LeishMANIAdb
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Not1 N-terminal domain, CCR4-Not complex component-domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Not1 N-terminal domain, CCR4-Not complex component-domain-containing protein
Gene product:
Not1 N-terminal domain - CCR4-Not complex component/NOT2 / NOT3 / NOT5 family - putative
Species:
Leishmania infantum
UniProt:
A4I1N2_LEIIN
TriTrypDb:
LINF_250025200
Length:
634

Annotations

Annotations by Jardim et al.

Transcription, General negative regulator of transcription subunit 5

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 8
GO:0005737 cytoplasm 2 8
GO:0030015 CCR4-NOT core complex 3 8
GO:0032991 protein-containing complex 1 8
GO:0043226 organelle 2 8
GO:0043227 membrane-bounded organelle 3 8
GO:0043229 intracellular organelle 3 8
GO:0043231 intracellular membrane-bounded organelle 4 8
GO:0110165 cellular anatomical entity 1 8
GO:0140535 intracellular protein-containing complex 2 8
GO:0000932 P-body 5 1
GO:0010494 cytoplasmic stress granule 5 1
GO:0035770 ribonucleoprotein granule 3 1
GO:0036464 cytoplasmic ribonucleoprotein granule 4 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0099080 supramolecular complex 2 1

Phosphorylation

Amastigote: 118
Promastigote: 270
Promastigote/Amastigote: 369

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I1N2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1N2

Function

Biological processes
Term Name Level Count
GO:0006355 regulation of DNA-templated transcription 6 8
GO:0009889 regulation of biosynthetic process 4 8
GO:0010468 regulation of gene expression 5 8
GO:0010556 regulation of macromolecule biosynthetic process 5 8
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 8
GO:0019222 regulation of metabolic process 3 8
GO:0031323 regulation of cellular metabolic process 4 8
GO:0031326 regulation of cellular biosynthetic process 5 8
GO:0050789 regulation of biological process 2 8
GO:0050794 regulation of cellular process 3 8
GO:0051171 regulation of nitrogen compound metabolic process 4 8
GO:0051252 regulation of RNA metabolic process 5 8
GO:0060255 regulation of macromolecule metabolic process 4 8
GO:0065007 biological regulation 1 8
GO:0080090 regulation of primary metabolic process 4 8
GO:1903506 regulation of nucleic acid-templated transcription 7 8
GO:2001141 regulation of RNA biosynthetic process 6 8
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 8 1
GO:0000956 nuclear-transcribed mRNA catabolic process 7 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006401 RNA catabolic process 5 1
GO:0006402 mRNA catabolic process 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009892 negative regulation of metabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010605 negative regulation of macromolecule metabolic process 5 1
GO:0010629 negative regulation of gene expression 6 1
GO:0016070 RNA metabolic process 5 1
GO:0016071 mRNA metabolic process 6 1
GO:0019439 aromatic compound catabolic process 4 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034655 nucleobase-containing compound catabolic process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0044270 cellular nitrogen compound catabolic process 4 1
GO:0046483 heterocycle metabolic process 3 1
GO:0046700 heterocycle catabolic process 4 1
GO:0048519 negative regulation of biological process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901361 organic cyclic compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 114 118 PF00656 0.546
CLV_C14_Caspase3-7 20 24 PF00656 0.567
CLV_NRD_NRD_1 131 133 PF00675 0.277
CLV_NRD_NRD_1 151 153 PF00675 0.316
CLV_NRD_NRD_1 405 407 PF00675 0.637
CLV_NRD_NRD_1 80 82 PF00675 0.316
CLV_PCSK_FUR_1 149 153 PF00082 0.316
CLV_PCSK_KEX2_1 151 153 PF00082 0.316
CLV_PCSK_KEX2_1 405 407 PF00082 0.602
CLV_PCSK_KEX2_1 49 51 PF00082 0.277
CLV_PCSK_PC1ET2_1 49 51 PF00082 0.316
CLV_PCSK_SKI1_1 13 17 PF00082 0.316
CLV_PCSK_SKI1_1 373 377 PF00082 0.801
CLV_PCSK_SKI1_1 50 54 PF00082 0.289
CLV_PCSK_SKI1_1 570 574 PF00082 0.316
CLV_PCSK_SKI1_1 96 100 PF00082 0.316
DEG_SCF_FBW7_1 463 469 PF00400 0.770
DEG_SPOP_SBC_1 275 279 PF00917 0.548
DEG_SPOP_SBC_1 281 285 PF00917 0.697
DEG_SPOP_SBC_1 449 453 PF00917 0.684
DEG_SPOP_SBC_1 593 597 PF00917 0.516
DOC_CKS1_1 463 468 PF01111 0.755
DOC_CYCLIN_yClb5_NLxxxL_5 501 510 PF00134 0.389
DOC_CYCLIN_yCln2_LP_2 297 300 PF00134 0.692
DOC_CYCLIN_yCln2_LP_2 454 460 PF00134 0.686
DOC_MAPK_gen_1 227 234 PF00069 0.669
DOC_MAPK_gen_1 72 79 PF00069 0.567
DOC_MAPK_MEF2A_6 227 234 PF00069 0.663
DOC_PP2B_LxvP_1 297 300 PF13499 0.692
DOC_PP2B_LxvP_1 454 457 PF13499 0.670
DOC_PP4_FxxP_1 221 224 PF00568 0.567
DOC_USP7_MATH_1 275 279 PF00917 0.668
DOC_USP7_MATH_1 280 284 PF00917 0.715
DOC_USP7_MATH_1 300 304 PF00917 0.685
DOC_USP7_MATH_1 36 40 PF00917 0.516
DOC_USP7_MATH_1 442 446 PF00917 0.687
DOC_USP7_MATH_1 466 470 PF00917 0.768
DOC_USP7_MATH_1 61 65 PF00917 0.523
DOC_USP7_UBL2_3 154 158 PF12436 0.456
DOC_USP7_UBL2_3 248 252 PF12436 0.697
DOC_USP7_UBL2_3 489 493 PF12436 0.646
DOC_USP7_UBL2_3 49 53 PF12436 0.516
DOC_USP7_UBL2_3 72 76 PF12436 0.516
DOC_WW_Pin1_4 243 248 PF00397 0.637
DOC_WW_Pin1_4 252 257 PF00397 0.641
DOC_WW_Pin1_4 262 267 PF00397 0.642
DOC_WW_Pin1_4 276 281 PF00397 0.724
DOC_WW_Pin1_4 290 295 PF00397 0.453
DOC_WW_Pin1_4 301 306 PF00397 0.654
DOC_WW_Pin1_4 366 371 PF00397 0.701
DOC_WW_Pin1_4 389 394 PF00397 0.718
DOC_WW_Pin1_4 396 401 PF00397 0.700
DOC_WW_Pin1_4 427 432 PF00397 0.669
DOC_WW_Pin1_4 459 464 PF00397 0.724
DOC_WW_Pin1_4 488 493 PF00397 0.591
LIG_14-3-3_CanoR_1 602 608 PF00244 0.516
LIG_BIR_II_1 1 5 PF00653 0.580
LIG_BIR_III_2 525 529 PF00653 0.511
LIG_BRCT_BRCA1_1 337 341 PF00533 0.690
LIG_BRCT_BRCA1_1 474 478 PF00533 0.533
LIG_BRCT_BRCA1_1 603 607 PF00533 0.516
LIG_EVH1_1 478 482 PF00568 0.740
LIG_FHA_1 187 193 PF00498 0.509
LIG_FHA_1 255 261 PF00498 0.680
LIG_FHA_1 351 357 PF00498 0.646
LIG_FHA_1 372 378 PF00498 0.792
LIG_FHA_1 449 455 PF00498 0.703
LIG_FHA_1 507 513 PF00498 0.509
LIG_FHA_2 324 330 PF00498 0.668
LIG_FHA_2 593 599 PF00498 0.520
LIG_FHA_2 604 610 PF00498 0.505
LIG_FHA_2 7 13 PF00498 0.492
LIG_Integrin_isoDGR_2 147 149 PF01839 0.316
LIG_LIR_Apic_2 219 224 PF02991 0.567
LIG_LIR_Gen_1 216 226 PF02991 0.479
LIG_LIR_Gen_1 23 33 PF02991 0.479
LIG_LIR_Gen_1 542 552 PF02991 0.516
LIG_LIR_Gen_1 604 610 PF02991 0.516
LIG_LIR_Nem_3 216 221 PF02991 0.479
LIG_LIR_Nem_3 23 28 PF02991 0.479
LIG_LIR_Nem_3 475 481 PF02991 0.595
LIG_LIR_Nem_3 550 556 PF02991 0.491
LIG_LIR_Nem_3 562 566 PF02991 0.516
LIG_LIR_Nem_3 604 610 PF02991 0.480
LIG_LIR_Nem_3 625 629 PF02991 0.513
LIG_LIR_Nem_3 89 94 PF02991 0.516
LIG_PCNA_PIPBox_1 546 555 PF02747 0.502
LIG_PCNA_yPIPBox_3 541 553 PF02747 0.502
LIG_Pex14_2 610 614 PF04695 0.477
LIG_PTB_Apo_2 65 72 PF02174 0.516
LIG_PTB_Phospho_1 65 71 PF10480 0.516
LIG_REV1ctd_RIR_1 170 178 PF16727 0.567
LIG_SH2_NCK_1 518 522 PF00017 0.516
LIG_SH2_SRC 518 521 PF00017 0.516
LIG_SH2_STAT3 140 143 PF00017 0.516
LIG_SH2_STAT3 529 532 PF00017 0.516
LIG_SH2_STAT3 557 560 PF00017 0.477
LIG_SH2_STAT5 529 532 PF00017 0.516
LIG_SH2_STAT5 566 569 PF00017 0.477
LIG_SH2_STAT5 605 608 PF00017 0.516
LIG_SH2_STAT5 628 631 PF00017 0.533
LIG_SH3_1 227 233 PF00018 0.661
LIG_SH3_1 388 394 PF00018 0.712
LIG_SH3_1 514 520 PF00018 0.516
LIG_SH3_3 227 233 PF00018 0.682
LIG_SH3_3 241 247 PF00018 0.578
LIG_SH3_3 388 394 PF00018 0.674
LIG_SH3_3 428 434 PF00018 0.701
LIG_SH3_3 460 466 PF00018 0.778
LIG_SH3_3 471 477 PF00018 0.619
LIG_SH3_3 514 520 PF00018 0.496
LIG_SH3_3 525 531 PF00018 0.448
LIG_SUMO_SIM_anti_2 208 214 PF11976 0.567
LIG_TRAF2_1 127 130 PF00917 0.567
LIG_TRAF2_1 384 387 PF00917 0.720
LIG_WRC_WIRS_1 218 223 PF05994 0.516
LIG_WRC_WIRS_1 62 67 PF05994 0.567
LIG_WRC_WIRS_1 88 93 PF05994 0.477
MOD_CDK_SPK_2 243 248 PF00069 0.690
MOD_CDK_SPK_2 267 272 PF00069 0.676
MOD_CDK_SPK_2 488 493 PF00069 0.653
MOD_CDK_SPxK_1 488 494 PF00069 0.644
MOD_CDK_SPxxK_3 366 373 PF00069 0.697
MOD_CK1_1 246 252 PF00069 0.675
MOD_CK1_1 351 357 PF00069 0.596
MOD_CK1_1 462 468 PF00069 0.709
MOD_CK1_1 469 475 PF00069 0.616
MOD_CK1_1 488 494 PF00069 0.314
MOD_CK2_1 115 121 PF00069 0.516
MOD_CK2_1 234 240 PF00069 0.671
MOD_CK2_1 267 273 PF00069 0.766
MOD_CK2_1 342 348 PF00069 0.677
MOD_CK2_1 36 42 PF00069 0.516
MOD_CK2_1 442 448 PF00069 0.758
MOD_CK2_1 592 598 PF00069 0.516
MOD_Cter_Amidation 130 133 PF01082 0.316
MOD_GlcNHglycan 109 112 PF01048 0.289
MOD_GlcNHglycan 117 120 PF01048 0.297
MOD_GlcNHglycan 337 340 PF01048 0.688
MOD_GlcNHglycan 350 353 PF01048 0.443
MOD_GlcNHglycan 379 382 PF01048 0.595
MOD_GlcNHglycan 38 41 PF01048 0.316
MOD_GlcNHglycan 443 447 PF01048 0.687
MOD_GSK3_1 213 220 PF00069 0.485
MOD_GSK3_1 243 250 PF00069 0.742
MOD_GSK3_1 252 259 PF00069 0.696
MOD_GSK3_1 262 269 PF00069 0.574
MOD_GSK3_1 271 278 PF00069 0.481
MOD_GSK3_1 335 342 PF00069 0.777
MOD_GSK3_1 350 357 PF00069 0.481
MOD_GSK3_1 371 378 PF00069 0.666
MOD_GSK3_1 438 445 PF00069 0.564
MOD_GSK3_1 458 465 PF00069 0.677
MOD_GSK3_1 592 599 PF00069 0.502
MOD_GSK3_1 97 104 PF00069 0.494
MOD_N-GLC_1 36 41 PF02516 0.284
MOD_NEK2_1 499 504 PF00069 0.579
MOD_NEK2_1 77 82 PF00069 0.516
MOD_NEK2_2 603 608 PF00069 0.516
MOD_PIKK_1 282 288 PF00454 0.577
MOD_PIKK_1 354 360 PF00454 0.677
MOD_PIKK_1 472 478 PF00454 0.711
MOD_PKA_2 601 607 PF00069 0.516
MOD_Plk_1 213 219 PF00069 0.516
MOD_Plk_1 328 334 PF00069 0.657
MOD_Plk_1 499 505 PF00069 0.336
MOD_Plk_2-3 186 192 PF00069 0.509
MOD_Plk_2-3 213 219 PF00069 0.516
MOD_Plk_4 174 180 PF00069 0.557
MOD_Plk_4 213 219 PF00069 0.516
MOD_Plk_4 450 456 PF00069 0.712
MOD_Plk_4 548 554 PF00069 0.492
MOD_Plk_4 603 609 PF00069 0.516
MOD_Plk_4 61 67 PF00069 0.567
MOD_ProDKin_1 243 249 PF00069 0.637
MOD_ProDKin_1 252 258 PF00069 0.637
MOD_ProDKin_1 262 268 PF00069 0.641
MOD_ProDKin_1 276 282 PF00069 0.724
MOD_ProDKin_1 290 296 PF00069 0.453
MOD_ProDKin_1 301 307 PF00069 0.654
MOD_ProDKin_1 366 372 PF00069 0.701
MOD_ProDKin_1 389 395 PF00069 0.718
MOD_ProDKin_1 396 402 PF00069 0.697
MOD_ProDKin_1 427 433 PF00069 0.665
MOD_ProDKin_1 459 465 PF00069 0.727
MOD_ProDKin_1 488 494 PF00069 0.583
MOD_SUMO_for_1 173 176 PF00179 0.567
MOD_SUMO_for_1 48 51 PF00179 0.516
MOD_SUMO_rev_2 219 228 PF00179 0.651
MOD_SUMO_rev_2 235 244 PF00179 0.673
MOD_SUMO_rev_2 369 375 PF00179 0.747
MOD_SUMO_rev_2 380 389 PF00179 0.642
MOD_SUMO_rev_2 45 55 PF00179 0.516
MOD_SUMO_rev_2 620 629 PF00179 0.477
MOD_SUMO_rev_2 95 100 PF00179 0.516
TRG_DiLeu_BaEn_1 10 15 PF01217 0.477
TRG_DiLeu_LyEn_5 10 15 PF01217 0.477
TRG_ENDOCYTIC_2 218 221 PF00928 0.477
TRG_ENDOCYTIC_2 25 28 PF00928 0.477
TRG_ENDOCYTIC_2 544 547 PF00928 0.477
TRG_ENDOCYTIC_2 587 590 PF00928 0.516
TRG_ENDOCYTIC_2 605 608 PF00928 0.516
TRG_ENDOCYTIC_2 626 629 PF00928 0.477
TRG_ER_diArg_1 149 152 PF00400 0.516
TRG_ER_diArg_1 514 517 PF00400 0.511
TRG_NES_CRM1_1 197 213 PF08389 0.560

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMJ8 Leptomonas seymouri 68% 94%
A0A3S5H7F0 Leishmania donovani 100% 100%
A4HE86 Leishmania braziliensis 87% 100%
C9ZK81 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9AXR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q9Q5 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS