Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I1H5_LEIIN

TriTrypDb:

LINF_250019200

Length:

255

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I1H5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1H5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	22	24	PF00675	0.636
CLV_NRD_NRD_1	239	241	PF00675	0.411
CLV_NRD_NRD_1	3	5	PF00675	0.639
CLV_PCSK_KEX2_1	239	241	PF00082	0.411
CLV_PCSK_SKI1_1	240	244	PF00082	0.381
CLV_PCSK_SKI1_1	60	64	PF00082	0.411
DOC_CDC14_PxL_1	91	99	PF14671	0.471
DOC_USP7_MATH_1	122	126	PF00917	0.533
DOC_USP7_MATH_1	138	142	PF00917	0.638
DOC_USP7_MATH_1	150	154	PF00917	0.542
DOC_USP7_MATH_1	168	172	PF00917	0.698
DOC_USP7_MATH_1	3	7	PF00917	0.611
DOC_USP7_MATH_1	35	39	PF00917	0.651
DOC_USP7_MATH_1	8	12	PF00917	0.503
DOC_WW_Pin1_4	174	179	PF00397	0.658
LIG_BRCT_BRCA1_1	5	9	PF00533	0.660
LIG_FHA_1	99	105	PF00498	0.396
LIG_FHA_2	113	119	PF00498	0.484
LIG_FHA_2	220	226	PF00498	0.473
LIG_FHA_2	48	54	PF00498	0.511
LIG_Integrin_RGD_1	230	232	PF01839	0.473
LIG_LIR_Gen_1	80	88	PF02991	0.526
LIG_LIR_Nem_3	245	249	PF02991	0.525
LIG_LIR_Nem_3	88	94	PF02991	0.416
LIG_LYPXL_yS_3	246	249	PF13949	0.528
LIG_PALB2_WD40_1	86	94	PF16756	0.421
LIG_PDZ_Class_3	250	255	PF00595	0.585
LIG_SH2_GRB2like	55	58	PF00017	0.469
LIG_SH2_SRC	192	195	PF00017	0.422
LIG_SH2_STAT5	192	195	PF00017	0.397
LIG_SH2_STAT5	55	58	PF00017	0.404
LIG_SH3_3	241	247	PF00018	0.407
LIG_TRAF2_1	56	59	PF00917	0.432
LIG_TYR_ITIM	244	249	PF00017	0.577
MOD_CK1_1	134	140	PF00069	0.659
MOD_CK1_1	33	39	PF00069	0.618
MOD_CK1_1	77	83	PF00069	0.628
MOD_CK2_1	112	118	PF00069	0.536
MOD_CK2_1	53	59	PF00069	0.403
MOD_CK2_1	96	102	PF00069	0.426
MOD_GlcNHglycan	10	13	PF01048	0.657
MOD_GlcNHglycan	136	139	PF01048	0.657
MOD_GlcNHglycan	140	143	PF01048	0.706
MOD_GlcNHglycan	33	36	PF01048	0.605
MOD_GlcNHglycan	37	40	PF01048	0.617
MOD_GlcNHglycan	71	74	PF01048	0.655
MOD_GlcNHglycan	76	79	PF01048	0.568
MOD_GlcNHglycan	98	101	PF01048	0.440
MOD_GSK3_1	134	141	PF00069	0.600
MOD_GSK3_1	145	152	PF00069	0.707
MOD_GSK3_1	169	176	PF00069	0.777
MOD_GSK3_1	31	38	PF00069	0.632
MOD_GSK3_1	49	56	PF00069	0.499
MOD_N-GLC_1	145	150	PF02516	0.551
MOD_N-GLC_2	156	158	PF02516	0.633
MOD_NEK2_1	62	67	PF00069	0.409
MOD_NEK2_1	69	74	PF00069	0.503
MOD_NEK2_2	112	117	PF00069	0.489
MOD_PIKK_1	62	68	PF00454	0.395
MOD_PKA_2	3	9	PF00069	0.614
MOD_PKA_2	83	89	PF00069	0.511
MOD_Plk_4	93	99	PF00069	0.447
MOD_ProDKin_1	174	180	PF00069	0.648
MOD_SUMO_rev_2	53	62	PF00179	0.416
TRG_DiLeu_BaEn_2	57	63	PF01217	0.477
TRG_DiLeu_BaEn_3	188	194	PF01217	0.412
TRG_DiLeu_BaEn_4	58	64	PF01217	0.414
TRG_ENDOCYTIC_2	246	249	PF00928	0.584
TRG_ER_diArg_1	238	240	PF00400	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXL9	Leptomonas seymouri	52%	95%
A0A1X0NMN4	Trypanosomatidae	32%	100%
A0A3Q8IBS1	Leishmania donovani	100%	100%
A4HE73	Leishmania braziliensis	79%	100%
C9ZJZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AXK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q9W2	Leishmania major	94%	100%