Leucine_Rich_repeat_-_putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine-rich repeat/Leucine Rich repeats (2 copies) - putative

Species:

Leishmania infantum

UniProt:

A4I1L7_LEIIN

TriTrypDb:

LINF_250023600

Length:

1160

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

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Expansion

Sequence features

A4I1L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1L7

Function

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Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	7
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	7
GO:0000398	mRNA splicing, via spliceosome	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006397	mRNA processing	7	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008380	RNA splicing	7	7

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0017069	snRNA binding	5	7
GO:0030620	U2 snRNA binding	6	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.683
CLV_C14_Caspase3-7	741	745	PF00656	0.692
CLV_MEL_PAP_1	576	582	PF00089	0.495
CLV_NRD_NRD_1	14	16	PF00675	0.409
CLV_NRD_NRD_1	21	23	PF00675	0.449
CLV_NRD_NRD_1	408	410	PF00675	0.535
CLV_NRD_NRD_1	584	586	PF00675	0.533
CLV_NRD_NRD_1	7	9	PF00675	0.434
CLV_NRD_NRD_1	765	767	PF00675	0.489
CLV_NRD_NRD_1	79	81	PF00675	0.404

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK0	Leptomonas seymouri	34%	100%
A0A3Q8ICF8	Leishmania donovani	99%	100%
A4HEH3	Leishmania braziliensis	66%	97%
E9AXQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q9S0	Leishmania major	90%	99%

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