LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
mitochondrial RNA binding complex 1 subunit - putative
Species:
Leishmania infantum
UniProt:
A4I1M2_LEIIN
TriTrypDb:
LINF_250024100
Length:
307

Annotations

Annotations by Jardim et al.

Nucleic acid binding, mitochondrial RNA binding complex 1 subunit Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4I1M2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1M2

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009451 RNA modification 5 1
GO:0009892 negative regulation of metabolic process 4 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0009894 regulation of catabolic process 4 1
GO:0009895 negative regulation of catabolic process 5 1
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0010605 negative regulation of macromolecule metabolic process 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0010628 positive regulation of gene expression 6 1
GO:0016070 RNA metabolic process 5 1
GO:0016553 base conversion or substitution editing 6 1
GO:0016554 cytidine to uridine editing 7 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031324 negative regulation of cellular metabolic process 5 1
GO:0031329 regulation of cellular catabolic process 5 1
GO:0031330 negative regulation of cellular catabolic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0043487 regulation of RNA stability 3 1
GO:0043488 regulation of mRNA stability 4 1
GO:0043489 RNA stabilization 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 6 1
GO:0046483 heterocycle metabolic process 3 1
GO:0048255 mRNA stabilization 5 1
GO:0048518 positive regulation of biological process 3 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051172 negative regulation of nitrogen compound metabolic process 5 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0051253 negative regulation of RNA metabolic process 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0061013 regulation of mRNA catabolic process 6 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0071704 organic substance metabolic process 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1902369 negative regulation of RNA catabolic process 7 1
GO:1902373 negative regulation of mRNA catabolic process 7 1
GO:1903311 regulation of mRNA metabolic process 6 1
GO:1903312 negative regulation of mRNA metabolic process 7 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 92 96 PF00656 0.712
CLV_NRD_NRD_1 156 158 PF00675 0.535
CLV_NRD_NRD_1 190 192 PF00675 0.695
CLV_NRD_NRD_1 195 197 PF00675 0.632
CLV_NRD_NRD_1 210 212 PF00675 0.518
CLV_NRD_NRD_1 230 232 PF00675 0.737
CLV_NRD_NRD_1 264 266 PF00675 0.677
CLV_NRD_NRD_1 274 276 PF00675 0.676
CLV_NRD_NRD_1 292 294 PF00675 0.746
CLV_PCSK_KEX2_1 195 197 PF00082 0.709
CLV_PCSK_KEX2_1 210 212 PF00082 0.503
CLV_PCSK_KEX2_1 230 232 PF00082 0.737
CLV_PCSK_KEX2_1 264 266 PF00082 0.675
CLV_PCSK_KEX2_1 274 276 PF00082 0.681
CLV_PCSK_KEX2_1 292 294 PF00082 0.746
CLV_PCSK_PC7_1 191 197 PF00082 0.696
CLV_PCSK_SKI1_1 103 107 PF00082 0.651
CLV_PCSK_SKI1_1 129 133 PF00082 0.528
CLV_PCSK_SKI1_1 151 155 PF00082 0.549
CLV_PCSK_SKI1_1 158 162 PF00082 0.508
DEG_Nend_UBRbox_1 1 4 PF02207 0.629
DOC_MAPK_gen_1 191 200 PF00069 0.606
DOC_PP4_FxxP_1 75 78 PF00568 0.677
DOC_USP7_MATH_1 236 240 PF00917 0.777
DOC_USP7_MATH_1 296 300 PF00917 0.727
DOC_WW_Pin1_4 232 237 PF00397 0.778
DOC_WW_Pin1_4 241 246 PF00397 0.679
DOC_WW_Pin1_4 74 79 PF00397 0.699
LIG_14-3-3_CanoR_1 191 195 PF00244 0.684
LIG_14-3-3_CanoR_1 230 236 PF00244 0.623
LIG_14-3-3_CanoR_1 300 305 PF00244 0.709
LIG_14-3-3_CanoR_1 42 49 PF00244 0.736
LIG_14-3-3_CanoR_1 9 17 PF00244 0.713
LIG_FHA_1 112 118 PF00498 0.609
LIG_FHA_2 163 169 PF00498 0.540
LIG_FHA_2 59 65 PF00498 0.611
LIG_LIR_Apic_2 72 78 PF02991 0.687
LIG_LIR_Gen_1 130 139 PF02991 0.521
LIG_LIR_Nem_3 130 135 PF02991 0.479
LIG_SH2_SRC 173 176 PF00017 0.611
LIG_SH2_STAP1 36 40 PF00017 0.697
LIG_SH2_STAT5 173 176 PF00017 0.451
LIG_SH3_2 238 243 PF14604 0.742
LIG_SH3_3 235 241 PF00018 0.820
LIG_TRAF2_2 268 273 PF00917 0.717
LIG_WRC_WIRS_1 150 155 PF05994 0.513
MOD_CDK_SPK_2 74 79 PF00069 0.637
MOD_CK1_1 127 133 PF00069 0.482
MOD_CK1_1 234 240 PF00069 0.803
MOD_CK1_1 5 11 PF00069 0.769
MOD_CK1_1 50 56 PF00069 0.793
MOD_CK1_1 59 65 PF00069 0.803
MOD_CK1_1 69 75 PF00069 0.690
MOD_CK1_1 99 105 PF00069 0.527
MOD_CK2_1 149 155 PF00069 0.514
MOD_CK2_1 162 168 PF00069 0.393
MOD_CK2_1 58 64 PF00069 0.612
MOD_Cter_Amidation 262 265 PF01082 0.841
MOD_GlcNHglycan 13 16 PF01048 0.759
MOD_GlcNHglycan 132 135 PF01048 0.518
MOD_GlcNHglycan 238 241 PF01048 0.842
MOD_GlcNHglycan 30 33 PF01048 0.525
MOD_GlcNHglycan 36 39 PF01048 0.637
MOD_GlcNHglycan 52 55 PF01048 0.808
MOD_GlcNHglycan 58 61 PF01048 0.789
MOD_GlcNHglycan 97 101 PF01048 0.620
MOD_GSK3_1 107 114 PF00069 0.524
MOD_GSK3_1 232 239 PF00069 0.723
MOD_GSK3_1 276 283 PF00069 0.665
MOD_GSK3_1 296 303 PF00069 0.709
MOD_GSK3_1 30 37 PF00069 0.646
MOD_GSK3_1 43 50 PF00069 0.610
MOD_GSK3_1 56 63 PF00069 0.619
MOD_GSK3_1 74 81 PF00069 0.647
MOD_N-GLC_1 280 285 PF02516 0.749
MOD_N-GLC_1 300 305 PF02516 0.815
MOD_N-GLC_1 90 95 PF02516 0.609
MOD_NEK2_1 66 71 PF00069 0.730
MOD_NEK2_2 124 129 PF00069 0.465
MOD_PK_1 107 113 PF00069 0.524
MOD_PK_1 2 8 PF00069 0.689
MOD_PKA_2 190 196 PF00069 0.692
MOD_PKA_2 50 56 PF00069 0.813
MOD_PKA_2 69 75 PF00069 0.649
MOD_Plk_1 107 113 PF00069 0.572
MOD_Plk_1 300 306 PF00069 0.767
MOD_Plk_4 107 113 PF00069 0.524
MOD_Plk_4 127 133 PF00069 0.290
MOD_ProDKin_1 232 238 PF00069 0.779
MOD_ProDKin_1 241 247 PF00069 0.677
MOD_ProDKin_1 74 80 PF00069 0.696
TRG_ER_diArg_1 194 196 PF00400 0.701
TRG_ER_diArg_1 229 231 PF00400 0.701
TRG_ER_diArg_1 291 293 PF00400 0.838

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1H0 Leptomonas seymouri 43% 96%
A0A3S7WZ80 Leishmania donovani 99% 100%
A4HEG8 Leishmania braziliensis 70% 99%
E9AXQ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q9R5 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS