Uncharacterized protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1K8_LEIIN

TriTrypDb:

LINF_250022700

Length:

145

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I1K8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1K8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	91	93	PF00675	0.466
CLV_PCSK_FUR_1	8	12	PF00082	0.611
CLV_PCSK_KEX2_1	10	12	PF00082	0.577
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.577
CLV_PCSK_SKI1_1	103	107	PF00082	0.448
DEG_MDM2_SWIB_1	33	41	PF02201	0.451
DOC_ANK_TNKS_1	10	17	PF00023	0.532
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.489
DOC_WW_Pin1_4	92	97	PF00397	0.520
LIG_14-3-3_CanoR_1	103	112	PF00244	0.520
LIG_APCC_ABBA_1	102	107	PF00400	0.566
LIG_APCC_ABBAyCdc20_2	101	107	PF00400	0.571
LIG_BRCT_BRCA1_1	24	28	PF00533	0.482
LIG_FHA_2	104	110	PF00498	0.568
LIG_LIR_Nem_3	109	115	PF02991	0.454
LIG_LIR_Nem_3	25	31	PF02991	0.473
LIG_Pex14_2	33	37	PF04695	0.457
LIG_SH2_GRB2like	65	68	PF00017	0.581
LIG_SH2_STAT3	31	34	PF00017	0.443
LIG_SH2_STAT5	32	35	PF00017	0.426
LIG_SH2_STAT5	60	63	PF00017	0.418
LIG_SH3_5	130	134	PF00018	0.592
LIG_TRAF2_1	87	90	PF00917	0.519
MOD_CK2_1	103	109	PF00069	0.242
MOD_CK2_1	84	90	PF00069	0.523
MOD_GlcNHglycan	112	115	PF01048	0.484
MOD_GlcNHglycan	137	140	PF01048	0.648
MOD_GlcNHglycan	37	40	PF01048	0.454
MOD_GSK3_1	2	9	PF00069	0.512
MOD_NEK2_1	3	8	PF00069	0.514
MOD_PKB_1	101	109	PF00069	0.470
MOD_Plk_1	67	73	PF00069	0.499
MOD_Plk_4	117	123	PF00069	0.542
MOD_ProDKin_1	92	98	PF00069	0.516
TRG_DiLeu_BaEn_4	89	95	PF01217	0.515
TRG_ER_diArg_1	100	103	PF00400	0.483
TRG_Pf-PMV_PEXEL_1	92	97	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8J8	Leptomonas seymouri	80%	100%
A0A0S4IKV2	Bodo saltans	47%	100%
A0A1X0NY74	Trypanosomatidae	65%	100%
A0A3Q8IDC5	Leishmania donovani	100%	100%
A0A422NL14	Trypanosoma rangeli	62%	100%
A4HEI2	Leishmania braziliensis	87%	100%
C9ZK50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9AXP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q9S9	Leishmania major	99%	100%