SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania infantum

UniProt:

A4I1M6_LEIIN

TriTrypDb:

LINF_250024600

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1M6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1M6

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	3
GO:0032259	methylation	2	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	20
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0008716	D-alanine-D-alanine ligase activity	5	17
GO:0016740	transferase activity	2	17
GO:0016874	ligase activity	2	17
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	17
GO:0016881	acid-amino acid ligase activity	4	17
GO:0017076	purine nucleotide binding	4	17
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0043169	cation binding	3	17
GO:0046872	metal ion binding	4	17
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17
GO:0008168	methyltransferase activity	4	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.341
CLV_NRD_NRD_1	24	26	PF00675	0.399
CLV_NRD_NRD_1	305	307	PF00675	0.487
CLV_PCSK_KEX2_1	396	398	PF00082	0.224
CLV_PCSK_KEX2_1	449	451	PF00082	0.466
CLV_PCSK_KEX2_1	47	49	PF00082	0.343
CLV_PCSK_KEX2_1	474	476	PF00082	0.471
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.207
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.497
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.343
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.486
CLV_PCSK_PC7_1	470	476	PF00082	0.449
CLV_PCSK_SKI1_1	107	111	PF00082	0.267
CLV_PCSK_SKI1_1	178	182	PF00082	0.210
CLV_PCSK_SKI1_1	228	232	PF00082	0.288
CLV_PCSK_SKI1_1	26	30	PF00082	0.377
CLV_PCSK_SKI1_1	332	336	PF00082	0.291
CLV_PCSK_SKI1_1	389	393	PF00082	0.201
CLV_PCSK_SKI1_1	446	450	PF00082	0.531
CLV_PCSK_SKI1_1	470	474	PF00082	0.502
DEG_Nend_UBRbox_1	1	4	PF02207	0.399
DEG_SPOP_SBC_1	479	483	PF00917	0.450
DEG_SPOP_SBC_1	494	498	PF00917	0.455
DEG_SPOP_SBC_1	511	515	PF00917	0.740
DOC_CYCLIN_RxL_1	326	337	PF00134	0.318
DOC_CYCLIN_RxL_1	446	454	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	109	115	PF00134	0.424
DOC_MAPK_gen_1	104	111	PF00069	0.459
DOC_MAPK_gen_1	44	53	PF00069	0.328
DOC_MAPK_MEF2A_6	76	83	PF00069	0.277
DOC_MAPK_NFAT4_5	76	84	PF00069	0.408
DOC_PP1_RVXF_1	105	112	PF00149	0.418
DOC_PP1_RVXF_1	179	186	PF00149	0.407
DOC_PP1_RVXF_1	240	246	PF00149	0.422
DOC_PP1_RVXF_1	387	394	PF00149	0.357
DOC_PP1_RVXF_1	428	435	PF00149	0.349
DOC_PP4_FxxP_1	434	437	PF00568	0.565
DOC_USP7_MATH_1	11	15	PF00917	0.522
DOC_USP7_MATH_1	480	484	PF00917	0.595
DOC_USP7_MATH_1	494	498	PF00917	0.527
DOC_USP7_MATH_1	503	507	PF00917	0.584
DOC_USP7_MATH_1	511	515	PF00917	0.479
DOC_USP7_UBL2_3	3	7	PF12436	0.585
DOC_USP7_UBL2_3	347	351	PF12436	0.366
DOC_USP7_UBL2_3	76	80	PF12436	0.380
DOC_WW_Pin1_4	170	175	PF00397	0.430
LIG_14-3-3_CanoR_1	25	35	PF00244	0.217
LIG_14-3-3_CanoR_1	323	329	PF00244	0.357
LIG_14-3-3_CanoR_1	376	383	PF00244	0.399
LIG_14-3-3_CanoR_1	5	11	PF00244	0.399
LIG_BRCT_BRCA1_1	430	434	PF00533	0.340
LIG_BRCT_BRCA1_1	68	72	PF00533	0.417
LIG_deltaCOP1_diTrp_1	283	291	PF00928	0.301
LIG_FHA_2	409	415	PF00498	0.430
LIG_FHA_2	63	69	PF00498	0.304
LIG_Integrin_RGD_1	365	367	PF01839	0.403
LIG_LIR_Apic_2	431	437	PF02991	0.552
LIG_LIR_Gen_1	119	126	PF02991	0.441
LIG_LIR_Gen_1	192	198	PF02991	0.381
LIG_LIR_Gen_1	217	227	PF02991	0.387
LIG_LIR_Gen_1	253	261	PF02991	0.371
LIG_LIR_Gen_1	274	280	PF02991	0.326
LIG_LIR_Gen_1	30	39	PF02991	0.409
LIG_LIR_Gen_1	406	417	PF02991	0.543
LIG_LIR_Gen_1	9	18	PF02991	0.340
LIG_LIR_Nem_3	119	124	PF02991	0.412
LIG_LIR_Nem_3	19	24	PF02991	0.378
LIG_LIR_Nem_3	192	197	PF02991	0.440
LIG_LIR_Nem_3	207	213	PF02991	0.424
LIG_LIR_Nem_3	217	223	PF02991	0.412
LIG_LIR_Nem_3	253	259	PF02991	0.371
LIG_LIR_Nem_3	274	278	PF02991	0.329
LIG_LIR_Nem_3	30	36	PF02991	0.461
LIG_LIR_Nem_3	406	412	PF02991	0.471
LIG_LIR_Nem_3	9	13	PF02991	0.418
LIG_NRP_CendR_1	528	529	PF00754	0.492
LIG_Pex14_2	197	201	PF04695	0.450
LIG_SH2_CRK	121	125	PF00017	0.446
LIG_SH2_CRK	21	25	PF00017	0.398
LIG_SH2_CRK	210	214	PF00017	0.430
LIG_SH2_CRK	220	224	PF00017	0.430
LIG_SH2_CRK	409	413	PF00017	0.333
LIG_SH2_NCK_1	121	125	PF00017	0.446
LIG_SH2_NCK_1	220	224	PF00017	0.357
LIG_SH2_STAP1	33	37	PF00017	0.377
LIG_SH2_STAT5	196	199	PF00017	0.395
LIG_SH2_STAT5	220	223	PF00017	0.390
LIG_SH2_STAT5	233	236	PF00017	0.438
LIG_SH2_STAT5	255	258	PF00017	0.426
LIG_SH2_STAT5	310	313	PF00017	0.411
LIG_SH3_3	168	174	PF00018	0.440
LIG_SH3_3	176	182	PF00018	0.441
LIG_SH3_3	429	435	PF00018	0.375
LIG_SH3_3	85	91	PF00018	0.366
LIG_TRAF2_1	56	59	PF00917	0.419
LIG_TYR_ITAM	207	223	PF00017	0.430
LIG_TYR_ITIM	238	243	PF00017	0.458
LIG_TYR_ITIM	407	412	PF00017	0.464
MOD_CK1_1	20	26	PF00069	0.515
MOD_CK1_1	423	429	PF00069	0.400
MOD_CK1_1	482	488	PF00069	0.564
MOD_CK1_1	493	499	PF00069	0.524
MOD_CK1_1	505	511	PF00069	0.621
MOD_CK1_1	512	518	PF00069	0.503
MOD_CK1_1	521	527	PF00069	0.508
MOD_CK2_1	521	527	PF00069	0.479
MOD_CK2_1	94	100	PF00069	0.357
MOD_GlcNHglycan	118	121	PF01048	0.244
MOD_GlcNHglycan	235	238	PF01048	0.333
MOD_GlcNHglycan	482	485	PF01048	0.536
MOD_GlcNHglycan	486	489	PF01048	0.545
MOD_GlcNHglycan	492	495	PF01048	0.527
MOD_GlcNHglycan	498	501	PF01048	0.550
MOD_GlcNHglycan	505	508	PF01048	0.545
MOD_GlcNHglycan	514	517	PF01048	0.459
MOD_GlcNHglycan	520	523	PF01048	0.546
MOD_GlcNHglycan	85	88	PF01048	0.287
MOD_GSK3_1	116	123	PF00069	0.441
MOD_GSK3_1	127	134	PF00069	0.436
MOD_GSK3_1	318	325	PF00069	0.333
MOD_GSK3_1	474	481	PF00069	0.577
MOD_GSK3_1	490	497	PF00069	0.476
MOD_GSK3_1	501	508	PF00069	0.589
MOD_GSK3_1	510	517	PF00069	0.473
MOD_GSK3_1	518	525	PF00069	0.516
MOD_GSK3_1	62	69	PF00069	0.405
MOD_GSK3_1	94	101	PF00069	0.416
MOD_N-GLC_1	518	523	PF02516	0.504
MOD_N-GLC_2	38	40	PF02516	0.391
MOD_NEK2_1	27	32	PF00069	0.402
MOD_NEK2_1	420	425	PF00069	0.410
MOD_NEK2_1	82	87	PF00069	0.513
MOD_NEK2_2	11	16	PF00069	0.506
MOD_PKA_1	199	205	PF00069	0.407
MOD_PKA_1	473	479	PF00069	0.472
MOD_PKA_2	322	328	PF00069	0.288
MOD_PKA_2	375	381	PF00069	0.407
MOD_PKA_2	474	480	PF00069	0.481
MOD_PKB_1	159	167	PF00069	0.407
MOD_Plk_1	11	17	PF00069	0.458
MOD_Plk_1	403	409	PF00069	0.489
MOD_Plk_1	413	419	PF00069	0.470
MOD_Plk_1	98	104	PF00069	0.476
MOD_Plk_2-3	403	409	PF00069	0.460
MOD_Plk_4	161	167	PF00069	0.435
MOD_Plk_4	345	351	PF00069	0.508
MOD_ProDKin_1	170	176	PF00069	0.430
MOD_SUMO_rev_2	192	202	PF00179	0.444
MOD_SUMO_rev_2	41	49	PF00179	0.343
MOD_SUMO_rev_2	73	82	PF00179	0.389
TRG_DiLeu_BaLyEn_6	447	452	PF01217	0.627
TRG_ENDOCYTIC_2	121	124	PF00928	0.447
TRG_ENDOCYTIC_2	21	24	PF00928	0.382
TRG_ENDOCYTIC_2	210	213	PF00928	0.457
TRG_ENDOCYTIC_2	220	223	PF00928	0.426
TRG_ENDOCYTIC_2	240	243	PF00928	0.462
TRG_ENDOCYTIC_2	33	36	PF00928	0.440
TRG_ENDOCYTIC_2	409	412	PF00928	0.433
TRG_ER_diArg_1	158	161	PF00400	0.407
TRG_NLS_Bipartite_1	455	477	PF00514	0.425
TRG_NLS_MonoExtN_4	470	477	PF00514	0.451
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILV0	Leptomonas seymouri	38%	100%
A0A0S4JLQ2	Bodo saltans	38%	100%
A0A0S4JPH7	Bodo saltans	61%	82%
A0A1X0P879	Trypanosomatidae	37%	100%
A0A1X0P8J8	Trypanosomatidae	23%	100%
A0A3Q8ID63	Leishmania donovani	37%	100%
A0A3R7MWC4	Trypanosoma rangeli	38%	100%
A0A3R7P2U3	Trypanosoma rangeli	24%	100%
A0A422NGJ1	Trypanosoma rangeli	75%	68%
A4HFA0	Leishmania braziliensis	38%	100%
A4HNM9	Leishmania braziliensis	21%	100%
A4I2H5	Leishmania infantum	37%	100%
C9ZK70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	69%
C9ZX10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AYN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
Q4Q8T5	Leishmania major	38%	100%
V5B7P8	Trypanosoma cruzi	37%	100%
V5BHW2	Trypanosoma cruzi	70%	100%
V5BQK1	Trypanosoma cruzi	23%	100%