Pyruvate metabolism, pyruvate dehydrogenase E1 beta subunit
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 25 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 8 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005967 | mitochondrial pyruvate dehydrogenase complex | 3 | 1 |
| GO:0032991 | protein-containing complex | 1 | 1 |
| GO:0045254 | pyruvate dehydrogenase complex | 4 | 1 |
| GO:0098798 | mitochondrial protein-containing complex | 2 | 1 |
| GO:1902494 | catalytic complex | 2 | 1 |
| GO:1990204 | oxidoreductase complex | 3 | 1 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pescher et al. (upgregulation) | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
|
Lahav et al. - mRNA
- Protein
|
Related structures:
AlphaFold database: A4I1L9
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006082 | organic acid metabolic process | 3 | 12 |
| GO:0006084 | acetyl-CoA metabolic process | 5 | 12 |
| GO:0006085 | acetyl-CoA biosynthetic process | 6 | 12 |
| GO:0006086 | acetyl-CoA biosynthetic process from pyruvate | 7 | 12 |
| GO:0006090 | pyruvate metabolic process | 7 | 12 |
| GO:0006139 | nucleobase-containing compound metabolic process | 3 | 12 |
| GO:0006163 | purine nucleotide metabolic process | 5 | 12 |
| GO:0006164 | purine nucleotide biosynthetic process | 6 | 12 |
| GO:0006637 | acyl-CoA metabolic process | 4 | 12 |
| GO:0006725 | cellular aromatic compound metabolic process | 3 | 12 |
| GO:0006753 | nucleoside phosphate metabolic process | 4 | 12 |
| GO:0006790 | sulfur compound metabolic process | 3 | 12 |
| GO:0006793 | phosphorus metabolic process | 3 | 12 |
| GO:0006796 | phosphate-containing compound metabolic process | 4 | 12 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 12 |
| GO:0008152 | metabolic process | 1 | 12 |
| GO:0009058 | biosynthetic process | 2 | 12 |
| GO:0009117 | nucleotide metabolic process | 5 | 12 |
| GO:0009150 | purine ribonucleotide metabolic process | 6 | 12 |
| GO:0009152 | purine ribonucleotide biosynthetic process | 7 | 12 |
| GO:0009165 | nucleotide biosynthetic process | 6 | 12 |
| GO:0009259 | ribonucleotide metabolic process | 5 | 12 |
| GO:0009260 | ribonucleotide biosynthetic process | 6 | 12 |
| GO:0009987 | cellular process | 1 | 12 |
| GO:0018130 | heterocycle biosynthetic process | 4 | 12 |
| GO:0019438 | aromatic compound biosynthetic process | 4 | 12 |
| GO:0019637 | organophosphate metabolic process | 3 | 12 |
| GO:0019693 | ribose phosphate metabolic process | 4 | 12 |
| GO:0019752 | carboxylic acid metabolic process | 5 | 12 |
| GO:0032787 | monocarboxylic acid metabolic process | 6 | 12 |
| GO:0033865 | nucleoside bisphosphate metabolic process | 5 | 12 |
| GO:0033866 | nucleoside bisphosphate biosynthetic process | 6 | 12 |
| GO:0033875 | ribonucleoside bisphosphate metabolic process | 6 | 12 |
| GO:0034030 | ribonucleoside bisphosphate biosynthetic process | 7 | 12 |
| GO:0034032 | purine nucleoside bisphosphate metabolic process | 5 | 12 |
| GO:0034033 | purine nucleoside bisphosphate biosynthetic process | 6 | 12 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 12 |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 4 | 12 |
| GO:0035383 | thioester metabolic process | 3 | 12 |
| GO:0035384 | thioester biosynthetic process | 4 | 12 |
| GO:0043436 | oxoacid metabolic process | 4 | 12 |
| GO:0043603 | amide metabolic process | 3 | 12 |
| GO:0043604 | amide biosynthetic process | 4 | 12 |
| GO:0044237 | cellular metabolic process | 2 | 12 |
| GO:0044238 | primary metabolic process | 2 | 12 |
| GO:0044249 | cellular biosynthetic process | 3 | 12 |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 4 | 12 |
| GO:0044272 | sulfur compound biosynthetic process | 4 | 12 |
| GO:0044281 | small molecule metabolic process | 2 | 12 |
| GO:0046390 | ribose phosphate biosynthetic process | 5 | 12 |
| GO:0046483 | heterocycle metabolic process | 3 | 12 |
| GO:0055086 | nucleobase-containing small molecule metabolic process | 3 | 12 |
| GO:0071616 | acyl-CoA biosynthetic process | 5 | 12 |
| GO:0071704 | organic substance metabolic process | 2 | 12 |
| GO:0072521 | purine-containing compound metabolic process | 4 | 12 |
| GO:0072522 | purine-containing compound biosynthetic process | 5 | 12 |
| GO:0090407 | organophosphate biosynthetic process | 4 | 12 |
| GO:1901135 | carbohydrate derivative metabolic process | 3 | 12 |
| GO:1901137 | carbohydrate derivative biosynthetic process | 4 | 12 |
| GO:1901293 | nucleoside phosphate biosynthetic process | 5 | 12 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 12 |
| GO:1901362 | organic cyclic compound biosynthetic process | 4 | 12 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 12 |
| GO:1901566 | organonitrogen compound biosynthetic process | 4 | 12 |
| GO:1901576 | organic substance biosynthetic process | 3 | 12 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 12 |
| GO:0004738 | pyruvate dehydrogenase activity | 4 | 12 |
| GO:0004739 | pyruvate dehydrogenase (acetyl-transferring) activity | 5 | 12 |
| GO:0016491 | oxidoreductase activity | 2 | 12 |
| GO:0016624 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor | 4 | 12 |
| GO:0016903 | oxidoreductase activity, acting on the aldehyde or oxo group of donors | 3 | 12 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 26 | 30 | PF00656 | 0.425 |
| CLV_C14_Caspase3-7 | 308 | 312 | PF00656 | 0.389 |
| CLV_NRD_NRD_1 | 2 | 4 | PF00675 | 0.432 |
| CLV_PCSK_KEX2_1 | 2 | 4 | PF00082 | 0.432 |
| CLV_PCSK_KEX2_1 | 346 | 348 | PF00082 | 0.302 |
| CLV_PCSK_PC1ET2_1 | 346 | 348 | PF00082 | 0.432 |
| CLV_PCSK_SKI1_1 | 19 | 23 | PF00082 | 0.359 |
| CLV_PCSK_SKI1_1 | 227 | 231 | PF00082 | 0.238 |
| CLV_PCSK_SKI1_1 | 280 | 284 | PF00082 | 0.191 |
| CLV_PCSK_SKI1_1 | 346 | 350 | PF00082 | 0.335 |
| CLV_PCSK_SKI1_1 | 7 | 11 | PF00082 | 0.513 |
| DEG_Nend_UBRbox_1 | 1 | 4 | PF02207 | 0.433 |
| DOC_CDC14_PxL_1 | 158 | 166 | PF14671 | 0.382 |
| DOC_CYCLIN_RxL_1 | 2 | 13 | PF00134 | 0.462 |
| DOC_MAPK_gen_1 | 221 | 231 | PF00069 | 0.399 |
| DOC_MAPK_gen_1 | 276 | 284 | PF00069 | 0.407 |
| DOC_MAPK_gen_1 | 71 | 79 | PF00069 | 0.449 |
| DOC_PP2B_LxvP_1 | 310 | 313 | PF13499 | 0.382 |
| DOC_PP4_FxxP_1 | 136 | 139 | PF00568 | 0.382 |
| DOC_PP4_FxxP_1 | 213 | 216 | PF00568 | 0.284 |
| DOC_USP7_MATH_1 | 119 | 123 | PF00917 | 0.434 |
| DOC_USP7_MATH_1 | 148 | 152 | PF00917 | 0.382 |
| DOC_USP7_MATH_1 | 30 | 34 | PF00917 | 0.508 |
| DOC_USP7_MATH_2 | 313 | 319 | PF00917 | 0.382 |
| DOC_USP7_UBL2_3 | 243 | 247 | PF12436 | 0.505 |
| DOC_WW_Pin1_4 | 321 | 326 | PF00397 | 0.382 |
| LIG_14-3-3_CanoR_1 | 19 | 27 | PF00244 | 0.342 |
| LIG_14-3-3_CanoR_1 | 280 | 285 | PF00244 | 0.393 |
| LIG_14-3-3_CanoR_1 | 316 | 323 | PF00244 | 0.382 |
| LIG_14-3-3_CanoR_1 | 7 | 16 | PF00244 | 0.520 |
| LIG_14-3-3_CterR_2 | 347 | 350 | PF00244 | 0.316 |
| LIG_BIR_III_4 | 174 | 178 | PF00653 | 0.382 |
| LIG_BRCT_BRCA1_1 | 150 | 154 | PF00533 | 0.425 |
| LIG_BRCT_BRCA1_1 | 198 | 202 | PF00533 | 0.444 |
| LIG_BRCT_BRCA1_1 | 303 | 307 | PF00533 | 0.382 |
| LIG_FHA_1 | 203 | 209 | PF00498 | 0.326 |
| LIG_FHA_1 | 60 | 66 | PF00498 | 0.382 |
| LIG_FHA_2 | 24 | 30 | PF00498 | 0.271 |
| LIG_FHA_2 | 281 | 287 | PF00498 | 0.394 |
| LIG_LIR_Apic_2 | 210 | 216 | PF02991 | 0.298 |
| LIG_LIR_Gen_1 | 101 | 109 | PF02991 | 0.382 |
| LIG_LIR_Gen_1 | 304 | 314 | PF02991 | 0.382 |
| LIG_LIR_Nem_3 | 101 | 105 | PF02991 | 0.425 |
| LIG_LIR_Nem_3 | 304 | 310 | PF02991 | 0.382 |
| LIG_PCNA_yPIPBox_3 | 328 | 342 | PF02747 | 0.393 |
| LIG_Pex14_2 | 213 | 217 | PF04695 | 0.283 |
| LIG_SH2_CRK | 158 | 162 | PF00017 | 0.393 |
| LIG_SH2_NCK_1 | 158 | 162 | PF00017 | 0.393 |
| LIG_SH2_SRC | 309 | 312 | PF00017 | 0.382 |
| LIG_SH2_STAP1 | 198 | 202 | PF00017 | 0.444 |
| LIG_SH2_STAP1 | 326 | 330 | PF00017 | 0.382 |
| LIG_SH2_STAT5 | 309 | 312 | PF00017 | 0.382 |
| LIG_SH3_3 | 163 | 169 | PF00018 | 0.382 |
| LIG_SUMO_SIM_anti_2 | 228 | 233 | PF11976 | 0.486 |
| LIG_SUMO_SIM_par_1 | 188 | 193 | PF11976 | 0.385 |
| LIG_TRAF2_1 | 40 | 43 | PF00917 | 0.397 |
| LIG_UBA3_1 | 271 | 277 | PF00899 | 0.425 |
| LIG_WRC_WIRS_1 | 102 | 107 | PF05994 | 0.425 |
| MOD_CDK_SPxxK_3 | 321 | 328 | PF00069 | 0.382 |
| MOD_CK2_1 | 280 | 286 | PF00069 | 0.413 |
| MOD_GlcNHglycan | 10 | 13 | PF01048 | 0.445 |
| MOD_GlcNHglycan | 117 | 120 | PF01048 | 0.182 |
| MOD_GlcNHglycan | 125 | 128 | PF01048 | 0.182 |
| MOD_GlcNHglycan | 142 | 145 | PF01048 | 0.182 |
| MOD_GlcNHglycan | 32 | 35 | PF01048 | 0.302 |
| MOD_GlcNHglycan | 93 | 96 | PF01048 | 0.208 |
| MOD_GSK3_1 | 115 | 122 | PF00069 | 0.439 |
| MOD_GSK3_1 | 19 | 26 | PF00069 | 0.477 |
| MOD_GSK3_1 | 198 | 205 | PF00069 | 0.462 |
| MOD_GSK3_1 | 267 | 274 | PF00069 | 0.388 |
| MOD_GSK3_1 | 280 | 287 | PF00069 | 0.502 |
| MOD_N-GLC_1 | 23 | 28 | PF02516 | 0.238 |
| MOD_NEK2_1 | 10 | 15 | PF00069 | 0.485 |
| MOD_NEK2_1 | 123 | 128 | PF00069 | 0.416 |
| MOD_NEK2_2 | 119 | 124 | PF00069 | 0.413 |
| MOD_PIKK_1 | 148 | 154 | PF00454 | 0.396 |
| MOD_PIKK_1 | 331 | 337 | PF00454 | 0.382 |
| MOD_PKA_2 | 267 | 273 | PF00069 | 0.409 |
| MOD_PKA_2 | 315 | 321 | PF00069 | 0.382 |
| MOD_Plk_1 | 227 | 233 | PF00069 | 0.407 |
| MOD_Plk_1 | 23 | 29 | PF00069 | 0.245 |
| MOD_Plk_1 | 284 | 290 | PF00069 | 0.382 |
| MOD_Plk_2-3 | 303 | 309 | PF00069 | 0.497 |
| MOD_Plk_4 | 119 | 125 | PF00069 | 0.515 |
| MOD_Plk_4 | 267 | 273 | PF00069 | 0.398 |
| MOD_ProDKin_1 | 321 | 327 | PF00069 | 0.382 |
| MOD_SUMO_for_1 | 220 | 223 | PF00179 | 0.382 |
| MOD_SUMO_rev_2 | 223 | 229 | PF00179 | 0.471 |
| MOD_SUMO_rev_2 | 36 | 46 | PF00179 | 0.417 |
| TRG_DiLeu_BaEn_2 | 41 | 47 | PF01217 | 0.397 |
| TRG_ENDOCYTIC_2 | 158 | 161 | PF00928 | 0.393 |
| TRG_ER_diArg_1 | 1 | 3 | PF00400 | 0.437 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P5M5 | Leptomonas seymouri | 31% | 95% |
| A0A0N0P8J5 | Leptomonas seymouri | 88% | 100% |
| A0A0S4J2J6 | Bodo saltans | 72% | 100% |
| A0A1X0NJN2 | Trypanosomatidae | 34% | 95% |
| A0A1X0NY97 | Trypanosomatidae | 77% | 100% |
| A0A3Q8IJ06 | Leishmania donovani | 32% | 96% |
| A0A3S7WZ91 | Leishmania donovani | 100% | 100% |
| A0A422N7P1 | Trypanosoma rangeli | 31% | 96% |
| A0A422NGI4 | Trypanosoma rangeli | 78% | 100% |
| A2CI50 | Chlorokybus atmophyticus | 42% | 100% |
| A4HEH1 | Leishmania braziliensis | 94% | 100% |
| A4HM44 | Leishmania braziliensis | 32% | 100% |
| A4IAQ6 | Leishmania infantum | 32% | 96% |
| A6KXB3 | Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC 11154) | 26% | 100% |
| A6VKQ3 | Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z) | 22% | 100% |
| C9ZK62 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 76% | 100% |
| D0A2G0 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 35% | 95% |
| E9AEI2 | Leishmania major | 32% | 100% |
| E9AXQ3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 97% | 100% |
| E9B5P3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 33% | 100% |
| G0RYE0 | Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) | 59% | 92% |
| O34591 | Bacillus subtilis (strain 168) | 37% | 100% |
| O44451 | Caenorhabditis elegans | 60% | 99% |
| O64688 | Arabidopsis thaliana | 42% | 86% |
| O66113 | Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) | 57% | 76% |
| P09061 | Pseudomonas putida | 40% | 100% |
| P0A0A1 | Staphylococcus aureus (strain Mu50 / ATCC 700699) | 37% | 100% |
| P0A0A2 | Staphylococcus aureus (strain MW2) | 37% | 100% |
| P0A0A3 | Staphylococcus aureus | 37% | 100% |
| P11177 | Homo sapiens | 60% | 97% |
| P11966 | Bos taurus | 59% | 97% |
| P21839 | Bos taurus | 34% | 89% |
| P21874 | Geobacillus stearothermophilus | 39% | 100% |
| P21882 | Bacillus subtilis (strain 168) | 37% | 100% |
| P21953 | Homo sapiens | 35% | 89% |
| P26269 | Ascaris suum | 57% | 97% |
| P27746 | Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) | 39% | 100% |
| P32473 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 59% | 96% |
| P35488 | Acholeplasma laidlawii | 34% | 100% |
| P35738 | Rattus norvegicus | 34% | 90% |
| P37941 | Bacillus subtilis (strain 168) | 39% | 100% |
| P47515 | Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) | 33% | 100% |
| P49432 | Rattus norvegicus | 59% | 97% |
| P51266 | Porphyra purpurea | 44% | 100% |
| P52904 | Pisum sativum | 63% | 97% |
| P55573 | Sinorhizobium fredii (strain NBRC 101917 / NGR234) | 23% | 100% |
| P75391 | Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) | 32% | 100% |
| P99063 | Staphylococcus aureus (strain N315) | 37% | 100% |
| P9WF02 | Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) | 37% | 75% |
| P9WIS0 | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) | 32% | 100% |
| P9WIS1 | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | 32% | 100% |
| Q09171 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 61% | 96% |
| Q0J0H4 | Oryza sativa subsp. japonica | 64% | 93% |
| Q10G39 | Oryza sativa subsp. japonica | 44% | 88% |
| Q1ACL0 | Chara vulgaris | 42% | 100% |
| Q1RJX3 | Rickettsia bellii (strain RML369-C) | 55% | 100% |
| Q1XDM1 | Neopyropia yezoensis | 44% | 100% |
| Q2QM55 | Oryza sativa subsp. japonica | 42% | 90% |
| Q32RM2 | Zygnema circumcarinatum | 42% | 100% |
| Q32RS0 | Staurastrum punctulatum | 43% | 100% |
| Q38799 | Arabidopsis thaliana | 64% | 96% |
| Q4Q9R8 | Leishmania major | 99% | 100% |
| Q4UKQ7 | Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) | 55% | 100% |
| Q55FN7 | Dictyostelium discoideum | 39% | 95% |
| Q58092 | Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) | 22% | 100% |
| Q5HGZ0 | Staphylococcus aureus (strain COL) | 37% | 100% |
| Q5HQ75 | Staphylococcus epidermidis (strain ATCC 35984 / RP62A) | 37% | 100% |
| Q5RE79 | Pongo abelii | 60% | 97% |
| Q5SLR3 | Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) | 42% | 100% |
| Q68XA8 | Rickettsia typhi (strain ATCC VR-144 / Wilmington) | 54% | 100% |
| Q6ABX8 | Leifsonia xyli subsp. xyli (strain CTCB07) | 34% | 100% |
| Q6B8T1 | Gracilaria tenuistipitata var. liui | 43% | 100% |
| Q6GAC0 | Staphylococcus aureus (strain MSSA476) | 37% | 100% |
| Q6GHZ1 | Staphylococcus aureus (strain MRSA252) | 37% | 100% |
| Q6P3A8 | Mus musculus | 34% | 90% |
| Q6Z1G7 | Oryza sativa subsp. japonica | 64% | 94% |
| Q72GU2 | Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) | 41% | 100% |
| Q7K5K3 | Drosophila melanogaster | 59% | 96% |
| Q85FX1 | Cyanidioschyzon merolae (strain NIES-3377 / 10D) | 45% | 100% |
| Q86HX0 | Dictyostelium discoideum | 63% | 98% |
| Q8CPN2 | Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) | 37% | 100% |
| Q8MA03 | Chaetosphaeridium globosum | 44% | 100% |
| Q92IS2 | Rickettsia conorii (strain ATCC VR-613 / Malish 7) | 56% | 100% |
| Q9C6Z3 | Arabidopsis thaliana | 42% | 86% |
| Q9D051 | Mus musculus | 59% | 97% |
| Q9I1M1 | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 39% | 100% |
| Q9LDY2 | Arabidopsis thaliana | 35% | 98% |
| Q9MUR4 | Mesostigma viride | 42% | 100% |
| Q9R9N4 | Rhizobium meliloti (strain 1021) | 54% | 76% |
| Q9SAV3 | Arabidopsis thaliana | 35% | 99% |
| Q9TLS3 | Cyanidium caldarium | 41% | 100% |
| Q9ZDR3 | Rickettsia prowazekii (strain Madrid E) | 54% | 100% |
| V5BIR9 | Trypanosoma cruzi | 34% | 95% |
| V5DIT8 | Trypanosoma cruzi | 75% | 100% |