EFP_N domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Elongation factor P (EF-P) KOW-like domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I1L2_LEIIN

TriTrypDb:

LINF_250023100

Length:

233

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I1L2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1L2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003746	translation elongation factor activity	4	3
GO:0005488	binding	1	3
GO:0008135	translation factor activity, RNA binding	3	3
GO:0045182	translation regulator activity	1	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	82	84	PF00675	0.281
CLV_PCSK_KEX2_1	52	54	PF00082	0.326
CLV_PCSK_KEX2_1	6	8	PF00082	0.582
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.276
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.582
CLV_PCSK_SKI1_1	104	108	PF00082	0.385
CLV_PCSK_SKI1_1	184	188	PF00082	0.467
CLV_PCSK_SKI1_1	192	196	PF00082	0.348
CLV_PCSK_SKI1_1	35	39	PF00082	0.427
CLV_PCSK_SKI1_1	85	89	PF00082	0.268
DEG_Nend_Nbox_1	1	3	PF02207	0.552
DEG_SPOP_SBC_1	25	29	PF00917	0.640
DOC_CYCLIN_RxL_1	99	111	PF00134	0.392
DOC_MAPK_FxFP_2	118	121	PF00069	0.370
DOC_MAPK_gen_1	3	11	PF00069	0.638
DOC_MAPK_gen_1	41	50	PF00069	0.467
DOC_MAPK_gen_1	99	107	PF00069	0.396
DOC_MAPK_MEF2A_6	41	50	PF00069	0.481
DOC_MAPK_MEF2A_6	99	107	PF00069	0.396
DOC_MAPK_NFAT4_5	43	51	PF00069	0.481
DOC_PP1_RVXF_1	102	108	PF00149	0.386
DOC_PP4_FxxP_1	118	121	PF00568	0.370
DOC_USP7_MATH_1	134	138	PF00917	0.482
DOC_USP7_MATH_1	16	20	PF00917	0.675
DOC_USP7_MATH_1	25	29	PF00917	0.715
DOC_USP7_UBL2_3	184	188	PF12436	0.407
DOC_USP7_UBL2_3	216	220	PF12436	0.411
DOC_WW_Pin1_4	121	126	PF00397	0.551
LIG_FHA_1	10	16	PF00498	0.672
LIG_FHA_1	200	206	PF00498	0.503
LIG_FHA_2	193	199	PF00498	0.442
LIG_LIR_Gen_1	167	175	PF02991	0.421
LIG_LIR_Gen_1	94	103	PF02991	0.431
LIG_LIR_Nem_3	167	172	PF02991	0.433
LIG_LIR_Nem_3	94	98	PF02991	0.431
LIG_SH2_CRK	55	59	PF00017	0.481
LIG_SH2_STAT5	178	181	PF00017	0.371
LIG_SH3_3	12	18	PF00018	0.739
LIG_SH3_3	128	134	PF00018	0.480
LIG_SH3_3	215	221	PF00018	0.477
LIG_SUMO_SIM_par_1	200	207	PF11976	0.446
LIG_WRC_WIRS_1	193	198	PF05994	0.365
MOD_CK1_1	29	35	PF00069	0.605
MOD_CK2_1	134	140	PF00069	0.458
MOD_CK2_1	192	198	PF00069	0.364
MOD_CMANNOS	2	5	PF00535	0.628
MOD_GlcNHglycan	107	110	PF01048	0.376
MOD_GlcNHglycan	18	21	PF01048	0.726
MOD_GSK3_1	170	177	PF00069	0.447
MOD_GSK3_1	25	32	PF00069	0.652
MOD_GSK3_1	5	12	PF00069	0.674
MOD_GSK3_1	74	81	PF00069	0.501
MOD_NEK2_1	105	110	PF00069	0.373
MOD_PIKK_1	29	35	PF00454	0.650
MOD_PIKK_1	60	66	PF00454	0.467
MOD_Plk_1	170	176	PF00069	0.495
MOD_Plk_4	174	180	PF00069	0.501
MOD_Plk_4	192	198	PF00069	0.304
MOD_Plk_4	26	32	PF00069	0.657
MOD_ProDKin_1	121	127	PF00069	0.554
TRG_DiLeu_BaEn_1	101	106	PF01217	0.396
TRG_DiLeu_LyEn_5	101	106	PF01217	0.396
TRG_ENDOCYTIC_2	55	58	PF00928	0.469
TRG_ER_diArg_1	102	105	PF00400	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFC1	Leptomonas seymouri	88%	97%
A0A0S4IL43	Bodo saltans	69%	94%
A0A1X0NYW1	Trypanosomatidae	77%	100%
A0A3R7KDV7	Trypanosoma rangeli	77%	100%
A0A3S7WZ68	Leishmania donovani	100%	100%
A4HEH8	Leishmania braziliensis	89%	100%
C9ZK54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
E9AXP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q9S5	Leishmania major	99%	100%