Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4I1J8_LEIIN

TriTrypDb:

LINF_250021700

Length:

940

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I1J8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1J8

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.691
CLV_NRD_NRD_1	512	514	PF00675	0.346
CLV_NRD_NRD_1	919	921	PF00675	0.765
CLV_NRD_NRD_1	93	95	PF00675	0.621
CLV_PCSK_KEX2_1	512	514	PF00082	0.346
CLV_PCSK_KEX2_1	6	8	PF00082	0.682
CLV_PCSK_KEX2_1	720	722	PF00082	0.335
CLV_PCSK_KEX2_1	919	921	PF00082	0.704
CLV_PCSK_KEX2_1	93	95	PF00082	0.624
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.682
CLV_PCSK_PC1ET2_1	720	722	PF00082	0.313
CLV_PCSK_SKI1_1	538	542	PF00082	0.335
CLV_PCSK_SKI1_1	585	589	PF00082	0.344
CLV_PCSK_SKI1_1	590	594	PF00082	0.335
CLV_Separin_Metazoa	705	709	PF03568	0.389
DEG_Nend_UBRbox_3	1	3	PF02207	0.766
DEG_SPOP_SBC_1	812	816	PF00917	0.611
DEG_SPOP_SBC_1	859	863	PF00917	0.699
DOC_ANK_TNKS_1	92	99	PF00023	0.630
DOC_CDC14_PxL_1	358	366	PF14671	0.558
DOC_CYCLIN_RxL_1	535	545	PF00134	0.335
DOC_CYCLIN_yCln2_LP_2	234	237	PF00134	0.663
DOC_MAPK_DCC_7	603	611	PF00069	0.313
DOC_MAPK_gen_1	590	599	PF00069	0.335
DOC_MAPK_gen_1	603	611	PF00069	0.313
DOC_MAPK_gen_1	919	925	PF00069	0.762
DOC_MAPK_JIP1_4	593	599	PF00069	0.335
DOC_MAPK_MEF2A_6	603	611	PF00069	0.313
DOC_PP2B_LxvP_1	234	237	PF13499	0.694
DOC_PP2B_LxvP_1	315	318	PF13499	0.551
DOC_PP2B_LxvP_1	874	877	PF13499	0.767
DOC_PP4_FxxP_1	533	536	PF00568	0.335
DOC_USP7_MATH_1	107	111	PF00917	0.597
DOC_USP7_MATH_1	114	118	PF00917	0.616
DOC_USP7_MATH_1	120	124	PF00917	0.692
DOC_USP7_MATH_1	227	231	PF00917	0.703
DOC_USP7_MATH_1	306	310	PF00917	0.708
DOC_USP7_MATH_1	363	367	PF00917	0.666
DOC_USP7_MATH_1	60	64	PF00917	0.667
DOC_USP7_MATH_1	695	699	PF00917	0.453
DOC_USP7_MATH_1	73	77	PF00917	0.588
DOC_USP7_MATH_1	859	863	PF00917	0.671
DOC_USP7_MATH_1	877	881	PF00917	0.560
DOC_USP7_MATH_1	89	93	PF00917	0.554
DOC_WW_Pin1_4	172	177	PF00397	0.734
DOC_WW_Pin1_4	225	230	PF00397	0.689
DOC_WW_Pin1_4	250	255	PF00397	0.729
DOC_WW_Pin1_4	338	343	PF00397	0.634
DOC_WW_Pin1_4	39	44	PF00397	0.628
DOC_WW_Pin1_4	424	429	PF00397	0.684
DOC_WW_Pin1_4	431	436	PF00397	0.528
DOC_WW_Pin1_4	440	445	PF00397	0.581
DOC_WW_Pin1_4	46	51	PF00397	0.618
DOC_WW_Pin1_4	62	67	PF00397	0.479
DOC_WW_Pin1_4	644	649	PF00397	0.306
DOC_WW_Pin1_4	727	732	PF00397	0.335
DOC_WW_Pin1_4	759	764	PF00397	0.612
DOC_WW_Pin1_4	797	802	PF00397	0.670
DOC_WW_Pin1_4	865	870	PF00397	0.757
DOC_WW_Pin1_4	912	917	PF00397	0.620
LIG_14-3-3_CanoR_1	221	229	PF00244	0.753
LIG_14-3-3_CanoR_1	275	282	PF00244	0.596
LIG_14-3-3_CanoR_1	327	332	PF00244	0.638
LIG_14-3-3_CanoR_1	696	704	PF00244	0.313
LIG_14-3-3_CanoR_1	878	883	PF00244	0.749
LIG_Actin_WH2_2	472	489	PF00022	0.335
LIG_APCC_ABBAyCdc20_2	585	591	PF00400	0.335
LIG_BRCT_BRCA1_1	308	312	PF00533	0.727
LIG_BRCT_BRCA1_1	906	910	PF00533	0.578
LIG_CtBP_PxDLS_1	182	186	PF00389	0.737
LIG_eIF4E_1	338	344	PF01652	0.691
LIG_eIF4E_1	636	642	PF01652	0.335
LIG_EVH1_2	316	320	PF00568	0.690
LIG_FHA_1	132	138	PF00498	0.567
LIG_FHA_1	185	191	PF00498	0.555
LIG_FHA_1	563	569	PF00498	0.335
LIG_FHA_1	577	583	PF00498	0.335
LIG_FHA_1	614	620	PF00498	0.335
LIG_FHA_1	629	635	PF00498	0.335
LIG_FHA_1	925	931	PF00498	0.606
LIG_FHA_2	36	42	PF00498	0.708
LIG_FHA_2	414	420	PF00498	0.766
LIG_FHA_2	552	558	PF00498	0.421
LIG_FHA_2	825	831	PF00498	0.710
LIG_FHA_2	846	852	PF00498	0.617
LIG_KLC1_Yacidic_2	553	557	PF13176	0.405
LIG_LIR_Apic_2	390	394	PF02991	0.695
LIG_LIR_Apic_2	532	536	PF02991	0.335
LIG_LIR_Apic_2	633	639	PF02991	0.335
LIG_LIR_Nem_3	175	180	PF02991	0.732
LIG_LIR_Nem_3	212	216	PF02991	0.627
LIG_LIR_Nem_3	309	315	PF02991	0.651
LIG_LIR_Nem_3	465	469	PF02991	0.335
LIG_MLH1_MIPbox_1	308	312	PF16413	0.727
LIG_MYND_1	232	236	PF01753	0.720
LIG_MYND_1	46	50	PF01753	0.690
LIG_PAM2_1	561	573	PF00658	0.335
LIG_REV1ctd_RIR_1	211	219	PF16727	0.604
LIG_SH2_CRK	171	175	PF00017	0.715
LIG_SH2_CRK	177	181	PF00017	0.685
LIG_SH2_CRK	466	470	PF00017	0.335
LIG_SH2_GRB2like	655	658	PF00017	0.335
LIG_SH2_NCK_1	546	550	PF00017	0.453
LIG_SH2_PTP2	391	394	PF00017	0.695
LIG_SH2_SRC	29	32	PF00017	0.613
LIG_SH2_SRC	655	658	PF00017	0.453
LIG_SH2_STAP1	389	393	PF00017	0.635
LIG_SH2_STAT5	257	260	PF00017	0.771
LIG_SH2_STAT5	296	299	PF00017	0.732
LIG_SH2_STAT5	311	314	PF00017	0.495
LIG_SH2_STAT5	391	394	PF00017	0.695
LIG_SH2_STAT5	454	457	PF00017	0.335
LIG_SH2_STAT5	470	473	PF00017	0.335
LIG_SH2_STAT5	497	500	PF00017	0.335
LIG_SH2_STAT5	555	558	PF00017	0.338
LIG_SH2_STAT5	570	573	PF00017	0.335
LIG_SH2_STAT5	655	658	PF00017	0.335
LIG_SH2_STAT5	674	677	PF00017	0.340
LIG_SH3_1	40	46	PF00018	0.705
LIG_SH3_1	873	879	PF00018	0.775
LIG_SH3_3	138	144	PF00018	0.666
LIG_SH3_3	19	25	PF00018	0.658
LIG_SH3_3	204	210	PF00018	0.648
LIG_SH3_3	226	232	PF00018	0.622
LIG_SH3_3	297	303	PF00018	0.653
LIG_SH3_3	40	46	PF00018	0.705
LIG_SH3_3	433	439	PF00018	0.630
LIG_SH3_3	769	775	PF00018	0.676
LIG_SH3_3	873	879	PF00018	0.760
LIG_SH3_CIN85_PxpxPR_1	778	783	PF14604	0.663
LIG_SUMO_SIM_anti_2	838	845	PF11976	0.734
LIG_SUMO_SIM_par_1	181	188	PF11976	0.615
LIG_SUMO_SIM_par_1	330	337	PF11976	0.625
LIG_SUMO_SIM_par_1	847	854	PF11976	0.653
LIG_SUMO_SIM_par_1	927	934	PF11976	0.746
LIG_TRAF2_1	154	157	PF00917	0.629
LIG_TRFH_1	358	362	PF08558	0.669
LIG_TYR_ITIM	568	573	PF00017	0.335
LIG_UBA3_1	713	720	PF00899	0.349
LIG_UBA3_1	736	742	PF00899	0.583
LIG_WW_1	26	29	PF00397	0.590
LIG_WW_3	605	609	PF00397	0.335
LIG_WW_3	771	775	PF00397	0.641
LIG_WW_3	875	879	PF00397	0.770
MOD_CDC14_SPxK_1	917	920	PF00782	0.702
MOD_CDK_SPK_2	250	255	PF00069	0.630
MOD_CDK_SPK_2	343	348	PF00069	0.698
MOD_CDK_SPK_2	644	649	PF00069	0.310
MOD_CDK_SPK_2	797	802	PF00069	0.663
MOD_CDK_SPK_2	914	919	PF00069	0.697
MOD_CDK_SPxK_1	914	920	PF00069	0.699
MOD_CDK_SPxxK_3	172	179	PF00069	0.737
MOD_CDK_SPxxK_3	912	919	PF00069	0.696
MOD_CK1_1	172	178	PF00069	0.706
MOD_CK1_1	184	190	PF00069	0.551
MOD_CK1_1	274	280	PF00069	0.626
MOD_CK1_1	287	293	PF00069	0.695
MOD_CK1_1	35	41	PF00069	0.726
MOD_CK1_1	375	381	PF00069	0.617
MOD_CK1_1	413	419	PF00069	0.701
MOD_CK1_1	429	435	PF00069	0.630
MOD_CK1_1	49	55	PF00069	0.614
MOD_CK1_1	548	554	PF00069	0.335
MOD_CK1_1	628	634	PF00069	0.335
MOD_CK1_1	72	78	PF00069	0.711
MOD_CK1_1	759	765	PF00069	0.643
MOD_CK1_1	814	820	PF00069	0.614
MOD_CK1_1	845	851	PF00069	0.605
MOD_CK1_1	861	867	PF00069	0.776
MOD_CK1_1	906	912	PF00069	0.637
MOD_CK2_1	35	41	PF00069	0.628
MOD_CK2_1	413	419	PF00069	0.762
MOD_CK2_1	520	526	PF00069	0.335
MOD_CK2_1	551	557	PF00069	0.421
MOD_CK2_1	824	830	PF00069	0.715
MOD_CK2_1	836	842	PF00069	0.559
MOD_GlcNHglycan	134	137	PF01048	0.676
MOD_GlcNHglycan	141	144	PF01048	0.566
MOD_GlcNHglycan	171	174	PF01048	0.716
MOD_GlcNHglycan	292	295	PF01048	0.709
MOD_GlcNHglycan	329	332	PF01048	0.675
MOD_GlcNHglycan	375	378	PF01048	0.590
MOD_GlcNHglycan	431	434	PF01048	0.647
MOD_GlcNHglycan	53	56	PF01048	0.605
MOD_GlcNHglycan	547	550	PF01048	0.335
MOD_GlcNHglycan	626	630	PF01048	0.335
MOD_GlcNHglycan	697	700	PF01048	0.507
MOD_GlcNHglycan	71	74	PF01048	0.774
MOD_GlcNHglycan	758	761	PF01048	0.674
MOD_GlcNHglycan	763	766	PF01048	0.684
MOD_GlcNHglycan	783	786	PF01048	0.665
MOD_GlcNHglycan	844	847	PF01048	0.756
MOD_GlcNHglycan	86	90	PF01048	0.555
MOD_GSK3_1	216	223	PF00069	0.625
MOD_GSK3_1	271	278	PF00069	0.583
MOD_GSK3_1	283	290	PF00069	0.732
MOD_GSK3_1	35	42	PF00069	0.711
MOD_GSK3_1	395	402	PF00069	0.708
MOD_GSK3_1	409	416	PF00069	0.555
MOD_GSK3_1	431	438	PF00069	0.648
MOD_GSK3_1	493	500	PF00069	0.453
MOD_GSK3_1	572	579	PF00069	0.435
MOD_GSK3_1	609	616	PF00069	0.335
MOD_GSK3_1	660	667	PF00069	0.344
MOD_GSK3_1	68	75	PF00069	0.621
MOD_GSK3_1	791	798	PF00069	0.790
MOD_GSK3_1	832	839	PF00069	0.716
MOD_GSK3_1	85	92	PF00069	0.649
MOD_GSK3_1	858	865	PF00069	0.804
MOD_GSK3_1	877	884	PF00069	0.528
MOD_GSK3_1	900	907	PF00069	0.631
MOD_GSK3_1	910	917	PF00069	0.569
MOD_LATS_1	31	37	PF00433	0.715
MOD_N-GLC_1	290	295	PF02516	0.741
MOD_N-GLC_1	373	378	PF02516	0.634
MOD_N-GLC_1	561	566	PF02516	0.389
MOD_N-GLC_1	865	870	PF02516	0.712
MOD_NEK2_1	131	136	PF00069	0.588
MOD_NEK2_1	271	276	PF00069	0.671
MOD_NEK2_1	282	287	PF00069	0.487
MOD_NEK2_1	571	576	PF00069	0.349
MOD_NEK2_1	641	646	PF00069	0.459
MOD_NEK2_1	68	73	PF00069	0.670
MOD_NEK2_1	732	737	PF00069	0.541
MOD_NEK2_1	758	763	PF00069	0.618
MOD_NEK2_1	836	841	PF00069	0.636
MOD_NEK2_1	844	849	PF00069	0.623
MOD_NEK2_1	904	909	PF00069	0.625
MOD_PIKK_1	399	405	PF00454	0.681
MOD_PIKK_1	743	749	PF00454	0.528
MOD_PIKK_1	814	820	PF00454	0.689
MOD_PIKK_1	881	887	PF00454	0.700
MOD_PK_1	221	227	PF00069	0.669
MOD_PKA_2	220	226	PF00069	0.744
MOD_PKA_2	274	280	PF00069	0.669
MOD_PKA_2	32	38	PF00069	0.759
MOD_PKA_2	462	468	PF00069	0.335
MOD_PKA_2	695	701	PF00069	0.389
MOD_PKA_2	877	883	PF00069	0.633
MOD_Plk_1	561	567	PF00069	0.389
MOD_Plk_1	743	749	PF00069	0.518
MOD_Plk_2-3	791	797	PF00069	0.751
MOD_Plk_4	209	215	PF00069	0.683
MOD_Plk_4	316	322	PF00069	0.703
MOD_Plk_4	375	381	PF00069	0.727
MOD_Plk_4	387	393	PF00069	0.534
MOD_Plk_4	493	499	PF00069	0.355
MOD_Plk_4	520	526	PF00069	0.335
MOD_Plk_4	551	557	PF00069	0.421
MOD_Plk_4	732	738	PF00069	0.431
MOD_Plk_4	845	851	PF00069	0.603
MOD_Plk_4	878	884	PF00069	0.653
MOD_ProDKin_1	172	178	PF00069	0.734
MOD_ProDKin_1	225	231	PF00069	0.690
MOD_ProDKin_1	250	256	PF00069	0.729
MOD_ProDKin_1	338	344	PF00069	0.636
MOD_ProDKin_1	39	45	PF00069	0.629
MOD_ProDKin_1	424	430	PF00069	0.684
MOD_ProDKin_1	431	437	PF00069	0.529
MOD_ProDKin_1	440	446	PF00069	0.571
MOD_ProDKin_1	46	52	PF00069	0.618
MOD_ProDKin_1	62	68	PF00069	0.481
MOD_ProDKin_1	644	650	PF00069	0.306
MOD_ProDKin_1	727	733	PF00069	0.335
MOD_ProDKin_1	759	765	PF00069	0.618
MOD_ProDKin_1	797	803	PF00069	0.669
MOD_ProDKin_1	865	871	PF00069	0.758
MOD_ProDKin_1	912	918	PF00069	0.619
MOD_SUMO_rev_2	155	161	PF00179	0.622
MOD_SUMO_rev_2	346	352	PF00179	0.572
MOD_SUMO_rev_2	825	833	PF00179	0.674
TRG_DiLeu_BaEn_1	705	710	PF01217	0.335
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.691
TRG_DiLeu_BaLyEn_6	402	407	PF01217	0.669
TRG_DiLeu_LyEn_5	705	710	PF01217	0.389
TRG_ENDOCYTIC_2	10	13	PF00928	0.787
TRG_ENDOCYTIC_2	177	180	PF00928	0.626
TRG_ENDOCYTIC_2	198	201	PF00928	0.696
TRG_ENDOCYTIC_2	389	392	PF00928	0.698
TRG_ENDOCYTIC_2	466	469	PF00928	0.335
TRG_ENDOCYTIC_2	570	573	PF00928	0.335
TRG_ENDOCYTIC_2	674	677	PF00928	0.453
TRG_ER_diArg_1	511	513	PF00400	0.346
TRG_ER_diArg_1	918	920	PF00400	0.704
TRG_NES_CRM1_1	705	717	PF08389	0.335
TRG_NLS_MonoCore_2	719	724	PF00514	0.313
TRG_NLS_MonoExtN_4	718	724	PF00514	0.389
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.686
TRG_Pf-PMV_PEXEL_1	506	510	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	590	595	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	608	613	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I119	Leptomonas seymouri	48%	99%
A0A3Q8IFC6	Leishmania donovani	99%	100%
A4HEK0	Leishmania braziliensis	74%	100%
E9AXN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q9T9	Leishmania major	91%	100%