LeishMANIAdb
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Clusterin-associated protein 1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Clusterin-associated protein 1
Gene product:
Putative intraflagellar transport protein A1
Species:
Leishmania infantum
UniProt:
A4I1I7_LEIIN
TriTrypDb:
LINF_250020500
Length:
487

Annotations

Annotations by Jardim et al.

Flagella, intraflagellar transport A1 (PIFTA1) Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005929 cilium 4 9
GO:0042995 cell projection 2 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0110165 cellular anatomical entity 1 9
GO:0120025 plasma membrane bounded cell projection 3 9
GO:0005813 centrosome 3 1
GO:0005815 microtubule organizing center 2 1
GO:0030990 intraciliary transport particle 2 1
GO:0030992 intraciliary transport particle B 2 1
GO:0032991 protein-containing complex 1 1
GO:0031514 motile cilium 5 1

Expansion

Sequence features

A4I1I7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1I7

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 9
GO:0016043 cellular component organization 3 9
GO:0030030 cell projection organization 4 9
GO:0071840 cellular component organization or biogenesis 2 9
GO:0006810 transport 3 1
GO:0006996 organelle organization 4 1
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
GO:0010970 transport along microtubule 4 1
GO:0022607 cellular component assembly 4 1
GO:0030031 cell projection assembly 5 1
GO:0030705 cytoskeleton-dependent intracellular transport 4 1
GO:0031503 protein-containing complex localization 2 1
GO:0035720 intraciliary anterograde transport 4 1
GO:0035735 intraciliary transport involved in cilium assembly 4 1
GO:0042073 intraciliary transport 3 1
GO:0044782 cilium organization 5 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0060271 cilium assembly 6 1
GO:0070925 organelle assembly 5 1
GO:0099111 microtubule-based transport 4 1
GO:0120031 plasma membrane bounded cell projection assembly 6 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 455 459 PF00656 0.777
CLV_NRD_NRD_1 179 181 PF00675 0.391
CLV_NRD_NRD_1 294 296 PF00675 0.547
CLV_NRD_NRD_1 309 311 PF00675 0.655
CLV_NRD_NRD_1 314 316 PF00675 0.811
CLV_NRD_NRD_1 385 387 PF00675 0.794
CLV_NRD_NRD_1 423 425 PF00675 0.763
CLV_PCSK_KEX2_1 179 181 PF00082 0.391
CLV_PCSK_KEX2_1 309 311 PF00082 0.784
CLV_PCSK_KEX2_1 314 316 PF00082 0.791
CLV_PCSK_KEX2_1 384 386 PF00082 0.748
CLV_PCSK_KEX2_1 423 425 PF00082 0.763
CLV_PCSK_PC7_1 310 316 PF00082 0.802
CLV_PCSK_SKI1_1 106 110 PF00082 0.438
CLV_PCSK_SKI1_1 182 186 PF00082 0.335
CLV_PCSK_SKI1_1 426 430 PF00082 0.810
DEG_APCC_DBOX_1 181 189 PF00400 0.357
DEG_Kelch_Keap1_1 465 470 PF01344 0.720
DEG_SCF_FBW7_1 322 327 PF00400 0.798
DOC_CDC14_PxL_1 15 23 PF14671 0.357
DOC_CYCLIN_RxL_1 179 189 PF00134 0.397
DOC_CYCLIN_RxL_1 257 266 PF00134 0.438
DOC_MAPK_gen_1 76 83 PF00069 0.342
DOC_MAPK_MEF2A_6 76 83 PF00069 0.344
DOC_MAPK_NFAT4_5 76 84 PF00069 0.391
DOC_PP1_RVXF_1 258 265 PF00149 0.438
DOC_PP1_RVXF_1 60 66 PF00149 0.357
DOC_PP4_FxxP_1 27 30 PF00568 0.357
DOC_USP7_MATH_1 145 149 PF00917 0.415
DOC_USP7_MATH_1 204 208 PF00917 0.422
DOC_USP7_MATH_1 324 328 PF00917 0.671
DOC_USP7_MATH_1 403 407 PF00917 0.745
DOC_USP7_MATH_1 448 452 PF00917 0.739
DOC_USP7_MATH_1 457 461 PF00917 0.700
DOC_USP7_MATH_2 448 454 PF00917 0.719
DOC_USP7_UBL2_3 105 109 PF12436 0.391
DOC_USP7_UBL2_3 212 216 PF12436 0.357
DOC_USP7_UBL2_3 271 275 PF12436 0.492
DOC_USP7_UBL2_3 296 300 PF12436 0.598
DOC_USP7_UBL2_3 76 80 PF12436 0.357
DOC_WW_Pin1_4 320 325 PF00397 0.801
LIG_14-3-3_CanoR_1 170 177 PF00244 0.342
LIG_14-3-3_CanoR_1 62 66 PF00244 0.391
LIG_14-3-3_CanoR_1 7 16 PF00244 0.482
LIG_Actin_WH2_2 287 302 PF00022 0.637
LIG_Actin_WH2_2 90 107 PF00022 0.357
LIG_BIR_II_1 1 5 PF00653 0.484
LIG_BRCT_BRCA1_1 147 151 PF00533 0.357
LIG_BRCT_BRCA1_1 467 471 PF00533 0.737
LIG_Clathr_ClatBox_1 21 25 PF01394 0.357
LIG_EH1_1 91 99 PF00400 0.438
LIG_FHA_1 10 16 PF00498 0.418
LIG_FHA_1 187 193 PF00498 0.369
LIG_FHA_1 51 57 PF00498 0.417
LIG_FHA_2 109 115 PF00498 0.391
LIG_FHA_2 358 364 PF00498 0.766
LIG_FHA_2 42 48 PF00498 0.415
LIG_GBD_Chelix_1 100 108 PF00786 0.357
LIG_Integrin_RGD_1 161 163 PF01839 0.492
LIG_LIR_Apic_2 25 30 PF02991 0.357
LIG_LIR_Gen_1 115 126 PF02991 0.391
LIG_LIR_Nem_3 115 121 PF02991 0.372
LIG_LIR_Nem_3 148 154 PF02991 0.350
LIG_LIR_Nem_3 2 6 PF02991 0.458
LIG_LIR_Nem_3 257 262 PF02991 0.365
LIG_LIR_Nem_3 64 69 PF02991 0.438
LIG_LYPXL_yS_3 18 21 PF13949 0.357
LIG_MLH1_MIPbox_1 148 152 PF16413 0.391
LIG_NRBOX 180 186 PF00104 0.391
LIG_PDZ_Class_1 482 487 PF00595 0.673
LIG_PTB_Apo_2 231 238 PF02174 0.438
LIG_PTB_Apo_2 258 265 PF02174 0.357
LIG_REV1ctd_RIR_1 63 71 PF16727 0.358
LIG_SH2_GRB2like 241 244 PF00017 0.438
LIG_SH2_GRB2like 334 337 PF00017 0.680
LIG_SH2_NCK_1 334 338 PF00017 0.679
LIG_SH2_SRC 241 244 PF00017 0.422
LIG_SH2_SRC 334 337 PF00017 0.680
LIG_SH2_SRC 46 49 PF00017 0.357
LIG_SH2_STAT3 255 258 PF00017 0.357
LIG_SH2_STAT5 255 258 PF00017 0.357
LIG_TRAF2_1 349 352 PF00917 0.736
LIG_TRAF2_1 93 96 PF00917 0.357
LIG_TYR_ITIM 16 21 PF00017 0.357
LIG_UBA3_1 97 105 PF00899 0.357
LIG_WRC_WIRS_1 24 29 PF05994 0.304
LIG_WRC_WIRS_1 6 11 PF05994 0.416
MOD_CK1_1 141 147 PF00069 0.364
MOD_CK1_1 169 175 PF00069 0.342
MOD_CK1_1 23 29 PF00069 0.357
MOD_CK1_1 451 457 PF00069 0.699
MOD_CK1_1 460 466 PF00069 0.611
MOD_CK1_1 473 479 PF00069 0.600
MOD_CK2_1 108 114 PF00069 0.391
MOD_CK2_1 200 206 PF00069 0.393
MOD_CK2_1 23 29 PF00069 0.357
MOD_CK2_1 324 330 PF00069 0.747
MOD_CK2_1 352 358 PF00069 0.767
MOD_CK2_1 41 47 PF00069 0.438
MOD_CK2_1 450 456 PF00069 0.802
MOD_CK2_1 464 470 PF00069 0.576
MOD_CK2_1 5 11 PF00069 0.419
MOD_Cter_Amidation 312 315 PF01082 0.813
MOD_GlcNHglycan 202 205 PF01048 0.438
MOD_GlcNHglycan 228 231 PF01048 0.391
MOD_GlcNHglycan 311 314 PF01048 0.784
MOD_GlcNHglycan 351 357 PF01048 0.728
MOD_GlcNHglycan 360 363 PF01048 0.674
MOD_GlcNHglycan 467 470 PF01048 0.678
MOD_GlcNHglycan 47 51 PF01048 0.391
MOD_GlcNHglycan 478 482 PF01048 0.644
MOD_GSK3_1 141 148 PF00069 0.345
MOD_GSK3_1 200 207 PF00069 0.410
MOD_GSK3_1 226 233 PF00069 0.430
MOD_GSK3_1 320 327 PF00069 0.743
MOD_GSK3_1 352 359 PF00069 0.701
MOD_GSK3_1 448 455 PF00069 0.734
MOD_GSK3_1 456 463 PF00069 0.670
MOD_GSK3_1 46 53 PF00069 0.415
MOD_GSK3_1 465 472 PF00069 0.507
MOD_GSK3_1 473 480 PF00069 0.647
MOD_GSK3_1 5 12 PF00069 0.414
MOD_N-GLC_1 128 133 PF02516 0.438
MOD_N-GLC_1 186 191 PF02516 0.410
MOD_N-GLC_1 200 205 PF02516 0.363
MOD_NEK2_1 462 467 PF00069 0.716
MOD_NEK2_1 9 14 PF00069 0.409
MOD_PIKK_1 186 192 PF00454 0.371
MOD_PKA_1 309 315 PF00069 0.736
MOD_PKA_2 169 175 PF00069 0.342
MOD_PKA_2 309 315 PF00069 0.749
MOD_PKA_2 61 67 PF00069 0.391
MOD_PKB_1 164 172 PF00069 0.357
MOD_PKB_1 424 432 PF00069 0.812
MOD_Plk_1 116 122 PF00069 0.391
MOD_Plk_1 414 420 PF00069 0.758
MOD_Plk_1 438 444 PF00069 0.734
MOD_Plk_1 50 56 PF00069 0.438
MOD_Plk_2-3 363 369 PF00069 0.784
MOD_Plk_2-3 452 458 PF00069 0.641
MOD_Plk_2-3 470 476 PF00069 0.683
MOD_Plk_2-3 5 11 PF00069 0.419
MOD_Plk_4 146 152 PF00069 0.391
MOD_Plk_4 195 201 PF00069 0.438
MOD_Plk_4 414 420 PF00069 0.750
MOD_Plk_4 61 67 PF00069 0.357
MOD_ProDKin_1 320 326 PF00069 0.800
MOD_SUMO_rev_2 131 136 PF00179 0.438
MOD_SUMO_rev_2 205 213 PF00179 0.357
MOD_SUMO_rev_2 240 248 PF00179 0.431
MOD_SUMO_rev_2 281 287 PF00179 0.513
MOD_SUMO_rev_2 292 302 PF00179 0.599
TRG_DiLeu_BaEn_1 11 16 PF01217 0.421
TRG_DiLeu_BaEn_1 414 419 PF01217 0.757
TRG_DiLeu_BaEn_1 439 444 PF01217 0.736
TRG_DiLeu_LyEn_5 11 16 PF01217 0.421
TRG_DiLeu_LyEn_5 439 444 PF01217 0.736
TRG_ENDOCYTIC_2 18 21 PF00928 0.357
TRG_ENDOCYTIC_2 259 262 PF00928 0.357
TRG_ER_diArg_1 164 167 PF00400 0.357
TRG_ER_diArg_1 179 182 PF00400 0.357
TRG_ER_diArg_1 309 311 PF00400 0.792
TRG_ER_diArg_1 344 347 PF00400 0.742
TRG_ER_diArg_1 384 386 PF00400 0.761
TRG_ER_diArg_1 422 424 PF00400 0.765
TRG_ER_diArg_1 440 443 PF00400 0.816
TRG_Pf-PMV_PEXEL_1 179 183 PF00026 0.391

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKV6 Leptomonas seymouri 76% 100%
A0A0S4IPW0 Bodo saltans 53% 100%
A0A3S7WZA7 Leishmania donovani 100% 100%
A4HEE7 Leishmania braziliensis 88% 100%
C9ZJX9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 100%
E9AXM2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q9V0 Leishmania major 97% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS