LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4I1K2_LEIIN
TriTrypDb:
LINF_250022100 *
Length:
811

Annotations

Annotations by Jardim et al.

Protein kinase, kinase Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 495
Promastigote/Amastigote: 496

Expansion

Sequence features

A4I1K2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1K2

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 8
GO:0006793 phosphorus metabolic process 3 8
GO:0006796 phosphate-containing compound metabolic process 4 8
GO:0006807 nitrogen compound metabolic process 2 8
GO:0008152 metabolic process 1 8
GO:0009987 cellular process 1 8
GO:0016310 phosphorylation 5 8
GO:0019538 protein metabolic process 3 8
GO:0036211 protein modification process 4 8
GO:0043170 macromolecule metabolic process 3 8
GO:0043412 macromolecule modification 4 8
GO:0044237 cellular metabolic process 2 8
GO:0044238 primary metabolic process 2 8
GO:0071704 organic substance metabolic process 2 8
GO:1901564 organonitrogen compound metabolic process 3 8
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 8
GO:0003824 catalytic activity 1 8
GO:0004672 protein kinase activity 3 8
GO:0005488 binding 1 8
GO:0005524 ATP binding 5 8
GO:0016301 kinase activity 4 8
GO:0016740 transferase activity 2 8
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 8
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 8
GO:0017076 purine nucleotide binding 4 8
GO:0030554 adenyl nucleotide binding 5 8
GO:0032553 ribonucleotide binding 3 8
GO:0032555 purine ribonucleotide binding 4 8
GO:0032559 adenyl ribonucleotide binding 5 8
GO:0035639 purine ribonucleoside triphosphate binding 4 8
GO:0036094 small molecule binding 2 8
GO:0043167 ion binding 2 8
GO:0043168 anion binding 3 8
GO:0097159 organic cyclic compound binding 2 8
GO:0097367 carbohydrate derivative binding 2 8
GO:0140096 catalytic activity, acting on a protein 2 8
GO:1901265 nucleoside phosphate binding 3 8
GO:1901363 heterocyclic compound binding 2 8
GO:0004674 protein serine/threonine kinase activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 356 360 PF00656 0.705
CLV_NRD_NRD_1 137 139 PF00675 0.615
CLV_NRD_NRD_1 404 406 PF00675 0.551
CLV_NRD_NRD_1 466 468 PF00675 0.687
CLV_NRD_NRD_1 786 788 PF00675 0.430
CLV_PCSK_FUR_1 342 346 PF00082 0.656
CLV_PCSK_FUR_1 402 406 PF00082 0.453
CLV_PCSK_KEX2_1 137 139 PF00082 0.618
CLV_PCSK_KEX2_1 344 346 PF00082 0.662
CLV_PCSK_KEX2_1 402 404 PF00082 0.635
CLV_PCSK_KEX2_1 466 468 PF00082 0.637
CLV_PCSK_KEX2_1 474 476 PF00082 0.573
CLV_PCSK_KEX2_1 484 486 PF00082 0.720
CLV_PCSK_KEX2_1 786 788 PF00082 0.376
CLV_PCSK_KEX2_1 795 797 PF00082 0.376
CLV_PCSK_PC1ET2_1 344 346 PF00082 0.664
CLV_PCSK_PC1ET2_1 474 476 PF00082 0.788
CLV_PCSK_PC1ET2_1 484 486 PF00082 0.720
CLV_PCSK_PC1ET2_1 795 797 PF00082 0.430
CLV_PCSK_SKI1_1 138 142 PF00082 0.611
CLV_PCSK_SKI1_1 192 196 PF00082 0.571
CLV_PCSK_SKI1_1 216 220 PF00082 0.494
CLV_PCSK_SKI1_1 335 339 PF00082 0.554
CLV_PCSK_SKI1_1 417 421 PF00082 0.348
CLV_PCSK_SKI1_1 695 699 PF00082 0.430
CLV_PCSK_SKI1_1 786 790 PF00082 0.376
CLV_PCSK_SKI1_1 795 799 PF00082 0.376
DEG_SPOP_SBC_1 89 93 PF00917 0.785
DOC_ANK_TNKS_1 543 550 PF00023 0.734
DOC_CDC14_PxL_1 775 783 PF14671 0.430
DOC_CKS1_1 23 28 PF01111 0.747
DOC_CKS1_1 78 83 PF01111 0.710
DOC_MAPK_gen_1 500 509 PF00069 0.755
DOC_MAPK_MEF2A_6 451 459 PF00069 0.490
DOC_MAPK_MEF2A_6 628 636 PF00069 0.376
DOC_PP2B_LxvP_1 411 414 PF13499 0.440
DOC_PP2B_LxvP_1 660 663 PF13499 0.430
DOC_PP2B_PxIxI_1 270 276 PF00149 0.765
DOC_PP4_FxxP_1 299 302 PF00568 0.432
DOC_SPAK_OSR1_1 298 302 PF12202 0.435
DOC_USP7_MATH_1 15 19 PF00917 0.685
DOC_USP7_MATH_1 159 163 PF00917 0.696
DOC_USP7_MATH_1 542 546 PF00917 0.723
DOC_USP7_MATH_1 551 555 PF00917 0.762
DOC_USP7_MATH_1 88 92 PF00917 0.733
DOC_WW_Pin1_4 138 143 PF00397 0.568
DOC_WW_Pin1_4 155 160 PF00397 0.585
DOC_WW_Pin1_4 199 204 PF00397 0.678
DOC_WW_Pin1_4 22 27 PF00397 0.705
DOC_WW_Pin1_4 267 272 PF00397 0.785
DOC_WW_Pin1_4 510 515 PF00397 0.737
DOC_WW_Pin1_4 563 568 PF00397 0.676
DOC_WW_Pin1_4 626 631 PF00397 0.417
DOC_WW_Pin1_4 77 82 PF00397 0.745
LIG_14-3-3_CanoR_1 155 159 PF00244 0.720
LIG_14-3-3_CanoR_1 263 273 PF00244 0.690
LIG_14-3-3_CanoR_1 367 376 PF00244 0.661
LIG_14-3-3_CanoR_1 69 79 PF00244 0.813
LIG_14-3-3_CanoR_1 706 712 PF00244 0.501
LIG_14-3-3_CanoR_1 796 803 PF00244 0.378
LIG_APCC_ABBA_1 219 224 PF00400 0.490
LIG_APCC_ABBAyCdc20_2 124 130 PF00400 0.595
LIG_APCC_ABBAyCdc20_2 433 439 PF00400 0.376
LIG_BIR_III_2 139 143 PF00653 0.582
LIG_deltaCOP1_diTrp_1 230 236 PF00928 0.503
LIG_EVH1_1 78 82 PF00568 0.710
LIG_FHA_1 158 164 PF00498 0.816
LIG_FHA_1 2 8 PF00498 0.708
LIG_FHA_1 283 289 PF00498 0.618
LIG_FHA_1 460 466 PF00498 0.515
LIG_FHA_2 354 360 PF00498 0.791
LIG_FHA_2 600 606 PF00498 0.430
LIG_FHA_2 638 644 PF00498 0.430
LIG_FHA_2 677 683 PF00498 0.385
LIG_FHA_2 744 750 PF00498 0.473
LIG_FHA_2 768 774 PF00498 0.408
LIG_FHA_2 796 802 PF00498 0.376
LIG_LIR_Apic_2 20 26 PF02991 0.663
LIG_LIR_Apic_2 4 9 PF02991 0.775
LIG_LIR_Apic_2 624 630 PF02991 0.430
LIG_LIR_Apic_2 76 81 PF02991 0.704
LIG_LIR_Gen_1 141 150 PF02991 0.571
LIG_LIR_Gen_1 189 198 PF02991 0.488
LIG_LIR_Gen_1 230 239 PF02991 0.496
LIG_LIR_Gen_1 269 280 PF02991 0.664
LIG_LIR_Gen_1 359 369 PF02991 0.695
LIG_LIR_Gen_1 425 430 PF02991 0.430
LIG_LIR_Nem_3 122 128 PF02991 0.702
LIG_LIR_Nem_3 141 146 PF02991 0.331
LIG_LIR_Nem_3 170 176 PF02991 0.509
LIG_LIR_Nem_3 189 193 PF02991 0.353
LIG_LIR_Nem_3 230 236 PF02991 0.503
LIG_LIR_Nem_3 269 275 PF02991 0.697
LIG_LIR_Nem_3 425 429 PF02991 0.376
LIG_LIR_Nem_3 618 622 PF02991 0.390
LIG_LIR_Nem_3 704 708 PF02991 0.430
LIG_MAD2 192 200 PF02301 0.595
LIG_Pex14_2 599 603 PF04695 0.430
LIG_Pex14_2 705 709 PF04695 0.376
LIG_Pex14_2 718 722 PF04695 0.376
LIG_REV1ctd_RIR_1 805 811 PF16727 0.501
LIG_SH2_CRK 23 27 PF00017 0.727
LIG_SH2_CRK 408 412 PF00017 0.435
LIG_SH2_CRK 421 425 PF00017 0.376
LIG_SH2_CRK 619 623 PF00017 0.376
LIG_SH2_NCK_1 612 616 PF00017 0.451
LIG_SH2_NCK_1 619 623 PF00017 0.407
LIG_SH2_PTP2 272 275 PF00017 0.765
LIG_SH2_PTP2 578 581 PF00017 0.512
LIG_SH2_PTP2 6 9 PF00017 0.675
LIG_SH2_SRC 228 231 PF00017 0.509
LIG_SH2_SRC 6 9 PF00017 0.780
LIG_SH2_SRC 612 615 PF00017 0.424
LIG_SH2_STAP1 117 121 PF00017 0.728
LIG_SH2_STAP1 132 136 PF00017 0.431
LIG_SH2_STAP1 176 180 PF00017 0.503
LIG_SH2_STAP1 181 185 PF00017 0.481
LIG_SH2_STAP1 461 465 PF00017 0.585
LIG_SH2_STAT5 179 182 PF00017 0.439
LIG_SH2_STAT5 228 231 PF00017 0.509
LIG_SH2_STAT5 272 275 PF00017 0.765
LIG_SH2_STAT5 292 295 PF00017 0.250
LIG_SH2_STAT5 305 308 PF00017 0.498
LIG_SH2_STAT5 461 464 PF00017 0.452
LIG_SH2_STAT5 578 581 PF00017 0.512
LIG_SH2_STAT5 6 9 PF00017 0.780
LIG_SH2_STAT5 708 711 PF00017 0.385
LIG_SH2_STAT5 764 767 PF00017 0.376
LIG_SH3_3 160 166 PF00018 0.699
LIG_SH3_3 197 203 PF00018 0.651
LIG_SH3_3 241 247 PF00018 0.563
LIG_SH3_3 303 309 PF00018 0.480
LIG_SH3_3 315 321 PF00018 0.403
LIG_SH3_3 384 390 PF00018 0.757
LIG_SH3_3 576 582 PF00018 0.525
LIG_SH3_3 76 82 PF00018 0.748
LIG_SUMO_SIM_anti_2 554 562 PF11976 0.572
LIG_SUMO_SIM_par_1 448 456 PF11976 0.430
LIG_SUMO_SIM_par_1 561 566 PF11976 0.665
LIG_SUMO_SIM_par_1 780 785 PF11976 0.430
LIG_TRAF2_1 167 170 PF00917 0.523
LIG_TRAF2_1 250 253 PF00917 0.743
LIG_TRAF2_1 753 756 PF00917 0.420
LIG_TRAF2_1 798 801 PF00917 0.410
LIG_TRAF2_2 567 572 PF00917 0.713
LIG_TRFH_1 709 713 PF08558 0.501
LIG_TYR_ITIM 406 411 PF00017 0.446
LIG_TYR_ITIM 419 424 PF00017 0.376
LIG_TYR_ITIM 617 622 PF00017 0.376
LIG_WRC_WIRS_1 423 428 PF05994 0.430
LIG_WRC_WIRS_1 600 605 PF05994 0.430
LIG_WRC_WIRS_1 677 682 PF05994 0.421
LIG_WRC_WIRS_1 702 707 PF05994 0.430
LIG_WW_2 83 86 PF00397 0.725
MOD_CDK_SPxxK_3 138 145 PF00069 0.569
MOD_CDK_SPxxK_3 563 570 PF00069 0.738
MOD_CK1_1 151 157 PF00069 0.755
MOD_CK1_1 18 24 PF00069 0.769
MOD_CK1_1 274 280 PF00069 0.596
MOD_CK1_1 352 358 PF00069 0.767
MOD_CK1_1 518 524 PF00069 0.748
MOD_CK1_1 54 60 PF00069 0.708
MOD_CK1_1 552 558 PF00069 0.794
MOD_CK1_1 64 70 PF00069 0.647
MOD_CK1_1 73 79 PF00069 0.537
MOD_CK1_1 740 746 PF00069 0.397
MOD_CK1_1 91 97 PF00069 0.570
MOD_CK1_1 98 104 PF00069 0.700
MOD_CK2_1 475 481 PF00069 0.743
MOD_CK2_1 492 498 PF00069 0.756
MOD_CK2_1 542 548 PF00069 0.723
MOD_CK2_1 795 801 PF00069 0.376
MOD_GlcNHglycan 12 15 PF01048 0.794
MOD_GlcNHglycan 150 153 PF01048 0.675
MOD_GlcNHglycan 163 166 PF01048 0.720
MOD_GlcNHglycan 209 212 PF01048 0.658
MOD_GlcNHglycan 351 354 PF01048 0.639
MOD_GlcNHglycan 369 372 PF01048 0.588
MOD_GlcNHglycan 380 383 PF01048 0.657
MOD_GlcNHglycan 477 480 PF01048 0.762
MOD_GlcNHglycan 53 56 PF01048 0.731
MOD_GlcNHglycan 544 547 PF01048 0.776
MOD_GlcNHglycan 640 643 PF01048 0.376
MOD_GlcNHglycan 687 690 PF01048 0.424
MOD_GlcNHglycan 739 742 PF01048 0.417
MOD_GSK3_1 10 17 PF00069 0.737
MOD_GSK3_1 151 158 PF00069 0.683
MOD_GSK3_1 18 25 PF00069 0.699
MOD_GSK3_1 234 241 PF00069 0.496
MOD_GSK3_1 263 270 PF00069 0.680
MOD_GSK3_1 331 338 PF00069 0.526
MOD_GSK3_1 345 352 PF00069 0.641
MOD_GSK3_1 447 454 PF00069 0.420
MOD_GSK3_1 475 482 PF00069 0.792
MOD_GSK3_1 510 517 PF00069 0.732
MOD_GSK3_1 54 61 PF00069 0.716
MOD_GSK3_1 549 556 PF00069 0.774
MOD_GSK3_1 622 629 PF00069 0.376
MOD_GSK3_1 67 74 PF00069 0.611
MOD_GSK3_1 685 692 PF00069 0.445
MOD_GSK3_1 763 770 PF00069 0.501
MOD_GSK3_1 88 95 PF00069 0.703
MOD_LATS_1 343 349 PF00433 0.712
MOD_N-GLC_1 518 523 PF02516 0.768
MOD_N-GLC_1 638 643 PF02516 0.501
MOD_N-GLC_1 663 668 PF02516 0.430
MOD_NEK2_1 1 6 PF00069 0.799
MOD_NEK2_1 153 158 PF00069 0.577
MOD_NEK2_1 175 180 PF00069 0.517
MOD_NEK2_1 281 286 PF00069 0.617
MOD_NEK2_1 369 374 PF00069 0.600
MOD_NEK2_1 446 451 PF00069 0.430
MOD_NEK2_1 492 497 PF00069 0.717
MOD_NEK2_1 507 512 PF00069 0.727
MOD_NEK2_1 553 558 PF00069 0.615
MOD_NEK2_1 599 604 PF00069 0.430
MOD_NEK2_1 60 65 PF00069 0.717
MOD_NEK2_1 754 759 PF00069 0.503
MOD_NEK2_1 782 787 PF00069 0.430
MOD_NEK2_2 271 276 PF00069 0.763
MOD_PIKK_1 204 210 PF00454 0.718
MOD_PIKK_1 25 31 PF00454 0.822
MOD_PIKK_1 389 395 PF00454 0.615
MOD_PIKK_1 565 571 PF00454 0.652
MOD_PIKK_1 58 64 PF00454 0.794
MOD_PIKK_1 71 77 PF00454 0.593
MOD_PK_1 451 457 PF00069 0.500
MOD_PKA_1 466 472 PF00069 0.646
MOD_PKA_1 483 489 PF00069 0.754
MOD_PKA_1 795 801 PF00069 0.376
MOD_PKA_2 154 160 PF00069 0.775
MOD_PKA_2 338 344 PF00069 0.627
MOD_PKA_2 466 472 PF00069 0.646
MOD_PKA_2 70 76 PF00069 0.737
MOD_PKA_2 795 801 PF00069 0.376
MOD_PKB_1 69 77 PF00069 0.819
MOD_Plk_1 181 187 PF00069 0.533
MOD_Plk_1 234 240 PF00069 0.490
MOD_Plk_1 518 524 PF00069 0.796
MOD_Plk_1 571 577 PF00069 0.557
MOD_Plk_1 604 610 PF00069 0.430
MOD_Plk_1 663 669 PF00069 0.430
MOD_Plk_1 754 760 PF00069 0.430
MOD_Plk_4 1 7 PF00069 0.736
MOD_Plk_4 175 181 PF00069 0.494
MOD_Plk_4 18 24 PF00069 0.626
MOD_Plk_4 319 325 PF00069 0.438
MOD_Plk_4 422 428 PF00069 0.430
MOD_Plk_4 556 562 PF00069 0.775
MOD_Plk_4 604 610 PF00069 0.430
MOD_Plk_4 724 730 PF00069 0.501
MOD_ProDKin_1 138 144 PF00069 0.556
MOD_ProDKin_1 155 161 PF00069 0.588
MOD_ProDKin_1 199 205 PF00069 0.676
MOD_ProDKin_1 22 28 PF00069 0.706
MOD_ProDKin_1 267 273 PF00069 0.783
MOD_ProDKin_1 510 516 PF00069 0.734
MOD_ProDKin_1 563 569 PF00069 0.674
MOD_ProDKin_1 626 632 PF00069 0.417
MOD_ProDKin_1 77 83 PF00069 0.745
MOD_SUMO_for_1 440 443 PF00179 0.376
MOD_SUMO_rev_2 486 492 PF00179 0.776
MOD_SUMO_rev_2 717 723 PF00179 0.444
TRG_DiLeu_BaLyEn_6 411 416 PF01217 0.480
TRG_ENDOCYTIC_2 125 128 PF00928 0.531
TRG_ENDOCYTIC_2 272 275 PF00928 0.765
TRG_ENDOCYTIC_2 408 411 PF00928 0.432
TRG_ENDOCYTIC_2 421 424 PF00928 0.297
TRG_ENDOCYTIC_2 578 581 PF00928 0.512
TRG_ENDOCYTIC_2 612 615 PF00928 0.392
TRG_ENDOCYTIC_2 619 622 PF00928 0.355
TRG_ENDOCYTIC_2 708 711 PF00928 0.376
TRG_ENDOCYTIC_2 791 794 PF00928 0.376
TRG_ER_diArg_1 136 138 PF00400 0.553
TRG_ER_diArg_1 402 405 PF00400 0.597
TRG_ER_diArg_1 465 467 PF00400 0.665
TRG_ER_diArg_1 786 788 PF00400 0.376
TRG_NES_CRM1_1 701 712 PF08389 0.501
TRG_NLS_Bipartite_1 466 487 PF00514 0.696
TRG_NLS_MonoExtC_3 343 349 PF00514 0.662
TRG_NLS_MonoExtC_3 482 488 PF00514 0.731
TRG_NLS_MonoExtN_4 342 348 PF00514 0.661

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMK2 Leptomonas seymouri 64% 93%
A0A3S7WZ58 Leishmania donovani 100% 94%
A0A422NL22 Trypanosoma rangeli 33% 100%
A4HEJ6 Leishmania braziliensis 83% 100%
E9AXN6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q9T5 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS