LeishMANIAdb
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Putative casein kinase I

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative casein kinase I
Gene product:
casein kinase I - putative
Species:
Leishmania infantum
UniProt:
A4I1K4_LEIIN
TriTrypDb:
LINF_250022300
Length:
518

Annotations

Annotations by Jardim et al.

Protein kinase, casein kinase I

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 2
Pissara et al. yes yes: 18
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

A4I1K4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1K4

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 15
GO:0006793 phosphorus metabolic process 3 15
GO:0006796 phosphate-containing compound metabolic process 4 15
GO:0006807 nitrogen compound metabolic process 2 15
GO:0008152 metabolic process 1 15
GO:0009987 cellular process 1 15
GO:0016310 phosphorylation 5 15
GO:0019538 protein metabolic process 3 15
GO:0036211 protein modification process 4 15
GO:0043170 macromolecule metabolic process 3 15
GO:0043412 macromolecule modification 4 15
GO:0044237 cellular metabolic process 2 15
GO:0044238 primary metabolic process 2 15
GO:0071704 organic substance metabolic process 2 15
GO:1901564 organonitrogen compound metabolic process 3 15
GO:0006810 transport 3 2
GO:0006897 endocytosis 5 2
GO:0007165 signal transduction 2 2
GO:0016192 vesicle-mediated transport 4 2
GO:0018105 peptidyl-serine phosphorylation 6 2
GO:0018193 peptidyl-amino acid modification 5 2
GO:0018209 peptidyl-serine modification 6 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0065007 biological regulation 1 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 15
GO:0003824 catalytic activity 1 15
GO:0004672 protein kinase activity 3 15
GO:0005488 binding 1 15
GO:0005524 ATP binding 5 15
GO:0016301 kinase activity 4 15
GO:0016740 transferase activity 2 15
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 15
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 15
GO:0017076 purine nucleotide binding 4 15
GO:0030554 adenyl nucleotide binding 5 15
GO:0032553 ribonucleotide binding 3 15
GO:0032555 purine ribonucleotide binding 4 15
GO:0032559 adenyl ribonucleotide binding 5 15
GO:0035639 purine ribonucleoside triphosphate binding 4 15
GO:0036094 small molecule binding 2 15
GO:0043167 ion binding 2 15
GO:0043168 anion binding 3 15
GO:0097159 organic cyclic compound binding 2 15
GO:0097367 carbohydrate derivative binding 2 15
GO:0140096 catalytic activity, acting on a protein 2 15
GO:1901265 nucleoside phosphate binding 3 15
GO:1901363 heterocyclic compound binding 2 15
GO:0004674 protein serine/threonine kinase activity 4 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 124 126 PF00675 0.546
CLV_NRD_NRD_1 169 171 PF00675 0.346
CLV_NRD_NRD_1 263 265 PF00675 0.376
CLV_NRD_NRD_1 341 343 PF00675 0.559
CLV_NRD_NRD_1 409 411 PF00675 0.568
CLV_NRD_NRD_1 53 55 PF00675 0.442
CLV_PCSK_KEX2_1 169 171 PF00082 0.331
CLV_PCSK_KEX2_1 263 265 PF00082 0.376
CLV_PCSK_KEX2_1 341 343 PF00082 0.498
CLV_PCSK_KEX2_1 349 351 PF00082 0.507
CLV_PCSK_KEX2_1 409 411 PF00082 0.568
CLV_PCSK_KEX2_1 447 449 PF00082 0.473
CLV_PCSK_KEX2_1 453 455 PF00082 0.518
CLV_PCSK_KEX2_1 503 505 PF00082 0.575
CLV_PCSK_PC1ET2_1 349 351 PF00082 0.470
CLV_PCSK_PC1ET2_1 447 449 PF00082 0.468
CLV_PCSK_PC1ET2_1 453 455 PF00082 0.513
CLV_PCSK_PC1ET2_1 503 505 PF00082 0.575
CLV_PCSK_PC7_1 345 351 PF00082 0.407
CLV_PCSK_SKI1_1 174 178 PF00082 0.303
CLV_PCSK_SKI1_1 198 202 PF00082 0.412
CLV_PCSK_SKI1_1 21 25 PF00082 0.364
CLV_PCSK_SKI1_1 242 246 PF00082 0.352
CLV_PCSK_SKI1_1 295 299 PF00082 0.362
CLV_PCSK_SKI1_1 303 307 PF00082 0.408
CLV_PCSK_SKI1_1 317 321 PF00082 0.435
CLV_PCSK_SKI1_1 341 345 PF00082 0.425
CLV_PCSK_SKI1_1 504 508 PF00082 0.613
CLV_PCSK_SKI1_1 85 89 PF00082 0.539
DEG_APCC_DBOX_1 169 177 PF00400 0.331
DEG_APCC_DBOX_1 263 271 PF00400 0.382
DEG_SCF_FBW7_2 304 310 PF00400 0.384
DOC_CKS1_1 304 309 PF01111 0.481
DOC_CKS1_1 414 419 PF01111 0.574
DOC_CYCLIN_RxL_1 324 332 PF00134 0.423
DOC_CYCLIN_RxL_1 345 354 PF00134 0.374
DOC_CYCLIN_yCln2_LP_2 379 385 PF00134 0.592
DOC_MAPK_gen_1 125 132 PF00069 0.489
DOC_MAPK_gen_1 210 218 PF00069 0.334
DOC_MAPK_gen_1 231 238 PF00069 0.322
DOC_MAPK_gen_1 349 355 PF00069 0.455
DOC_MAPK_gen_1 42 52 PF00069 0.409
DOC_MAPK_MEF2A_6 125 134 PF00069 0.446
DOC_MAPK_MEF2A_6 43 52 PF00069 0.404
DOC_PP1_RVXF_1 223 229 PF00149 0.331
DOC_PP1_RVXF_1 325 332 PF00149 0.416
DOC_PP2B_LxvP_1 353 356 PF13499 0.431
DOC_PP2B_LxvP_1 379 382 PF13499 0.572
DOC_PP4_FxxP_1 414 417 PF00568 0.546
DOC_PP4_FxxP_1 507 510 PF00568 0.564
DOC_USP7_MATH_1 2 6 PF00917 0.580
DOC_USP7_MATH_1 373 377 PF00917 0.683
DOC_USP7_MATH_1 392 396 PF00917 0.534
DOC_USP7_MATH_1 471 475 PF00917 0.598
DOC_USP7_MATH_1 499 503 PF00917 0.583
DOC_USP7_MATH_1 89 93 PF00917 0.522
DOC_USP7_UBL2_3 313 317 PF12436 0.389
DOC_USP7_UBL2_3 51 55 PF12436 0.392
DOC_WW_Pin1_4 106 111 PF00397 0.598
DOC_WW_Pin1_4 303 308 PF00397 0.484
DOC_WW_Pin1_4 388 393 PF00397 0.560
DOC_WW_Pin1_4 413 418 PF00397 0.584
DOC_WW_Pin1_4 506 511 PF00397 0.600
LIG_14-3-3_CanoR_1 125 129 PF00244 0.559
LIG_14-3-3_CanoR_1 169 174 PF00244 0.344
LIG_14-3-3_CanoR_1 327 332 PF00244 0.424
LIG_14-3-3_CanoR_1 350 356 PF00244 0.426
LIG_14-3-3_CanoR_1 396 401 PF00244 0.583
LIG_14-3-3_CanoR_1 409 413 PF00244 0.560
LIG_14-3-3_CanoR_1 475 481 PF00244 0.512
LIG_14-3-3_CanoR_1 504 510 PF00244 0.539
LIG_AP2alpha_1 33 37 PF02296 0.412
LIG_APCC_ABBAyCdc20_2 193 199 PF00400 0.331
LIG_BIR_II_1 1 5 PF00653 0.562
LIG_BRCT_BRCA1_1 268 272 PF00533 0.331
LIG_BRCT_BRCA1_1 327 331 PF00533 0.406
LIG_BRCT_BRCA1_1 361 365 PF00533 0.539
LIG_BRCT_BRCA1_1 410 414 PF00533 0.540
LIG_deltaCOP1_diTrp_1 439 445 PF00928 0.448
LIG_FHA_1 294 300 PF00498 0.356
LIG_FHA_2 304 310 PF00498 0.389
LIG_FHA_2 425 431 PF00498 0.615
LIG_FHA_2 490 496 PF00498 0.544
LIG_FHA_2 9 15 PF00498 0.454
LIG_LIR_Apic_2 411 417 PF02991 0.540
LIG_LIR_Gen_1 145 155 PF02991 0.433
LIG_LIR_Gen_1 269 278 PF02991 0.331
LIG_LIR_Gen_1 336 344 PF02991 0.396
LIG_LIR_Gen_1 439 450 PF02991 0.447
LIG_LIR_Nem_3 224 230 PF02991 0.345
LIG_LIR_Nem_3 269 275 PF02991 0.362
LIG_LIR_Nem_3 318 322 PF02991 0.543
LIG_LIR_Nem_3 32 36 PF02991 0.496
LIG_LIR_Nem_3 336 340 PF02991 0.303
LIG_LIR_Nem_3 439 445 PF02991 0.472
LIG_LIR_Nem_3 66 72 PF02991 0.435
LIG_LYPXL_yS_3 59 62 PF13949 0.428
LIG_MYND_3 425 429 PF01753 0.564
LIG_Pex14_2 33 37 PF04695 0.529
LIG_PTB_Apo_2 27 34 PF02174 0.427
LIG_SH2_CRK 337 341 PF00017 0.458
LIG_SH2_CRK 69 73 PF00017 0.428
LIG_SH2_STAP1 438 442 PF00017 0.465
LIG_SH2_STAP1 64 68 PF00017 0.397
LIG_SH2_STAT5 141 144 PF00017 0.382
LIG_SH2_STAT5 166 169 PF00017 0.287
LIG_SH2_STAT5 189 192 PF00017 0.438
LIG_SH2_STAT5 217 220 PF00017 0.435
LIG_SH2_STAT5 250 253 PF00017 0.360
LIG_SH2_STAT5 276 279 PF00017 0.362
LIG_SH2_STAT5 322 325 PF00017 0.392
LIG_SH3_2 510 515 PF14604 0.539
LIG_SH3_3 131 137 PF00018 0.398
LIG_SH3_3 372 378 PF00018 0.589
LIG_SH3_3 507 513 PF00018 0.604
LIG_SUMO_SIM_anti_2 129 134 PF11976 0.381
LIG_SUMO_SIM_par_1 175 181 PF11976 0.399
LIG_SUMO_SIM_par_1 393 405 PF11976 0.692
LIG_TRAF2_1 307 310 PF00917 0.417
LIG_UBA3_1 343 349 PF00899 0.374
MOD_CK1_1 106 112 PF00069 0.540
MOD_CK1_1 172 178 PF00069 0.354
MOD_CK1_1 399 405 PF00069 0.636
MOD_CK1_1 408 414 PF00069 0.574
MOD_CK1_1 474 480 PF00069 0.603
MOD_CK1_1 63 69 PF00069 0.352
MOD_CK1_1 92 98 PF00069 0.540
MOD_CK2_1 303 309 PF00069 0.412
MOD_CK2_1 8 14 PF00069 0.616
MOD_Cter_Amidation 347 350 PF01082 0.355
MOD_GlcNHglycan 361 364 PF01048 0.714
MOD_GlcNHglycan 469 472 PF01048 0.572
MOD_GlcNHglycan 497 500 PF01048 0.721
MOD_GSK3_1 113 120 PF00069 0.608
MOD_GSK3_1 124 131 PF00069 0.519
MOD_GSK3_1 299 306 PF00069 0.338
MOD_GSK3_1 325 332 PF00069 0.337
MOD_GSK3_1 383 390 PF00069 0.660
MOD_GSK3_1 392 399 PF00069 0.725
MOD_GSK3_1 401 408 PF00069 0.668
MOD_GSK3_1 467 474 PF00069 0.517
MOD_GSK3_1 495 502 PF00069 0.660
MOD_N-GLC_1 106 111 PF02516 0.547
MOD_N-GLC_1 117 122 PF02516 0.507
MOD_N-GLC_1 29 34 PF02516 0.433
MOD_N-GLC_1 368 373 PF02516 0.663
MOD_N-GLC_1 488 493 PF02516 0.562
MOD_N-GLC_1 92 97 PF02516 0.573
MOD_N-GLC_2 165 167 PF02516 0.282
MOD_N-GLC_2 321 323 PF02516 0.301
MOD_N-GLC_2 364 366 PF02516 0.557
MOD_NEK2_1 128 133 PF00069 0.444
MOD_NEK2_1 22 27 PF00069 0.389
MOD_NEK2_1 244 249 PF00069 0.417
MOD_NEK2_1 259 264 PF00069 0.302
MOD_NEK2_1 329 334 PF00069 0.431
MOD_NEK2_1 351 356 PF00069 0.600
MOD_NEK2_1 488 493 PF00069 0.710
MOD_PIKK_1 329 335 PF00454 0.363
MOD_PIKK_1 464 470 PF00454 0.500
MOD_PIKK_1 489 495 PF00454 0.559
MOD_PK_1 396 402 PF00069 0.576
MOD_PKA_1 169 175 PF00069 0.346
MOD_PKA_1 231 237 PF00069 0.303
MOD_PKA_2 124 130 PF00069 0.538
MOD_PKA_2 169 175 PF00069 0.333
MOD_PKA_2 408 414 PF00069 0.588
MOD_PKA_2 474 480 PF00069 0.505
MOD_Plk_1 128 134 PF00069 0.444
MOD_Plk_1 402 408 PF00069 0.551
MOD_Plk_1 92 98 PF00069 0.579
MOD_Plk_4 172 178 PF00069 0.394
MOD_Plk_4 396 402 PF00069 0.665
MOD_Plk_4 92 98 PF00069 0.570
MOD_ProDKin_1 106 112 PF00069 0.599
MOD_ProDKin_1 303 309 PF00069 0.489
MOD_ProDKin_1 388 394 PF00069 0.562
MOD_ProDKin_1 413 419 PF00069 0.585
MOD_ProDKin_1 506 512 PF00069 0.601
MOD_SUMO_for_1 200 203 PF00179 0.323
MOD_SUMO_for_1 50 53 PF00179 0.424
MOD_SUMO_rev_2 35 44 PF00179 0.369
MOD_SUMO_rev_2 63 68 PF00179 0.355
TRG_DiLeu_BaEn_2 267 273 PF01217 0.282
TRG_DiLeu_BaLyEn_6 393 398 PF01217 0.574
TRG_ENDOCYTIC_2 148 151 PF00928 0.383
TRG_ENDOCYTIC_2 227 230 PF00928 0.303
TRG_ENDOCYTIC_2 337 340 PF00928 0.393
TRG_ENDOCYTIC_2 59 62 PF00928 0.447
TRG_ENDOCYTIC_2 69 72 PF00928 0.453
TRG_ER_diArg_1 169 171 PF00400 0.331
TRG_ER_diArg_1 340 342 PF00400 0.445
TRG_ER_diArg_1 515 518 PF00400 0.556
TRG_NLS_Bipartite_1 42 59 PF00514 0.385
TRG_NLS_MonoExtN_4 54 59 PF00514 0.434
TRG_Pf-PMV_PEXEL_1 341 346 PF00026 0.414
TRG_Pf-PMV_PEXEL_1 70 74 PF00026 0.428

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3F5 Leptomonas seymouri 40% 100%
A0A0N1I2H3 Leptomonas seymouri 31% 100%
A0A0N1IKB0 Leptomonas seymouri 31% 91%
A0A1X0NZS9 Trypanosomatidae 46% 100%
A0A3Q8IJ66 Leishmania donovani 46% 100%
A0A3Q8ISA0 Leishmania donovani 42% 100%
A0A3R7K1Y6 Trypanosoma rangeli 27% 78%
A0A3S7WNZ6 Leishmania donovani 33% 100%
A0A3S7WZA2 Leishmania donovani 100% 100%
A0A422NL83 Trypanosoma rangeli 52% 100%
A4H436 Leishmania braziliensis 33% 100%
A4HEI6 Leishmania braziliensis 79% 99%
A4HFV0 Leishmania braziliensis 31% 93%
A4HMD1 Leishmania braziliensis 46% 100%
A4HSC0 Leishmania infantum 33% 100%
A4I638 Leishmania infantum 42% 100%
A4IAZ8 Leishmania infantum 46% 100%
A7E3X2 Bos taurus 42% 100%
C9ZK43 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
C9ZM31 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 75%
E9AKA2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AXN8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9AZ78 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B1C3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B5Y1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 100%
O96999 Leishmania major 32% 100%
P39962 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 99%
Q4Q6U1 Leishmania major 41% 100%
Q4Q9T3 Leishmania major 93% 97%
Q62761 Rattus norvegicus 41% 100%
Q8BN21 Mus musculus 28% 100%
Q8BTH8 Mus musculus 41% 100%
Q9NHE1 Leishmania major 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS