5	2
GO:0016874	ligase activity	2	2
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	2
GO:0016881	acid-amino acid ligase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.342
CLV_NRD_NRD_1	157	159	PF00675	0.287
CLV_NRD_NRD_1	326	328	PF00675	0.398
CLV_NRD_NRD_1	369	371	PF00675	0.448
CLV_NRD_NRD_1	50	52	PF00675	0.416
CLV_PCSK_KEX2_1	157	159	PF00082	0.287
CLV_PCSK_KEX2_1	326	328	PF00082	0.398
CLV_PCSK_KEX2_1	369	371	PF00082	0.547
CLV_PCSK_KEX2_1	50	52	PF00082	0.409
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.398
CLV_PCSK_SKI1_1	119	123	PF00082	0.296
CLV_PCSK_SKI1_1	157	161	PF00082	0.376
CLV_PCSK_SKI1_1	291	295	PF00082	0.405
DEG_Nend_Nbox_1	1	3	PF02207	0.554
DOC_CYCLIN_RxL_1	285	299	PF00134	0.339
DOC_PP2B_LxvP_1	30	33	PF13499	0.460
DOC_USP7_MATH_1	176	180	PF00917	0.534
DOC_USP7_MATH_1	19	23	PF00917	0.528
DOC_USP7_MATH_1	196	200	PF00917	0.489
DOC_USP7_MATH_1	259	263	PF00917	0.271
DOC_USP7_MATH_1	26	30	PF00917	0.494
DOC_USP7_MATH_1	269	273	PF00917	0.271
DOC_USP7_MATH_1	35	39	PF00917	0.437
DOC_WW_Pin1_4	12	17	PF00397	0.535
DOC_WW_Pin1_4	171	176	PF00397	0.297
DOC_WW_Pin1_4	191	196	PF00397	0.542
LIG_14-3-3_CanoR_1	20	24	PF00244	0.429
LIG_14-3-3_CanoR_1	36	44	PF00244	0.398
LIG_14-3-3_CanoR_1	7	16	PF00244	0.505
LIG_14-3-3_CanoR_1	76	84	PF00244	0.396
LIG_eIF4E_1	349	355	PF01652	0.372
LIG_FHA_1	108	114	PF00498	0.405
LIG_FHA_1	163	169	PF00498	0.306
LIG_FHA_1	211	217	PF00498	0.442
LIG_FHA_1	281	287	PF00498	0.329
LIG_FHA_1	307	313	PF00498	0.291
LIG_FHA_2	222	228	PF00498	0.303
LIG_FHA_2	318	324	PF00498	0.304
LIG_LIR_Apic_2	262	267	PF02991	0.271
LIG_LIR_Gen_1	139	147	PF02991	0.405
LIG_LIR_Gen_1	166	177	PF02991	0.308
LIG_LIR_Gen_1	227	235	PF02991	0.322
LIG_LIR_Gen_1	351	356	PF02991	0.439
LIG_LIR_Nem_3	139	145	PF02991	0.405
LIG_LIR_Nem_3	166	172	PF02991	0.294
LIG_LIR_Nem_3	227	231	PF02991	0.326
LIG_LIR_Nem_3	262	268	PF02991	0.312
LIG_LIR_Nem_3	351	355	PF02991	0.443
LIG_PCNA_PIPBox_1	58	67	PF02747	0.504
LIG_PCNA_yPIPBox_3	51	65	PF02747	0.352
LIG_Pex14_1	352	356	PF04695	0.438
LIG_Pex14_2	120	124	PF04695	0.331
LIG_SH2_CRK	222	226	PF00017	0.372
LIG_SH2_PTP2	228	231	PF00017	0.406
LIG_SH2_PTP2	265	268	PF00017	0.398
LIG_SH2_STAP1	222	226	PF00017	0.348
LIG_SH2_STAP1	65	69	PF00017	0.491
LIG_SH2_STAT5	219	222	PF00017	0.323
LIG_SH2_STAT5	228	231	PF00017	0.307
LIG_SH2_STAT5	265	268	PF00017	0.290
LIG_SH2_STAT5	356	359	PF00017	0.481
LIG_SH3_1	93	99	PF00018	0.483
LIG_SH3_3	13	19	PF00018	0.449
LIG_SH3_3	169	175	PF00018	0.357
LIG_SH3_3	263	269	PF00018	0.393
LIG_SH3_3	93	99	PF00018	0.490
LIG_SH3_CIN85_PxpxPR_1	31	36	PF14604	0.457
LIG_SUMO_SIM_par_1	230	236	PF11976	0.379
LIG_SUMO_SIM_par_1	292	299	PF11976	0.382
LIG_SUMO_SIM_par_1	382	388	PF11976	0.442
LIG_TRAF2_1	320	323	PF00917	0.306
LIG_TYR_ITIM	220	225	PF00017	0.363
LIG_TYR_ITIM	226	231	PF00017	0.355
LIG_WRC_WIRS_1	160	165	PF05994	0.214
LIG_WRC_WIRS_1	313	318	PF05994	0.271
MOD_CDK_SPK_2	15	20	PF00069	0.442
MOD_CK1_1	106	112	PF00069	0.287
MOD_CK1_1	18	24	PF00069	0.418
MOD_CK1_1	185	191	PF00069	0.682
MOD_CK1_1	3	9	PF00069	0.537
MOD_CK1_1	383	389	PF00069	0.410
MOD_CK2_1	196	202	PF00069	0.573
MOD_CK2_1	221	227	PF00069	0.308
MOD_CK2_1	317	323	PF00069	0.303
MOD_CK2_1	345	351	PF00069	0.398
MOD_GlcNHglycan	105	108	PF01048	0.301
MOD_GlcNHglycan	125	128	PF01048	0.312
MOD_GlcNHglycan	178	181	PF01048	0.658
MOD_GlcNHglycan	184	187	PF01048	0.698
MOD_GlcNHglycan	276	279	PF01048	0.287
MOD_GlcNHglycan	358	361	PF01048	0.518
MOD_GlcNHglycan	362	365	PF01048	0.502
MOD_GlcNHglycan	37	40	PF01048	0.704
MOD_GlcNHglycan	45	48	PF01048	0.539
MOD_GlcNHglycan	77	80	PF01048	0.505
MOD_GSK3_1	102	109	PF00069	0.285
MOD_GSK3_1	119	126	PF00069	0.278
MOD_GSK3_1	14	21	PF00069	0.438
MOD_GSK3_1	176	183	PF00069	0.571
MOD_GSK3_1	235	242	PF00069	0.352
MOD_GSK3_1	280	287	PF00069	0.346
MOD_GSK3_1	3	10	PF00069	0.536
MOD_GSK3_1	35	42	PF00069	0.546
MOD_GSK3_1	356	363	PF00069	0.432
MOD_N-GLC_1	122	127	PF02516	0.284
MOD_NEK2_1	103	108	PF00069	0.286
MOD_NEK2_1	239	244	PF00069	0.441
MOD_NEK2_1	284	289	PF00069	0.396
MOD_NEK2_1	312	317	PF00069	0.441
MOD_NEK2_1	345	350	PF00069	0.326
MOD_NEK2_1	354	359	PF00069	0.423
MOD_NEK2_1	380	385	PF00069	0.361
MOD_PIKK_1	306	312	PF00454	0.405
MOD_PIKK_1	70	76	PF00454	0.429
MOD_PKA_2	19	25	PF00069	0.500
MOD_PKA_2	35	41	PF00069	0.397
MOD_PKA_2	75	81	PF00069	0.438
MOD_PKB_1	5	13	PF00069	0.500
MOD_Plk_2-3	372	378	PF00069	0.425
MOD_Plk_4	19	25	PF00069	0.500
MOD_Plk_4	221	227	PF00069	0.327
MOD_Plk_4	380	386	PF00069	0.418
MOD_Plk_4	39	45	PF00069	0.375
MOD_Plk_4	80	86	PF00069	0.466
MOD_ProDKin_1	12	18	PF00069	0.532
MOD_ProDKin_1	171	177	PF00069	0.297
MOD_ProDKin_1	191	197	PF00069	0.534
MOD_SUMO_for_1	316	319	PF00179	0.271
TRG_DiLeu_BaEn_1	227	232	PF01217	0.315
TRG_ENDOCYTIC_2	222	225	PF00928	0.329
TRG_ENDOCYTIC_2	228	231	PF00928	0.336
TRG_ENDOCYTIC_2	265	268	PF00928	0.405
TRG_ER_diArg_1	156	158	PF00400	0.287
TRG_ER_diArg_1	368	370	PF00400	0.434
TRG_ER_diArg_1	4	7	PF00400	0.481
TRG_ER_diArg_1	49	51	PF00400	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I9	Leptomonas seymouri	67%	100%
A0A0S4JKM7	Bodo saltans	36%	100%
A0A1X0NYS8	Trypanosomatidae	46%	100%
A0A3Q8ICG6	Leishmania donovani	99%	100%
A0A3R7MC75	Trypanosoma rangeli	43%	100%
A4HE92	Leishmania braziliensis	77%	96%
C9ZK87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AXS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
P40506	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q0J7N5	Oryza sativa subsp. japonica	35%	100%
Q4Q9P9	Leishmania major	91%	100%
Q69S81	Oryza sativa subsp. japonica	34%	100%
Q8GXR5	Arabidopsis thaliana	35%	100%
Q9HAB8	Homo sapiens	32%	100%
Q9LZM3	Arabidopsis thaliana	31%	100%
Q9USK7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
V5BS04	Trypanosoma cruzi	45%	100%