MPN domain-containing protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1K7_LEIIN

TriTrypDb:

LINF_250022600

Length:

326

Annotations

Annotations by Jardim et al.

Translation, Eukaryotic translation initiation factor 3 subunit F

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005852	eukaryotic translation initiation factor 3 complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I1K7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1K7

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0016310	phosphorylation	5	3
GO:0044237	cellular metabolic process	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008233	peptidase activity	3	2
GO:0008237	metallopeptidase activity	4	2
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016787	hydrolase activity	2	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.496
CLV_NRD_NRD_1	214	216	PF00675	0.620
CLV_NRD_NRD_1	22	24	PF00675	0.363
CLV_NRD_NRD_1	286	288	PF00675	0.448
CLV_NRD_NRD_1	305	307	PF00675	0.555
CLV_NRD_NRD_1	68	70	PF00675	0.477
CLV_NRD_NRD_1	73	75	PF00675	0.511
CLV_PCSK_KEX2_1	214	216	PF00082	0.626
CLV_PCSK_KEX2_1	22	24	PF00082	0.340
CLV_PCSK_KEX2_1	256	258	PF00082	0.653
CLV_PCSK_KEX2_1	286	288	PF00082	0.466
CLV_PCSK_KEX2_1	305	307	PF00082	0.424
CLV_PCSK_KEX2_1	67	69	PF00082	0.440
CLV_PCSK_KEX2_1	72	74	PF00082	0.419
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.340
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.653
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.432
CLV_PCSK_PC7_1	68	74	PF00082	0.427
CLV_PCSK_SKI1_1	145	149	PF00082	0.553
CLV_PCSK_SKI1_1	273	277	PF00082	0.421
CLV_PCSK_SKI1_1	69	73	PF00082	0.477
DEG_APCC_DBOX_1	152	160	PF00400	0.415
DEG_APCC_DBOX_1	184	192	PF00400	0.566
DEG_ODPH_VHL_1	156	168	PF01847	0.520
DOC_CKS1_1	8	13	PF01111	0.403
DOC_PP1_RVXF_1	128	134	PF00149	0.512
DOC_PP4_FxxP_1	139	142	PF00568	0.394
DOC_USP7_MATH_1	228	232	PF00917	0.683
DOC_WW_Pin1_4	125	130	PF00397	0.573
DOC_WW_Pin1_4	7	12	PF00397	0.414
LIG_14-3-3_CanoR_1	153	157	PF00244	0.422
LIG_14-3-3_CanoR_1	73	83	PF00244	0.460
LIG_APCC_ABBA_1	115	120	PF00400	0.417
LIG_BIR_II_1	1	5	PF00653	0.492
LIG_BRCT_BRCA1_1	105	109	PF00533	0.396
LIG_BRCT_BRCA1_1	135	139	PF00533	0.344
LIG_BRCT_BRCA1_1	268	272	PF00533	0.557
LIG_eIF4E_1	75	81	PF01652	0.378
LIG_FHA_1	126	132	PF00498	0.507
LIG_FHA_1	170	176	PF00498	0.493
LIG_FHA_1	204	210	PF00498	0.521
LIG_FHA_1	41	47	PF00498	0.287
LIG_FHA_1	75	81	PF00498	0.372
LIG_FHA_2	240	246	PF00498	0.560
LIG_FHA_2	308	314	PF00498	0.582
LIG_FHA_2	47	53	PF00498	0.391
LIG_FHA_2	74	80	PF00498	0.462
LIG_FHA_2	92	98	PF00498	0.472
LIG_LIR_Apic_2	136	142	PF02991	0.371
LIG_LIR_Nem_3	245	250	PF02991	0.452
LIG_OCRL_FandH_1	108	120	PF00620	0.352
LIG_SH2_STAT3	75	78	PF00017	0.399
LIG_SH2_STAT5	196	199	PF00017	0.525
LIG_SH2_STAT5	30	33	PF00017	0.250
LIG_SH2_STAT5	75	78	PF00017	0.392
LIG_TRAF2_1	222	225	PF00917	0.644
MOD_CDK_SPK_2	125	130	PF00069	0.450
MOD_CK1_1	169	175	PF00069	0.578
MOD_CK2_1	239	245	PF00069	0.564
MOD_CK2_1	307	313	PF00069	0.572
MOD_GlcNHglycan	230	233	PF01048	0.514
MOD_GlcNHglycan	84	87	PF01048	0.443
MOD_GSK3_1	166	173	PF00069	0.504
MOD_GSK3_1	46	53	PF00069	0.347
MOD_N-GLC_1	307	312	PF02516	0.616
MOD_NEK2_2	143	148	PF00069	0.456
MOD_PIKK_1	266	272	PF00454	0.547
MOD_PIKK_1	74	80	PF00454	0.394
MOD_PKA_1	73	79	PF00069	0.486
MOD_PKA_2	152	158	PF00069	0.401
MOD_PKA_2	73	79	PF00069	0.414
MOD_PKB_1	257	265	PF00069	0.602
MOD_Plk_1	143	149	PF00069	0.518
MOD_Plk_4	103	109	PF00069	0.397
MOD_Plk_4	133	139	PF00069	0.389
MOD_Plk_4	170	176	PF00069	0.510
MOD_Plk_4	280	286	PF00069	0.524
MOD_Plk_4	294	300	PF00069	0.549
MOD_ProDKin_1	125	131	PF00069	0.561
MOD_ProDKin_1	7	13	PF00069	0.411
MOD_SUMO_rev_2	199	205	PF00179	0.540
TRG_DiLeu_BaEn_4	211	217	PF01217	0.460
TRG_DiLeu_BaEn_4	95	101	PF01217	0.453
TRG_ER_diArg_1	214	216	PF00400	0.643
TRG_ER_diArg_1	285	287	PF00400	0.415
TRG_ER_diArg_1	67	69	PF00400	0.414
TRG_ER_diArg_1	73	75	PF00400	0.472
TRG_NLS_MonoCore_2	21	26	PF00514	0.365
TRG_NLS_MonoExtN_4	22	27	PF00514	0.456
TRG_NLS_MonoExtN_4	69	76	PF00514	0.484
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X4	Leptomonas seymouri	73%	99%
A0A1X0NYA8	Trypanosomatidae	34%	94%
A0A3Q8IDI4	Leishmania donovani	100%	100%
A0A3R7MHX6	Trypanosoma rangeli	33%	99%
C9ZK49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	96%
E9AXP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q9T0	Leishmania major	99%	100%
V5DIT1	Trypanosoma cruzi	30%	94%