MPN domain-containing protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1K7_LEIIN

TriTrypDb:

LINF_250022600

Length:

326

Annotations

Annotations by Jardim et al.

Translation, Eukaryotic translation initiation factor 3 subunit F

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005852	eukaryotic translation initiation factor 3 complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I1K7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1K7

Function

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Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0016310	phosphorylation	5	3
GO:0044237	cellular metabolic process	2	3

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008233	peptidase activity	3	2
GO:0008237	metallopeptidase activity	4	2
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016787	hydrolase activity	2	2
GO:0140096	catalytic activity, acting on a protein	2	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.496
CLV_NRD_NRD_1	214	216	PF00675	0.620
CLV_NRD_NRD_1	22	24	PF00675	0.363
CLV_NRD_NRD_1	286	288	PF00675	0.448
CLV_NRD_NRD_1	305	307	PF00675	0.555
CLV_NRD_NRD_1	68	70	PF00675	0.477
CLV_NRD_NRD_1	73	75	PF00675	0.511
CLV_PCSK_KEX2_1	214	216	PF00082	0.626
CLV_PCSK_KEX2_1	22	24	PF00082	0.340
CLV_PCSK_KEX2_1	256	258	PF00082	0.653

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X4	Leptomonas seymouri	73%	99%
A0A1X0NYA8	Trypanosomatidae	34%	94%
A0A3Q8IDI4	Leishmania donovani	100%	100%
A0A3R7MHX6	Trypanosoma rangeli	33%	99%
C9ZK49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	96%
E9AXP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q9T0	Leishmania major	99%	100%
V5DIT1	Trypanosoma cruzi	30%	94%

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