Mitochondrial RNA binding complex 1 subunit

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding complex 1 subunit - putative

Species:

Leishmania infantum

UniProt:

A4I1K0_LEIIN

TriTrypDb:

LINF_250021900

Length:

746

Annotations

Annotations by Jardim et al.

Nucleic acid binding, mitochondrial RNA binding complex 1 subunit Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I1K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1K0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016553	base conversion or substitution editing	6	1
GO:0016554	cytidine to uridine editing	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.349
CLV_C14_Caspase3-7	30	34	PF00656	0.682
CLV_NRD_NRD_1	181	183	PF00675	0.280
CLV_NRD_NRD_1	25	27	PF00675	0.724
CLV_NRD_NRD_1	254	256	PF00675	0.280
CLV_NRD_NRD_1	412	414	PF00675	0.280
CLV_NRD_NRD_1	573	575	PF00675	0.415
CLV_PCSK_KEX2_1	181	183	PF00082	0.280
CLV_PCSK_KEX2_1	25	27	PF00082	0.724
CLV_PCSK_KEX2_1	254	256	PF00082	0.280
CLV_PCSK_KEX2_1	412	414	PF00082	0.280
CLV_PCSK_KEX2_1	573	575	PF00082	0.421
CLV_PCSK_PC7_1	408	414	PF00082	0.280
CLV_PCSK_SKI1_1	102	106	PF00082	0.280
CLV_PCSK_SKI1_1	191	195	PF00082	0.413
CLV_PCSK_SKI1_1	262	266	PF00082	0.332
CLV_PCSK_SKI1_1	603	607	PF00082	0.528
DOC_CYCLIN_yCln2_LP_2	169	175	PF00134	0.250
DOC_MAPK_gen_1	703	711	PF00069	0.385
DOC_MAPK_RevD_3	167	182	PF00069	0.347
DOC_PP1_RVXF_1	260	267	PF00149	0.332
DOC_PP4_FxxP_1	336	339	PF00568	0.280
DOC_PP4_FxxP_1	346	349	PF00568	0.280
DOC_PP4_FxxP_1	568	571	PF00568	0.396
DOC_USP7_MATH_1	120	124	PF00917	0.383
DOC_USP7_MATH_1	201	205	PF00917	0.211
DOC_USP7_MATH_1	230	234	PF00917	0.425
DOC_USP7_MATH_1	321	325	PF00917	0.267
DOC_USP7_MATH_1	439	443	PF00917	0.272
DOC_USP7_MATH_1	545	549	PF00917	0.379
DOC_USP7_MATH_1	563	567	PF00917	0.496
DOC_USP7_MATH_1	572	576	PF00917	0.410
DOC_USP7_MATH_1	85	89	PF00917	0.375
DOC_WW_Pin1_4	157	162	PF00397	0.370
DOC_WW_Pin1_4	335	340	PF00397	0.279
DOC_WW_Pin1_4	418	423	PF00397	0.280
LIG_14-3-3_CanoR_1	107	112	PF00244	0.420
LIG_14-3-3_CanoR_1	573	577	PF00244	0.480
LIG_14-3-3_CanoR_1	737	742	PF00244	0.411
LIG_Actin_WH2_2	689	707	PF00022	0.403
LIG_AP2alpha_2	132	134	PF02296	0.280
LIG_APCC_ABBA_1	270	275	PF00400	0.411
LIG_APCC_ABBAyCdc20_2	262	268	PF00400	0.211
LIG_APCC_ABBAyCdc20_2	574	580	PF00400	0.487
LIG_BIR_II_1	1	5	PF00653	0.583
LIG_BIR_III_4	440	444	PF00653	0.280
LIG_BRCT_BRCA1_1	122	126	PF00533	0.360
LIG_BRCT_BRCA1_1	65	69	PF00533	0.759
LIG_Clathr_ClatBox_1	83	87	PF01394	0.347
LIG_deltaCOP1_diTrp_1	238	245	PF00928	0.347
LIG_deltaCOP1_diTrp_1	304	310	PF00928	0.308
LIG_EH1_1	504	512	PF00400	0.280
LIG_FHA_1	106	112	PF00498	0.323
LIG_FHA_1	148	154	PF00498	0.327
LIG_FHA_1	343	349	PF00498	0.323
LIG_FHA_1	394	400	PF00498	0.339
LIG_FHA_1	432	438	PF00498	0.344
LIG_FHA_1	458	464	PF00498	0.425
LIG_FHA_1	490	496	PF00498	0.267
LIG_FHA_2	623	629	PF00498	0.495
LIG_HP1_1	82	86	PF01393	0.347
LIG_Integrin_isoDGR_2	601	603	PF01839	0.470
LIG_LIR_Apic_2	345	349	PF02991	0.277
LIG_LIR_Apic_2	565	571	PF02991	0.421
LIG_LIR_Gen_1	123	134	PF02991	0.308
LIG_LIR_Gen_1	237	247	PF02991	0.371
LIG_LIR_Gen_1	304	315	PF02991	0.308
LIG_LIR_Gen_1	396	405	PF02991	0.353
LIG_LIR_Gen_1	96	104	PF02991	0.345
LIG_LIR_Nem_3	123	129	PF02991	0.308
LIG_LIR_Nem_3	237	243	PF02991	0.371
LIG_LIR_Nem_3	304	310	PF02991	0.308
LIG_LIR_Nem_3	396	400	PF02991	0.353
LIG_LIR_Nem_3	580	585	PF02991	0.388
LIG_LIR_Nem_3	691	696	PF02991	0.347
LIG_LIR_Nem_3	715	720	PF02991	0.346
LIG_LIR_Nem_3	96	101	PF02991	0.358
LIG_PCNA_yPIPBox_3	486	495	PF02747	0.377
LIG_Pex14_1	240	244	PF04695	0.425
LIG_PTB_Apo_2	423	430	PF02174	0.280
LIG_PTB_Phospho_1	423	429	PF10480	0.425
LIG_Rb_pABgroove_1	641	649	PF01858	0.317
LIG_SH2_CRK	98	102	PF00017	0.381
LIG_SH2_NCK_1	387	391	PF00017	0.300
LIG_SH2_SRC	31	34	PF00017	0.702
LIG_SH2_STAP1	31	35	PF00017	0.684
LIG_SH2_STAP1	578	582	PF00017	0.503
LIG_SH2_STAT5	244	247	PF00017	0.425
LIG_SH2_STAT5	519	522	PF00017	0.280
LIG_SH2_STAT5	717	720	PF00017	0.325
LIG_SH3_3	130	136	PF00018	0.280
LIG_SH3_3	139	145	PF00018	0.280
LIG_SH3_3	169	175	PF00018	0.405
LIG_SH3_3	244	250	PF00018	0.280
LIG_SH3_3	396	402	PF00018	0.300
LIG_SH3_3	76	82	PF00018	0.567
LIG_SUMO_SIM_anti_2	508	514	PF11976	0.280
LIG_SUMO_SIM_anti_2	524	530	PF11976	0.280
LIG_SUMO_SIM_par_1	459	469	PF11976	0.277
LIG_SUMO_SIM_par_1	82	88	PF11976	0.347
LIG_TRFH_1	568	572	PF08558	0.473
LIG_WRC_WIRS_1	86	91	PF05994	0.392
LIG_WW_2	79	82	PF00397	0.567
LIG_WW_3	570	574	PF00397	0.501
MOD_CK1_1	156	162	PF00069	0.336
MOD_CK1_1	329	335	PF00069	0.298
MOD_CK1_1	338	344	PF00069	0.292
MOD_CK1_1	442	448	PF00069	0.297
MOD_CK1_1	54	60	PF00069	0.721
MOD_CK1_1	688	694	PF00069	0.376
MOD_CK1_1	96	102	PF00069	0.435
MOD_CK2_1	622	628	PF00069	0.342
MOD_Cter_Amidation	252	255	PF01082	0.280
MOD_GlcNHglycan	155	158	PF01048	0.428
MOD_GlcNHglycan	197	200	PF01048	0.313
MOD_GlcNHglycan	203	206	PF01048	0.298
MOD_GlcNHglycan	219	222	PF01048	0.300
MOD_GlcNHglycan	328	331	PF01048	0.348
MOD_GlcNHglycan	350	353	PF01048	0.280
MOD_GlcNHglycan	355	358	PF01048	0.280
MOD_GlcNHglycan	440	444	PF01048	0.270
MOD_GlcNHglycan	465	471	PF01048	0.383
MOD_GlcNHglycan	515	518	PF01048	0.287
MOD_GlcNHglycan	558	561	PF01048	0.549
MOD_GlcNHglycan	56	59	PF01048	0.726
MOD_GlcNHglycan	565	568	PF01048	0.410
MOD_GlcNHglycan	607	610	PF01048	0.339
MOD_GlcNHglycan	648	651	PF01048	0.467
MOD_GlcNHglycan	65	68	PF01048	0.693
MOD_GSK3_1	105	112	PF00069	0.285
MOD_GSK3_1	149	156	PF00069	0.363
MOD_GSK3_1	230	237	PF00069	0.425
MOD_GSK3_1	334	341	PF00069	0.295
MOD_GSK3_1	418	425	PF00069	0.373
MOD_GSK3_1	431	438	PF00069	0.208
MOD_GSK3_1	439	446	PF00069	0.095
MOD_GSK3_1	59	66	PF00069	0.673
MOD_GSK3_1	737	744	PF00069	0.440
MOD_N-GLC_1	201	206	PF02516	0.384
MOD_N-GLC_1	230	235	PF02516	0.304
MOD_N-GLC_1	431	436	PF02516	0.419
MOD_N-GLC_1	622	627	PF02516	0.491
MOD_N-GLC_1	688	693	PF02516	0.444
MOD_N-GLC_1	96	101	PF02516	0.365
MOD_NEK2_1	153	158	PF00069	0.379
MOD_NEK2_1	342	347	PF00069	0.269
MOD_NEK2_1	457	462	PF00069	0.392
MOD_NEK2_1	556	561	PF00069	0.547
MOD_NEK2_1	646	651	PF00069	0.441
MOD_NEK2_1	720	725	PF00069	0.229
MOD_NEK2_1	741	746	PF00069	0.466
MOD_NEK2_2	120	125	PF00069	0.425
MOD_PIKK_1	135	141	PF00454	0.280
MOD_PIKK_1	210	216	PF00454	0.280
MOD_PIKK_1	255	261	PF00454	0.328
MOD_PIKK_1	443	449	PF00454	0.273
MOD_PIKK_1	484	490	PF00454	0.430
MOD_PIKK_1	586	592	PF00454	0.595
MOD_PIKK_1	70	76	PF00454	0.486
MOD_PIKK_1	96	102	PF00454	0.425
MOD_PK_1	673	679	PF00069	0.507
MOD_PKA_2	27	33	PF00069	0.734
MOD_PKA_2	572	578	PF00069	0.482
MOD_PKA_2	586	592	PF00069	0.515
MOD_PKA_2	63	69	PF00069	0.682
MOD_PKB_1	51	59	PF00069	0.685
MOD_Plk_1	431	437	PF00069	0.392
MOD_Plk_1	622	628	PF00069	0.360
MOD_Plk_1	96	102	PF00069	0.365
MOD_Plk_4	149	155	PF00069	0.211
MOD_Plk_4	329	335	PF00069	0.364
MOD_Plk_4	362	368	PF00069	0.300
MOD_Plk_4	374	380	PF00069	0.280
MOD_Plk_4	458	464	PF00069	0.411
MOD_Plk_4	505	511	PF00069	0.281
MOD_Plk_4	622	628	PF00069	0.333
MOD_Plk_4	667	673	PF00069	0.476
MOD_Plk_4	85	91	PF00069	0.364
MOD_ProDKin_1	157	163	PF00069	0.370
MOD_ProDKin_1	335	341	PF00069	0.279
MOD_ProDKin_1	418	424	PF00069	0.280
TRG_ENDOCYTIC_2	244	247	PF00928	0.392
TRG_ENDOCYTIC_2	387	390	PF00928	0.300
TRG_ENDOCYTIC_2	519	522	PF00928	0.347
TRG_ENDOCYTIC_2	717	720	PF00928	0.353
TRG_ENDOCYTIC_2	98	101	PF00928	0.330
TRG_ER_diArg_1	181	183	PF00400	0.281
TRG_ER_diArg_1	24	26	PF00400	0.718
TRG_ER_diArg_1	254	256	PF00400	0.280
TRG_ER_diArg_1	572	574	PF00400	0.434
TRG_NES_CRM1_1	635	648	PF08389	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT36	Leptomonas seymouri	63%	100%
A0A1X0NYA6	Trypanosomatidae	52%	100%
A0A3R7MPK5	Trypanosoma rangeli	51%	100%
A0A3S7WZ63	Leishmania donovani	99%	100%
A4HEJ8	Leishmania braziliensis	84%	100%
C9ZK34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AXN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q9T7	Leishmania major	94%	100%
V5BHU4	Trypanosoma cruzi	51%	100%