Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PRP38 family - putative

Species:

Leishmania infantum

UniProt:

A4I1H4_LEIIN

TriTrypDb:

LINF_250019100

Length:

659

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	3
GO:0032991	protein-containing complex	1	3
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	3
GO:1990904	ribonucleoprotein complex	2	3
GO:0071011	precatalytic spliceosome	4	2

Expansion

Sequence features

A4I1H4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1H4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006396	RNA processing	6	3
GO:0006397	mRNA processing	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0008380	RNA splicing	7	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0016071	mRNA metabolic process	6	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	424	428	PF00656	0.520
CLV_C14_Caspase3-7	52	56	PF00656	0.728
CLV_C14_Caspase3-7	583	587	PF00656	0.746
CLV_C14_Caspase3-7	616	620	PF00656	0.604
CLV_NRD_NRD_1	114	116	PF00675	0.593
CLV_NRD_NRD_1	122	124	PF00675	0.537
CLV_NRD_NRD_1	292	294	PF00675	0.326
CLV_NRD_NRD_1	366	368	PF00675	0.397
CLV_NRD_NRD_1	537	539	PF00675	0.618
CLV_NRD_NRD_1	629	631	PF00675	0.651
CLV_NRD_NRD_1	645	647	PF00675	0.591
CLV_NRD_NRD_1	649	651	PF00675	0.590
CLV_NRD_NRD_1	96	98	PF00675	0.503
CLV_PCSK_KEX2_1	114	116	PF00082	0.593
CLV_PCSK_KEX2_1	122	124	PF00082	0.537
CLV_PCSK_KEX2_1	261	263	PF00082	0.546
CLV_PCSK_KEX2_1	292	294	PF00082	0.326
CLV_PCSK_KEX2_1	366	368	PF00082	0.397
CLV_PCSK_KEX2_1	535	537	PF00082	0.629
CLV_PCSK_KEX2_1	629	631	PF00082	0.663
CLV_PCSK_KEX2_1	645	647	PF00082	0.589
CLV_PCSK_KEX2_1	96	98	PF00082	0.503
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.546
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.661
CLV_PCSK_SKI1_1	103	107	PF00082	0.400
CLV_PCSK_SKI1_1	129	133	PF00082	0.676
CLV_PCSK_SKI1_1	262	266	PF00082	0.444
CLV_PCSK_SKI1_1	302	306	PF00082	0.597
CLV_PCSK_SKI1_1	315	319	PF00082	0.499
CLV_PCSK_SKI1_1	417	421	PF00082	0.462
CLV_PCSK_SKI1_1	603	607	PF00082	0.705
CLV_PCSK_SKI1_1	646	650	PF00082	0.541
CLV_Separin_Metazoa	263	267	PF03568	0.511
DEG_Nend_UBRbox_2	1	3	PF02207	0.622
DEG_SPOP_SBC_1	179	183	PF00917	0.694
DEG_SPOP_SBC_1	199	203	PF00917	0.711
DOC_ANK_TNKS_1	493	500	PF00023	0.707
DOC_CDC14_PxL_1	388	396	PF14671	0.303
DOC_CYCLIN_RxL_1	259	267	PF00134	0.505
DOC_CYCLIN_RxL_1	413	424	PF00134	0.510
DOC_MAPK_gen_1	366	376	PF00069	0.374
DOC_MAPK_gen_1	629	640	PF00069	0.596
DOC_MAPK_MEF2A_6	367	376	PF00069	0.370
DOC_MAPK_MEF2A_6	633	642	PF00069	0.568
DOC_MAPK_NFAT4_5	633	641	PF00069	0.597
DOC_MAPK_RevD_3	522	538	PF00069	0.722
DOC_PP1_RVXF_1	601	607	PF00149	0.701
DOC_PP2B_LxvP_1	13	16	PF13499	0.407
DOC_PP4_FxxP_1	389	392	PF00568	0.380
DOC_PP4_FxxP_1	42	45	PF00568	0.565
DOC_PP4_FxxP_1	6	9	PF00568	0.488
DOC_USP7_MATH_1	180	184	PF00917	0.690
DOC_USP7_MATH_1	186	190	PF00917	0.643
DOC_USP7_MATH_1	192	196	PF00917	0.679
DOC_USP7_MATH_1	200	204	PF00917	0.578
DOC_USP7_MATH_1	467	471	PF00917	0.738
DOC_USP7_MATH_1	605	609	PF00917	0.608
DOC_WW_Pin1_4	193	198	PF00397	0.773
DOC_WW_Pin1_4	335	340	PF00397	0.399
DOC_WW_Pin1_4	35	40	PF00397	0.632
LIG_14-3-3_CanoR_1	349	355	PF00244	0.461
LIG_14-3-3_CanoR_1	378	382	PF00244	0.359
LIG_14-3-3_CanoR_1	645	649	PF00244	0.580
LIG_Actin_WH2_2	215	230	PF00022	0.532
LIG_APCC_ABBA_1	572	577	PF00400	0.713
LIG_BIR_III_4	586	590	PF00653	0.767
LIG_BRCT_BRCA1_1	477	481	PF00533	0.744
LIG_Clathr_ClatBox_1	573	577	PF01394	0.755
LIG_CSL_BTD_1	428	431	PF09270	0.413
LIG_FHA_1	157	163	PF00498	0.621
LIG_FHA_1	205	211	PF00498	0.484
LIG_FHA_1	282	288	PF00498	0.516
LIG_FHA_1	637	643	PF00498	0.577
LIG_FHA_1	90	96	PF00498	0.432
LIG_FHA_2	303	309	PF00498	0.577
LIG_FHA_2	351	357	PF00498	0.398
LIG_FHA_2	419	425	PF00498	0.510
LIG_FHA_2	45	51	PF00498	0.771
LIG_GBD_Chelix_1	342	350	PF00786	0.477
LIG_GBD_Chelix_1	368	376	PF00786	0.428
LIG_LIR_Apic_2	41	45	PF02991	0.565
LIG_LIR_Gen_1	150	161	PF02991	0.509
LIG_LIR_Gen_1	207	213	PF02991	0.455
LIG_LIR_Gen_1	384	394	PF02991	0.428
LIG_LIR_Gen_1	653	659	PF02991	0.574
LIG_LIR_Nem_3	150	156	PF02991	0.507
LIG_LIR_Nem_3	207	211	PF02991	0.461
LIG_LIR_Nem_3	274	279	PF02991	0.402
LIG_LIR_Nem_3	384	389	PF02991	0.424
LIG_LIR_Nem_3	427	432	PF02991	0.496
LIG_LIR_Nem_3	505	511	PF02991	0.624
LIG_LIR_Nem_3	653	659	PF02991	0.574
LIG_PAM2_1	267	279	PF00658	0.518
LIG_PCNA_PIPBox_1	354	363	PF02747	0.499
LIG_PCNA_yPIPBox_3	417	430	PF02747	0.495
LIG_PDZ_Class_2	654	659	PF00595	0.575
LIG_PTAP_UEV_1	196	201	PF05743	0.689
LIG_PTB_Apo_2	82	89	PF02174	0.560
LIG_PTB_Phospho_1	82	88	PF10480	0.554
LIG_Rb_LxCxE_1	396	416	PF01857	0.471
LIG_SH2_CRK	327	331	PF00017	0.489
LIG_SH2_NCK_1	379	383	PF00017	0.371
LIG_SH2_PTP2	231	234	PF00017	0.486
LIG_SH2_STAT3	320	323	PF00017	0.430
LIG_SH2_STAT5	208	211	PF00017	0.488
LIG_SH2_STAT5	231	234	PF00017	0.487
LIG_SH2_STAT5	243	246	PF00017	0.464
LIG_SH2_STAT5	320	323	PF00017	0.391
LIG_SH2_STAT5	375	378	PF00017	0.387
LIG_SH2_STAT5	379	382	PF00017	0.349
LIG_SH2_STAT5	386	389	PF00017	0.323
LIG_SH2_STAT5	656	659	PF00017	0.598
LIG_SH3_3	141	147	PF00018	0.539
LIG_SH3_3	194	200	PF00018	0.680
LIG_SH3_3	438	444	PF00018	0.515
LIG_SH3_3	521	527	PF00018	0.594
LIG_SH3_3	621	627	PF00018	0.679
LIG_SUMO_SIM_anti_2	555	566	PF11976	0.734
LIG_SUMO_SIM_anti_2	639	644	PF11976	0.555
LIG_TRAF2_1	163	166	PF00917	0.505
LIG_TRAF2_1	26	29	PF00917	0.606
LIG_TRFH_1	379	383	PF08558	0.470
LIG_TYR_ITIM	325	330	PF00017	0.417
MOD_CK1_1	149	155	PF00069	0.522
MOD_CK1_1	182	188	PF00069	0.723
MOD_CK1_1	195	201	PF00069	0.700
MOD_CK1_1	204	210	PF00069	0.502
MOD_CK1_1	281	287	PF00069	0.537
MOD_CK1_1	48	54	PF00069	0.775
MOD_CK1_1	529	535	PF00069	0.606
MOD_CK1_1	59	65	PF00069	0.686
MOD_CK1_1	599	605	PF00069	0.782
MOD_CK2_1	160	166	PF00069	0.454
MOD_CK2_1	23	29	PF00069	0.629
MOD_CK2_1	302	308	PF00069	0.566
MOD_CK2_1	35	41	PF00069	0.685
MOD_CK2_1	44	50	PF00069	0.762
MOD_CK2_1	507	513	PF00069	0.645
MOD_Cter_Amidation	643	646	PF01082	0.620
MOD_GlcNHglycan	139	142	PF01048	0.724
MOD_GlcNHglycan	182	185	PF01048	0.652
MOD_GlcNHglycan	188	191	PF01048	0.596
MOD_GlcNHglycan	197	200	PF01048	0.724
MOD_GlcNHglycan	203	206	PF01048	0.624
MOD_GlcNHglycan	25	28	PF01048	0.642
MOD_GlcNHglycan	293	296	PF01048	0.613
MOD_GlcNHglycan	41	45	PF01048	0.689
MOD_GlcNHglycan	47	50	PF01048	0.776
MOD_GlcNHglycan	598	601	PF01048	0.761
MOD_GlcNHglycan	619	623	PF01048	0.734
MOD_GlcNHglycan	62	65	PF01048	0.699
MOD_GlcNHglycan	77	80	PF01048	0.551
MOD_GSK3_1	132	139	PF00069	0.648
MOD_GSK3_1	156	163	PF00069	0.427
MOD_GSK3_1	166	173	PF00069	0.509
MOD_GSK3_1	178	185	PF00069	0.662
MOD_GSK3_1	195	202	PF00069	0.711
MOD_GSK3_1	40	47	PF00069	0.755
MOD_GSK3_1	463	470	PF00069	0.652
MOD_GSK3_1	55	62	PF00069	0.715
MOD_N-GLC_1	55	60	PF02516	0.757
MOD_NEK2_1	244	249	PF00069	0.626
MOD_NEK2_1	264	269	PF00069	0.495
MOD_NEK2_1	448	453	PF00069	0.516
MOD_NEK2_1	636	641	PF00069	0.533
MOD_NEK2_2	644	649	PF00069	0.588
MOD_PIKK_1	253	259	PF00454	0.544
MOD_PIKK_1	467	473	PF00454	0.704
MOD_PIKK_1	475	481	PF00454	0.700
MOD_PKA_2	291	297	PF00069	0.493
MOD_PKA_2	377	383	PF00069	0.422
MOD_PKA_2	596	602	PF00069	0.559
MOD_PKA_2	644	650	PF00069	0.657
MOD_PKA_2	75	81	PF00069	0.596
MOD_Plk_1	149	155	PF00069	0.550
MOD_Plk_4	149	155	PF00069	0.584
MOD_Plk_4	204	210	PF00069	0.539
MOD_Plk_4	529	535	PF00069	0.570
MOD_Plk_4	638	644	PF00069	0.556
MOD_ProDKin_1	193	199	PF00069	0.772
MOD_ProDKin_1	335	341	PF00069	0.394
MOD_ProDKin_1	35	41	PF00069	0.633
MOD_SUMO_rev_2	274	284	PF00179	0.448
MOD_SUMO_rev_2	615	620	PF00179	0.779
TRG_DiLeu_BaEn_3	335	341	PF01217	0.493
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.498
TRG_ENDOCYTIC_2	208	211	PF00928	0.501
TRG_ENDOCYTIC_2	231	234	PF00928	0.486
TRG_ENDOCYTIC_2	327	330	PF00928	0.370
TRG_ENDOCYTIC_2	386	389	PF00928	0.423
TRG_ENDOCYTIC_2	656	659	PF00928	0.598
TRG_ER_diArg_1	113	115	PF00400	0.606
TRG_ER_diArg_1	122	124	PF00400	0.531
TRG_ER_diArg_1	291	293	PF00400	0.307
TRG_ER_diArg_1	365	367	PF00400	0.440
TRG_ER_diArg_1	536	538	PF00400	0.668
TRG_ER_diArg_1	629	631	PF00400	0.663
TRG_ER_diArg_1	95	97	PF00400	0.499
TRG_NLS_MonoCore_2	534	539	PF00514	0.656
TRG_Pf-PMV_PEXEL_1	509	513	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	523	528	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	538	542	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP9	Leptomonas seymouri	62%	100%
A0A1X0NM33	Trypanosomatidae	32%	100%
A0A3Q8IDC3	Leishmania donovani	100%	100%
A0A422P1Y9	Trypanosoma rangeli	33%	100%
A4HE72	Leishmania braziliensis	83%	100%
C9ZJZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AXK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q9W3	Leishmania major	93%	100%