LeishMANIAdb
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GTP-binding nuclear protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
GTP-binding nuclear protein
Gene product:
GTP-binding protein - putative
Species:
Leishmania infantum
UniProt:
A4I1I6_LEIIN
TriTrypDb:
LINF_250020400
Length:
216

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, GTP-binding

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 8
Forrest at al. (procyclic) yes yes: 8
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 20
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 20
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
TermNameLevelCount
GO:0005634 nucleus 5 10
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0043229 intracellular organelle 3 10
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0110165 cellular anatomical entity 1 10
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Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I1I6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1I6

Function

Biological processes
TermNameLevelCount
GO:0000054 ribosomal subunit export from nucleus 3 1
GO:0006606 protein import into nucleus 5 1
GO:0006810 transport 3 10
GO:0006886 intracellular protein transport 4 1
GO:0006913 nucleocytoplasmic transport 5 10
GO:0008104 protein localization 4 10
GO:0009987 cellular process 1 10
GO:0015031 protein transport 4 10
GO:0031503 protein-containing complex localization 2 1
GO:0033036 macromolecule localization 2 10
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 10
GO:0003824 catalytic activity 1 10
GO:0003924 GTPase activity 7 10
GO:0005488 binding 1 10
GO:0005525 GTP binding 5 10
GO:0016462 pyrophosphatase activity 5 10
GO:0016787 hydrolase activity 2 10
GO:0016817 hydrolase activity, acting on acid anhydrides 3 10
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 10
GO:0017076 purine nucleotide binding 4 10
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 140 142 PF00675 0.297
CLV_PCSK_KEX2_1 29 31 PF00082 0.262
CLV_PCSK_KEX2_1 38 40 PF00082 0.262
CLV_PCSK_PC1ET2_1 29 31 PF00082 0.262
CLV_PCSK_PC1ET2_1 38 40 PF00082 0.262
CLV_PCSK_SKI1_1 107 111 PF00082 0.262
CLV_PCSK_SKI1_1 13 17 PF00082 0.262
CLV_PCSK_SKI1_1 130 134 PF00082 0.262
CLV_PCSK_SKI1_1 135 139 PF00082 0.262
CLV_PCSK_SKI1_1 30 34 PF00082 0.399
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P2Z9 Leptomonas seymouri 27% 92%
A0A0N0P3A0 Leptomonas seymouri 31% 80%
A0A0N0P3G2 Leptomonas seymouri 25% 100%
A0A0N0P6K4 Leptomonas seymouri 90% 100%
A0A0N0P6P8 Leptomonas seymouri 30% 100%
A0A0N0P8I1 Leptomonas seymouri 30% 97%
A0A0N0P971 Leptomonas seymouri 30% 100%
A0A0N1HU31 Leptomonas seymouri 25% 87%
A0A0N1HYV5 Leptomonas seymouri 30% 100%
A0A0N1I011 Leptomonas seymouri 28% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS