LeishMANIAdb
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Putative diacylglycerol acyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative diacylglycerol acyltransferase
Gene product:
diacylglycerol acyltransferase - putative
Species:
Leishmania infantum
UniProt:
A4I1K9_LEIIN
TriTrypDb:
LINF_250022800
Length:
611

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, diacylglycerol acyltransferase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005789 endoplasmic reticulum membrane 4 3
GO:0016020 membrane 2 7
GO:0031090 organelle membrane 3 3
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4I1K9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1K9

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 1
GO:0006638 neutral lipid metabolic process 4 1
GO:0006639 acylglycerol metabolic process 5 1
GO:0006641 triglyceride metabolic process 6 1
GO:0006643 membrane lipid metabolic process 4 1
GO:0008152 metabolic process 1 1
GO:0008610 lipid biosynthetic process 4 1
GO:0009058 biosynthetic process 2 1
GO:0009987 cellular process 1 1
GO:0019432 triglyceride biosynthetic process 6 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0045017 glycerolipid biosynthetic process 4 1
GO:0046460 neutral lipid biosynthetic process 4 1
GO:0046463 acylglycerol biosynthetic process 5 1
GO:0046467 membrane lipid biosynthetic process 4 1
GO:0046486 glycerolipid metabolic process 4 1
GO:0071704 organic substance metabolic process 2 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0004144 diacylglycerol O-acyltransferase activity 7 5
GO:0008374 O-acyltransferase activity 5 9
GO:0016411 acylglycerol O-acyltransferase activity 6 5
GO:0016740 transferase activity 2 9
GO:0016746 acyltransferase activity 3 9
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 402 406 PF00656 0.495
CLV_NRD_NRD_1 152 154 PF00675 0.306
CLV_NRD_NRD_1 289 291 PF00675 0.313
CLV_NRD_NRD_1 373 375 PF00675 0.318
CLV_NRD_NRD_1 446 448 PF00675 0.254
CLV_NRD_NRD_1 482 484 PF00675 0.249
CLV_NRD_NRD_1 54 56 PF00675 0.450
CLV_NRD_NRD_1 554 556 PF00675 0.473
CLV_NRD_NRD_1 589 591 PF00675 0.495
CLV_PCSK_KEX2_1 152 154 PF00082 0.355
CLV_PCSK_KEX2_1 240 242 PF00082 0.461
CLV_PCSK_KEX2_1 289 291 PF00082 0.313
CLV_PCSK_KEX2_1 372 374 PF00082 0.315
CLV_PCSK_KEX2_1 482 484 PF00082 0.258
CLV_PCSK_KEX2_1 54 56 PF00082 0.446
CLV_PCSK_KEX2_1 554 556 PF00082 0.473
CLV_PCSK_PC1ET2_1 240 242 PF00082 0.504
CLV_PCSK_PC1ET2_1 482 484 PF00082 0.287
CLV_PCSK_PC7_1 369 375 PF00082 0.209
CLV_PCSK_SKI1_1 152 156 PF00082 0.336
CLV_PCSK_SKI1_1 488 492 PF00082 0.248
CLV_PCSK_SKI1_1 541 545 PF00082 0.351
DEG_APCC_DBOX_1 152 160 PF00400 0.581
DEG_Nend_UBRbox_2 1 3 PF02207 0.756
DEG_SPOP_SBC_1 265 269 PF00917 0.611
DOC_CKS1_1 190 195 PF01111 0.703
DOC_CKS1_1 214 219 PF01111 0.637
DOC_CKS1_1 283 288 PF01111 0.620
DOC_CYCLIN_yClb5_NLxxxL_5 421 428 PF00134 0.463
DOC_MAPK_gen_1 289 296 PF00069 0.547
DOC_MAPK_gen_1 472 481 PF00069 0.464
DOC_MAPK_gen_1 482 491 PF00069 0.436
DOC_MAPK_gen_1 554 561 PF00069 0.273
DOC_MAPK_HePTP_8 479 491 PF00069 0.516
DOC_MAPK_MEF2A_6 289 298 PF00069 0.495
DOC_MAPK_MEF2A_6 408 417 PF00069 0.489
DOC_MAPK_MEF2A_6 421 428 PF00069 0.458
DOC_MAPK_MEF2A_6 482 491 PF00069 0.450
DOC_MAPK_MEF2A_6 554 561 PF00069 0.248
DOC_PP2B_LxvP_1 182 185 PF13499 0.624
DOC_PP2B_LxvP_1 365 368 PF13499 0.448
DOC_PP2B_LxvP_1 424 427 PF13499 0.516
DOC_PP2B_LxvP_1 565 568 PF13499 0.315
DOC_PP4_FxxP_1 335 338 PF00568 0.377
DOC_PP4_FxxP_1 533 536 PF00568 0.283
DOC_USP7_MATH_1 171 175 PF00917 0.670
DOC_USP7_MATH_1 207 211 PF00917 0.711
DOC_USP7_MATH_1 30 34 PF00917 0.689
DOC_USP7_MATH_1 441 445 PF00917 0.473
DOC_USP7_MATH_1 454 458 PF00917 0.444
DOC_USP7_MATH_1 465 469 PF00917 0.431
DOC_USP7_UBL2_3 484 488 PF12436 0.516
DOC_WW_Pin1_4 189 194 PF00397 0.748
DOC_WW_Pin1_4 19 24 PF00397 0.737
DOC_WW_Pin1_4 213 218 PF00397 0.641
DOC_WW_Pin1_4 241 246 PF00397 0.645
DOC_WW_Pin1_4 25 30 PF00397 0.745
DOC_WW_Pin1_4 282 287 PF00397 0.622
DOC_WW_Pin1_4 492 497 PF00397 0.473
LIG_14-3-3_CanoR_1 141 151 PF00244 0.588
LIG_14-3-3_CanoR_1 289 295 PF00244 0.521
LIG_14-3-3_CanoR_1 319 323 PF00244 0.315
LIG_14-3-3_CanoR_1 447 451 PF00244 0.473
LIG_14-3-3_CanoR_1 54 58 PF00244 0.633
LIG_ActinCP_TwfCPI_2 335 344 PF01115 0.377
LIG_BRCT_BRCA1_1 266 270 PF00533 0.635
LIG_BRCT_BRCA1_1 65 69 PF00533 0.650
LIG_DLG_GKlike_1 290 298 PF00625 0.516
LIG_eIF4E_1 360 366 PF01652 0.448
LIG_FHA_1 310 316 PF00498 0.394
LIG_FHA_1 412 418 PF00498 0.489
LIG_FHA_1 493 499 PF00498 0.473
LIG_FHA_1 60 66 PF00498 0.645
LIG_FHA_2 39 45 PF00498 0.638
LIG_FHA_2 572 578 PF00498 0.248
LIG_Integrin_isoDGR_2 92 94 PF01839 0.450
LIG_LIR_Apic_2 210 214 PF02991 0.683
LIG_LIR_Apic_2 318 323 PF02991 0.304
LIG_LIR_Apic_2 334 338 PF02991 0.235
LIG_LIR_Gen_1 297 307 PF02991 0.289
LIG_LIR_Gen_1 321 332 PF02991 0.354
LIG_LIR_Gen_1 66 76 PF02991 0.655
LIG_LIR_LC3C_4 457 462 PF02991 0.473
LIG_LIR_Nem_3 278 282 PF02991 0.586
LIG_LIR_Nem_3 297 302 PF02991 0.447
LIG_LIR_Nem_3 359 363 PF02991 0.463
LIG_LIR_Nem_3 378 384 PF02991 0.516
LIG_LIR_Nem_3 392 396 PF02991 0.473
LIG_LIR_Nem_3 516 522 PF02991 0.475
LIG_Pex14_1 331 335 PF04695 0.377
LIG_Pex14_1 581 585 PF04695 0.248
LIG_Pex14_2 348 352 PF04695 0.558
LIG_PTB_Apo_2 542 549 PF02174 0.377
LIG_PTB_Phospho_1 542 548 PF10480 0.377
LIG_SH2_CRK 320 324 PF00017 0.369
LIG_SH2_CRK 548 552 PF00017 0.315
LIG_SH2_NCK_1 320 324 PF00017 0.304
LIG_SH2_NCK_1 509 513 PF00017 0.499
LIG_SH2_PTP2 425 428 PF00017 0.495
LIG_SH2_PTP2 522 525 PF00017 0.378
LIG_SH2_STAT5 142 145 PF00017 0.593
LIG_SH2_STAT5 260 263 PF00017 0.550
LIG_SH2_STAT5 320 323 PF00017 0.355
LIG_SH2_STAT5 328 331 PF00017 0.256
LIG_SH2_STAT5 357 360 PF00017 0.494
LIG_SH2_STAT5 381 384 PF00017 0.482
LIG_SH2_STAT5 425 428 PF00017 0.516
LIG_SH2_STAT5 522 525 PF00017 0.505
LIG_SH2_STAT5 530 533 PF00017 0.275
LIG_SH2_STAT5 585 588 PF00017 0.248
LIG_SH3_3 15 21 PF00018 0.719
LIG_SH3_3 182 188 PF00018 0.690
LIG_SH3_3 211 217 PF00018 0.681
LIG_SH3_3 335 341 PF00018 0.285
LIG_SH3_3 381 387 PF00018 0.590
LIG_SH3_3 493 499 PF00018 0.473
LIG_SH3_3 558 564 PF00018 0.256
LIG_SH3_3 565 571 PF00018 0.240
LIG_SH3_3 99 105 PF00018 0.663
LIG_SUMO_SIM_anti_2 312 318 PF11976 0.292
LIG_SUMO_SIM_anti_2 457 462 PF11976 0.450
LIG_SUMO_SIM_par_1 293 300 PF11976 0.322
LIG_SUMO_SIM_par_1 312 318 PF11976 0.171
LIG_SUMO_SIM_par_1 557 563 PF11976 0.273
LIG_TRAF2_1 115 118 PF00917 0.594
LIG_TRAF2_1 490 493 PF00917 0.448
LIG_TRFH_1 548 552 PF08558 0.299
LIG_TYR_ITIM 520 525 PF00017 0.409
LIG_WRC_WIRS_1 298 303 PF05994 0.390
LIG_WRC_WIRS_1 332 337 PF05994 0.359
LIG_WRC_WIRS_1 390 395 PF05994 0.473
LIG_WW_3 22 26 PF00397 0.648
MOD_CDK_SPK_2 241 246 PF00069 0.645
MOD_CDK_SPxK_1 189 195 PF00069 0.702
MOD_CDK_SPxK_1 19 25 PF00069 0.689
MOD_CDK_SPxxK_3 282 289 PF00069 0.613
MOD_CK1_1 176 182 PF00069 0.666
MOD_CK1_1 234 240 PF00069 0.697
MOD_CK1_1 266 272 PF00069 0.723
MOD_CK1_1 278 284 PF00069 0.524
MOD_CK1_1 297 303 PF00069 0.476
MOD_CK1_1 318 324 PF00069 0.295
MOD_CK1_1 63 69 PF00069 0.670
MOD_CK1_1 77 83 PF00069 0.584
MOD_CK2_1 112 118 PF00069 0.597
MOD_CK2_1 507 513 PF00069 0.491
MOD_Cter_Amidation 238 241 PF01082 0.492
MOD_Cter_Amidation 52 55 PF01082 0.365
MOD_DYRK1A_RPxSP_1 19 23 PF00069 0.740
MOD_GlcNHglycan 173 176 PF01048 0.432
MOD_GlcNHglycan 179 182 PF01048 0.455
MOD_GlcNHglycan 217 220 PF01048 0.463
MOD_GlcNHglycan 222 225 PF01048 0.427
MOD_GlcNHglycan 440 444 PF01048 0.259
MOD_GlcNHglycan 451 454 PF01048 0.285
MOD_GlcNHglycan 75 79 PF01048 0.480
MOD_GSK3_1 173 180 PF00069 0.636
MOD_GSK3_1 203 210 PF00069 0.734
MOD_GSK3_1 25 32 PF00069 0.638
MOD_GSK3_1 278 285 PF00069 0.602
MOD_GSK3_1 290 297 PF00069 0.414
MOD_GSK3_1 38 45 PF00069 0.568
MOD_GSK3_1 59 66 PF00069 0.657
MOD_GSK3_1 83 90 PF00069 0.753
MOD_NEK2_1 194 199 PF00069 0.620
MOD_NEK2_1 294 299 PF00069 0.283
MOD_NEK2_1 309 314 PF00069 0.377
MOD_NEK2_1 315 320 PF00069 0.488
MOD_NEK2_1 602 607 PF00069 0.315
MOD_NEK2_1 61 66 PF00069 0.590
MOD_NEK2_2 406 411 PF00069 0.465
MOD_OFUCOSY 438 445 PF10250 0.315
MOD_PIKK_1 13 19 PF00454 0.702
MOD_PIKK_1 80 86 PF00454 0.806
MOD_PKA_2 234 240 PF00069 0.667
MOD_PKA_2 318 324 PF00069 0.315
MOD_PKA_2 446 452 PF00069 0.448
MOD_PKA_2 53 59 PF00069 0.648
MOD_Plk_1 465 471 PF00069 0.516
MOD_Plk_2-3 38 44 PF00069 0.598
MOD_Plk_4 290 296 PF00069 0.432
MOD_Plk_4 454 460 PF00069 0.460
MOD_Plk_4 465 471 PF00069 0.431
MOD_ProDKin_1 189 195 PF00069 0.750
MOD_ProDKin_1 19 25 PF00069 0.741
MOD_ProDKin_1 213 219 PF00069 0.639
MOD_ProDKin_1 241 247 PF00069 0.634
MOD_ProDKin_1 282 288 PF00069 0.619
MOD_ProDKin_1 492 498 PF00069 0.473
MOD_SUMO_rev_2 145 151 PF00179 0.604
MOD_SUMO_rev_2 44 50 PF00179 0.581
TRG_DiLeu_BaLyEn_6 249 254 PF01217 0.568
TRG_ENDOCYTIC_2 360 363 PF00928 0.435
TRG_ENDOCYTIC_2 381 384 PF00928 0.448
TRG_ENDOCYTIC_2 425 428 PF00928 0.516
TRG_ENDOCYTIC_2 522 525 PF00928 0.488
TRG_ENDOCYTIC_2 530 533 PF00928 0.259
TRG_ENDOCYTIC_2 548 551 PF00928 0.340
TRG_ER_diArg_1 139 142 PF00400 0.616
TRG_ER_diArg_1 151 153 PF00400 0.522
TRG_ER_diArg_1 289 291 PF00400 0.514
TRG_ER_diArg_1 371 374 PF00400 0.516
TRG_ER_diArg_1 538 541 PF00400 0.429
TRG_ER_diArg_1 554 556 PF00400 0.221
TRG_Pf-PMV_PEXEL_1 55 60 PF00026 0.431
TRG_Pf-PMV_PEXEL_1 590 595 PF00026 0.495
TRG_Pf-PMV_PEXEL_1 597 601 PF00026 0.448

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE36 Leptomonas seymouri 55% 94%
A0A3R7NQK7 Trypanosoma rangeli 45% 100%
A0A3S7WZ82 Leishmania donovani 100% 100%
A4HEI1 Leishmania braziliensis 77% 99%
C9ZK51 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9AXP3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q9S8 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS