Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4I1N5_LEIIN

TriTrypDb:

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1N5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.634
CLV_NRD_NRD_1	144	146	PF00675	0.616
CLV_NRD_NRD_1	201	203	PF00675	0.549
CLV_NRD_NRD_1	204	206	PF00675	0.563
CLV_NRD_NRD_1	210	212	PF00675	0.599
CLV_NRD_NRD_1	3	5	PF00675	0.481
CLV_NRD_NRD_1	37	39	PF00675	0.555
CLV_NRD_NRD_1	395	397	PF00675	0.698
CLV_NRD_NRD_1	457	459	PF00675	0.692
CLV_NRD_NRD_1	57	59	PF00675	0.390
CLV_NRD_NRD_1	91	93	PF00675	0.480
CLV_PCSK_FUR_1	393	397	PF00082	0.691
CLV_PCSK_KEX2_1	144	146	PF00082	0.616
CLV_PCSK_KEX2_1	200	202	PF00082	0.591
CLV_PCSK_KEX2_1	3	5	PF00082	0.481
CLV_PCSK_KEX2_1	39	41	PF00082	0.565
CLV_PCSK_KEX2_1	395	397	PF00082	0.698
CLV_PCSK_KEX2_1	457	459	PF00082	0.692
CLV_PCSK_KEX2_1	56	58	PF00082	0.426
CLV_PCSK_KEX2_1	91	93	PF00082	0.480
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.519
CLV_PCSK_SKI1_1	395	399	PF00082	0.598
DEG_APCC_DBOX_1	57	65	PF00400	0.460
DOC_CDC14_PxL_1	70	78	PF14671	0.518
DOC_CKS1_1	14	19	PF01111	0.434
DOC_MAPK_gen_1	209	218	PF00069	0.656
DOC_MIT_MIM_1	388	397	PF04212	0.599
DOC_PP1_RVXF_1	112	118	PF00149	0.527
DOC_PP2B_LxvP_1	72	75	PF13499	0.519
DOC_USP7_MATH_1	126	130	PF00917	0.674
DOC_USP7_MATH_1	170	174	PF00917	0.679
DOC_USP7_MATH_1	183	187	PF00917	0.489
DOC_USP7_MATH_1	386	390	PF00917	0.457
DOC_USP7_MATH_1	66	70	PF00917	0.484
DOC_WW_Pin1_4	108	113	PF00397	0.509
DOC_WW_Pin1_4	13	18	PF00397	0.487
DOC_WW_Pin1_4	217	222	PF00397	0.724
DOC_WW_Pin1_4	290	295	PF00397	0.839
DOC_WW_Pin1_4	303	308	PF00397	0.595
DOC_WW_Pin1_4	86	91	PF00397	0.483
LIG_14-3-3_CanoR_1	101	108	PF00244	0.548
LIG_14-3-3_CanoR_1	152	158	PF00244	0.625
LIG_14-3-3_CanoR_1	431	437	PF00244	0.504
LIG_14-3-3_CanoR_1	49	53	PF00244	0.491
LIG_14-3-3_CanoR_1	56	62	PF00244	0.546
LIG_Clathr_ClatBox_1	130	134	PF01394	0.659
LIG_FHA_1	148	154	PF00498	0.715
LIG_FHA_1	194	200	PF00498	0.714
LIG_FHA_1	316	322	PF00498	0.715
LIG_FHA_1	80	86	PF00498	0.538
LIG_FHA_2	320	326	PF00498	0.789
LIG_FHA_2	432	438	PF00498	0.503
LIG_LIR_Gen_1	359	368	PF02991	0.554
LIG_LIR_Nem_3	179	184	PF02991	0.709
LIG_LIR_Nem_3	280	286	PF02991	0.725
LIG_LIR_Nem_3	359	365	PF02991	0.558
LIG_LIR_Nem_3	71	76	PF02991	0.476
LIG_LYPXL_S_1	72	76	PF13949	0.520
LIG_LYPXL_yS_3	73	76	PF13949	0.523
LIG_NRBOX	393	399	PF00104	0.606
LIG_RPA_C_Fungi	147	159	PF08784	0.629
LIG_RPA_C_Fungi	196	208	PF08784	0.611
LIG_SH2_CRK	181	185	PF00017	0.703
LIG_SH2_CRK	362	366	PF00017	0.559
LIG_SH2_CRK	87	91	PF00017	0.481
LIG_SH2_SRC	371	374	PF00017	0.664
LIG_SH2_SRC	400	403	PF00017	0.728
LIG_SH2_STAP1	371	375	PF00017	0.584
LIG_SH2_STAP1	41	45	PF00017	0.524
LIG_SH2_STAP1	466	470	PF00017	0.608
LIG_SH2_STAT3	41	44	PF00017	0.524
LIG_SH3_1	258	264	PF00018	0.788
LIG_SH3_3	11	17	PF00018	0.453
LIG_SH3_3	233	239	PF00018	0.780
LIG_SH3_3	257	263	PF00018	0.774
LIG_SUMO_SIM_anti_2	129	134	PF11976	0.662
LIG_SUMO_SIM_anti_2	440	445	PF11976	0.552
LIG_SUMO_SIM_par_1	129	134	PF11976	0.601
LIG_TRAF2_1	138	141	PF00917	0.714
LIG_TRAF2_1	407	410	PF00917	0.582
LIG_WW_3	306	310	PF00397	0.618
MOD_CDC14_SPxK_1	111	114	PF00782	0.491
MOD_CDC14_SPxK_1	306	309	PF00782	0.662
MOD_CDC14_SPxK_1	89	92	PF00782	0.477
MOD_CDK_SPK_2	13	18	PF00069	0.443
MOD_CDK_SPK_2	86	91	PF00069	0.483
MOD_CDK_SPxK_1	108	114	PF00069	0.499
MOD_CDK_SPxK_1	303	309	PF00069	0.808
MOD_CDK_SPxK_1	86	92	PF00069	0.482
MOD_CK1_1	110	116	PF00069	0.676
MOD_CK1_1	191	197	PF00069	0.478
MOD_CK1_1	246	252	PF00069	0.675
MOD_CK1_1	303	309	PF00069	0.714
MOD_CK1_1	374	380	PF00069	0.447
MOD_CK2_1	319	325	PF00069	0.792
MOD_CK2_1	374	380	PF00069	0.447
MOD_CK2_1	405	411	PF00069	0.557
MOD_CK2_1	431	437	PF00069	0.504
MOD_Cter_Amidation	36	39	PF01082	0.444
MOD_GlcNHglycan	172	175	PF01048	0.667
MOD_GlcNHglycan	247	251	PF01048	0.667
MOD_GlcNHglycan	302	305	PF01048	0.678
MOD_GlcNHglycan	382	385	PF01048	0.589
MOD_GlcNHglycan	427	430	PF01048	0.384
MOD_GlcNHglycan	492	495	PF01048	0.477
MOD_GSK3_1	103	110	PF00069	0.759
MOD_GSK3_1	166	173	PF00069	0.622
MOD_GSK3_1	185	192	PF00069	0.595
MOD_GSK3_1	315	322	PF00069	0.763
MOD_GSK3_1	75	82	PF00069	0.533
MOD_GSK3_1	95	102	PF00069	0.464
MOD_LATS_1	252	258	PF00433	0.727
MOD_LATS_1	99	105	PF00433	0.495
MOD_N-GLC_1	290	295	PF02516	0.751
MOD_NEK2_1	166	171	PF00069	0.600
MOD_NEK2_1	490	495	PF00069	0.465
MOD_NEK2_2	68	73	PF00069	0.464
MOD_PIKK_1	103	109	PF00454	0.551
MOD_PIKK_1	284	290	PF00454	0.772
MOD_PIKK_1	43	49	PF00454	0.470
MOD_PKA_1	57	63	PF00069	0.455
MOD_PKA_2	319	325	PF00069	0.700
MOD_PKA_2	48	54	PF00069	0.516
MOD_PKA_2	57	63	PF00069	0.532
MOD_Plk_4	126	132	PF00069	0.748
MOD_Plk_4	371	377	PF00069	0.675
MOD_Plk_4	57	63	PF00069	0.455
MOD_Plk_4	68	74	PF00069	0.472
MOD_ProDKin_1	108	114	PF00069	0.508
MOD_ProDKin_1	13	19	PF00069	0.484
MOD_ProDKin_1	217	223	PF00069	0.724
MOD_ProDKin_1	290	296	PF00069	0.840
MOD_ProDKin_1	303	309	PF00069	0.595
MOD_ProDKin_1	86	92	PF00069	0.482
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.690
TRG_ENDOCYTIC_2	181	184	PF00928	0.699
TRG_ENDOCYTIC_2	362	365	PF00928	0.574
TRG_ENDOCYTIC_2	452	455	PF00928	0.590
TRG_ENDOCYTIC_2	73	76	PF00928	0.523
TRG_ER_diArg_1	143	145	PF00400	0.616
TRG_ER_diArg_1	199	202	PF00400	0.612
TRG_ER_diArg_1	38	41	PF00400	0.562
TRG_ER_diArg_1	393	396	PF00400	0.686
TRG_ER_diArg_1	457	459	PF00400	0.686
TRG_ER_diArg_1	56	58	PF00400	0.424
TRG_ER_diArg_1	90	92	PF00400	0.477
TRG_Pf-PMV_PEXEL_1	144	149	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	396	401	PF00026	0.711

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1G6	Leptomonas seymouri	37%	100%
A0A3Q8IDF4	Leishmania donovani	99%	100%
A4HE89	Leishmania braziliensis	73%	100%
E9AXR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q9Q2	Leishmania major	86%	100%