Mitochondrial RNA binding complex 1 subunit

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding complex 1 subunit - putative

Species:

Leishmania infantum

UniProt:

A4I1K0_LEIIN

TriTrypDb:

LINF_250021900

Length:

746

Annotations

Annotations by Jardim et al.

Nucleic acid binding, mitochondrial RNA binding complex 1 subunit Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I1K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1K0

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.349
CLV_C14_Caspase3-7	30	34	PF00656	0.682
CLV_NRD_NRD_1	181	183	PF00675	0.280
CLV_NRD_NRD_1	25	27	PF00675	0.724
CLV_NRD_NRD_1	254	256	PF00675	0.280
CLV_NRD_NRD_1	412	414	PF00675	0.280
CLV_NRD_NRD_1	573	575	PF00675	0.415
CLV_PCSK_KEX2_1	181	183	PF00082	0.280
CLV_PCSK_KEX2_1	25	27	PF00082	0.724
CLV_PCSK_KEX2_1	254	256	PF00082	0.280

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT36	Leptomonas seymouri	63%	100%
A0A1X0NYA6	Trypanosomatidae	52%	100%
A0A3R7MPK5	Trypanosoma rangeli	51%	100%
A0A3S7WZ63	Leishmania donovani	99%	100%
A4HEJ8	Leishmania braziliensis	84%	100%
C9ZK34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AXN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q9T7	Leishmania major	94%	100%
V5BHU4	Trypanosoma cruzi	51%	100%

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